Abstract: A first remote memory access link is established between a first communications interface card on the first computing device and a second communications interface card on the second computing device. In response to an error associated with the first remote memory access link, messages are copied from a segmented queue associated with the first communications interface card to a segmented queue associated with a third communications interface card on the first computing device. A second remote memory access link between the third communications interface card and a fourth communications interface card is activated on the second computing device, and messages are resent from the segmented queue associated with the third communications interface card to the fourth communications interface card through the second remote memory access link. The second computing device discards duplicate received messages, if any.

Abstract: A writing application on a computing device can reference a tail pointer to write messages to message buffers that a peer-to-peer data link replicates in memory of another computing device. The message buffers are divided into at least two queue segments, where each segment has several buffers. Messages are read from the buffers by a reading application on one of the computing devices using an advancing head pointer by reading a message from a next message buffer when determining that the next message buffer has been newly written. The tail pointer is advanced from one message buffer to another within a same queue segment after writing messages. The tail pointer is advanced from a message buffer of a current queue segment to a message buffer of a next queue segment when determining that the head pointer does not indicate any of the buffers of the next queue segment.

Abstract: The invention provides compositions for preventing or treating kidney disease comprising vitamin E, vitamin C, and a carotenoid and methods for preventing and treating kidney disease comprising administering such compositions to an animal susceptible to or suffering from kidney disease. In a preferred embodiment, the composition is admixed with one or more food ingredients to produce a food composition useful for preventing or treating kidney disease.

Abstract: The present invention provides, in part, compounds of Formula I: and pharmaceutically acceptable salts thereof and N-oxides thereof; processes and intermediates for preparation of; and compositions and uses thereof. The present invention further provides D1 agonists with reduced D1R desensitization, D1 agonists with a reduced ?-arrestin recruitment activity relative to Dopamine, D1 agonists interacting significantly with the Ser188 but not significantly with the Ser202 of a D1R when binding to the D1R, D1 agonists interacting less strongly with the Asp103 and interacting less strongly with the Ser198 of a D1R when binding to the D1R, and their uses.

Abstract: The present invention provides, in part, compounds of Formula I: and pharmaceutically acceptable salts thereof and N-oxides thereof; processes and intermediates for preparation of; and compositions and uses thereof. The present invention further provides D1 agonists with reduced D1R desensitization, D1 agonists with a reduced ?-arrestin recruitment activity relative to Dopamine, D1 agonists interacting significantly with the Ser188 but not significantly with the Ser202 of a D1R when binding to the D1R, D1 agonists interacting less strongly with the Asp103 and interacting less strongly with the Ser198 of a D1R when binding to the D1R, and their uses.

Abstract: The present specification provides a high availability system. In one aspect a replicator is situated between a plurality of servers and a network. Each server is configured to execute a plurality of identical message processors. The replicator is configured to forward messages to two or more of the identical message processors, and to accept a response to the message as being valid if there is a quorum of identical responses.

Abstract: Methods for treating feline hyperthyroidism comprising (1) administering to a feline an antithyroid agent in conjunction with feeding the feline a composition comprising from about 0.1 to less than about 1 mg/kg iodine or (2) feeding the feline a composition comprising from about 0.1 to less than about 1 mg/kg selenium on a dry matter basis.

Abstract: An exercise apparatus includes a frame; a platform configured to receive a person in a standing position, the platform connected to the frame; a handheld component configured to be held by a person standing on the platform; and an impeller-driven fluid circulation system. Manipulation of the handheld component by a person standing on the platform results in driving of the impeller and circulation of fluid within the fluid circulation system. The platform may rock from side to side, whereby a person standing on the platform must maintain balance while manipulating the handheld component. The handheld component may simulate a paddle and may include an elongate shaft. In this respect, the paddle component is used by a person standing on the platform as if the paddle component were a paddle used in paddleboarding, including manipulating the paddle component through a rowing motion that preferably would be experienced when actually paddleboarding.

Abstract: A load estimation system and method for estimating vehicle load includes a tire rotation counter for generating a rotation count from rotation of a tire; apparatus for measuring distance travelled by the vehicle; an effective radius calculator for calculating effective radius of the tire from the distance travelled and the rotation count; and a load estimation calculator for calculating the load carried by the vehicle tire from the effective radius of the tire. A center of gravity height estimation may be made from an estimated total load carried by the tires supporting the vehicle pursuant to an estimation of effective radius for each tire and a calculated load carried by each tire from respective effective radii.

Abstract: A system to initiate funding of a plurality of merchant accounts may include one or more computers configured to receive input specifying at least one payment item having a payment amount, determine a convenience fee based on the at least one payment amount, select a first merchant account based on the at least one specified payment item, and select a second merchant account associated with the convenience fee. The one or more computers may also be configured to receive a single input specifying credit card information, link the payment amount, received credit card information and the first merchant account to form a first transaction, and link the convenience fee, received credit card information and second merchant account to form a second transaction.

Abstract: The present invention provides methods and compositions for inducing expression of Ube3a in a cell by contacting the cell with a topoisomerase inhibitor. Particular embodiments include a method of treating a genomic imprinting disorder, such as Angelman syndrome, in a subject by administering to the subject an effective amount of a topoisomerase inhibitor.

Abstract: A system to initiate funding of a plurality of merchant accounts may include one or more computers configured to receive input specifying at least one payment item having a payment amount, determine a convenience fee based on the at least one payment amount, select a first merchant account based on the at least one specified payment item, and select a second merchant account associated with the convenience fee. The one or more computers may also be configured to receive a single input specifying credit card information, link the payment amount, received credit card information and the first merchant account to form a first transaction, and link the convenience fee, received credit card information and second merchant account to form a second transaction.

Abstract: An exercise apparatus includes a frame; a platform configured to receive a person in a standing position, the platform connected to the frame; a handheld component configured to be held by a person standing on the platform; and an impeller-driven fluid circulation system. Manipulation of the handheld component by a person standing on the platform results in driving of the impeller and circulation of fluid within the fluid circulation system. The platform may rock from side to side, whereby a person standing on the platform must maintain balance while manipulating the handheld component. The handheld component may simulate a paddle and may include an elongate shaft. In this respect, the paddle component is used by a person standing on the platform as if the paddle component were a paddle used in paddleboarding, including manipulating the paddle component through a rowing motion that preferably would be experienced when actually paddleboarding.

Abstract: An exercise apparatus includes a frame; a platform configured to receive a person in a standing position, the platform connected to the frame; a handheld component configured to be held by a person standing on the platform; and an impeller-driven fluid circulation system. Manipulation of the handheld component by a person standing on the platform results in driving of the impeller and circulation of fluid within the fluid circulation system. The platform may rock from side to side, whereby a person standing on the platform must maintain balance while manipulating the handheld component. The handheld component may simulate a paddle and may include an elongate shaft. In this respect, the paddle component is used by a person standing on the platform as if the paddle component were a paddle used in paddleboarding, including manipulating the paddle component through a rowing motion that preferably would be experienced when actually paddleboarding.

Abstract: A pneumatic radial tire has a chipper in place of a traditional apex, the chipper located between a carcass main portion and turnup portion. The chipper layer may be composed of a chopped carbon fiber and aramid composite reinforced elastomeric layer. The tire sidewalls have a radial height SH and a section width SW located within a range of 0.4 to 0.44 of the sidewall radial height SH measured from the bead core. The section width SW may further be located within a range of 0.1? to 0.3? inches from a radially outward end of the chipper layer in a radial direction. The tread may of a dual layer construction, having a radially inward first layer formed of a relatively low rolling resistance compound and a radially outward second layer formed of a compound containing silica.

Abstract: A pneumatic radial tire having a circumferentially extending equatorial plane of the tire, the tire comprising a carcass, a tread radially outward of the carcass, the carcass comprising at least one carcass reinforcing ply, opposing bead portions, and opposing sidewalls, the carcass reinforcing ply having a main portion extending between the opposing bead portions and a pair of turnup portions, each turnup portion extending from one end of the main portion, each bead portion having a bead core, and a reinforcement cavity outward of each bead core, the cavity located between the main portion and one turnup portion of the at least one reinforcing ply, the tire characterized by: the tread comprising a radially outer tread cap and a radially inner tread base radially underneath the tread cap, the tread base comprising a rubber composition comprising from 15 to 45 phr of styrene-butadiene rubber; from 20 to 50 phr of polybutadiene; and from 10 to 35 phr of natural or synthetic polyisoprene, and from 35 to 65 ph

Abstract: A pneumatic tire includes a tread base comprised of a first material, a tread cap comprised of a second material, and a plurality of plugs comprised of a third material. The tread cap is disposed radially outward of the tread base and in operational contact with a ground surface. The plurality of plugs are disposed at least partially within the tread cap. The plurality of plugs yield a tread stiffness in one direction greater than stiffness in at least one other direction.

Abstract: The invention relates to a tire having a rubber tread comprised of cap/base construction where the tread outer cap rubber layer contains the running surface of the tread and the tread base rubber layer underlies the tread cap layer wherein the base layer provides a transition zone between the tread cap layer and the remainder of the tire carcass and is not intended to be ground-contacting. For this invention, the tread base rubber layer is comprised of three distinct zones, namely a circumferential annular central rubber zone positioned between two lateral annular rubber zones. In one aspect, the rubber tread cap layer and zoned rubber tread base layer are co-extruded together to form an integral tread rubber composite.

Abstract: A pneumatic radial tire having a circumferentially extending equatorial plane of the tire, the tire comprising a carcass, a tread radially outward of the carcass, the carcass comprising at least one carcass reinforcing ply, opposing bead portions, and opposing sidewalls, the carcass reinforcing ply having a main portion extending between the opposing bead portions and a pair of turnup portions, each turnup portion extending from one end of the main portion, each bead portion having a bead core, and a reinforcement cavity outward of each bead core, the cavity located between the main portion and one turnup portion of the at least one reinforcing ply, the tire characterized by: the tread comprising a radially outer tread cap and a radially inner tread base radially underneath the tread cap, the tread base comprising a rubber composition comprising from 15 to 45 phr of styrene-butadiene rubber; from 20 to 50 phr of polybutadiene; and from 10 to 35 phr of natural or synthetic polyisoprene, and from 35 to 65 ph