Patents by Inventor Arul M. Chinnaiyan

Arul M. Chinnaiyan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SYSTEMS AND METHODS FOR DETERMINING A TREATMENT COURSE OF ACTION
    Publication number: 20150141391
    Abstract: The present disclosure relates to methods of determining a treatment course of action. In particular, the present disclosure relates to mutations in the gene encoding estrogen receptor and their association with responsiveness to estrogen therapies for cancer.
    Type: Application
    Filed: October 14, 2014
    Publication date: May 21, 2015
    Inventors: Arul M. Chinnaiyan, Dan Robinson, Yi-Mi Wu
  • RECURRENT GENE FUSIONS IN PROSTATE CANCER
    Publication number: 20140364331
    Abstract: The present invention relates to compositions and methods for cancer diagnosis, research and therapy, including but not limited to, cancer markers. In particular, the present invention relates to recurrent gene fusions as diagnostic markers and clinical targets for prostate cancer.
    Type: Application
    Filed: June 11, 2014
    Publication date: December 11, 2014
    Inventors: Arul M. Chinnaiyan, Xiaosong Wang
  • ADRB2 cancer markers
    Patent number: 8900819
    Abstract: The present invention relates to compositions and methods for cancer diagnosis, research and therapy, including but not limited to, cancer markers. In particular, the present invention relates to ADRB2 markers for cancer.
    Type: Grant
    Filed: November 1, 2011
    Date of Patent: December 2, 2014
    Assignee: The Regents of The University of Michigan
    Inventors: Arul M. Chinnaiyan, Jindan Yu, Rohit Mehra
  • Gene fusion targeted therapy
    Patent number: 8759301
    Abstract: The present invention relates to compositions and methods for cancer therapy, including but not limited to, targeted inhibition of cancer markers. In particular, the present invention relates to recurrent gene fusions as clinical targets for prostate cancer.
    Type: Grant
    Filed: February 10, 2011
    Date of Patent: June 24, 2014
    Assignee: The Regents of The University of Michigan
    Inventors: Arul M. Chinnaiyan, Xiaoju Wang, Ram Shankar Mani
  • Compositions and methods for inhibiting MMSET
    Patent number: 8697407
    Abstract: The present invention relates to agents that find use in the treatment, management, and/or study of cancer. In particular, the present invention relates to agents (e.g., small molecules, nucleic acids) that affect MMSET expression or activity.
    Type: Grant
    Filed: February 11, 2011
    Date of Patent: April 15, 2014
    Assignee: The Regents of The University of Michigan
    Inventors: Arul M. Chinnaiyan, Sooryanaryana Lnu, Qi Cao, Irfan Asangani
  • METABOLOMIC PROFILING OF CANCER
    Publication number: 20140051601
    Abstract: The present invention relates to cancer markers. In particular, the present invention provides metabolites that are differentially present in prostate cancer.
    Type: Application
    Filed: August 2, 2013
    Publication date: February 20, 2014
    Applicants: METABOLAN INC., THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Arul M. Chinnaiyan, Arun Sreekumar, Matthew W. Mitchell, Kay A. Lawton, Alvin Berger, Christopher Beecher
  • METABOLOMIC PROFILING OF PROSTATE CANCER
    Publication number: 20130261022
    Abstract: The present invention relates to cancer markers. In particular, the present invention provides metabolites and panels of metabolites that are differentially present in cancer (e.g., prostate or breast cancer).
    Type: Application
    Filed: March 12, 2013
    Publication date: October 3, 2013
    Applicant: The Regents of The University of Michigan
    Inventors: Arul M. Chinnaiyan, Thekkelnaycke Rajendiran
  • Compositions and methods for inhibiting EZH2
    Patent number: 8524682
    Abstract: The present invention relates to therapeutic targets for cancer. In particular, the present invention relates to small molecules and nucleic acids that target EZH2 expression in prostate cancer.
    Type: Grant
    Filed: May 12, 2010
    Date of Patent: September 3, 2013
    Assignee: The Regents of the University of Michigan
    Inventors: Arul M. Chinnaiyan, Sooryanarayana Lnu, Qi Cao
  • PROSTATE CANCER MARKERS AND USES THEREOF
    Publication number: 20130225433
    Abstract: The present invention relates to compositions and methods for cancer diagnosis, research and therapy, including but not limited to, cancer markers. In particular, the present invention relates to mutations in cancer markers as diagnostic markers and clinical targets for prostate cancer.
    Type: Application
    Filed: February 28, 2013
    Publication date: August 29, 2013
    Applicant: THE REGENTS OF THE UNIVERSITYS OF MICHAGAN
    Inventors: Arul M. Chinnaiyan, Scott A. Tomlins
  • PSEUDOGENES AND USES THEREOF
    Publication number: 20130189679
    Abstract: The present invention relates to compositions and methods for cancer diagnosis, research and therapy, including but not limited to, cancer markers. In particular, the present invention relates to pseudogenes as diagnostic markers and clinical targets for prostate cancer.
    Type: Application
    Filed: December 19, 2012
    Publication date: July 25, 2013
    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Arul M. Chinnaiyan, Chandan Kumar-Sinha, Shanker Kalyana-Sundaram
  • RECURRENT GENE FUSIONS IN BREAST CANCER
    Publication number: 20130096021
    Abstract: The present disclosure relates to compositions and methods for cancer diagnosis, research and therapy, including but not limited to, cancer markers. In particular, the present disclosure relates to gene fusions as diagnostic markers and clinical targets for breast cancer.
    Type: Application
    Filed: September 27, 2012
    Publication date: April 18, 2013
    Inventors: Arul M. Chinnaiyan, Chandan Kumar-Sinha, Dan Robinson, Shanker Kalyana-Sundaram
  • DNA METHYLATION PROFILES IN CANCER
    Publication number: 20130022974
    Abstract: The present invention relates to compositions and methods for cancer diagnosis, research and therapy, including but not limited to, cancer markers. In particular, the present invention relates to methylation levels of genes (e.g., in CGI islands of the promoter regions) as diagnostic markers and clinical targets for prostate cancer.
    Type: Application
    Filed: June 14, 2012
    Publication date: January 24, 2013
    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Arul M. Chinnaiyan, Mohan Saravana Dhanasekaran, Jung Kim
  • Gene fusion targeted therapy
    Patent number: 8143232
    Abstract: The present invention relates to compositions and methods for cancer therapy, including but not limited to, targeted inhibition of cancer markers. In particular, the present invention relates to recurrent gene fusions as clinical targets for prostate cancer.
    Type: Grant
    Filed: March 3, 2010
    Date of Patent: March 27, 2012
    Assignee: The Regents of the University of Michigan
    Inventors: Arul M. Chinnaiyan, Jindan Yu, Ram Shankar Mani
  • ADRB2 Cancer Markers
    Publication number: 20120046196
    Abstract: The present invention relates to compositions and methods for cancer diagnosis, research and therapy, including but not limited to, cancer markers. In particular, the present invention relates to ADRB2 markers for cancer.
    Type: Application
    Filed: November 1, 2011
    Publication date: February 23, 2012
    Applicant: The Regents of the University of Michigan
    Inventors: Arul M. Chinnaiyan, Jindan Yu, Rohit Mehra
  • PARP1 TARGETED THERAPY
    Publication number: 20120035244
    Abstract: The present invention relates to compositions and methods for cancer therapy, including but not limited to, targeted inhibition of cancer markers. In particular, the present invention relates to PARP1 proteins and nucleic acids as clinical and research targets for cancer.
    Type: Application
    Filed: July 27, 2011
    Publication date: February 9, 2012
    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Arul M. Chinnaiyan, J. Chad Brenner, Anastasia Yocum
  • RECURRENT GENE FUSIONS IN CANCER
    Publication number: 20120015839
    Abstract: The present invention relates to compositions and methods for cancer diagnosis, research and therapy, including but not limited to, cancer markers. In particular, the present invention relates to recurrent gene fusions as diagnostic markers and clinical targets for cancer (e.g., prostate cancer).
    Type: Application
    Filed: January 8, 2010
    Publication date: January 19, 2012
    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventor: Arul M. Chinnaiyan
  • ADRB2 cancer markers
    Patent number: 8058003
    Abstract: The present invention relates to compositions and methods for cancer diagnosis, research and therapy, including but not limited to, cancer markers. In particular, the present invention relates to ADRB2 markers for cancer.
    Type: Grant
    Filed: January 18, 2008
    Date of Patent: November 15, 2011
    Assignee: The Regents of the University of Michigan
    Inventors: Arul M. Chinnaiyan, Jindan Yu, Rohit Mehra
  • COMPOSITIONS AND METHODS FOR INHIBITING EZH2
    Publication number: 20110251216
    Abstract: The present invention relates to therapeutic targets for cancer. In particular, the present invention relates to small molecules and nucleic acids that target EZH2 expression in cancer (e.g., prostate cancer, breast cancer, other solid tumors, multiple myeloma).
    Type: Application
    Filed: February 10, 2011
    Publication date: October 13, 2011
    Applicant: The Regents of The University of Michigan
    Inventors: Arul M. Chinnaiyan, Sooryanaryana Lnu, Qi Cao
  • USING PHAGE EPITOPES TO PROFILE THE IMMUNE RESPONSE
    Publication number: 20110237461
    Abstract: The present disclosure provides compositions and methods for using one or more polypeptide probes to profile an immune response. The polypeptide probe can be used to detect one or more antibodies from a sample. Furthermore, the present disclosure provides methods and compositions for characterizing a cancer based on the detection of one or more antibodies, such as autoantibodies.
    Type: Application
    Filed: March 17, 2011
    Publication date: September 29, 2011
    Applicants: THE REGENTS OF THE UNIVERSITY OF MICHIGAN, ARMUNE BIOSCIENCES, INC.
    Inventors: Arul M. Chinnaiyan, Xiaoju Wang, Alex Tsodikov, Jeanne Ohrnberger
  • COMPOSITIONS AND METHODS FOR INHIBITING MMSET
    Publication number: 20110207198
    Abstract: The present invention relates to agents that find use in the treatment, management, and/or study of cancer. In particular, the present invention relates to agents (e.g., small molecules, nucleic acids) that affect MMSET expression or activity.
    Type: Application
    Filed: February 11, 2011
    Publication date: August 25, 2011
    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Arul M. Chinnaiyan, Sooryanaryana Lnu, Qi Cao, Irfan Asangani