Abstract: Described herein is a unique cell culture media that allows optimal growth of multiple cell types in the same system such as an organ-on-chip or organoid. Also described herein is use of the cell culture media in growing multiple cardiovascular cell types simultaneously in a single device or producing induced pluripotent stem cell (iPSC)-derived cardiac organoids containing iPSC derived-endothelial cells (iPSC-ECs) and iPSC derived-cardiomyocytes (iPSC-CMs). In some embodiments, a formulation for the cell culture media includes a base medium including glucose, a pH indicator, salts, amino acids, and vitamins; recombinant human albumin; L-ascorbic acid 2-phosphate; and at least one or more of insulin, vascular endothelial growth factor (VEGF), epidermal growth factor (EGF), basic fibroblast growth factor (bFGF), a synthetic analogue of insulin-like growth factor (IGF)-I, heparin, or hydrocortisone.

Abstract: In various aspects, systems and methods are provided for operating an oxygen-fired catalyst regenerator with flue gas recycle and CO2 capture. An oxygen-fired catalyst regenerator contrasts with an air-fired regenerator. The oxygen-fired catalyst regenerator substantially reduces nitrogen within the system, which facilitates CO2 capture by reducing the energy required to capture CO2. In various aspects, a first portion of the regenerator flue gas is passed to a CO2 capture system and a second portion is recycled to the regenerator. Before the flue gas is recycled or diverted to the CO2 capture, it is passed to various processes that remove and/or reduce SOx, NOx, particulate, and water content. In various aspects, a portion of the treated flue gas may be combined with substantially pure O2 and recycled to the regenerator.

Abstract: Provided herein are populations of bone marrow mesenchymal stem cells (MSCs) and CD34+ hematopoietic stem/progenitor cells (HSPCs), and methods of isolation and co-administration thereof. In particular, cell populations and methods of co-administration thereof are provided for enhancing tissue (e.g., bladder) regeneration.

Abstract: The present invention is directed to compounds and compositions comprising thereof. Further, methods of use such as for the treatment and prevention of a disorder associated with binding of IGF2BP1 to an RNA in a subject in need thereof are also provided.

Abstract: The present disclosure is directed to a compound or compositions comprising the same for decreasing vascular permeability and the prevention or inhibition of metastasis in a cancer.

Abstract: Described herein are particular infection model systems, methods of studying infection, and method of screening compounds in various model systems. Particularly, SARS-CoV-2 is studied in these organ and infection models.

Abstract: Described herein is a human, cardiovascular platform for assessing cardiotoxicity of novel/existing chemotherapeutic agents that takes advantage of microfluidic organ chip systems to examine interaction between hiPSC-derived cardiovascular cells in an integrated system. Human induced pluripotent stem cell derived cardiomyocytes (hiPSC-CMs) and human induced pluripotent stem cell derived endothelial cells (hiPSC-ECs) can serve as an in-vitro platform for assessing disease pathology, including infectious disease, evaluate drug efficacy, toxicity, cardiotoxicity and cardioprotection. This includes evaluating VEGFR2/PDGFR-inhibiting tyrosine kinase inhibitors and drug efficacy in a viral infection model, including coronaviruses. They are scalable, functionally-active cell types that mimic the cells comprising the myocardium and systemic vasculature.

Abstract: Techniques regarding the development and/or analysis of one or more quantum computing programs are provided. For example, one or more embodiments described herein can comprise a system, which can comprise a memory that can store computer executable components. The system can also comprise a processor, operably coupled to the memory, and that can execute the computer executable components stored in the memory. The computer executable components can comprise a circuit component, operatively coupled to the processor, that can create a quantum computing program over a period of time. The computer executable components can also comprise a visualization component, operatively coupled to the processor, that can generates a quantum state visualization that depicts a characterization of the quantum computing program over the period of time.

Abstract: The invention provides Angelonia plants comprising a recessive amf1-1 allele that confers to the plant a desired flower color, wherein said flower color is of a higher intensity when at least two copies of said allele are present in a plant when compared to the flower color of a plant lacking said at least two alleles and methods for producing a plant produced by crossing such plants with themselves or with another plant, such as a plant of another genotype. The invention further relates to seeds and plants produced by crossing Angelonia plants comprising a recessive amf1-1 allele. The invention further relates to parts of such plants.

Abstract: An organic substrate and method of making with optimal thermal warp characteristics is disclosed. The organic substrate has one or more top layers and one or more bottom layers. A chip footprint region is a surface region on each of the top and bottom layers that is defined as the projection of one or more semiconductor chips (chips) on the surface of each of the top and bottom layers. One or more top removal patterns are located on and may or may not remove material from the surface of one or more of the top layers within the chip footprint region of the respective top layer. One or more bottom removal patterns are located on and remove material from the surface of one or more of the bottom layers outside the chip footprint region of the respective bottom layer. The removal of the material from one or more of the top layers and/or bottom layers changes and optimizes a thermal warp of the organic substrate.

Abstract: One embodiment relates to seed and plants of inbred pepper line PPL1511. Another embodiment relates to the plants, seeds and tissue cultures of inbred pepper line PPL1511, and to methods for producing a pepper plant produced by crossing such plants with themselves, with another pepper plant, such as a plant of another genotype, or with vegetatively propagating said plant. Another embodiment further relates to seeds and plants produced by such crossing. Further embodiments relate to parts of such plants, including the fruit and gametes of such plants. Further embodiments relate to hybrid produced by using inbred pepper line PPL1511 as a parent, said hybrids including XPP2617, XPP2618, SPP2622, SPP2628, XP2657, XPP2658, XPP2659, XPP2660, and XPP2663.

Abstract: An organic substrate and method of making with optimal thermal warp characteristics is disclosed. The organic substrate has one or more top layers and one or more bottom layers. A chip footprint region is a surface region on each of the top and bottom layers that is defined as the projection of one or more semiconductor chips (chips) on the surface of each of the top and bottom layers. One or more top removal patterns are located on and may or may not remove material from the surface of one or more of the top layers within the chip footprint region of the respective top layer. One or more bottom removal patterns are located on and remove material from the surface of one or more of the bottom layers outside the chip footprint region of the respective bottom layer. The removal of the material from one or more of the top layers and/or bottom layers changes and optimizes a thermal warp of the organic substrate.

Abstract: A pressure testing module separable from and configured to be coupled with a tool base that is to be coupled along a downhole tool string to be conveyed within a wellbore extending into a subterranean formation. The pressure testing module includes a chamber and a piston assembly slidably disposed within the chamber, thus dividing the chamber into a first chamber portion and a second chamber portion. The piston assembly is operable to move in response to hydraulic fluid being pumped into the first chamber portion and to draw formation fluid of the wellbore into the second chamber portion in response to the movement of the piston assembly.

Abstract: Provided herein are anti-inflammatory peptide amphiphiles (AIF-PAs) and methods of use thereof. In particular, nanofiber of AIF-PAs are provided and methods of use thereof in the treatment of inflammatory bowel diseases (e.g., Crohn's disease).

Abstract: One embodiment relates to seed and plants of inbred pepper line PPL1511. Another embodiment relates to the plants, seeds and tissue cultures of inbred pepper line PPL1511, and to methods for producing a pepper plant produced by crossing such plants with themselves, with another pepper plant, such as a plant of another genotype, or with vegetatively propagating said plant. Another embodiment further relates to seeds and plants produced by such crossing. Further embodiments relate to parts of such plants, including the fruit and gametes of such plants. Further embodiments relate to hybrid produced by using inbred pepper line PPL1511 as a parent, said hybrids including XPP2617, XPP2618, SPP2622, SPP2628, XP2657, XPP2658, XPP2659, XPP2660, and XPP2663.

Abstract: Methods for expanding beating cardiomyocytes, comprising treating the beating cardiomyocytes with one or more Wnt agonists, one or more bioactive lipids or a combination of one or more Wnt agonists and one or more bioactive lipids. Methods for differentiating stem cells, including iPS cells, into beating cardiomyocytes, comprising treating the iPS cells with a combination of one or more Wnt agonists and one or more bioactive lipids. Compositions and kits for regenerative medicine, comprising beating cardiomyocytes, one or more Wnt agonists and one or more bioactive lipids.

Abstract: The present invention provides compositions and methods for the regeneration of tissue. In particular, the present invention provides mesenchymal stem cells (MSCs) and endothelial progenitor cells (EPCs) for bladder regeneration.

Abstract: A pressure testing module separable from and configured to be coupled with a tool base that is to be coupled along a downhole tool string to be conveyed within a wellbore extending into a subterranean formation. The pressure testing module includes a chamber and a piston assembly slidably disposed within the chamber, thus dividing the chamber into a first chamber portion and a second chamber portion. The piston assembly is operable to move in response to hydraulic fluid being pumped into the first chamber portion and to draw formation fluid of the wellbore into the second chamber portion in response to the movement of the piston assembly.

Abstract: A method includes determining, by a computer, measures of recency for a plurality of issues that are associated with a plurality of devices of a computer system; and determining, by the computer, measures of frequency for the plurality of issues. The method includes prioritizing, by the computer, the plurality of issues for review based on the determined measures of recency and frequency.

Abstract: A pressure testing module separable from and configured to be coupled with a tool base that is to be coupled along a downhole tool string to be conveyed within a wellbore extending into a subterranean formation. The pressure testing module includes a chamber and a piston assembly slidably disposed within the chamber, thus dividing the chamber into a first chamber portion and a second chamber portion. The piston assembly is operable to move in response to hydraulic fluid being pumped into the first chamber portion and to draw formation fluid of the wellbore into the second chamber portion in response to the movement of the piston assembly.