Abstract: Pharmaceutical compositions of metabotropic glutamate 5 receptor (mGlu5) antagonists or a pharmacologically acceptable salt thereof are disclosed. The compositions contain the therapeutic active compound with non-ionic polymer and ionic polymer, binder and fillers in either matrix pellet, matrix tablet or coated pellets. The compositions provide a pH-independent in vitro release profile with NMT 70% in one hour, NMT 85% in 4 hour, and NLT 80% m 8 hours. The compositions are useful for the treatment of CNS disorders, such as Treatment-Resistant Depression (TRD) and Fragile X Syndrome.

Abstract: A rescue breathing apparatus is disclosed. The apparatus is an automatic rescue breathing unit (ARBU) device that includes two sub-systems—an airway device keying mechanism and a ventilation unit. The keying mechanism may trigger and determine breath profile and parameters delivered by the ventilation unit. The ARBU device may connect to an air/oxygen source via a pressure regulator. The ARBU device may include a manifold, a keying chamber, an adult channel for providing breath to adult patients, a child channel for providing breath to child patients, and an infant channel for providing breath to infant patients. The ARBU device may also include a constant flow channel.

Abstract: A standard deviation based method for detection and quantification of stiction in a control valve in a process control loop is provided, the process control loop having a sensor for measuring a process parameter or variable (PV) and a controller for controlling the control valve, whereby the controller compares the process parameter or variable (PV) to a set point value (SP) for a stable operation of the process and provides an output signal (OP) for controlling the control valve.

Abstract: A tourniquet for occluding blood flow to a limb is improved by the addition of proximal and distal strain gauges. The proximal strain gauge may be monitored under conditions of total blood flow occlusion for time-varying signals indicative of volumetric limb changes arising from the subject's blood flow in the proximal section of the limb. Upon a change in limb occlusion pressure, the signals from the proximal strain gauge can be observed to change also, and the working pressure in the tourniquet can be adjusted safely in response. Automated control systems may further use inputs from a distal strain gauge and/or from a sensor that detects induced pressure changes within the tourniquet to improve the control of the tourniquet working pressure during operation to avoid unwanted blood flow past the tourniquet.

Abstract: A rescue breathing apparatus is disclosed. The apparatus is an automatic rescue breathing unit (ARBU) device that includes two sub-systems—an airway device keying mechanism and a ventilation unit. The keying mechanism may trigger and determine breath profile and parameters delivered by the ventilation unit. The ARBU device may connect to an air/oxygen source via a pressure regulator. The ARBU device may include a manifold, a keying chamber, an adult channel for providing breath to adult patients, a child channel for providing breath to child patients, and an infant channel for providing breath to infant patients. The ARBU device may also include a constant flow channel.

Abstract: Disclosed autonomous mobile robot systems can be used to safely and efficiently navigate through a facility while avoiding objects in the path of the autonomous mobile robot during completion of a task. Specifically, a first bounded area based on first sensor data may be generated around an autonomous mobile robot where the first sensor data is used to identify objects in a travel path for the autonomous mobile robot and determine a speed for navigating the facility. A second bounded area of a size less than the first bounded area may be generated around the autonomous mobile robot based on speed information from propulsion components of the autonomous mobile robot. A new travel path and new speed information may be generated based on identifying an object in the travel path, dimensional measurements of a space around the object, and a current size of the second bounded area.

Abstract: A tourniquet for occluding blood flow to a limb is improved by the addition of proximal and distal strain gauges. The proximal strain gauge may be monitored under conditions of total blood flow occlusion for time-varying signals indicative of volumetric limb changes arising from the subject's blood flow in the proximal section of the limb. Upon a change in limb occlusion pressure, the signals from the proximal strain gauge can be observed to change also, and the working pressure in the tourniquet can be adjusted safely in response. Automated control systems may further use inputs from a distal strain gauge and/or from a sensor that detects induced pressure changes within the tourniquet to improve the control of the tourniquet working pressure during operation to avoid unwanted blood flow past the tourniquet.

Abstract: The method for generating captions, subtitles and dubbing for audiovisual media uses a machine learning-based approach for automatically generating captions from the audio portion of audiovisual media, and further translates the captions to produce both subtitles and dubbing. A speech component of an audio portion of audiovisual media is converted into at least one text string which includes at least one word. Temporal start and end points for the at least one word are determined, and the at least one word is visually inserted into the video portion of the audiovisual media. The temporal start and end points for the at least one word are synchronized with corresponding temporal start and end points of the speech component of the audio portion of the audiovisual media. A latency period may be selectively inserted into broadcast of the audiovisual media such that the synchronization may be selectively adjusted during the latency period.

Abstract: A tourniquet for occluding blood flow to a limb is improved by the addition of proximal and distal strain gauges. The proximal strain gauge may be monitored under conditions of total blood flow occlusion for time-varying signals indicative of volumetric limb changes arising from the subject's blood flow in the proximal section of the limb. Upon a change in limb occlusion pressure, the signals from the proximal strain gauge can be observed to change also, and the working pressure in the tourniquet can be adjusted safely in response. Automated control systems may further use inputs from a distal strain gauge and/or from a sensor that detects induced pressure changes within the tourniquet to improve the control of the tourniquet working pressure during operation to avoid unwanted blood flow past the tourniquet.

Abstract: Systems and methods are provided herein for coordinating movement of components of a workspace utilizing a controller device. The controller device may operate in a first state. The computing device may be associated with an interaction area having a first access point and a second access point, wherein a light curtain is generated at the first access point. While operating in the first state, access to the interaction area is restricted. The computing device may transition to operating in a second state based at least in part on detecting the first breach, wherein operating in the second state comprises enabling access to the interaction area at the second access point. While operating in the second state, a second breach of the light curtain may be detected and at least one remedial action performed based on the detection.

Abstract: Systems and methods are provided herein for utilizing controller device within a workspace. The controller device may operate in a first state to monitor a light curtain associated with an interaction area of the workspace and to cause an indication of the first state to be presented at an indicator device associated with the interaction area. While operating in the first state, the controller device may detect a breach of the light curtain. The controller device may perform at least one remedial action based at least in part on detecting the breach of the light curtain while operating in the first state.

Abstract: Disclosed herein are single-use integral indicators and methods and systems for employing the same. Such indicators and their uses are directed toward identifying and rendering inoperable single-procedure medical devices after their intended—and only—use.

Abstract: Exemplary embodiments relate to techniques for supplying increased power to an augmentation device without increasing battery size. For example, the load may be a motor that provides augmentation power to a joint of a prosthetic ankle, and which is generally powered by a battery. A reconfigurable electrical circuit may connect a supercapacitor in series with the battery to boost the power from the battery at times when a pulse of increased power is demanded. For instance, states of one or more switches of the electrical circuit may be changed in order to briefly disconnect the motor from the circuit just prior to a powered plantarflexion phase of a gait cycle of the ankle, and then to reconnect the motor to a reconfigured circuit to provide a power boost. The circuit may also be reconfigured to allow the battery to recharge the supercapacitor during periods of nominal power demand.

Abstract: Disclosed herein are single use indicators and methods for employing the same. Such indicators and their uses are directed towards identifying the discharge status of single procedure devices, which are typically, but not limited to, medical devices.

Abstract: Disclosed autonomous mobile robot systems can be used to safely and efficiently navigate through a facility while avoiding objects in the path of the autonomous mobile robot during completion of a task. Specifically, a safety zone of a first size may be generated around an autonomous mobile robot based at least in part on first data from a first set of sensors associated with the autonomous mobile robot that are configured to identify an object within the safety zone. Information indicating a current speed of the autonomous mobile robot from associated propulsion components may be received and utilized to update the first size and a shape of the safety zone. Instructions to cease propulsion of the autonomous mobile robot may be transmitted to the propulsion components based on first data identifying the object within the updated first size of the safety zone.

Abstract: Disclosed herein are single-use integral indicators and methods and systems for employing the same. Such indicators and their uses are directed toward identifying and rendering inoperable single-procedure medical devices after their intended—and only—use.

Abstract: A method and system for controlling a tourniquet establishes a set of values for a characteristic of an induced pressure pulse in the tourniquet while the tourniquet is inflated to a working pressure which is at a predetermined offset above the limb occlusion pressure. Maximum and minimum thresholds for this characteristic value are established, such that during the working phase of application of the tourniquet the induced pressure pulse is continually monitored and the value of the characteristic is compared to the thresholds. If a threshold is reached the tourniquet is inflated or deflated accordingly to restore the value of the characteristic to within the thresholds. The characteristic of the induced pressure pulse, which may be e.g. pulse height, area under pulse or pulse width at a percentage of peak height, may also be used to determine behaviour of the pressure pulse by noting a variation in the rate of change as the tourniquet is inflated past the limb occlusion pressure.

Abstract: Disclosed autonomous mobile robot systems can be used to safely and efficiently navigate through a facility while avoiding objects in the path of the autonomous mobile robot during completion of a task. Specifically, a first bounded area based on first sensor data may be generated around an autonomous mobile robot where the first sensor data is used to identify objects in a travel path for the autonomous mobile robot and determine a speed for navigating the facility. A second bounded area of a size less than the first bounded area may be generated around the autonomous mobile robot based on speed information from propulsion components of the autonomous mobile robot. A new travel path and new speed information may be generated based on identifying an object in the travel path, dimensional measurements of a space around the object, and a current size of the second bounded area.

Abstract: Exemplary embodiments relate to techniques for supplying increased power to an augmentation device without increasing battery size. For example, the load may be a motor that provides augmentation power to a joint of a prosthetic ankle, and which is generally powered by a battery. A reconfigurable electrical circuit may connect a supercapacitor in series with the battery to boost the power from the battery at times when a pulse of increased power is demanded. For instance, states of one or more switches of the electrical circuit may be changed in order to briefly disconnect the motor from the circuit just prior to a powered plantarflexion phase of a gait cycle of the ankle, and then to reconnect the motor to a reconfigured circuit to provide a power boost. The circuit may also be reconfigured to allow the battery to recharge the supercapacitor during periods of nominal power demand.

Abstract: The present invention is directed to an electrolyte for an electrolytic capacitor. The capacitor has an electrolytic anode and an electrochemical cathode. The electrolyte has water, a water soluble organic salt, and a relatively weak organic acid. This electrolyte is chemically compatible to aluminum and tantalum oxide dielectrics and withstands higher voltage while maintaining good conductivity. This makes the electrolyte especially useful for high voltage applications, such as occur in an implantable cardiac defibrillator.