Patents by Inventor Ashutosh Chilkoti

Ashutosh Chilkoti has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Therapeutic agents comprising insulin and elastin-like peptides
    Patent number: 9127047
    Abstract: The present invention provides therapeutic agents and compositions comprising elastin-like peptides (ELPs) and therapeutic proteins. In some embodiments, the therapeutic protein is a GLP-1 receptor agonist, insulin, or Factor VII/VIIa, including functional analogs. The present invention further provides encoding polynucleotides, as well as methods of making and using the therapeutic agents. The therapeutic agents have improvements in relation to their use as therapeutics, including, inter alia, one or more of half-life, clearance and/or persistence in the body, solubility, and bioavailability.
    Type: Grant
    Filed: June 15, 2012
    Date of Patent: September 8, 2015
    Assignee: DUKE UNIVERSITY
    Inventor: Ashutosh Chilkoti
  • PHASE TRANSITION BIOPOLYMERS AND METHODS OF USE
    Publication number: 20150112022
    Abstract: The present disclosure describes environmentally responsive polypeptides capable of displaying stimuli-triggered conformational changes in a reversible or irreversible manner that may be accompanied by aggregation. Polypeptides include a number of repeated motifs and may be elastomeric or non-elastomeric. The polypeptides may be used to deliver therapeutics to a biological site and to develop bioactive polypeptides that are environmentally responsive.
    Type: Application
    Filed: December 16, 2014
    Publication date: April 23, 2015
    Inventors: Ashutosh Chilkoti, Felipe Garcia Quiroz, Miriam Amiram
  • THERAPEUTIC AGENTS COMPRISING ELASTIC PEPTIDES
    Publication number: 20150080306
    Abstract: The present invention provides therapeutic agents and compositions comprising elastic peptides and therapeutic proteins. Such peptides exhibit a flexible, extended conformation. In some embodiments, the therapeutic protein is a GLP-1 receptor agonist (e.g., GLP-1, exendin), insulin, or Factor VII/VIIa, including functional analogs. The present invention further provides encoding polynucleotides, as well as methods of making and using the therapeutic agents. The therapeutic agents have improvements in relation to their use as therapeutics, including, inter alia, one or more of half-life, clearance and/or persistance in the body, solubility, and bioavailability.
    Type: Application
    Filed: April 16, 2014
    Publication date: March 19, 2015
    Applicant: Duke University
    Inventor: Ashutosh Chilkoti
  • Phase transition biopolymers and methods of use
    Patent number: 8912310
    Abstract: The present disclosure describes environmentally responsive polypeptides capable of displaying stimuli-triggered conformational changes in a reversible or irreversible manner that may be accompanied by aggregation. Polypeptides include a number of repeated motifs and may be elastomeric or non-elastomeric. The polypeptides may be used to deliver therapeutics to a biological site and to develop bioactive polypeptides that are environmentally responsive.
    Type: Grant
    Filed: May 29, 2013
    Date of Patent: December 16, 2014
    Assignee: Duke University
    Inventors: Ashutosh Chilkoti, Felipe Garcia Quiroz
  • DIRECT DRUG DELIVERY SYSTEM BASED ON THERMALLY RESPONSIVE BIOPOLYMERS
    Publication number: 20140364371
    Abstract: A method for delivering a drug depot of a compound of interest to a selected region in a subject. The method comprises administering a composition directly to said region of interest, the composition comprising the compound of interest to be delivered (such as an antiinflammatory agent or a chemotherapeutic agent) and a polymer (such as an elastin-like peptide or ELP) that undergoes an inverse temperature phase transition, so that a sustained release of the compound of interest at the selected region is provided. Compositions useful for carrying out the invention are also described.
    Type: Application
    Filed: June 5, 2014
    Publication date: December 11, 2014
    Inventors: Lori A. Setton, Ashutosh Chilkoti, Virginia B. Kraus, Helawe Betre, Matthew R. Dreher
  • Therapeutic agents comprising fusions of vasoactive intestinal peptide and elastic peptides
    Patent number: 8841255
    Abstract: The present invention provides therapeutic agents and compositions comprising elastic peptides and therapeutic proteins. Such peptides exhibit a flexible, extended conformation. In some embodiments, the therapeutic protein is a GLP-1 receptor agonist (e.g., GLP-1, exendin), insulin, or Factor VII/VIIa, including functional analogs. The present invention further provides encoding polynucleotides, as well as methods of making and using the therapeutic agents. The therapeutic agents have improvements in relation to their use as therapeutics, including, inter alia, one or more of half-life, clearance and/or persistence in the body, solubility, and bioavailability.
    Type: Grant
    Filed: August 6, 2010
    Date of Patent: September 23, 2014
    Assignee: Duke University
    Inventor: Ashutosh Chilkoti
  • Detection and Assay Devices and Methods of Making and Using the Same
    Publication number: 20140228249
    Abstract: An article such as a biomolecular detector or biosensor having a nonfouling surface thereon includes: (a) a substrate having a surface portion; (b) a linking layer on the surface portion; and (c) a polymer layer formed on the linking layer; and (d) a first member of a specific binding pair (e.g., a protein, peptide, antibody, nucleic acid, etc.) bound to the polymer layer. Methods of making and using the articles are also described.
    Type: Application
    Filed: April 1, 2014
    Publication date: August 14, 2014
    Applicant: Sentilus, Inc.
    Inventors: Ashutosh CHILKOTI, Angus HUCKNALL
  • Detection assay devices and methods of making and using the same
    Patent number: 8796184
    Abstract: An article such as a biomolecular detector or biosensor having a nonfouling surface thereon includes: (a) a substrate having a surface portion; (b) a linking layer on the surface portion; and (c) a polymer layer formed on the linking layer; and (d) a first member of a specific binding pair (e.g., a protein, peptide, antibody, nucleic acid, etc.) bound to the polymer layer. Methods of making and using the articles are also described.
    Type: Grant
    Filed: March 17, 2009
    Date of Patent: August 5, 2014
    Assignee: Sentilus, Inc.
    Inventors: Ashutosh Chilkoti, Angus Hucknall
  • THERAPEUTIC AGENTS COMPRISING ELASTIC PEPTIDES
    Publication number: 20140213516
    Abstract: The present invention provides therapeutic agents and compositions comprising elastic peptides and therapeutic proteins. Such peptides exhibit a flexible, extended conformation. In some embodiments, the therapeutic protein is a GLP-1 receptor agonist (e.g., GLP-1, exendin), insulin, or Factor VII/VIIa, including functional analogs. The present invention further provides encoding polynucleotides, as well as methods of making and using the therapeutic agents. The therapeutic agents have improvements in relation to their use as therapeutics, including, inter alia, one or more of half-life, clearance and/or persistance in the body, solubility, and bioavailability.
    Type: Application
    Filed: March 4, 2014
    Publication date: July 31, 2014
    Applicant: Duke University
    Inventor: Ashutosh Chilkoti
  • Tunable Nonfouling Surface Of Oligoethylene Glycol
    Publication number: 20140180220
    Abstract: An article having a nonfouling surface thereon is comprises: (a) a substrate having a surface portion; (b) a linking layer on the surface portion; and (c) a polymer layer formed on the linking layer, preferably by the process of surface-initiated polymerization of monomeric units thereon, with each of the monomeric units comprising a monomer core group having at least one protein-resistant head group coupled thereto, to thereby form a brush molecule on the surface portion. The brush molecule comprising a stem formed from the polymerization of the monomer core groups, and a plurality of branches formed from the hydrophilic head group projecting from the stem. Methods of making and using such articles, are also described.
    Type: Application
    Filed: July 16, 2013
    Publication date: June 26, 2014
    Inventors: Ashutosh Chilkoti, Hongwei Ma
  • Therapeutic agents comprising elastic peptides
    Patent number: 8729018
    Abstract: The present invention provides therapeutic agents and compositions comprising elastic peptides and therapeutic proteins. Such peptides exhibit a flexible, extended conformation. In some embodiments, the therapeutic protein is a GLP-1 receptor agonist (e.g., GLP-1, exendin), insulin, or Factor VII/VIIa, including functional analogs. The present invention further provides encoding polynucleotides, as well as methods of making and using the therapeutic agents. The therapeutic agents have improvements in relation to their use as therapeutics, including, inter alia, one or more of half-life, clearance and/or persistance in the body, solubility, and bioavailability.
    Type: Grant
    Filed: March 12, 2013
    Date of Patent: May 20, 2014
    Assignee: Duke University
    Inventor: Ashutosh Chilkoti
  • METHODS AND COMPOSITIONS FOR MODULATING DRUG-POLYMER ARCHITECTURE, PHARMACOKINETICS AND BIODISTRIBUTION
    Publication number: 20140024600
    Abstract: Drug-polymer chemotherapeutics are provided having improved therapeutic efficacy and reduced dose-limiting toxicity. Methods are also provided for modulating the architecture, pharmacokinetics and biodistribution of drug-polymers and for reducing the dependence of transition temperature on concentration for drug-polymers.
    Type: Application
    Filed: July 15, 2013
    Publication date: January 23, 2014
    Applicant: DUKE UNIVERSITY
    Inventors: Ashutosh Chilkoti, John A. MacKay, Matthew R. Dreher
  • PHASE TRANSITION BIOPOLYMERS AND METHODS OF USE
    Publication number: 20130281624
    Abstract: The present disclosure describes environmentally responsive polypeptides capable of displaying stimuli-triggered conformational changes in a reversible or irreversible manner that may be accompanied by aggregation. Polypeptides include a number of repeated motifs and may be elastomeric or non-elastomeric. The polypeptides may be used to deliver therapeutics to a biological site and to develop bioactive polypeptides that are environmentally responsive.
    Type: Application
    Filed: May 29, 2013
    Publication date: October 24, 2013
    Inventors: Ashutosh Chilkoti, Felipe Garcia Quiroz, Miriam Amiram
  • Biomolecule polymer conjugates and methods for making the same
    Patent number: 8497356
    Abstract: Methods for producing biomolecule-polymer conjugates, such as polypeptide-polymer conjugates, include attachment of an initiator agent to a biomolecule and in situ polymerization of a polymer from defined sites on the biomolecule. The conjugates may have desirable pharmacological properties and may be used therapeutically.
    Type: Grant
    Filed: February 17, 2010
    Date of Patent: July 30, 2013
    Assignee: Duke University
    Inventors: Ashutosh Chilkoti, Weiping Gao
  • Phase transition biopolymers and methods of use
    Patent number: 8470967
    Abstract: The present disclosure describes environmentally responsive polypeptides capable of displaying stimuli-triggered conformational changes in a reversible or irreversible manner that may be accompanied by aggregation. Polypeptides include a number of repeated motifs and may be elastomeric or non-elastomeric. The polypeptides may be used to deliver therapeutics to a biological site and to develop bioactive polypeptides that are environmentally responsive.
    Type: Grant
    Filed: September 26, 2011
    Date of Patent: June 25, 2013
    Assignee: Duke University
    Inventors: Ashutosh Chilkoti, Felipe Garcia Quiroz, Miriam Amiram
  • DETECTION DEVICES AND RELATED METHODS OF USE
    Publication number: 20130157889
    Abstract: Disclosed are devices and methods for detecting analytes from a sample.
    Type: Application
    Filed: May 17, 2011
    Publication date: June 20, 2013
    Applicant: DUKE UNIVERSITY
    Inventors: Ashutosh Chilkoti, Angus Hucknall
  • FUSION PEPTIDE THERAPEUTIC COMPOSITIONS
    Publication number: 20130143802
    Abstract: Therapeutic compositions containing fusion proteins (FPs) including elastin-like peptides (ELPs) and peptide active therapeutic agents, and methods of making and using such compositions and fusion proteins. Therapeutic compositions of such type enable improved efficacy of the peptide active therapeutic agent to be achieved, in relation to the peptide active therapeutic agent alone. Enhanced efficacy of the peptide active therapeutic agent in the therapeutic composition may include improved solubility, bioavailability, bio-unavailability, half-life. etc., as compared to corresponding compositions containing the same peptide active therapeutic agent without associated ELPs.
    Type: Application
    Filed: July 9, 2012
    Publication date: June 6, 2013
    Applicant: PHASEBIO PHARMACEUTICALS, INC.
    Inventor: Ashutosh Chilkoti
  • THERAPEUTIC AGENTS COMPRISING ELASTIN-LIKE PEPTIDES
    Publication number: 20130085104
    Abstract: The present invention provides therapeutic agents and compositions comprising elastin-like peptides (ELPs) and therapeutic proteins. In some embodiments, the therapeutic protein is a GLP-1 receptor agonist, insulin, or Factor VII/VIIa, including functional analogs. The present invention further provides encoding polynucleotides, as well as methods of making and using the therapeutic agents. The therapeutic agents have improvements in relation to their use as therapeutics, including, inter alia, one or more of half-life, clearance and/or persistance in the body, solubility, and bioavailability.
    Type: Application
    Filed: June 15, 2012
    Publication date: April 4, 2013
    Applicant: DUKE UNIVERSITY
    Inventor: Ashutosh Chilkoti
  • THERAPEUTIC AGENTS COMPRISING ELASTIN-LIKE PEPTIDES
    Publication number: 20130085099
    Abstract: The present invention provides therapeutic agents and compositions comprising elastin-like peptides (ELPs) and therapeutic proteins. In some embodiments, the therapeutic protein is a GLP-1 receptor agonist, insulin, or Factor VII/VIIa, including functional analogs. The present invention further provides encoding polynucleotides, as well as methods of making and using the therapeutic agents. The therapeutic agents have improvements in relation to their use as therapeutics, including, inter alia, one or more of half-life, clearance and/or persistence in the body, solubility, and bioavailability.
    Type: Application
    Filed: June 15, 2012
    Publication date: April 4, 2013
    Applicant: DUKE UNIVERSITY
    Inventor: Ashutosh Chilkoti
  • THERAPEUTIC AGENTS COMPRISING ELASTIN-LIKE PEPTIDES
    Publication number: 20130079277
    Abstract: The present invention provides therapeutic agents and compositions comprising elastin-like peptides (ELPs) and therapeutic proteins. In some embodiments, the therapeutic protein is a GLP-1 receptor agonist, insulin, or Factor VII/VIIa, including functional analogs. The present invention further provides encoding polynucleotides, as well as methods of making and using the therapeutic agents. The therapeutic agents have improvements in relation to their use as therapeutics, including, inter alia, one or more of half-life, clearance and/or persistance in the body, solubility, and bioavailability.
    Type: Application
    Filed: April 13, 2012
    Publication date: March 28, 2013
    Applicant: DUKE UNIVERSITY
    Inventor: Ashutosh Chilkoti