Abstract: Various bispecific antibodies that specifically bind to both blood coagulation factor IX/activated blood coagulation factor IX and blood coagulation factor X and functionally substitute for the cofactor function of blood coagulation factor VIII, that is, the function to promote activation of blood coagulation factor X by activated blood coagulation factor IX, were produced. From these antibodies, multispecific antigen-binding molecules having a high activity of functionally substituting for blood coagulation factor VIII were successfully discovered.

Abstract: Solid state imaging devices and electronic devices are disclosed. In one example, an imaging device includes photoelectric conversion sections arranged on a first chip and at least a part of each of detection circuits, an arbiter, and a signal processing circuit arranged on a second chip stacked on the first chip. A first region in the first chip in which the photoelectric conversion sections is arrayed and a second region in the second chip in which at least a part of each of the detection circuits is arrayed are at least partially superimposed in a stacking direction, and a logic circuit including the arbiter and the signal processing circuit is arranged in a third region at least partially adjacent to the second region in the second chip.

Abstract: Various bispecific antibodies that specifically bind to both blood coagulation factor IX/activated blood coagulation factor IX and blood coagulation factor X and functionally substitute for the cofactor function of blood coagulation factor VIII, that is, the function to promote activation of blood coagulation factor X by activated blood coagulation factor IX, were produced. From these antibodies, multispecific antigen-binding molecules having a high activity of functionally substituting for blood coagulation factor VIII were successfully discovered.

Abstract: Imaging devices with increased numbers of parallel analog-digital converters with maintained chip size are disclosed. In one example, an imaging device has a stacked chip structure including semiconductor chips of first through third layers. A pixel array is formed on the semiconductor chip of the first layer. An analog circuit of an analog-digital converter is disposed on the semiconductor chip of the second or third layer. A digital circuit of the analog-digital converter is disposed on the other of the semiconductor chip of the second or third layer.

Abstract: A liquid ejecting apparatus includes a liquid ejecting head that has an ejection surface including a first nozzle row configured to eject a first ink and a second nozzle row configured to eject a second ink. The liquid ejecting head is configured to be held in a first posture in which the ejection surface is inclined with respect to a horizontal plane. The dynamic surface tension of the first ink is higher than the dynamic surface tension of the second ink. In the first posture, the first nozzle row is positioned above the second nozzle row with respect to a gravity direction.

Abstract: An aqueous ink jet ink composition is for use in an ink jet recording method. The method includes ejecting ink from an ink jet head including nozzles. The nozzles are configured such that a shape of a side wall surface is a scalloped shape in which a scallop width S1 and a notch depth S2 satisfy S1/S2?4. The aqueous ink jet ink composition includes a pigment and a solvent that contains a specific compound.

Abstract: A damper device includes an input-side rotating member, an intermediate rotating member, an output-side rotating member, and an elastic body. The elastic body is located in a clearance in a circumferential direction between each of a plurality of corresponding portions in which a hook portion of the input-side rotating member and a hook portion of the output-side rotating member face each other and the intermediate rotating member. A part of the corresponding portions is a first corresponding portion configured in such a manner that the elastic body is separated from the output-side rotating member and in contact with the input-side rotating member. The remainder of the corresponding portions is a second corresponding portion configured in such a manner that the elastic body is separated from the input-side rotating member and is in contact with the output-side rotating member.

Abstract: Various bispecific antibodies that specifically bind to both blood coagulation factor DC/activated blood coagulation factor IX and blood coagulation factor X and functionally substitute for the cofactor function of blood coagulation factor VIII, that is, the function to promote activation of blood coagulation factor X by activated blood coagulation factor IX, were produced. From these antibodies, multispecific antigen-binding molecules having a high activity of functionally substituting for blood coagulation factor VIII were successfully discovered.

Abstract: The present inventors attempted to produce antibodies that neutralize the activity of a substance having an activity of functionally substituting for FVIII to be used for the method of measuring the reactivity of FVIII in the presence of a substance having an activity of functionally substituting for FVIII. As a result, the inventors discovered that by using the produced antibodies, FVIII activity in the plasma of a hemophilia A patient can be evaluated accurately by one-stage clotting assay based on APTT, and also that FVIII inhibitor titer in the plasma of a hemophilia A patient carrying a FVIII inhibitor can be evaluated accurately by Bethesda assay based on APTT.

Abstract: A liquid discharging apparatus includes a first head, a second head, a third head, and a fourth head. The first head has a first part and a second part. The second part is coupled to the first part in a first direction. The second part has a width in a first direction that is shorter than a width of the first part in a second direction. A third part coupled to the first part has a width shorter than the width of the first part in the second direction and is at a position different from the second part in the second direction. The second head includes fourth, fifth, and sixth parts that are arranged similarly to the first, second, and third parts. Parts of the first, second, third, and fourth heads are positioned, respectfully, in the second part, the third part, the fifth part, and the sixth part.

Abstract: a part of a first head is positioned in the second part, a part of a second head is positioned in the third part, a part of a third head is positioned in the fifth part, a part of a fourth head is positioned in the sixth part, and a first color is cyan and a third color is magenta.

Abstract: A control device of a vehicle includes between an engine and an automatic transmission a fluid transmission device transmitting power from a pump impeller coupled to the engine via a fluid to a turbine impeller coupled to the automatic transmission. The control device determines occurrence of a lost-drive state of the fluid transmission device based on an increase amount of a rotation speed of the engine after a predetermined time during start of the engine.

Abstract: a part of a first head is positioned in the second part, a part of a second head is positioned in the third part, a part of a third head is positioned in the fifth part, a part of a fourth head is positioned in the sixth part, and a first color is cyan and a third color is magenta.

Abstract: A liquid discharging apparatus includes a first head, a second head, a third head, and a fourth head. The first head has a first part and a second part. The second part is coupled to the first part in a first direction. The second part has a width in a first direction that is shorter than a width of the first part in a second direction. A third part coupled to the first part has a width shorter than the width of the first part in the second direction and is at a position different from the second part in the second direction. The second head includes fourth, fifth, and sixth parts that are arranged similarly to the first, second, and third parts. Parts of the first, second, third, and fourth heads are positioned, respectfully, in the second part, the third part, the fifth part, and the sixth part.

Abstract: In a torsional vibration reducing device, a protrusion projecting radially outward of the rotating body is formed on an inner wall surface. The protrusion is formed on a rotation direction side of a rotating body relative to a straight line passing through a rotation center of the rotating body and a center of a rolling element when the rolling element is located in a middle between both end positions to which the rolling element swings within the roller chamber, and while the rolling element is located at an end portion of a roller chamber on the rotation direction side of the rotating body, a gap is equal to or less than a predetermined value between the rolling element and a wall surface of the roller chamber on a straight line passing through a rotation center of the rotating body and a tip of the protrusion.

Abstract: An aqueous ink jet ink composition is for use in an ink jet recording method. The method includes ejecting ink from an ink jet head including nozzles. The nozzles are configured such that a shape of a side wall surface is a scalloped shape in which a scallop width S1 and a notch depth S2 satisfy S1/S2?4. The aqueous ink jet ink composition includes a pigment and a solvent that contains a specific compound.

Abstract: A liquid ejecting apparatus includes a flow path member including a common liquid chamber communicating with each of a plurality of nozzles formed in a nozzle surface, via a corresponding pressure generating chamber, a supply port provided in an inner wall of the common liquid chamber to supply a liquid to the common liquid chamber, a discharge port provided in a ceiling of the common liquid chamber to discharge an air bubble from the common liquid chamber, and a wall continuously extending from the inner wall, and including a surface opposing the discharge port.

Abstract: A control device of a vehicle includes between an engine and an automatic transmission a fluid transmission device transmitting power from a pump impeller coupled to the engine via a fluid to a turbine impeller coupled to the automatic transmission. The control device determines occurrence of a lost-drive state of the fluid transmission device based on an increase amount of a rotation speed of the engine after a predetermined time during start of the engine.

Abstract: Various bispecific antibodies that specifically bind to both blood coagulation factor IX/activated blood coagulation factor IX and blood coagulation factor X and functionally substitute for the cofactor function of blood coagulation factor VIII, that is, the function to promote activation of blood coagulation factor X by activated blood coagulation factor IX, were produced. From these antibodies, multispecific antigen-binding molecules having a high activity of functionally substituting for blood coagulation factor VIII were successfully discovered.

Abstract: Various bispecific antibodies that specifically bind to both blood coagulation factor IX/activated blood coagulation factor IX and blood coagulation factor X and functionally substitute for the cofactor function of blood coagulation factor VIII, that is, the function to promote activation of blood coagulation factor X by activated blood coagulation factor IX, were produced. From these antibodies, multispecific antigen-binding molecules having a high activity of functionally substituting for blood coagulation factor VIII were successfully discovered.