Abstract: Various bispecific antibodies that specifically bind to both blood coagulation factor IX/activated blood coagulation factor IX and blood coagulation factor X and functionally substitute for the cofactor function of blood coagulation factor VIII, that is, the function to promote activation of blood coagulation factor X by activated blood coagulation factor IX, were produced. From these antibodies, multispecific antigen-binding molecules having a high activity of functionally substituting for blood coagulation factor VIII were successfully discovered.

Abstract: Various bispecific antibodies that specifically bind to both blood coagulation factor IX/activated blood coagulation factor IX and blood coagulation factor X and functionally substitute for the cofactor function of blood coagulation factor VIII, that is, the function to promote activation of blood coagulation factor X by activated blood coagulation factor IX, were produced. From these antibodies, multispecific antigen-binding molecules having a high activity of functionally substituting for blood coagulation factor VIII were successfully discovered.

Abstract: An ink jet recording apparatus records an image on a recording material by ejecting a first ink composition through at least one first liquid ejecting nozzle having an open end. The ink jet recording apparatus also includes a platen having a surface on which the recording medium is placed. The surface is away from the open end at a distance PG satisfying the relationship 0.5 mm<PG<2.5 mm. The first ink composition that has been ejected through the first liquid ejecting nozzle is split into a main droplet having a flying velocity Vm and at least one satellite droplet including a satellite droplet having a flying velocity Vs. The flying velocities Vm and Vs satisfy the relationship Vm?Vs<3 m/s.

Abstract: A map is provided that has an unlimited region where a take-off slip-engagement the next time is repeatedly executed indefinitely, a limited region where the take-off slip-engagement the next time is repeatedly executed only once, and a prohibited region where the take-off slip-engagement the next time is prohibited, and has a generated heat amount during the take-off slip-engagement and an elapsed time after the lock-up slip-engagement ends as variables. Therefore, a region in which the take-off slip-engagement the next time had been prohibited because the take-off slip-engagement the next time is unable to be repeatedly executed indefinitely even though it is able to be repeatedly executed only once is made the limited region, so the take-off slip-engagement the next time is allowed to be repeatedly executed only once.

Abstract: Various bispecific antibodies that specifically bind to both blood coagulation factor IX/activated blood coagulation factor IX and blood coagulation factor X and functionally substitute for the cofactor function of blood coagulation factor VIII, that is, the function to promote activation of blood coagulation factor X by activated blood coagulation factor IX, were produced. From these antibodies, multispecific antigen-binding molecules having a high activity of functionally substituting for blood coagulation factor VIII were successfully discovered.

Abstract: An ink jet recording apparatus records an image on a recording material by ejecting a first ink composition through at least one first liquid ejecting nozzle having an open end. The ink jet recording apparatus also includes a platen having a surface on which the recording medium is placed. The surface is away from the open end at a distance PG satisfying the relationship 0.5 mm<PG<2.5 mm. The first ink composition that has been ejected through the first liquid ejecting nozzle is split into a main droplet having a flying velocity Vm and at least one satellite droplet including a satellite droplet having a flying velocity Vs. The flying velocities Vm and Vs satisfy the relationship Vm?Vs<3 m/s.

Abstract: An ink jet recording apparatus records an image on a recording material by ejecting a first ink composition through at least one first liquid ejecting nozzle having an open end. The ink jet recording apparatus also includes a platen having a surface on which the recording medium is placed. The surface is away from the open end at a distance PG satisfying the relationship 0.5 mm<PG<2.5 mm. The first ink composition that has been ejected through the first liquid ejecting nozzle is split into a main droplet having a flying velocity Vm and at least one satellite droplet including a satellite droplet having a flying velocity Vs. The flying velocities Vm and Vs satisfy the relationship Vm?Vs<3 m/s.

Abstract: Various bispecific antibodies that specifically bind to both blood coagulation factor IX/activated blood coagulation factor IX and blood coagulation factor X and functionally substitute for the cofactor function of blood coagulation factor VIII, that is, the function to promote activation of blood coagulation factor X by activated blood coagulation factor IX, were produced. From these antibodies, multispecific antigen-binding molecules having a high activity of functionally substituting for blood coagulation factor VIII were successfully discovered.

Abstract: A map is provided that has an unlimited region where a take-off slip-engagement the next time is repeatedly executed indefinitely, a limited region where the take-off slip-engagement the next time is repeatedly executed only once, and a prohibited region where the take-off slip-engagement the next time is prohibited, and has a generated heat amount during the take-off slip-engagement and an elapsed time after the lock-up slip-engagement ends as variables. Therefore, a region in which the take-off slip-engagement the next time had been prohibited because the take-off slip-engagement the next time is unable to be repeatedly executed indefinitely even though it is able to be repeatedly executed only once is made the limited region, so the take-off slip-engagement the next time is allowed to be repeatedly executed only once.

Abstract: Various bispecific antibodies that specifically bind to both blood coagulation factor IX/activated blood coagulation factor IX and blood coagulation factor X and functionally substitute for the cofactor function of blood coagulation factor VIII, that is, the function to promote activation of blood coagulation factor X by activated blood coagulation factor IX, were produced. From these antibodies, multispecific antigen-binding molecules having a high activity of functionally substituting for blood coagulation factor VIII were successfully discovered.

Abstract: A liquid ejecting apparatus includes a liquid ejection head that reciprocates, a liquid supplying flow channel supplies a ink to the liquid ejection head, a non-return valve in the liquid supplying flow channel that opens when ink flows from an upstream region to a downstream region where the liquid ejection head is located and closes when ink flows from the downstream region to the upstream region, a volume changing unit that changes a volume of an inner space, and a stirring unit that stirs ink stored therein in accordance with the volume change of the volume changing unit, the stirring unit being disposed separately from the volume changing unit and they are disposed in the liquid supplying flow channel between the non-return valve and the liquid ejection head.

Abstract: An ink jet recording apparatus records an image on a recording material by ejecting a first ink composition through at least one first liquid ejecting nozzle having an open end. The ink jet recording apparatus also includes a platen having a surface on which the recording medium is placed. The surface is away from the open end at a distance PG satisfying the relationship 0.5 mm<PG<2.5 mm. The first ink composition that has been ejected through the first liquid ejecting nozzle is split into a main droplet having a flying velocity Vm and at least one satellite droplet including a satellite droplet having a flying velocity Vs. The flying velocities Vm and Vs satisfy the relationship Vm?Vs<3 m/s.

Abstract: A liquid ejecting apparatus includes a liquid ejection head that reciprocates, a liquid supplying flow channel supplies a ink to the liquid ejection head, a non-return valve in the liquid supplying flow channel that opens when ink flows from an upstream region to a downstream region where the liquid ejection head is located and closes when ink flows from the downstream region to the upstream region, a volume changing unit that changes a volume of an inner space, and a stirring unit that stirs ink stored therein in accordance with the volume change of the volume changing unit, the stirring unit being disposed separately from the volume changing unit and they are disposed in the liquid supplying flow channel between the non-return valve and the liquid ejection head.

Abstract: The charged particle beam device of this invention separately detects secondary signal particles emitted from the surface of a sample, dark field signal particles scattered within and transmitted through the sample, bright field signal particles transmitted through the sample without being scattered within the sample, and thereby allows the operator to observe the image with an optimum contrast according to applications. In order to detect only the dark field transmitted signal particles scattered within the sample, among the transmitted signal particles obtained by the primary charged particle beams having transmitted through the thin film sample, the device includes a transmitted signal conversion member having an opening through which the bright field transmitted signal particles not being scattered within the sample can pass, and a detection means for detecting signals colliding against the conversion member.

Abstract: A printing apparatus includes: a white-colored ink nozzle which ejects white-colored ink; a colored ink nozzle which ejects colored ink different from the white-colored ink; a scanning mechanism which moves the nozzles and a print medium, onto which the ejected ink is landed, relative to each other; and a controller which controls the ink ejection of the nozzles and the scanning mechanism. The controller forms a color line by ejecting the colored ink onto the print medium, while relatively moving the nozzle with respect to the print medium in a first direction, and then the controller ejects the white-colored ink on the color line so as to draw white lines intersecting the color line by moving the nozzle and the print medium relative to each other in a second direction intersecting the first direction.

Abstract: An object of the present invention is to provide a scanning electron microscope including decelerating-electric-field forming means for decreasing the energy of a beam of electrons reaching a sample, and being capable of selectively detecting BSEs with high efficiency. To this end, the scanning electron microscope including the decelerating-electric-field forming means has a detector for detecting electrons. The detector includes a part for receiving the electrons at a position which is positioned outside trajectories of SEs accelerated by the decelerating-electric-field forming means, and which is further away from the optical axis of the beam of electrons than the trajectories of the SEs.

Abstract: The charged particle beam device of this invention separately detects secondary signal particles emitted from the surface of a sample, dark field signal particles scattered within and transmitted through the sample, bright field signal particles transmitted through the sample without being scattered within the sample, and thereby allows the operator to observe the image with an optimum contrast according to applications. In order to detect only the dark field transmitted signal particles scattered within the sample, among the transmitted signal particles obtained by the primary charged particle beams having transmitted through the thin film sample, the device includes a transmitted signal conversion member having an opening through which the bright field transmitted signal particles not being scattered within the sample can pass, and a detection means for detecting signals colliding against the conversion member.

Abstract: The charged particle beam device of this invention separately detects secondary signal particles emitted from the surface of a sample, dark field signal particles scattered within and transmitted through the sample, bright field signal particles transmitted through the sample without being scattered within the sample, and thereby allows the operator to observe the image with an optimum contrast according to applications. In order to detect only the dark field transmitted signal particles scattered within the sample, among the transmitted signal particles obtained by the primary charged particle beams having transmitted through the thin film sample, the device includes a transmitted signal conversion member having an opening through which the bright field transmitted signal particles not being scattered within the sample can pass, and a detection means for detecting signals colliding against the conversion member.

Abstract: The present invention relates to a pharmaceutical composition which includes a tissue factor inhibitor, which is administered after the onset of a thromboembolic ischemic disease, particularly after thrombus or embolus formation; a secondary thrombus formation inhibitor which includes a tissue factor inhibitor, which is administered after primary thrombus formation; a blood flow reduction inhibitor which includes a tissue factor inhibitor to be administered after thrombus formation or embolism formation; and a method of suppressing secondary thrombus formation by inhibiting tissue factor function following formation of a primary thrombus.

Abstract: An object of the present invention is to provide a scanning electron microscope including decelerating-electric-field forming means for decreasing the energy of a beam of electrons reaching a sample, and being capable of selectively detecting BSEs with high efficiency. To this end, the scanning electron microscope including the decelerating-electric-field forming means has a detector for detecting electrons. The detector includes a part for receiving the electrons at a position which is positioned outside trajectories of SEs accelerated by the decelerating-electric-field forming means, and which is further away from the optical axis of the beam of electrons than the trajectories of the SEs.