Patents by Inventor Attila A. Seyhan

Attila A. Seyhan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inhibition of viral gene expression using small interfering RNA
    Patent number: 8426380
    Abstract: The invention provides methods, compositions, and kits comprising small interfering RNA (shRNA or siRNA) that are useful for inhibition of viral-mediated gene expression. Small interfering RNAs as described herein can be used in methods of treatment of HCV infection. ShRNA and siRNA constructs targetING the internal ribosome entry site (IRES) sequence of HCV are described.
    Type: Grant
    Filed: March 2, 2011
    Date of Patent: April 23, 2013
    Assignee: Somagenics, Inc.
    Inventors: Roger L. Kaspar, Heini Ilves, Attila A. Seyhan, Alexander V. Vlassov, Brian H. Johnston
  • INHIBITION OF VIRAL GENE EXPRESSION USING SMALL INTERFERING RNA
    Publication number: 20120220033
    Abstract: The invention provides methods, compositions, and kits comprising small interfering RNA (shRNA or siRNA) that are useful for inhibition of viral-mediated gene expression. Small interfering RNAs as described herein can be used in methods of treatment of HCV infection. ShRNA and siRNA constructs targetING the internal ribosome entry site (IRES) sequence of HCV are described.
    Type: Application
    Filed: January 27, 2012
    Publication date: August 30, 2012
    Inventors: ROGER L. KASPAR, HEINI ILVES, ATTILA A. SEYHAN, ALEXANDER V. VLASSOV, BRIAN H. JOHNSTON
  • Inhibition of Viral Gene Expression Using Small Interfering RNA
    Publication number: 20110269816
    Abstract: The invention provides methods, compositions, and kits comprising small interfering RNA (shRNA or siRNA) that are useful for inhibition of viral-mediated gene expression. Small interfering RNAs as described herein can be used in methods of treatment of HCV infection. ShRNA and siRNA constructs targetING the internal ribosome entry site (IRES) sequence of HCV are described.
    Type: Application
    Filed: March 2, 2011
    Publication date: November 3, 2011
    Inventors: Roger L. Kaspar, Heini Ilves, Attila A. Seyhan, Alexander V. Vlassov, Brian H. Johnston
  • Inhibition of viral gene expression using small interfering RNA
    Patent number: 7902351
    Abstract: The invention provides methods, compositions, and kits comprising small interfering RNA (shRNA or siRNA) that are useful for inhibition of viral-mediated gene expression. Small interfering RNAs as described herein can be used in methods of treatment of HCV infection. ShRNA and siRNA constructs targetING the internal ribosome entry site (IRES) sequence of HCV are described.
    Type: Grant
    Filed: June 1, 2006
    Date of Patent: March 8, 2011
    Assignee: SomaGenics Inc.
    Inventors: Roger L. Kaspar, Heini Ilves, Attila A. Seyhan, Alexander V. Vlassov, Brian H. Johnston
  • Small interfering rnas that efficiently inhibit viral expression and methods of use thereof
    Publication number: 20090170794
    Abstract: The invention provides methods, compositions, and kits comprising small interfering RNA (shRNA or siRNA) which are useful for inhibition of viralmediated gene expression. Small interfering RNAs as described herein may be used in methods of treatment of HCV infection. ShRNA and siRNA constructs that target the internal ribosome entry site (IRES) sequence of HCV are described.
    Type: Application
    Filed: September 12, 2005
    Publication date: July 2, 2009
    Applicant: SomaGenics Inc.
    Inventors: Roger L. Kaspar, Heine Ilves, Attila A. Seyhan, Alexander V. Vlassov, Brian H. Johnston
  • Inhibition of viral gene expression using small interfering RNA
    Publication number: 20070149470
    Abstract: The invention provides methods, compositions, and kits comprising small interfering RNA (shRNA or siRNA) that are useful for inhibition of viral-mediated gene expression. Small interfering RNAs as described herein can be used in methods of treatment of HCV infection. ShRNA and siRNA constructs targetING the internal ribosome entry site (IRES) sequence of HCV are described.
    Type: Application
    Filed: June 1, 2006
    Publication date: June 28, 2007
    Inventors: Roger Kaspar, Heini Ilves, Attila Seyhan, Alexander Vlassov, Brian Johnston
  • Methods of preparation of gene-specific oligonucleotide libraries and uses thereof
    Publication number: 20060051789
    Abstract: Methods of preparing gene-specific oligonucleotide libraries are disclosed. In one embodiment a double-stranded RNA corresponding to both sense and antisense strands of mRNA is digested by ribonuclease to produce short RNA fragments. In subsequent ligation steps, flanking oligoribonucleotides of defined sequences may be attached to the 3- and 5-ends of each fragment by RNA ligase (such as T4 RNA ligase). The products of ligation can be reverse transcribed and PCR amplified (RT-PCR) using the oligonucleotides attached to the gene-derived sequences as primer-binding sites. Various methods for incorporating libraries into expression vectors allowing expression of either siRNAs or shRNAs are also disclosed.
    Type: Application
    Filed: July 1, 2005
    Publication date: March 9, 2006
    Inventors: Sergei Kazakov, Alexander Vlassov, Anne Dallas, Attila Seyhan, Levente Egry, Heini Ilves, Roger Kaspar, Brian Johnston