Abstract: A processor employs a plurality of fetch and decode pipelines by dividing an instruction stream into instruction blocks with identified boundaries. The processor includes a branch predictor that generates branch predictions. Each branch prediction corresponds to a branch instruction and includes a prediction that the corresponding branch is to be taken or not taken. In addition, each branch prediction identifies both an end of the current branch prediction window and the start of another branch prediction window. Using these known boundaries, the processor provides different sequential fetch streams to different ones of the plurality of fetch and decode states, which concurrently process the instructions of the different fetch streams, thereby improving overall instruction throughput at the processor.

Abstract: A processor employs a plurality of op cache pipelines to concurrently provide previously decoded operations to a dispatch stage of an instruction pipeline. In response to receiving a first branch prediction at a processor, the processor selects a first op cache pipeline of the plurality of op cache pipelines of the processor based on the first branch prediction, and provides a first set of operations associated with the first branch prediction to the dispatch queue via the selected first op cache pipeline.

Abstract: Described herein are methods for using compounds that activate pyruvate kinase.

Abstract: Techniques for performing instruction fetch operations are provided. The techniques include determining instruction addresses for a primary branch prediction path; requesting that a level 0 translation lookaside buffer (“TLB”) caches address translations for the primary branch prediction path; determining either or both of alternate control flow path instruction addresses and lookahead control flow path instruction addresses; and requesting that either the level 0 TLB or an alternative level TLB caches address translations for either or both of the alternate control flow path instruction addresses and the lookahead control flow path instruction addresses.

Abstract: A product order fulfillment system including a multi-level transport system and a lifting transport system. Each level of the multi-level transport system having a corresponding independent asynchronous level transport system separate and distinct from the asynchronous level transport system corresponding to each other level of the multi-level transport system. Each independent lift axis of the lifting transport system being configured to independently hold at least one case and being communicably coupled to each asynchronous level transport system so as to provide for exchange of the at least one case between each asynchronous level transport system and each independent lift axis. Each independent lift axis is communicably coupled to each other independent lift axis of the more than one lift axis and forms a common output of mixed cases so as to create an ordered sequence of mixed cases in accordance to a predetermined case out ordered sequence.

Abstract: Systems and methods using EMR and other directed energies emitted at surfaces, objects and body parts, to kill, neutralize, eliminate, remove or otherwise treat or influence objects, species, dirt, weeds, worms, pests, bacteria, viruses, parasites, fungi, other pathogens and other organic and inorganic matter from target surfaces are disclosed. One embodiment includes selecting an at least one first set of parameters of directed energy, wherein the at least one first set of parameters may include one or more of a wavelength, frequency, amplitude, duration, acceleration, deceleration, pulsation, and pulsation period; emitting the directed energy based on the selected at least one first set of parameters at a target surface; measuring in real-time the temperature of the target surface; and pausing the emitting of directed energy once a trigger occurs. This process may be repeated with different sets of parameters and directed energies and carried out in series or simultaneously.

Abstract: A method and/or system that can be implemented on a computing device or tables or board game or otherwise uses a rule set to evaluate data about a situation and actors in order to provide advice regarding strategies for influencing actors and/or other outputs.

Abstract: A method and/or system that can be implemented on a computing device or tables or board game or otherwise uses a rule set to evaluate data about a situation and actors in order to provide advice regarding strategies for influencing actors and/or other outputs.

Abstract: The embodiments provide provides devices, instruments, and associated methods for treating joint pain. A joint is evaluated using magnetic resonance imaging to detect any defects in the subchondral bone. For example, using T2-weighted MRI images, bone marrow lesions or edemas can be identified, and using T1-weighted MRI images, associated regions of sclerotic bone adjacent to the bone marrow lesion can be identified. The treatment method may involve introducing a bone void filler material at the site to address the bone marrow lesion or edema, and/or drilling and inserting an implant to address the sclerotic bone, bone marrow lesion or edema, and insufficiency or stress fractures. An access path is mapped to a location in the subchondral region where the insufficiency fracture resides. The access path attempts to preserve an articular surface of the joint. A reinforcing member that stabilizes the insufficiency fracture is then implanted via the access path.

Abstract: The present invention provides a recombinant oncolytic Herpes Simplex Virus (oHSV) comprising a non-HSV ligand specific for a molecule (protein, lipid, or carbohydrate determinant) present on the surface of a cell (such as a cancer cell) and one or more copies of one or more microRNA target sequences inserted into one or more HSV gene loci, preferably one or more HSV gene(s) required for replication of HSV in normal (i.e., non-cancerous) cells. The invention further provides stocks and pharmaceutical compositions comprising the inventive oHSV and methods for killing tumor cells employing the inventive oHSV.

Abstract: Provided herein are antigenically stealthed HSV particles, and methods of use of the antigenically-stealthed HSV particles.

Abstract: A product order fulfillment system including a multi-level transport system and a lifting transport system. Each level of the multi-level transport system having a corresponding independent asynchronous level transport system separate and distinct from the asynchronous level transport system corresponding to each other level of the multi-level transport system. Each independent lift axis of the lifting transport system being configured to independently hold at least one case and being communicably coupled to each asynchronous level transport system so as to provide for exchange of the at least one case between each asynchronous level transport system and each independent lift axis. Each independent lift axis is communicably coupled to each other independent lift axis of the more than one lift axis and forms a common output of mixed cases so as to create an ordered sequence of mixed cases in accordance to a predetermined case out ordered sequence.

Abstract: Provided herein are various embodiments relating to antibodies that bind LILRB2. Anti-LILRB2 antibodies can be used in methods to treat disease, for example, cancer.

Abstract: Provided herein are various embodiments relating to antibodies that bind LILRB2. Anti-LILRB2 antibodies can be used in methods to treat disease, for example, cancer.

Abstract: Provided herein are various embodiments relating to antibodies that bind LILRB2. Anti-LILRB2 antibodies can be used in methods to treat disease, for example, cancer.

Abstract: A database system comprises a plurality of processing modules arranged to process data objects from a plurality of data object servers based upon a database query from a client computer system. A control task module is arranged to iteratively dynamically assign data objects from the plurality of data object servers to each of the plurality of processing modules based upon processing activity associated with the processing module during the database query from the client computer system. Alternatively, or in addition to, the control task module is arranged to iteratively dynamically assign data objects from the plurality of data object servers to each of the plurality of processing modules based upon a characteristic of the data objects to be dynamically assigned to the processing module during the database query from the client computer system.

Abstract: In one embodiment, the invention provides an HSV vector comprising a mutant gB and/or a mutant gH glycoprotein, where the viral envelope further comprises a non-native ligand specific for a protein present on the surface of a predetermined cell type. In another embodiment, the invention provides an HSV vector comprising (a) a mutant gC and/or gD envelope glycoprotein which comprises a non-native ligand specific for a protein present on the surface of a predetermined cell type; and (b) a mutant envelope glycoprotein other than gD.

Abstract: Provided herein are various embodiments relating to antibodies that bind LILRB2. Anti-LILRB2 antibodies can be used in methods to treat disease, for example, cancer.

Abstract: A query that is frequently processed to access an object storage is identified. Results from the query returned from the object storage is transformed into a relational database format as a materialized view. When the query is submitted a subsequent time, updated results are managed from the materialized view, other materialized views, and/or the object storage when needed.

Abstract: The present invention provides a recombinant herpes simplex virus (HSV), comprising (a) a mutation of the glycoprotein B (gB) at position 285 or 549, (b) a plurality of copies of one or more microRNA target sequences inserted into a locus of an HSV gene required for HSV replication, wherein said target sequence is the reverse complement of microRNA miR-124 and wherein said target sequence is present in the ICP4 gene, and (c) a transgene encoding a matrix metalloproteinase. The present invention also provides a method of killing a cancerous cell using a recombinant HSV according to the invention and a pharmaceutical composition comprising a pharmaceutically acceptable carrier and a recombinant HSV according to the invention.