Abstract: Techniques for management of data in multi-storage systems allow managing storage of data in one of the multiple storages (e.g., a HDD) based on the information associated with the storage and/or access of data (e.g., logical hits of data in a cache memory) in another one of the storages (e.g., a cache memory) of the multi-storage system. In one aspect, information associated with storage and/or access of data in a volatile (or non-persistent) storage environment is provided for managing the storage of data in a non-volatile (or persistent) storage environment. By way of example, data access information associated with a volatile storage environment (e.g., logical hits of data in a cache) can be effectively communicated to a non-volatile storage environment, for example, as information that can be indicative of data temperatures. Moreover, the information obtained from a non-volatile storage environment can be persistently stored for and/or in the non-volatile environment (e.g.

Abstract: The embodiments provide devices and methods that both strengthen the bone and stimulate the bone. Bone fractures or non-unions are stabilized, integrated or healed, which results in reduction of a bone defect, such as a bone marrow lesion or edema. In addition, the distribution of forces in a joint are restored or altered to relieve pain. In general, a joint is evaluated by taking an image of the joint and one or more subchondral defects are detected. At least one of the subchondral defects may be diagnosed as the source of pain and an extent of treatment for the subchondral defect is determined. The disclosed devices and techniques are particularly suited for treating chronic defects or injuries, where the patient's natural healing response has not resolved the defect. The present disclosure also provides several exemplary treatment modalities for the different extents of treatment needed.

Abstract: In one embodiment, the invention provides an HSV vector comprising a mutant gB and/or a mutant gH glycoprotein, where the viral envelope further comprises a non-native ligand specific for a protein present on the surface of a predetermined cell type. In another embodiment, the invention provides an HSV vector comprising (a) a mutant gC and/or gD envelope glycoprotein which comprises a non-native ligand specific for a protein present on the surface of a predetermined cell type; and (b) a mutant envelope glycoprotein other than gD.

Abstract: A multi-chip module, and method of fabricating the multi-chip module. The multi-chip module includes: a substrate containing multiple wiring layers, each wiring layer having first pads on a top surface of the substrate and second pads on a bottom surface of the substrate, wherein the second pads include split pad and a conventional pad; a first solder ball in direct physical contact with a contiguous bottom surface of the conventional pad and connected to a next level of packaging under the conventional pad, wherein the first solder ball has a first height; and a second solder ball in direct physical contact with first and second sections of the split pad separated by a gap, wherein the second solder ball has a second height that is sufficiently less than the first height such that the second solder ball is not connected to the next level of packaging.

Abstract: A furnace/boiler incorporates a dual injection grid arrangement as per present disclosure. The furnace includes an enclosure having burners projecting through walls of the lower half of the enclosure. The burners inject and ignite a supply of fuel and primary air. The combustion reaction takes place in a combustion chamber. The enclosure walls carry steam generating tubes which absorb radiative heat from the combustion flame to produce steam. The heat is also utilized by radiative/convective super-heater and reheater elements where steam flowing through the radiative/convective super-heater and reheater elements is superheated by the hot gas products of the combustion process. The hot gas combustion products are referred to as the exhaust or flue gas. The combustion products exit the combustion chamber at boiler nose and enter in the boiler/furnace area. The present grid arrangement inject chemicals to control the creating reactants particularly NOx and SO3 emissions.

Abstract: A multi-chip module and method of fabricating a multi-chip module. The multi-chip module includes: a substrate having a top surface and a bottom surface and containing multiple wiring layers, first pads on the top surface of the substrate and second pads on the bottom surface of the substrate; a first active component attached to a first group of the first pads and a second active component attached to a second group of the first pads; wherein at least one pad of the second pads is a split pad having a first section and a non-contiguous second section separated by a gap, the first section connected by a first wire of the multiple wires to a pad of the first group of first pads and the second section is connected by a second wire of the multiple wires to a pad of the second group of first pads.

Abstract: The present invention provides an HSV vector comprising an envelope comprising one or more mutant gB and/or gH envelope glycoproteins, whereby the HSV vector exhibits at least 25% increased rate-of-entry after 20 minutes when assayed at 30° C. or 37° C. in Vero cells after first incubating at 4° C. relative to a control HSV comprising wild-type gB and gH glycoproteins. The invention also provides a viral stock comprising the inventive HSV vector.

Abstract: A multi-chip module and method of fabricating a multi-chip module. The multi-chip module includes: a substrate having a top surface and a bottom surface and containing multiple wiring layers, first pads on the top surface of the substrate and second pads on the bottom surface of the substrate; a first active component attached to a first group of the first pads and a second active component attached to a second group of the first pads; wherein at least one pad of the second pads is a split pad having a first section and a non-contiguous second section separated by a gap, the first section connected by a first wire of the multiple wires to a pad of the first group of first pads and the second section is connected by a second wire of the multiple wires to a pad of the second group of first pads.

Abstract: The invention provides modified HSV vectors that exhibit enhanced entry of cells, either through direct infection and/or lateral spread. In one aspect, HSV vectors of the present invention can directly infect cells through interaction with cell proteins other than typical mediators of HSV infection. In another aspect, the invention provides an HSV vector, which exhibits lateral spread in cells typically resistant to HSV lateral spread, such as cells lacking gD receptors. The invention further provides DNA encoding mutant forms of the HSV gB and gH glycoproteins, stocks of the inventive virus, and methods for effecting viral targeting and efficient entry of cells. The invention also pertains to the use of the inventive vectors for treating cancers.

Abstract: The present invention provides a recombinant oncolytic Herpes Simplex Virus (oHSV) comprising a non-HSV ligand specific for a molecule (protein, lipid, or carbohydrate determinant) present on the surface of a cell (such as a cancer cell) and one or more copies of one or more microRNA target sequences inserted into one or more HSV gene loci, preferably one or more HSV gene(s) required for replication of HSV in normal (i.e., non-cancerous) cells. The invention further provides stocks and pharmaceutical compositions comprising the inventive oHSV and methods for killing tumor cells employing the inventive oHSV.

Abstract: A grid for distributing and mixing fluids in a duct includes a plurality of lances arranged in a first plane and configured to be positioned transverse to a direction of a first fluid flowing outside of the lances and within a predetermined flow area. Each of the plurality of lances has at least one first inlet and a plurality of outlet nozzles. One or more of the outlet nozzles is directed generally in the flow direction of the first fluid outside of the lances, and is configured to discharge a second fluid therefrom.

Abstract: A gas mixing device has a plurality of interleaved rows of adjustable louvers. When at least two flowing gas streams are received that are desired to be mixed, the louvers of each row directs the gas streams in a direction different from that of the adjacent rows, mixing the gas streams. When effectively only a single flowing gas stream is received, the louvers are positioned vertically thereby reducing the pressure drop across the gas mixing device.

Abstract: A pipette tip for use with a liquid handler is disclosed. The pipette tip includes a mandrel engaging portion positioned at a proximal end of the pipette tip and an elongated body extending distally from the mandrel engaging portion. The mandrel engaging portion includes an orifice at the proximal end of the pipette tip and an inner surface defining a lumen that is configured to engage a mandrel of a head of the liquid handler. The elongated body includes a proximal end portion adjacent the mandrel engaging portion, an intermediate portion, and a distal portion adjacent to an orifice at a distal end of the elongated body. The elongated body also includes an inner surface defining an interior cavity within the elongated body extending between the proximal end portion of the elongated body and the distal end. The elongated body has a wall thickness at the proximal end of the elongated body that does not exceed about 0.025 inches and a wall thickness adjacent the distal end that does not exceed about 0.

Abstract: A furnace/boiler incorporates a dual injection grid arrangement as per present disclosure. The furnace includes an enclosure having burners projecting through walls of the lower half of the enclosure. The burners inject and ignite a supply of fuel and primary air. The combustion reaction takes place in a combustion chamber. The enclosure walls carry steam generating tubes which absorb radiative heat from the combustion flame to produce steam. The heat is also utilized by radiative/convective super-heater and reheater elements where steam flowing through the radiative/convective super-heater and reheater elements is superheated by the hot gas products of the combustion process. The hot gas combustion products are referred to as the exhaust or flue gas. The combustion products exit the combustion chamber at boiler nose and enter in the boiler/furnace area. The present grid arrangement inject chemicals to control the creating reactants particularly NOx and SO3 emissions.

Abstract: The embodiments provide provides devices, instruments, and associated methods for treating joint pain. A joint is evaluated using magnetic resonance imaging to detect any defects in the subchondral bone. For example, using T2-weighted MRI images, bone marrow lesions or edemas can be identified, and using T1-weighted MRI images, associated regions of sclerotic bone adjacent to the bone marrow lesion can be identified. The treatment method may involve introducing a bone void filler material at the site to address the bone marrow lesion or edema, and/or drilling and inserting an implant to address the sclerotic bone, bone marrow lesion or edema, and insufficiency or stress fractures. An access path is mapped to a location in the subchondral region where the insufficiency fracture resides. The access path attempts to preserve an articular surface of the joint. A reinforcing member that stabilizes the insufficiency fracture is then implanted via the access path.

Abstract: A block management unification system and method for communicating a data file that includes a source component, a first rearrangement criterion, a first block encryption key, a second rearrangement criterion, a second block encryption key, a compression module, and an encryption module. The source component accesses the data file that is divided into a plurality of blocks. The first rearrangement criterion organize the blocks according to the first rearrangement criterion. The first block encryption key is inserted into the blocks. The second rearrangement criterion organize the blocks according to the second rearrangement criterion. The second block encryption key is inserted into the blocks. A compression module compresses the rearranged blocks. An encryption module encrypts the rearranged blocks with the first block encryption key and the second block encryption key.

Abstract: The present invention provides a recombinant oncolytic Herpes Simplex Virus (oHSV) comprising a non-HSV ligand specific for a molecule (protein, lipid, or carbohydrate determinant) present on the surface of a cell (such as a cancer cell) and one or more copies of one or more microRNA target sequences inserted into one or more HSV gene loci, preferably one or more HSV gene(s) required for replication of HSV in normal (i.e., non-cancerous) cells. The invention further provides stocks and pharmaceutical compositions comprising the inventive oHSV and methods for killing tumor cells employing the inventive oHSV.

Abstract: A flow control grid includes a plurality of channel assemblies connected to one another. Each of the plurality of channel assemblies defines a flow straightening section and a flow turning section. The flow turning section has an arcuate segment and a first substantially flat segment. The first substantially flat segment is positioned in the flow straightening section. The arcuate segment extends outwardly from the flow straightening section.

Abstract: A facsimile apparatus includes a user interface operative to facilitate communications between the apparatus and at least one user application in operative communication with the apparatus, a network interface operative to facilitate communications between the apparatus and an analog communications network and an IP communications network. The apparatus further includes a controller connected to the user interface and network interface. The controller is operative in a first mode to communicate with the analog communications network using a first facsimile protocol and being operative in at least a second mode to communicate with the IP communications network using the first facsimile protocol and a voice band data protocol.