Abstract: A loading, delivery, deployment and positioning system for a prosthetic heart valve device includes a stent that is biased to expand and adapted to collapse into the lumen of a delivery catheter. A torque wire of the system includes a distal threaded region, has length that is longer than a length of the delivery catheter, and is adapted for movement within the delivery catheter lumen. A stent cap is non-rotationally attached at or near the top of the stent and defines a channel and a pair of lateral locking grooves therethrough. A male engagement member of the system includes a threaded region adapted to threadingly engage the threaded region of the torque wire, a stem region extending distally from the threaded region; and engagement handles extending laterally from a distal end of the stem region, the engagement handles being adapted to detachably engage the stent cap.

Abstract: A method for improving accuracy of high resolution timers in a live partition migration comprises determining a status of each page of a plurality of pages to be copied from a source partition to a target partition during the live partition migration. One or more pages of the plurality of pages correspond to a respective high resolution timer. The method comprises determining that each of the one or more pages corresponding to a respective high resolution timer has a clean status. A clean status indicates that the corresponding page has been copied to the target partition and has not been modified subsequent to being copied to the target partition. The method also comprises halting operation of the source partition and initiating operation of the target partition in response to determining that each of the one or more pages corresponding to a respective high resolution timer has a clean status.

Abstract: Loading systems for prosthetic heart valve devices are disclosed. A loading funnel is provided within a watertight interior space that is at least partially filled or fillable with biocompatible fluid. Funnel may have a cylindrical end to which is connected a delivery catheter having a lumen that will receive the collapsed prosthetic heart valve device. An expanded prosthetic heart valve device may be placed within the funnel and pushed or pulled into the funnel which provides a predictable, reliable and repeatable surface for collapsing the prosthetic heart valve device. Ultimately the prosthetic heart valve device is collapsed and translated into the lumen of the delivery catheter for further translation therealong and release into the heart chamber of interest.

Abstract: Mechanisms are provided for implementing a patient health management system. The mechanisms analyze a patient electronic medical record (EMR) for an identified patient to identify a medical condition associated with the patient and identify, based on the results of the analysis, one or more exogenous data parameters associated with the medical condition. The exogenous data parameters are parameters specifying conditions outside the patient's body that affect the health of the patient with regard to the medical condition. The mechanisms retrieve exogenous data, corresponding to the exogenous data parameters, from one or more exogenous data sources and generate a health management plan for the patient based on the exogenous data. The health management plan comprises actions to be performed or not performed by the patient to thereby minimize effects of exogenous conditions, corresponding to the exogenous data parameters, on the health of the patient with regard to the medical condition.

Abstract: Techniques are described for routing service requests in a computer-implemented service environment. A received service request may be initially analyzed to determine a priority of the request. In some implementations, one or more actions may be automatically performed to provide an initial response to the requester. The text of the request may be analyzed to automatically determine a category of the request. In some implementations, a classification engine may determine the category of the request through use of a classification model that has been trained using one or more machine learning (ML) techniques and/or that employs Natural Language Processing (NLP). Based on the category, the request may be routed to agent(s) for handling. Routing may include generating a ticket that includes the request, the category, the priority, and/or other information, and the ticket may be provided to the appropriate agent(s) through a ticketing service.

Abstract: Embodiments of delivery systems, devices and methods for delivering a prosthetic heart valve device to a heart chamber for expanded implementation are disclosed. More specifically, methods, systems and devices are disclosed for delivering a self-expanding prosthetic mitral valve device to the left atrium, with no engagement of the left ventricle, the native mitral valve leaflets or the annular tissue downstream of the upper annular surface during delivery, and in some embodiments with no engagement of the ventricle, mitral valve leaflets and/or annular tissue located downstream of the upper annular surface by the delivered, positioned and expanded prosthetic mitral valve device.

Abstract: The present invention provides a prosthetic heart valve device with improved fit, apposition and/or paravalvular leakage mitigation. Thus, the prosthetic device comprises an anchoring structure for supporting prosthetic valve leaflets, wherein the anchoring structure comprises and/or is formed at least partially from a hydrophilic material designed to swell when contacted by the water solute in the patient's blood. Locating the hydrophilic material to provide swelling to improve the fit and/or apposition of the device to the patient's tissues results in, inter alia, improved paravalvular leakage mitigation. Some of the methods and mechanisms described herein may also be used to provide a seal against the septal hole created during transseptal delivery of the device.

Abstract: An example method of provisioning a virtual machine in a cloud system includes: receiving a request to provision the virtual machine in the cloud system; provisioning a first virtual machine managed by a hypervisor executing on a host computer in the cloud system, the hypervisor allocating resources to the first virtual machine; provisioning a nested hypervisor in the first virtual machine; and provisioning the virtual machine to execute on the nested hypervisor without re-virtualizing the resources allocated by the hypervisor to the nested hypervisor.

Abstract: Embodiments of delivery systems, devices and methods for delivering a prosthetic heart valve device to a heart chamber for expanded implementation are disclosed. More specifically, methods, systems and devices are disclosed for delivering a self-expanding prosthetic mitral valve device to the left atrium, with no engagement of the left ventricle, the native mitral valve leaflets or the annular tissue downstream of the upper annular surface during delivery, and in some embodiments with no engagement of the ventricle, mitral valve leaflets and/or annular tissue located downstream of the upper annular surface by the delivered, positioned and expanded prosthetic mitral valve device.

Abstract: Embodiments of delivery systems, devices and methods for delivering a prosthetic heart valve device to a heart chamber for expanded implementation are disclosed. More specifically, methods, systems and devices are disclosed for delivering a self-expanding prosthetic mitral valve device to the left atrium, with no engagement of the left ventricle, the native mitral valve leaflets or the annular tissue downstream of the upper annular surface during delivery, and in some embodiments with no engagement of the ventricle, mitral valve leaflets and/or annular tissue located downstream of the upper annular surface by the delivered, positioned and expanded prosthetic mitral valve device.

Abstract: A method modifies how content is broadcast based on the tone and format of the content. One or more processors retrieve a set of rules that describe a tone and format for proposed content that is to be broadcast to an intended target, and determine whether the proposed content conforms to the set of rules. In response to determining that the proposed content does not conform to the set of rules, the processor(s) modify how the proposed content is broadcast to the intended target. The processor(s) generate an enriched content of the modified content by applying, to the modified content, content metatags that describe a content of the modified content, and then analyze the enriched content to calculate a trustworthiness index (TI) for the enriched content. The processors further modify how content is broadcast to the intended target based on the TI of the enriched content.

Abstract: The invention provides methods, devices and systems for delivering, positioning and/or repositioning an expandable prosthetic heart valve in a patient's heart chamber. At least one non-looped wire and looped wire pair is operatively connected with an expanded prosthetic heart valve that is collapsed within a delivery catheter lumen having its distal end positioned in the subject heart chamber. The collapsed prosthetic heart valve is translated through the delivery catheter lumen to and out of its distal end where the prosthetic heart valve expands to a working configuration. The wire(s) of the non-looped and looped wire pair may be manipulated by pulling proximately or pushing distally to position or reposition the expanded prosthetic stent into position, then released from connection with the positioned stent and withdrawn from the patient.

Abstract: A device and method for predictably and controlling the collapsing of a collapsible and expandable stent for subsequent translation through a delivery sheath lumen to an anatomical target such as a heart valve or intravascular location for expansion and implantation. The loading device defines in inner lumen comprising a successively decreasing, from the proximal to the distal direction, inner diameter alternating between two sections of decreasing diameter and two sections of constant diameter until reaching the inner diameter of the delivery sheath. A fluid-filled reservoir is provided at the proximal end of the loading device that is configured to provide moisture or wetting for materials associated with or attached to the stent that require moisture retention. Thus, as the stent is being collapsed with the loading device, at least a portion of the stent may be immersed in the fluid reservoir to preserve the subject material.

Abstract: A device and method for predictably and controlling the collapsing of a collapsible and expandable stent for subsequent translation through a delivery sheath lumen to an anatomical target such as a heart valve or intravascular location for expansion and implantation. The loading device defines in inner lumen comprising a successively decreasing, from the proximal to the distal direction, inner diameter to a region of constant inner diameter wherein the stent is in a collapsed configuration. The device and method may provide for an at least partially collapsed configuration of the stent that may be further collapsed as a part of the implantation procedure and may comprise a stent that is pre-loaded for future use.

Abstract: Techniques for determining reliability of a workload migration activity are disclosed. In one embodiment, sub-tasks associated with the workload migration activity may be determined. Further, statistical data associated with an execution of the sub-tasks corresponding to different instances of the workload migration activity may be retrieved. Furthermore, a reliability model may be trained through machine learning using the statistical data to determine reliability of the workload migration activity. Then, the reliability of a new workload migration activity may be determined using the trained reliability model.

Abstract: A method adjusts a broadcasting system according to properties of content being broadcast. One or more processors receive a proposed content that is designed to be a component of an electronic broadcast by a broadcast system. The processor(s) determine a broadcast analysis pattern (BAP) for the proposed content, where the BAP describes the proposed content and an intended target of the electronic broadcast. The processor(s) retrieve a set of rules that describe a tone and format for particular content that is broadcast to the intended target, and determine whether the proposed content conforms to the set of rules. In response to determining that the proposed content does not conform to the set of rules, the processor(s) adjust the broadcasting system, where adjusting the broadcasting system modifies how content is broadcast to the intended target.

Abstract: Techniques are disclosed for automating GUI development from a GUI screen image that includes text information and one or more graphic user interface components. The GUI screen image is analyzed to extract text information and to identify the UI components included in the GUI screen. One or more text regions in the GUI screen image are detected and are replaced with placeholders. Images of one or more graphic user interface components in the GUI screen are extracted from the GUI screen image and are classified using a machine learning-based classifier. A GUI model is generated for the GUI based upon the classification results, locations of the one or more text regions, and locations of the one or more graphic user interface components. The generated model can then be used to generate one or more implementations (e.g., executable code) of the GUI, possibly for various platforms in different programming languages.

Abstract: A process and apparatus for quenching a hydrocracked stream to prepare it for hydroisomerization. A fractionated hydroisomerized stream is recycled to quench a hot hydrocracked stream prior to hydroisomerization. Sufficient quenching can inactivate the hydroisomerization catalyst bed. The hydroisomerization catalyst bed can be heated back to hydroisomerization temperature and can actively hydroisomerize again.

Abstract: A method for transferring memory pages to a first and a second page repository identifies pages in a memory sharing operation for transfer to a first page repository and pages in a memory migration operation for transfer to a second page repository. Pages in the memory migration operation may be prepared for transfer prior to transfer of the pages in the memory sharing operation. Transferring pages in the migration operation may remove the need to transfer pages in the memory sharing operation.

Abstract: A collapsible and expandable prosthetic heart valve stent is provided and comprising an outer section, a valve support defining a flow channel therethrough, a transition section configured to smoothly transition the outer section to the valve support. The valve support is disposed within an interior defined by the outer section, with the inflow end of the valve support disposed inside the outer section's interior. In some cases, the outflow end of the valve support is at least partially defined by the transition section. The prosthetic leaflets are disposed on the inner surface of the valve support's flow channel and are located at or above the annulus of the heart chamber. A paravalvular leakage mitigation system is attached to the stent to mitigate retrograde blood flow and/or regurgitation.