Abstract: Apparatus and methods for fluorescence imaging using radiofrequency multiplexed excitation. One apparatus splits an excitation laser beam into two arms of a Mach-Zehnder interferometer. The light in the first beam is frequency shifted by an acousto-optic deflector, which is driven by a phase-engineered radiofrequency comb designed to minimize peak-to-average power ratio. This RF comb generates multiple deflected optical beams possessing a range of output angles and frequency shifts. The second beam is shifted in frequency using an acousto-optic frequency shifter. After combining at a second beam splitter, the two beams are focused to a line on the sample using a conventional laser scanning microscope lens system. The acousto-optic deflectors frequency-encode the simultaneous excitation of an entire row of pixels, which enables detection and de-multiplexing of fluorescence images using a single photomultiplier tube and digital phase-coherent signal recovery techniques.

Abstract: A communication system that includes a cloud server that obtains first sensor data associated with a defined indoor area and second sensor data associated with each of a plurality of optical nodes in defined indoor area. The plurality of optical nodes includes a master communication device, a plurality of optical routing devices, and one or more service communication devices. The cloud server further obtains location coordinates of each of the plurality of optical nodes. The cloud server then causes the master communication device to form a laser beam-based wireless communication network in the defined indoor area. A free-space optical backhaul is constructed by establishing a point-to-point free-space laser link between each pair of optical nodes of the plurality of optical nodes and a RF supervisory link is established between each pair of optical nodes of the plurality of optical nodes for a network monitoring and control function.

Abstract: An imaging flow cytometry apparatus and method which allows registering multiple locations across a cell, and/or across multiple flow channels, in parallel using radio-frequency-tagged emission (FIRE) coupled with a parallel optical detection scheme toward increasing analysis throughput. An optical source is modulated by multiple RF frequencies to produce an optical interrogation beam having a spatially distributed beat frequency. This beam is directed to one or more focused streams of cells whose responsive fluorescence, in different frequencies, is registered in parallel by an optical detector.

Abstract: A method of measuring a distance between a vehicle and one or more objects, includes generating a modulation signal; generating a modulated light emitting diode (LED) transmission signal, via a vehicle LED driver assembly; transmitting a plurality of light beams based at least in part on the generated modulated LED transmission signal; capturing a reflection of the plurality of light beams off the one or more objects, utilizing one or more lens assemblies and a camera, the camera including an array of pixel sensors and being positioned on the vehicle; communicating a series of measurements representing the captured plurality of light beam reflections; calculating, utilizing the time-of-flight sensor module, time of flight measurements between the vehicle LED light assembly and the one or more objects and calculating distances, utilizing a depth processor module, between the vehicle LED light assembly and the one or more objects based on the time-of-flight measurements.

Abstract: Described herein is a solution to address the intrinsic nonlinearity of analog signals and the restrictions this places on the signals dynamic range. The subject matter described herein produces linear electro-optic modulation over a dramatically wider range of the input signal amplitude. This is accomplished by a distributed multiwavelength design that “folds” the large dynamic range across multiple linear subranges, with each subrange being addressed using an optical wavelength. As a result, the subrange within the wide dynamic range of the input signal is captured by the linear portion of the transfer function of a single transfer function. Several physical implementations of this subject are presented herein. This innovation enables the efficient use of optical links for the transmission and processing of analog and multilevel signals, overcoming the limitations that were once hindering progress in this field.

Abstract: A life-assisting system to enhance the quality of life for people with visual impairment. The system integrates state-of-the-art sensing and sensory stimulation with light detection and ranging (LiDAR), machine learning, and advanced haptic navigation to provide the visually impaired population with a real-time haptic map of the three-dimensional environment and auditory descriptions of objects within that environment. By allowing the visually impaired population to sense objects in the surrounding environment through haptic and auditory feedback, the disclosed system has the potential to promote individual independence, reduce anxiety and stress, facilitate access to educational and employment opportunities, and reduce social and economic gaps. To provide those benefits, the system uses multi-modal learning to convert higher dimensional (e.g., four-dimensional) scene data into lower dimensional (e.g., one-dimensional) auditory data and (e.g., two- or three-dimensional) haptic data.

Abstract: A communication system that includes a cloud server that obtains first sensor data associated with a defined indoor area and second sensor data associated with each of a plurality of optical nodes in defined indoor area. The plurality of optical nodes includes a master communication device, a plurality of optical routing devices, and one or more service communication devices. The cloud server further obtains location coordinates of each of the plurality of optical nodes. The cloud server then causes the master communication device to form a laser beam-based wireless communication network in the defined indoor area. A free-space optical backhaul is constructed by establishing a point-to-point free-space laser link between each pair of optical nodes of the plurality of optical nodes and a RF supervisory link is established between each pair of optical nodes of the plurality of optical nodes for a network monitoring and control function.

Abstract: An optical routing device that includes a mounting component which includes a rechargeable battery and a processor that communicates over-the-air with a master communication device or one or more service communication devices via RF supervisory links. The processor receives an instruction via the RF supervisory links to control a movement of the mounting component along with the optical routing component such that an angle or a direction of deflection of laser beams from an optical routing component of optical routing device is changed. The optical routing component includes two distinct laser beam handling regions configured to handle plurality of laser beams concurrently in which first laser beam in first wavelength is deflected via first region for downstream data communication in downstream path and second laser beam in second wavelength is deflected via second region for upstream data communication in upstream path for free-space optical communication independent of optical fibers.

Abstract: A communication system that includes a cloud server that obtains first sensor data associated with a defined indoor area and second sensor data associated with each of a plurality of optical nodes in defined indoor area. The plurality of optical nodes includes a master communication device, a plurality of optical routing devices, and one or more service communication devices. The cloud server further obtains location coordinates of each of the plurality of optical nodes. The cloud server then causes the master communication device to form a laser beam-based wireless communication network in the defined indoor area. A free-space optical backhaul is constructed by establishing a point-to-point free-space laser link between each pair of optical nodes of the plurality of optical nodes and a RF supervisory link is established between each pair of optical nodes of the plurality of optical nodes for a network monitoring and control function.

Abstract: A communication system that includes a master communication device at a first location in a defined indoor area, a service communication device at a second location in the defined indoor area, and passive optical routing devices at a plurality of locations in the defined indoor area. The master communication device obtains a first signal from a data source or a modem and directs a first laser beam carrying the first signal in a downstream path to a service communication device directly or via the plurality of passive optical routing devices based on defined connectivity criterions. The service communication device demodulates the first signal from the first laser beam, distributes one or more wireless signals to end-user devices, and further obtains one or more second signals from end-user devices and re-transmits obtained signals over second laser beam in upstream path to master communication device directly or via the passive optical routing devices.

Abstract: An imaging flow cytometry apparatus and method which allows registering multiple locations across a cell, and/or across multiple flow channels, in parallel using radio-frequency-tagged emission (FIRE) coupled with a parallel optical detection scheme toward increasing analysis throughput. An optical source is modulated by multiple RF frequencies to produce an optical interrogation beam having a spatially distributed beat frequency. This beam is directed to one or more focused streams of cells whose responsive fluorescence, in different frequencies, is registered in parallel by an optical detector.

Abstract: An optical routing device that includes a mounting component which includes a rechargeable battery and a processor that communicates over-the-air with a master communication device or one or more service communication devices via one or more RF supervisory links. The processor receives an instruction via the one or more RF supervisory links to control a movement of the mounting component along with the optical routing component such that an angle or a direction of deflection of one or more laser beams from an optical routing component of the optical routing device is changed. The optical routing component includes one or more laser beam handling regions configured to handle a plurality of laser beams concurrently in which a first laser beam is deflected via a first region for downstream data communication in downstream path and a second laser beam is deflected via a second region for upstream data communication in upstream path.

Abstract: An imaging flow cytometry apparatus and method which allows registering multiple locations across a cell, and/or across multiple flow channels, in parallel using radio-frequency-tagged emission (FIRE) coupled with a parallel optical detection scheme toward increasing analysis throughput. An optical source is modulated by multiple RF frequencies to produce an optical interrogation beam having a spatially distributed beat frequency. This beam is directed to one or more focused streams of cells whose responsive fluorescence, in different frequencies, is registered in parallel by an optical detector.

Abstract: An imaging flow cytometry apparatus and method which allows registering multiple locations across a cell, and/or across multiple flow channels, in parallel using radio-frequency-tagged emission (FIRE) coupled with a parallel optical detection scheme toward increasing analysis throughput. An optical source is modulated by multiple RF frequencies to produce an optical interrogation beam having a spatially distributed beat frequency. This beam is directed to one or more focused streams of cells whose responsive fluorescence, in different frequencies, is registered in parallel by an optical detector.

Abstract: Apparatus and methods for fluorescence imaging using radiofrequency multiplexed excitation. One apparatus splits an excitation laser beam into two arms of a Mach-Zehnder interferometer. The light in the first beam is frequency shifted by an acousto-optic deflector, which is driven by a phase-engineered radiofrequency comb designed to minimize peak-to-average power ratio. This RF comb generates multiple deflected optical beams possessing a range of output angles and frequency shifts. The second beam is shifted in frequency using an acousto-optic frequency shifter. After combining at a second beam splitter, the two beams are focused to a line on the sample using a conventional laser scanning microscope lens system. The acousto-optic deflectors frequency-encode the simultaneous excitation of an entire row of pixels, which enables detection and de-multiplexing of fluorescence images using a single photomultiplier tube and digital phase-coherent signal recovery techniques.

Abstract: Apparatus and methods for fluorescence imaging using radiofrequency multiplexed excitation. One apparatus splits an excitation laser beam into two arms of a Mach-Zehnder interferometer. The light in the first beam is frequency shifted by an acousto-optic deflector, which is driven by a phase-engineered radiofrequency comb designed to minimize peak-to-average power ratio. This RF comb generates multiple deflected optical beams possessing a range of output angles and frequency shifts. The second beam is shifted in frequency using an acousto-optic frequency shifter. After combining at a second beam splitter, the two beams are focused to a line on the sample using a conventional laser scanning microscope lens system. The acousto-optic deflectors frequency-encode the simultaneous excitation of an entire row of pixels, which enables detection and de-multiplexing of fluorescence images using a single photomultiplier tube and digital phase-coherent signal recovery techniques.

Abstract: An imaging flow cytometry apparatus and method which allows registering multiple locations across a cell, and/or across multiple flow channels, in parallel using radio-frequency-tagged emission (FIRE) coupled with a parallel optical detection scheme toward increasing analysis throughput. An optical source is modulated by multiple RF frequencies to produce an optical interrogation beam having a spatially distributed beat frequency. This beam is directed to one or more focused streams of cells whose responsive fluorescence, in different frequencies, is registered in parallel by an optical detector.

Abstract: Apparatus and methods for fluorescence imaging using radiofrequency multiplexed excitation. One apparatus splits an excitation laser beam into two arms of a Mach-Zehnder interferometer. The light in the first beam is frequency shifted by an acousto-optic deflector, which is driven by a phase-engineered radiofrequency comb designed to minimize peak-to-average power ratio. This RF comb generates multiple deflected optical beams possessing a range of output angles and frequency shifts. The second beam is shifted in frequency using an acousto-optic frequency shifter. After combining at a second beam splitter, the two beams are focused to a line on the sample using a conventional laser scanning microscope lens system. The acousto-optic deflectors frequency-encode the simultaneous excitation of an entire row of pixels, which enables detection and de-multiplexing of fluorescence images using a single photomultiplier tube and digital phase-coherent signal recovery techniques.

Abstract: Systems and methods for digital pathology in accordance with embodiments of the invention obtain a whole slide image of a microscope slide that includes a registration mark, wherein the registration mark is associated with a coordinate system. The method inputs the whole slide image into a region identification (RI) model to extract features of the whole slide image and generate feature vectors for the extracted features, detects a presence of a region of interest (ROI) based on the feature vectors, determines a set of coordinates of the ROI in the coordinate system, and translates a microscope stage of a microscope holding the microscope slide to a position corresponding to the coordinates of the ROI. The method captures a field of view (FOV) image with the microscope and inputs the FOV image into a grading model to determine a pathology score that indicates a likelihood of a presence of a disease.

Abstract: An imaging flow cytometry apparatus and method which allows registering multiple locations across a cell, and/or across multiple flow channels, in parallel using radio-frequency-tagged emission (FIRE) coupled with a parallel optical detection scheme toward increasing analysis throughput. An optical source is modulated by multiple RF frequencies to produce an optical interrogation beam having a spatially distributed beat frequency. This beam is directed to one or more focused streams of cells whose responsive fluorescence, in different frequencies, is registered in parallel by an optical detector.