Patents by Inventor Balwinder Singh

Balwinder Singh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 3,6-DIAZABICYCLO[3.1.1]HEPTAINES AS NEURONAL NICOTINIC ACETYCHOLINE RECEPTOR LIGANDS
    Publication number: 20140315880
    Abstract: The present invention relates to compounds that bind to and modulate the activity of neuronal nicotinic acetylcholine receptors, to processes for preparing these compounds, to pharmaceutical compositions containing these compounds, and to methods of using these compounds for treating a wide variety of conditions and disorders, including those associated with dysfunction of the central nervous system (CNS).
    Type: Application
    Filed: July 1, 2014
    Publication date: October 23, 2014
    Inventors: Srinivasa Rao Akireddy, Balwinder Singh Bhatti, Ronald Joseph Heemstra, Srinivasa V. Murthy, Jon-Paul Strachan, Yunde Xiao
  • NICOTINIC RECEPTOR NON-COMPETITIVE ANTAGONISTS
    Publication number: 20140288169
    Abstract: The present invention relates to compounds that modulate nicotinic receptors as non-competitive antagonists, methods for their synthesis, methods for their use, and their pharmaceutical compositions.
    Type: Application
    Filed: January 5, 2012
    Publication date: September 25, 2014
    Applicant: TARGACEPT, INC.
    Inventors: Srinivasa Rao Akireddy, Scott R. Breining, Matt S. Melvin, Srinivasa V. Murthy, Anatoly A. Mazurov, Balwinder Singh Bhatti, Jon-Paul Strachan, Ronald Joseph Heemstra, Todd Showalter, Yunde Xiao, Philip S. Hammond, Lan Miao, David Kombo, Daniel Yohannes, Jason Speake
  • NICOTINIC RECEPTOR NON-COMPETITIVE MODULATORS
    Publication number: 20140288185
    Abstract: The present invention relates to compounds that modulate nicotinic receptors as non-competitive antagonists, methods for their synthesis, methods for use, and their pharmaceutical compositions.
    Type: Application
    Filed: November 1, 2012
    Publication date: September 25, 2014
    Inventors: Srinivasa Rao Akireddy, Jason Speake, Balwinder Singh Bhatti, Daniel Yohannes, John Genus, Yunde Xiao
  • Nicotinic receptor non-competitive antagonists
    Patent number: 8809397
    Abstract: The present invention relates to compounds that modulate nicotinic receptors as non-competitive antagonists, methods for their synthesis, methods for use, and their pharmaceutical compositions.
    Type: Grant
    Filed: May 24, 2011
    Date of Patent: August 19, 2014
    Assignee: Targacept, Inc.
    Inventors: Srinivasa Rao Akireddy, Balwinder Singh Bhatti, Ronald Joseph Heemstra, Matt S. Melvin, Jason D. Speake, Yunde Xiao, Daniel Yohannes
  • 3,6-diazabicyclo[3.1.1]heptanes as neuronal nicotinic acetycholine receptor ligands
    Patent number: 8802694
    Abstract: The present invention relates to compounds that bind to and modulate the activity of neuronal nicotinic acetylcholine receptors, to processes for preparing these compounds, to pharmaceutical compositions containing these compounds, and to methods of using these compounds for treating a wide variety of conditions and disorders, including those associated with dysfunction of the central nervous system (CNS).
    Type: Grant
    Filed: December 3, 2010
    Date of Patent: August 12, 2014
    Assignee: Targacept, Inc.
    Inventors: Srinivasa Rao Akireddy, Balwinder Singh Bhatti, Ronald Joseph Heemstra, Srinivasa V. Murthy, Jon-Paul Strachan, Yunde Xiao
  • Enhanced spray cooling technique for wedge cooling
    Patent number: 8760014
    Abstract: A wedge cooling apparatus and method for cooling a rotating machine, such as a generator, disperses a spray of cooling fluid into the wedges of the generator. The spray cooling method results in a high heat transfer coefficient of about 2000-3000 W/m2C as opposed to conventional conduction cooling, which has a heat transfer coefficient of about 200-300 W/m2C. The apparatus and method of the present invention efficiently removes heat from high powered, high current density designed generators.
    Type: Grant
    Filed: July 13, 2011
    Date of Patent: June 24, 2014
    Assignee: Honeywell International Inc.
    Inventors: Balwinder Singh Birdi, Simon Waddell, William Scherzinger, Wayne Pearson, David Kane, Tom Phielix
  • Enhanced spray cooling technique for wedge cooling
    Patent number: 8729752
    Abstract: A wedge cooling apparatus and method for cooling a rotating machine, such as a generator, disperses a spray of cooling fluid into the wedges of the generator via a pipe that runs along the length of each of the wedges. The pipe may include a plurality of spray delivery devices to spray cooling fluid from the pipe to the inside of the wedges. The spray cooling method results in a high heat transfer coefficient of about 2000-3000 W/m2C as opposed to conventional conduction cooling, which has a heat transfer coefficient of about 200-300 W/m2C. The apparatus and method of the present invention efficiently removes heat from high powered, high current density designed generators.
    Type: Grant
    Filed: July 12, 2011
    Date of Patent: May 20, 2014
    Assignee: Honeywell International, Inc
    Inventors: Balwinder Singh Birdi, Simon Waddell, William Scherzinger
  • SYNTHESIS AND NOVEL SALT FORMS OF (R)-5-((E)-2-PYRROLIDIN-3YLVINYL)PYRIMIDINE
    Publication number: 20140066460
    Abstract: The present invention relates to the stereospecific synthesis of (R)-5-((E)-2-pyrrolidin-3-ylvinyl)pyrimidine, its salt forms, and novel polymorphic forms of these salts.
    Type: Application
    Filed: November 7, 2013
    Publication date: March 6, 2014
    Applicant: Targacept, Inc.
    Inventors: Srinivasa Rao Akireddy, Balwinder Singh Bhatti, Timothy J. Cuthbertson, Gary Maurice Dull, Craig Harrison Miller, Joseph Pike Mitchener, Julio A. Munoz, Pieter Albert Otten
  • System and a method for generating time bases in low power domain
    Patent number: 8644447
    Abstract: A digital frequency divider including a parallel output register, a presettable asynchronous counter and a decoder. The parallel output register contains a desired count value. The presettable asynchronous counter has its preset data inputs coupled to the output of the parallel output register. The decoder receives its input from the data outputs of the presettable asynchronous divider and its output coupled to the load input of the presettable asynchronous counter.
    Type: Grant
    Filed: November 25, 2009
    Date of Patent: February 4, 2014
    Assignee: STMicroelectronics International N.V.
    Inventors: Chandra Bhushan Prakash, Balwinder Singh Soni
  • Synthesis and novel salt forms of (R)-5-((E)-2-pyrrolidin-3YLVINYL)pyrimidine
    Patent number: 8604191
    Abstract: The present invention relates to the stereospecific synthesis of (R)-5-((E)-2-pyrrolidin-3-yl)pyrimidine, novel salt forms, and novel polymorphic forms of these salts.
    Type: Grant
    Filed: November 30, 2009
    Date of Patent: December 10, 2013
    Assignee: Targacept, Inc.
    Inventors: Srinivasa Rao Akireddy, Balwinder Singh Bhatti, Timothy J. Cuthbertson, Gary Maurice Dull, Craig Harrison Miller, Joseph Pike Mitchener, Jr., Julio A. Munoz, Pieter Albert Otten
  • NICOTINIC RECEPTOR NON-COMPETITIVE ANTAGONISTS
    Publication number: 20130203860
    Abstract: The present invention relates to compounds that modulate nicotinic receptors as non-competitive antagonists, methods for their synthesis, methods for use, and their pharmaceutical compositions.
    Type: Application
    Filed: May 24, 2011
    Publication date: August 8, 2013
    Inventors: Srinivasa Rao Akireddy, Balwinder Singh Bhatti, Ronald Joseph Heemstra, Matt S. Melvin, Jason D. Speake, Yunde Xiao, Daniel Yohannes
  • ENHANCED SPRAY COOLING TECHNIQUE FOR WEDGE COOLING
    Publication number: 20130015730
    Abstract: A wedge cooling apparatus and method for cooling a rotating machine, such as a generator, disperses a spray of cooling fluid into the wedges of the generator. The spray cooling method results in a high heat transfer coefficient of about 2000-3000 W/m2C as opposed to conventional conduction cooling, which has a heat transfer coefficient of about 200-300 W/m2C. The apparatus and method of the present invention efficiently removes heat from high powered, high current density designed generators.
    Type: Application
    Filed: July 13, 2011
    Publication date: January 17, 2013
    Applicant: Honeywell International Inc.
    Inventors: Simon Waddell, William Scherzinger, Balwinder Singh Birdi, Wayne Pearson, David Kane, Tom Phielix
  • ENHANCED SPRAY COOLING TECHNIQUE FOR WEDGE COOLING
    Publication number: 20130015729
    Abstract: A wedge cooling apparatus and method for cooling a rotating machine, such as a generator, disperses a spray of cooling fluid into the wedges of the generator via a pipe that runs along the length of each of the wedges. The pipe may include a plurality of spray delivery devices to spray cooling fluid from the pipe to the inside of the wedges. The spray cooling method results in a high heat transfer coefficient of about 2000-3000 W/m2C as opposed to conventional conduction cooling, which has a heat transfer coefficient of about 200-300 W/m2C. The apparatus and method of the present invention efficiently removes heat from high powered, high current density designed generators.
    Type: Application
    Filed: July 12, 2011
    Publication date: January 17, 2013
    Applicant: HONEYWELL INTERNATIONAL INC.
    Inventors: Balwinder Singh Birdi, Simon Waddell, William Scherzinger
  • 3,6-Diazabicyclo[3.1.1]heptanes as Neuronal Nicotinic Acetycholine Receptor Ligands
    Publication number: 20120309737
    Abstract: The present invention relates to compounds that bind to and modulate the activity of neuronal nicotinic acetylcholine receptors, to processes for preparing these compounds, to pharmaceutical compositions containing these compounds, and to methods of using these compounds for treating a wide variety of conditions and disorders, including those associated with dysfunction of the central nervous system (CNS).
    Type: Application
    Filed: December 3, 2010
    Publication date: December 6, 2012
    Applicant: Targacept, Inc.
    Inventors: Srinivasa Rao Akireddy, Balwinder Singh Bhatti, Ronald Joseph Heemstra, Srinivasa V. Murthy, Jon-Paul Strachan, Yunde Xiao
  • Compounds capable of activating cholinergic receptors
    Patent number: 8288420
    Abstract: Compounds incorporating aryl substituted olefinic amine are provided. Representative compounds are (4E)-N-methyl-5-(3-pyridyl)-4-penten-2-amine, (4E)-N-methyl-5-(5-pyrimidinyl)-4-penten-2-amine, (4E)-N-methyl-5-(5-methoxy-3-pyridyl)-4-penten-2-amine, (4E)-N-methyl-5-(6-amino-5-methyl-3-pyridyl)-4-penten-2-amine, (2R)-(4E)-N-methyl-5-(3-pyridyl)-4-penten-2-amine, (2R)-(4E)-N-methyl-5-(5-isopropoxy-3-pyridyl)-4-penten-2-amine, (4E)-N-methyl-5-(5-bromo-3-pyridyl)-4-penten-2-amine, (4E)-N-methyl-5-(5-ethoxy-3-pyridyl)-4-penten-2-amine, (2S)-(4E)-N-methyl-5-(3-pyridyl)-4-penten-2-amine, (4E)-N-methyl-5-(5-isopropoxy-3-pyridyl)-4-penten-2-amine and (2S)-(4E)-N-methyl-5-(5-isopropoxy-3-pyridyl)-4-penten-2-amine.
    Type: Grant
    Filed: May 10, 2010
    Date of Patent: October 16, 2012
    Assignee: Targacept, Inc.
    Inventors: William Scott Caldwell, Gary Maurice Dull, Balwinder Singh Bhatti, Srishakumar Basawannappa Hadimani, Haeil Park, Jared Miller Wagner, Peter A. Crooks
  • Compounds
    Patent number: 8153821
    Abstract: The present invention related to compounds that bind to and modulate the activity of neuronal nicotinic acetylcholine receptors, to novel salts thereof, to processes for preparing these compounds, to pharmaceutical compositions containing these compounds, and to methods of using these compounds for treating a wide variety of conditions and disorders, including those associated with dysfunction of the central nervous system (CNS).
    Type: Grant
    Filed: November 30, 2009
    Date of Patent: April 10, 2012
    Assignee: Targacept, Inc.
    Inventors: Srinivasa Rao Akireddy, Balwinder Singh Bhatti, Timothy J. Cuthbertson, Craig Harrison Miller, Joseph Pike Mitchener, Jr.
  • FUSED BENZOAZEPINES AS NEURONAL NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS
    Publication number: 20120053168
    Abstract: The present invention relates to compounds that bind to and modulate the activity of neuronal nicotinic acetylcholine receptors, to processes for preparing these compounds, to pharmaceutical compositions containing these compounds, and to methods of using these compounds for treating a wide variety of conditions and disorders, including those associated with dysfunction of the central nervous system (CNS).
    Type: Application
    Filed: February 16, 2010
    Publication date: March 1, 2012
    Applicant: Targacept, Inc.
    Inventors: Balwinder Singh Bhatti, Timothy J. Cuthbertson, Anatoly Mazurov, Joseph Pike Mitchener, Julio A. Munoz, Srinivasa V. Murthy, Yunde Xiao, Daniel Yohannes
  • SYNTHESIS AND NOVEL SALT FORMS OF (R)-5-((E)-2-PYRROLIDIN-3YLVINYL)PYRIMIDINE
    Publication number: 20110281895
    Abstract: The present invention relates to the stereospecific synthesis of (R)-5-((E)-2-pyrrolidin-3-yl)pyrimidine, novel salt forms, and novel polymorphic forms of these salts.
    Type: Application
    Filed: November 30, 2009
    Publication date: November 17, 2011
    Applicant: TARGACEPT, INC.
    Inventors: Srinivasa Rao Akireddy, Balwinder Singh Bhatti, Timothy J. Cuthbertson, Gary Maurice Dull, Craig Harrison Miller, Joseph Pike Mitchener, JR., Julio A. Munoz, Pieter Albert Otten
  • NOVEL COMPOUNDS
    Publication number: 20110269975
    Abstract: The present invention related to compounds that bind to and modulate the activity of neuronal nicotinic acetylcholine receptors, to novel salts thereof, to processes for preparing these compounds, to pharmaceutical compositions containing these compounds, and to methods of using these compounds for treating a wide variety of conditions and disorders, including those associated with dysfunction of the central nervous system (CNS).
    Type: Application
    Filed: November 30, 2009
    Publication date: November 3, 2011
    Applicant: Targacept, Inc.
    Inventors: Srinivasa Rao Akireddy, Balwinder Singh Bhatti, Timothy J. Cuthbertson, Craig Harrison Miller, Joseph Pike Mitchener, JR.
  • AMIDES OF DIAZABICYCLOOCTANES AND USES THEREOF
    Publication number: 20110263629
    Abstract: The present invention relates to compounds that bind to and modulate the activity of neuronal nicotinic acetylcholine receptors, to processes for preparing these compounds, to pharmaceutical compositions containing these compounds, and to methods of using these compounds for treating a wide variety of conditions and disorders, including those associated with dysfunction of the central nervous system (CNS).
    Type: Application
    Filed: September 2, 2009
    Publication date: October 27, 2011
    Applicant: Targacept, Inc.
    Inventors: Jon-Paul Strachan, Balwinder Singh Bhatti, Anatoly Mazurov, Jozef Klucik, Yunde Xiao, Philip S. Hammond, David Kombo, Lan Miao, Jason Daniel Speake, Daniel Yohannes