Patents by Inventor Barton F. Haynes

Barton F. Haynes has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10344077
    Abstract: The invention is directed to HIV-1 neutralizing antibodies, CD4 binding site and V3 glycan antibodies, and methods for their uses.
    Type: Grant
    Filed: March 21, 2016
    Date of Patent: July 9, 2019
    Assignee: DUKE UNIVERSITY
    Inventors: Barton F. Haynes, Ryan Meyerhoff, M. Anthony Moody, Hua-Xin Liao, Todd Bradley, Mattia Bonsignori
  • Patent number: 10322141
    Abstract: In certain aspects the invention provides immunogenic compositions comprising CH848 HIV-1 envelopes and their use in methods to induce immune responses in subjects, e.g., human subjects.
    Type: Grant
    Filed: March 31, 2015
    Date of Patent: June 18, 2019
    Assignees: DUKE UNIVERSITY, TRIAD NATIONAL SECURITY, LLC, THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Barton F. Haynes, Beatrice H. Hahn, George M. Shaw, Bette T. Korber, Peter T. Hraber
  • Publication number: 20190167783
    Abstract: The present invention relates, in general, to an HIV-1 vaccine and, in particular, to a B cell lineage-based vaccination protocol.
    Type: Application
    Filed: October 9, 2018
    Publication date: June 6, 2019
    Inventors: Barton F. HAYNES, Garnett KELSOE, Stephen HARRISON, Thomas B. KEPLER
  • Patent number: 10286057
    Abstract: The present invention relates, in general, to human immunodeficiency virus (HIV), and, in particular, to a vaccine for HIV-1, comprising synthetic V3 glycopeptides, and to methods of making and using same.
    Type: Grant
    Filed: April 15, 2014
    Date of Patent: May 14, 2019
    Assignees: Duke University, Sloan-Kettering Institute for Cancer Research, Dana-Farber Cancer Institute, Inc.
    Inventors: Barton F. Haynes, Hua-xin Liao, Samuel Danishefsky, Peter Park, Joseph Sodroski, Baptiste Aussedat, Yusuf Vohra
  • Patent number: 10273291
    Abstract: Antibody VRC01 represents a human immunoglobulin that neutralizes—˜90% of diverse HIV-1 isolates. To understand how such broadly neutralizing HIV-1 antibodies develop and recognize the viral envelope, we used X-ray crystallography and 454 pyrosequencing to characterize additional antibodies from HIV-1-infected individuals. Crystal structures revealed a convergent mode of binding of different antibodies to the same CD4-binding-site epitope. Antibody recognition was achieved through the evolution of complementary contact domains that were generated in diverse ways. Phylogenetic analysis of expressed heavy and light chains determined by deep sequencing revealed a common pathway of antibody heavy chain maturation confined to IGHV1-2*02 lineage that could pair with different light chains.
    Type: Grant
    Filed: March 23, 2012
    Date of Patent: April 30, 2019
    Assignees: Duke University, THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES OFFICE OF TECHNOLOGY TRANSFER, NATIONAL INSTITUTES OF HEALTH
    Inventors: John R. Mascola, Gary Nabel, Barton F. Haynes, Xueling Wu, Thomas B. Kepler, Peter Kwong
  • Patent number: 10232034
    Abstract: In certain aspects the invention provides a selection of HIV-1 envelopes suitable for use as immunogens, and methods of using these immunogens to induce neutralizing antibodies. In certain embodiments, the immunogens are designed to trimerize. In other embodiments, the immunogens comprise an immune modulating component.
    Type: Grant
    Filed: September 25, 2015
    Date of Patent: March 19, 2019
    Assignees: DUKE UNIVERSITY, LOS ALAMOS NATIONAL SECURITY, LLC
    Inventors: Barton F. Haynes, Hua-Xin Liao, Bette T. Korber, Peter T. Hraber
  • Patent number: 10183988
    Abstract: Disclosed herein are Complement factor H (CFH) inhibitors, such as anti-CFH antibodies and small molecules, and methods of using said inhibitors.
    Type: Grant
    Filed: June 7, 2014
    Date of Patent: January 22, 2019
    Assignee: Duke University
    Inventors: Edward F. Patz, Jr., Michael J. Campa, Elizabeth Gottlin, Barton F. Haynes, Hua-Xin Liao, Anthony M. Moody
  • Publication number: 20180360948
    Abstract: The present invention relates, in general, to HIV-1 and, in particular, to broadly neutralizing HIV-1 antibodies, and to HIV-1 immunogens and to methods of using such immunogens to induce the production of broadly neutralizing HIV-1 antibodies in a subject (e.g., a human).
    Type: Application
    Filed: January 8, 2018
    Publication date: December 20, 2018
    Inventors: Barton F. HAYNES, Hua-Xin LIAO, Rebecca M. LYNCH, Tongqing ZHOU, Feng GAO, Scott BOYD, George M. SHAW, Beatrice H. HAHN, Thomas B. KEPLER, Bette T. KORBER, Peter KWONG, John R. MASCOLA
  • Patent number: 10149902
    Abstract: In certain aspects the invention provides HIV-1 immunogens, including envelopes (CH505) and selections therefrom, and methods for swarm immunizations using combinations of HIV-1 envelopes.
    Type: Grant
    Filed: March 19, 2015
    Date of Patent: December 11, 2018
    Assignees: DUKE UNIVERSITY, LOS ALAMOS NATIONAL SECURITY, LLC
    Inventors: Barton F. Haynes, Feng Gao, Bette T. Korber, Peter T. Hraber
  • Publication number: 20180305411
    Abstract: The present invention relates, in general, to human immunodeficiency virus (HIV), and in particular to a vaccine for HIV-1 and to methods of making and using same.
    Type: Application
    Filed: June 27, 2018
    Publication date: October 25, 2018
    Inventors: Jerome KIM, Stephen HARRISON, Barton F. HAYNES, Georgia D. TOMARAS, Nelson MICHAEL
  • Publication number: 20180296665
    Abstract: The present invention relates, in general, to an immunogen and, in particular, to an immunogen for inducing antibodies that neutralizes a wide spectrum of HIV primary isolates and/or to an immunogen that induces a T cell immune response. The invention also relates to a method of inducing anti-HIV antibodies, and/or to a method of inducing a T cell immune response, using such an immunogen. The invention further relates to nucleic acid sequences encoding the present immunogens.
    Type: Application
    Filed: November 15, 2017
    Publication date: October 18, 2018
    Inventors: Barton F. Haynes, Feng Gao, Bette T. Korber, Beatrice H. Hahn, George M. Shaw, Denise Kothe, Ying Ying Li, Julie Decker, Hua-Xin Liao
  • Patent number: 10092638
    Abstract: The present invention relates, in general, to an HIV-1 vaccine and, in particular, to a B cell lineage-based vaccination protocol.
    Type: Grant
    Filed: October 3, 2012
    Date of Patent: October 9, 2018
    Assignees: DUKE UNIVERSITY, CHILDREN'S MEDICAL CENTER CORPORATION
    Inventors: Barton F. Haynes, Garnett Kelsoe, Stephen Harrison, Thomas B. Kepler
  • Publication number: 20180271973
    Abstract: In certain aspects the invention provides a selection of HIV-1 envelopes suitable for use as immunogens, and methods of using these immunogens in vaccination to induce neutralizing antibodies. In certain embodiments, the immunogens are designed to trimerize. In other embodiments, the immunogens and methods of using these comprise an immune modulating component.
    Type: Application
    Filed: December 23, 2015
    Publication date: September 27, 2018
    Inventors: Barton F. HAYNES, Hua-Xin LIAO, Bette T. KORBER, Peter T. HRABER
  • Patent number: 10076567
    Abstract: The present invention relates to peptides and compositions suitable for use in inducing anti-HIV-1 antibodies. The compositions comprise HIV-1 gp41 membrane proximal external region (MPER) peptide-liposome conjugates for induction of broadly reactive anti-HIV-1 antibodies. The invention also relates to methods of inducing neutralizing anti-HIV-1 antibodies using such compositions.
    Type: Grant
    Filed: September 29, 2014
    Date of Patent: September 18, 2018
    Assignees: DUKE UNIVERSITY, LOS ALAMOS NATIONAL SECURITY, LLC
    Inventors: Barton F. Haynes, Bette T. Korber, S. Munir Alam
  • Publication number: 20180256719
    Abstract: The invention is directed to HIV-1 neutralizing antibodies and methods for their uses.
    Type: Application
    Filed: March 21, 2016
    Publication date: September 13, 2018
    Applicants: Duke University, University of Maryland, College Park
    Inventors: Barton F. HAYNES, Hua-Xin LIAO, M. Anthony MOODY, LaTonya WILLIAMS, Kevin J. WIEHE, Gilad Adi OFEK
  • Publication number: 20180230201
    Abstract: The invention features a novel influenza antibody that specifically binds to influenza hemagglutinin and reduces or inhibits hemagglutinin binding to sialic acid. The invention also provides methods, compositions, and kits featuring the novel antibody and its use in preventing or treating influenza infection.
    Type: Application
    Filed: June 20, 2017
    Publication date: August 16, 2018
    Inventors: James Whittle, Stephen C. Harrison, Barton F. Haynes, Hua-Xin Liao, Michael Anthony Moody, Thomas B. Kepler, Aaron G. Schmidt
  • Patent number: 10040826
    Abstract: The present invention relates, in general, to human immunodeficiency virus (HIV), and in particular to a vaccine for HIV-1 and to methods of making and using same.
    Type: Grant
    Filed: July 5, 2012
    Date of Patent: August 7, 2018
    Assignees: DUKE UNIVERSITY, THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE ARMY, CHILDREN'S MEDICAL CENTER CORPORATION
    Inventors: Jerome Kim, Stephen Harrison, Barton F. Haynes, Georgia D. Tomaras, Nelson Michael
  • Publication number: 20180185471
    Abstract: The present invention relates, in general, to an immunogenic composition (e.g., a vaccine) and, in particular, to a polyvalent immunogenic composition, such as a polyvalent HIV vaccine, and to methods of using same. The invention further relates to methods that use a genetic algorithm to create sets of polyvalent antigens suitable for use, for example, in vaccination strategies.
    Type: Application
    Filed: December 15, 2017
    Publication date: July 5, 2018
    Inventors: Bette T. Korber, William Fischer, Norman Letvin, Hua-Xin Liao, Barton F. Haynes, Beatrice H. Hahn
  • Patent number: 10004800
    Abstract: The present invention relates, in general, to HIV-1 and, in particular, to broadly neutralizing HIV-1 antibodies, and to HIV-1 immunogens and to methods of using such immunogens to induce the production of broadly neutralizing HIV-1 antibodies in a subject (e.g., a human).
    Type: Grant
    Filed: September 12, 2013
    Date of Patent: June 26, 2018
    Assignees: Duke University, Los Alamos National Security, LLC, The Trustees of The University of Pennsylvania, Trustees of Boston University, The United States of America as Represented by The Secretary of the Department of Health and Human Services National Institutes of Health Office of Technology Transfer, The Board of Trustees of the Leland Stanford Junior University
    Inventors: Barton F. Haynes, Hua-Xin Liao, Rebecca M. Lynch, Tongqing Zhou, Feng Gao, Scott Boyd, George M. Shaw, Beatrice H. Hahn, Thomas B. Kepler, Bette T. Korber, Peter Kwong, John Mascola
  • Publication number: 20180161423
    Abstract: The present invention relates, in general, to human immunodeficiency virus (HIV), and, in particular, to a method of inducing neutralizing antibodies to HIV and to compounds and compositions suitable for use in such a method.
    Type: Application
    Filed: June 26, 2017
    Publication date: June 14, 2018
    Inventors: Barton F. HAYNES, S. Munir ALAM, Hua-Xin LIAO