Patents by Inventor Barton F. Haynes

Barton F. Haynes has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antigen specific fluorescent nanoparticles
    Publication number: 20090202651
    Abstract: The present invention relates, in general, to nanoparticles and, in particular, to nanoparticles coated with, for example, peptides, proteins, and/or carbohydrates, and to methods of producing and using same. The invention further relates to kits comprising the coated nanoparticles.
    Type: Application
    Filed: August 24, 2007
    Publication date: August 13, 2009
    Inventors: Michael A. Moody, Barton F. Haynes
  • POLYVALENT VACCINE
    Publication number: 20090198042
    Abstract: The present invention relates, in general, to an immunogenic composition (e.g., a vaccine) and, in particular, to a polyvalent immunogenic composition, such as a polyvalent HIV vaccine, and to methods of using same. The invention further relates to methods that use a genetic algorithm to create sets of polyvalent antigens suitable for use, for example, in vaccination strategies.
    Type: Application
    Filed: August 14, 2008
    Publication date: August 6, 2009
    Inventors: Bette T. KORBER, William Fischer, Hua-Xin Liao, Barton F. Haynes, Norman Letvin, Beatrice H. Hahn
  • Consensus/ancestral immunogens
    Publication number: 20090162384
    Abstract: The present invention relates, in general, to an immunogen and, in particular, to an immunogen for inducing antibodies that neutralize a wide spectrum of HIV primary isolates and/or to an immunogen that induces a T cell immune response. The invention also relates to a method of inducing anti-HIV antibodies, and/or to a method of inducing a T cell immune response, using such an immunogen. The invention further relates to nucleic acid sequences encoding the present immunogens.
    Type: Application
    Filed: September 6, 2007
    Publication date: June 25, 2009
    Applicants: DUKE UNIVERSITY, THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE UNIVERSITY OF ALABAMA RESEARCH FOUNDATION AT BIRMINGHAM
    Inventor: Barton F. Haynes
  • Multivalent Immunogen
    Publication number: 20090136522
    Abstract: The present invention relates, in general, to HIV and, in particular, to immunogens that present epitopes located in the membrane external proximal region (MPER) of HIV-I envelope gp41 in multivalent form and to methods of using same.
    Type: Application
    Filed: March 26, 2007
    Publication date: May 28, 2009
    Inventors: Barton F. Haynes, Michael Moody, Laurent Verkozcy, Bruce A. Sullenger, Juliana Layzer
  • Mycobacteria Expressing Hiv-1 and Malaria Antigens
    Publication number: 20080254061
    Abstract: Provided are recombinant mycobacteria expressing an HIV-1 antigen and a malarial antigen. Also provided are Mycobacterium smegmatis expressing an HIV-1 antigen. Further provided are vaccines capable of inducing an immune response in a mammal against HIV-1 and the malarial pathogen. Additionally provided are methods of inducing an immune response in a mammal against HIV-1 and a malarial pathogen. Also provided are methods of inducing an immune response in a mammal against HIV-1. The methods comprise infecting the mammal with any of the above-described mycobacteria.
    Type: Application
    Filed: January 11, 2006
    Publication date: October 16, 2008
    Inventors: William R. Jacobs, Norman L. Letvin, Mark Cayabyab, Barton F. Haynes, Hua-Xin Liao, Jae-Sung Yu, Avi-Hai Hovav
  • Immunogen
    Publication number: 20080213296
    Abstract: The present invention relates, in general, to an immunogen for inducing antibodies that neutralize a wide spectrum of HIV primary isolates. The invention also relates to a method of inducing anti-HIV antibodies using same.
    Type: Application
    Filed: September 14, 2004
    Publication date: September 4, 2008
    Applicant: DUKE UNIVERSITY
    Inventors: Barton F. Haynes, Dhavalkumar D. Patel, Munir Alam, Hua-Xin Liao
  • Polyvalent immunogen
    Patent number: 7195768
    Abstract: The present invention relates, generally, to a polyvalent immunogen and, more particularly, to a method of inducing neutralizing antibodies against HIV and to a polyvalent immunogen suitable for use in such a method.
    Type: Grant
    Filed: February 26, 2003
    Date of Patent: March 27, 2007
    Assignees: Duke University, The Regents of the University of California
    Inventors: Barton F. Haynes, Bette T. Korber, Robert M. De Lorimier
  • Polyvalent immunogen
    Patent number: 7172761
    Abstract: The present invention relates, generally, to a polyvalent immunogen and, more particularly, to a method of inducing neutralizing antibodies against HIV and to a polyvalent immunogen suitable for use in such a method.
    Type: Grant
    Filed: May 8, 2003
    Date of Patent: February 6, 2007
    Assignees: Duke University, The Regents of The University of California
    Inventors: Barton F. Haynes, Bette T. Korber, Robert M. De Lorimier, Hua-Xin Liao
  • Immunogenic peptides comprising a T-helper epitope and a B-cell neutralizing antibody epitope
    Patent number: 7153509
    Abstract: The present invention relates, generally, to a polyvalent immunogen and, more particularly, to a method of inducing neutralizing antibodies against HIV and to a polyvalent immunogen suitable for use in such a method.
    Type: Grant
    Filed: November 7, 2002
    Date of Patent: December 26, 2006
    Assignees: Duke University, The Regents of the University of Calforinia
    Inventors: Barton F. Haynes, Bette T. Korber, Robert M. De Lorimier
  • Immunogen comprising an HIV envelope protein, a ligand and H2 peptide
    Patent number: 7101552
    Abstract: The present invention relates, in general, to an immunogen and, in particular, to an immunogen for inducing antibodies that neutralize a wide spectrum of HIV primary isolates. The invention also relates to a method of inducing anti-HIV antibodies using same.
    Type: Grant
    Filed: September 24, 2001
    Date of Patent: September 5, 2006
    Assignee: Duke University
    Inventors: Barton F. Haynes, Dhavalkumar D. Patel, Munir Alam, Hua-Xin Liao
  • Immunogenic composition
    Patent number: 7078039
    Abstract: The present invention relates, in general, to human immunodeficiency virus (HIV) and, in particular, to an HLA-based HIV vaccine.
    Type: Grant
    Filed: October 27, 2004
    Date of Patent: July 18, 2006
    Assignees: Duke University, Beth Israel Deaconess Medical Center
    Inventors: Barton F. Haynes, Hua-Xin Liao, Norman Letvin
  • Method of inducing the production of antibodies to HIV
    Patent number: 7070787
    Abstract: The present invention relates, in general, to an immunogen and, in particular, to an immunogen for inducing antibodies that neutralize a wide spectrum of HIV primary isolates. The invention also relates to a method of inducing anti-HIV antibodies using same.
    Type: Grant
    Filed: August 25, 2003
    Date of Patent: July 4, 2006
    Assignee: Duke University
    Inventors: Barton F. Haynes, Dhavalkumar D. Patel, Munir Alam, Hua-Xin Liao
  • Immunogenic composition
    Patent number: 7052699
    Abstract: The present invention relates, in general, to human immunodeficiency virus (HIV) and, in particular, to an HLA-based HIV vaccine.
    Type: Grant
    Filed: January 9, 2004
    Date of Patent: May 30, 2006
    Assignees: Duke University, Beth Israel Deaconess Medical Center
    Inventors: Barton F. Haynes, Hua-Xin Liao, Norman Letvin
  • Substantially non-toxic biologically active mucosal adjuvants in vertebrate subjects
    Patent number: 7041294
    Abstract: A method of eliciting an immune response against an antigen in a vertebrate subject, the method comprising the steps of providing an antigen-adjuvant composition comprising the antigen and a substantially non-toxic adjuvant molecule having biological activity in mucosal tissues, and administering said antigen-adjuvant composition to the vertebrate subject in a manner such that initial contact occurs in mucosal tissue of the vertebrate subject, whereby an immune response is elicited. Cytokines are preferred adjuvants. Preferred cytokines are interleukin-1?(IL-1?) and interleukin-1? (IL-1?).
    Type: Grant
    Filed: June 5, 2001
    Date of Patent: May 9, 2006
    Assignee: Duke University
    Inventors: Herman F. Staats, Barton F. Haynes, Dhavalkumar D. Patel, Gregory D. Sempowski
  • Immunogen comprising an HIV envelope protein, a ligand and H2 peptide
    Patent number: 7033593
    Abstract: The invention relates to an immunogen comprising an HIV envelope protein bound to a ligand, which ligand upregulates at least one of the CD4 binding site and the CCR5 binding site on the protein, and bound to an HR-2 peptide. The invention also relates to a method of inducing anti-HIV antibodies using such an immunogen.
    Type: Grant
    Filed: September 17, 2003
    Date of Patent: April 25, 2006
    Assignee: Duke University
    Inventors: Barton F. Haynes, Dhavalkumar D. Patel, Munir Alam, Hua-Xin Liao
  • Human immunodeficiency virus immunogenic composition
    Patent number: 6982086
    Abstract: The present invention relates to a method of immunizing a patient against human immunodeficiency virus (HIV) and to an HLA-based immunogenic composition suitable for use in such a method.
    Type: Grant
    Filed: February 5, 2001
    Date of Patent: January 3, 2006
    Assignees: Duke University, Beth Israel Deaconess Medical Center
    Inventors: Barton F. Haynes, Hua-Xin Liao, Norman Letvin
  • Vaccine adjuvant
    Publication number: 20040202675
    Abstract: The present invention relates generally to K12 and more specifically to the use of K12 as a non-antigen specific activator of immune function.
    Type: Application
    Filed: December 9, 2003
    Publication date: October 14, 2004
    Applicant: DUKE UNIVERSITY
    Inventor: Barton F. Haynes
  • Human immunodeficiency virus vaccine
    Publication number: 20040197344
    Abstract: The present invention relates, in general, to human immunodeficiency virus (HIV) and, in particular, to an HLA-based HIV vaccine.
    Type: Application
    Filed: January 9, 2004
    Publication date: October 7, 2004
    Applicants: DUKE UNIVERSITY, BETH ISRAEL DEACONESS MEDICAL CENTER
    Inventors: Barton F. Haynes, Hua-Xin Liao, Norman Letvin
  • Immunogen
    Publication number: 20040132010
    Abstract: The present invention relates, in general, to an immunogen and, in particular, to an immunogen for inducing antibodies that neutralize a wide spectrum of HIV primary isolates. The invention also relates to a method of inducing anti-HIV antibodies using same.
    Type: Application
    Filed: September 17, 2003
    Publication date: July 8, 2004
    Applicant: DUKE UNIVERSITY
    Inventors: Barton F. Haynes, Dhavalkumar D. Patel, Munir Alam, Hua-Xin Liao
  • Thymic atrophy
    Publication number: 20040131619
    Abstract: The present invention relates, in general, to thymic atrophy and, in particular, to a method of treating or preventing thymic atrophy in septic shock.
    Type: Application
    Filed: September 30, 2003
    Publication date: July 8, 2004
    Applicant: DUKE UNIVERSITY
    Inventors: Gregory D. Sempowski, Barton F. Haynes