Patents by Inventor Barton F. Haynes

Barton F. Haynes has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTIBODY EVOLUTION IMMUNOGENS
    Publication number: 20150366961
    Abstract: The present invention relates, in general, to HIV-1 and, in particular, to broadly neutralizing HIV-1 antibodies, and to HIV-1 immunogens and to methods of using such immunogens to induce the production of broadly neutralizing HIV-1 antibodies in a subject (e.g., a human).
    Type: Application
    Filed: September 12, 2013
    Publication date: December 24, 2015
    Inventors: Barton F. HAYNES, Hua-Xin LIAO, Rebecca M. LYNCH, Tongqing ZHOU, Feng GAO, Scott BOYD, George M. SHAW, Beatrice H. HAHN, Thomas B. KEPLER, Bette T. KORBER, Peter KWONG, John MASCOLA
  • POLYVALENT VACCINE
    Publication number: 20150359875
    Abstract: The disclosure generally relates to an immunogenic composition (e.g., a vaccine) and, in particular, to a polyvalent immunogenic composition, such as a polyvalent HIV vaccine, and to methods of using same.
    Type: Application
    Filed: April 17, 2015
    Publication date: December 17, 2015
    Inventors: Bette T. KORBER, Simon Perkins, Tanmoy Bhattacharya, William M. Fischer, James Theiler, Norman Letvin, Barton F. Haynes, Beatrice H. Hahn, Karina Yusim, Carla Kuiken
  • VACCINE FORMULATION
    Publication number: 20150359874
    Abstract: The present invention relates, in general, to a method of inducing an immune response to HIV-1 in a mammal and, in particular, to a vaccine formulation suitable for use in such a method comprising an HIV-1 envelope (Env) immunogen comprising recombinant Envs with some degree of high-mannose glycan residues and a Toll-like receptor (TLR) agonist-supplemented squalene-based adjuvant.
    Type: Application
    Filed: March 5, 2013
    Publication date: December 17, 2015
    Inventors: Anthony M. Moody, Barton F. Haynes
  • SYNTHETIC ENV PROTEINS
    Publication number: 20150283227
    Abstract: The present invention relates, in general, to human immunodeficiency virus-1 (HIV-1), and, in particular to a vaccine for HIV-1 and to methods of making and using same. The present invention provides synthetic glycosylated HIV-1 peptides, method for their preparation and use.
    Type: Application
    Filed: October 28, 2013
    Publication date: October 8, 2015
    Inventors: Barton F. Haynes, Hua-Xin Liao, S. Munir Alam, Samuel Danishefsky, Baptiste Aussedat, Peter K. Park, Yusuf Vohra, Joseph Sodroski
  • POLYVALENT VACCINE
    Publication number: 20150265700
    Abstract: The present invention relates, in general, to an immunogenic composition (e.g., a vaccine) and, in particular, to a polyvalent immunogenic composition, such as a polyvalent HIV vaccine, and to methods of using same. The invention further relates to methods that use a genetic algorithm to create sets of polyvalent antigens suitable for use, for example, in vaccination strategies.
    Type: Application
    Filed: May 29, 2015
    Publication date: September 24, 2015
    Inventors: Bette T. KORBER, William Fischer, Norman Letvin, Hua-Xin Liao, Barton F. Haynes, Beatrice H. Hahn
  • ADCC-MEDIATING ANTIBODIES, COMBINATIONS AND USES THEREOF
    Publication number: 20150239961
    Abstract: The present invention relates, in general, to antibody-dependent cellular cytoxicity (ADCC)-mediating antibodies, and, in particular, to ADCC-mediating antibodies (and fragments thereof) suitable for use, for example, in reducing the risk of HIV-1 infection in a subject. The invention further relates to compositions comprising such antibodies or antibody fragments.
    Type: Application
    Filed: September 26, 2013
    Publication date: August 27, 2015
    Inventors: Barton F. Haynes, Mattia Bonsignori, Hua-xin Liao, Guido Ferrari, Michael A. Moody, Jerome Kim, Nelson Michael, Justin Pollara
  • Mosaic clade M human immunodeficiency virus type 1 (HIV-1) gag immunogens
    Patent number: 9044445
    Abstract: The present invention relates, in general, to an immunogenic composition (e.g., a vaccine) and, in particular, to a polyvalent immunogenic composition, such as a polyvalent HIV vaccine containing nucleic acids encoding HIV-1 gag mosaic proteins, and to methods of using same. The invention further relates to methods that use a genetic algorithm to create sets of polyvalent antigens suitable for use, for example, in vaccination strategies.
    Type: Grant
    Filed: August 14, 2009
    Date of Patent: June 2, 2015
    Assignees: LOS ALAMOS NATIONAL SECURITY, LLC, BETH ISRAEL DEACONESS MEDICAL CENTER, DUKE UNIERSITY, THE UAB RESEARCH FOUNDATION
    Inventors: Bette T. Korber, William Fischer, Norman Letvin, Hua-Xin Liao, Barton F. Haynes, Beatrice H. Hahn
  • METHOD OF INDUCING ANTIBODIES TO HUMAN IMMUNODEFICIENCY VIRUS INVOLVING THE ADMINISTRATION OF MPER PEPTIDE-LIPOSOME CONJUGATES
    Publication number: 20150147387
    Abstract: The present invention relates to a method of inducing the production in a patient of anti-HIV antibodies. The method comprises administering to a patient in need thereof an amount of at least one liposome-peptide conjugate in an amount sufficient to effect that induction. The peptide comprises a membrane external proximal region (MPER) epitope and the liposome comprises lysophosphorylcholine or phosphatidylserine.
    Type: Application
    Filed: February 3, 2015
    Publication date: May 28, 2015
    Inventors: Barton F. HAYNES, S. Munir Alam, Hua-Xin Liao
  • Nucleic acids encoding mosaic clade M human immunodeficiency virus type 1 (HIV-1) envelope immunogens
    Patent number: 9011873
    Abstract: The present invention relates to nucleic acids encoding mosaic clade M HIV-1 Env polypeptides and to compositions and vectors comprising same. The nucleic acids of the invention are suitable for use in inducing an immune response to HIV-1 in a human.
    Type: Grant
    Filed: April 26, 2011
    Date of Patent: April 21, 2015
    Assignees: Los Alamos National Security, LLC, Duke University, Beth Israel Deaconess Medical Center, The University of Alabama at Birmingham Research Foundation
    Inventors: Bette T. Korber, William Fischer, Hua-Xin Liao, Barton F. Haynes, Norman Letvin, Beatrice H. Hahn
  • Human immunodeficiency virus type 1 clade M mosaic gag polypeptides
    Patent number: 9011875
    Abstract: The present invention relates to mosaic HIV-1 group M Gag sequences and to a composition comprising same.
    Type: Grant
    Filed: February 17, 2012
    Date of Patent: April 21, 2015
    Assignees: Los Alamos National Security, LLC, Beth Israel Deaconess Medical Center, Duke University, The University of Alabama at Birmingham Research Foundation
    Inventors: Bette T. Korber, Simon Perkins, Tanmoy Bhattacharya, William M. Fischer, James Theiler, Norman Letvin, Barton F. Haynes, Beatrice H. Hahn, Karina Yusim, Carla Kuiken
  • VACCINE
    Publication number: 20150050309
    Abstract: The present invention relates, in-general, to Human immunodeficiency virus (HIV), and in particular to a carbohydrate-based vaccine for HIV and to methods of making and using same.
    Type: Application
    Filed: July 16, 2014
    Publication date: February 19, 2015
    Applicants: Duke University, University of Kansas
    Inventors: Barton F. HAYNES, Heather Desaire, Eden P. Go
  • Method of inducing antibodies to human immunodeficiency virus involving the administration of MPER peptide-liposome conjugates
    Patent number: 8956627
    Abstract: The present invention relates to a method of inducing the production in a patient of anti-HIV antibodies. The method comprises administering to a patient in need thereof an amount of at least one liposome-peptide conjugate in an amount sufficient to effect that induction. The peptide comprises a membrane external proximal region (MPER) epitope and the liposome comprises lysophosphorylcholine or phosphatidylserine.
    Type: Grant
    Filed: April 11, 2008
    Date of Patent: February 17, 2015
    Assignee: Duke University
    Inventors: Barton F. Haynes, S. Munir Alam, Hua-Xin Liao
  • Adjuvant
    Patent number: 8926995
    Abstract: The present invention relates, in general, to human immunodeficiency virus (HIV-1) and, in particular, to a method of enhancing an immune response to an HIV-1 immunogen, and to compounds and compositions suitable for use in such a method.
    Type: Grant
    Filed: November 23, 2011
    Date of Patent: January 6, 2015
    Assignee: Duke University
    Inventors: Barton F. Haynes, Laurent Verkoczy, M. Anthony Moody, Matt T. Holl, Masayuki Kuraoka, Garnett Kelsoe
  • VACCINE
    Publication number: 20140341949
    Abstract: The present invention relates, in general, to an HIV-1 vaccine and, in particular, to a B cell lineage-based vaccination protocol.
    Type: Application
    Filed: October 3, 2012
    Publication date: November 20, 2014
    Applicants: DUKE UNIVERSITY, Children's Medical Center Corporation
    Inventors: Barton F. Haynes, Garnett Kelsoe, Stephen Harrison, Thomas B. Kepler
  • V1V2 IMMUNOGENS
    Publication number: 20140335126
    Abstract: The present invention relates, in general, to human immunodeficiency virus (HIV), and in particular to a vaccine for HIV-1 and to methods of making and using same.
    Type: Application
    Filed: December 5, 2012
    Publication date: November 13, 2014
    Inventors: Barton F. Haynes, Huaxin Liao, Jerome Kim, Nelson Michael, Susan B. Zolla-Pazner
  • METHOD OF INDUCING NEUTRALIZING ANTIBODIES TO HUMAN IMMUNODEFICIENCY VIRUS
    Publication number: 20140322262
    Abstract: The present invention relates, in general, to human immunodeficiency virus (HIV), and, in particular, to a method of inducing neutralizing antibodies to HIV and to compounds and compositions suitable for use in such a method.
    Type: Application
    Filed: April 9, 2012
    Publication date: October 30, 2014
    Inventors: Leonard D. Spicer, Patrick N. Reardon, Barton F. Haynes, S. Munir Alam
  • HERPES SIMPLEX VIRUS
    Publication number: 20140302062
    Abstract: The present invention relates, in general to herpes simplex virus (HSV) and, particular, to antibodies that are specific for glycoprotein D (gD) of HSV. The invention also relates to prophylactic and therapeutic uses of such antibodies.
    Type: Application
    Filed: April 9, 2012
    Publication date: October 9, 2014
    Applicants: U.S. ARMY MEDICAL RESEARCH AND MATERIEL COMMAND, DUKE UNIVERSITY
    Inventors: Barton F. Haynes, Hua-Xin Liao, M. Anthony Moody, Georgia D. Tomaras, Jerome Kim, Nelson Michael
  • BROADLY NEUTRALIZING HUMAN ANTIBODY THAT RECOGNIZES THE RECEPTOR-BINDING POCKET OF INFLUENZA HEMAGGLUTININ
    Publication number: 20140302043
    Abstract: The invention features a novel influenza antibody that specifically binds to influenza hemagglutinin and reduces or inhibits hemagglutinin binding to sialic acid. The invention also provides methods, compositions, and kits featuring the novel antibody and its use in preventing or treating influenza infection.
    Type: Application
    Filed: February 3, 2014
    Publication date: October 9, 2014
    Applicants: DUKE UNIVERSITY, CHILDREN'S HOSPITAL BOSTON
    Inventors: James Whittle, Stephen C. Harrison, Barton F. Haynes, Hua-Xin Liao, M. Anthomy Moody, Thomas B. Kepler, Aaron G. Schmidt
  • METHOD OF INDUCING THE PRODUCTION OF PROTECTIVE ANTI-HIV-1 ANTIBODIES
    Publication number: 20140248301
    Abstract: The present invention relates, in general, to an immunogen for HIV vaccination and, in particular, to a method of inducing the production of protective anti-HIV antibodies by targeting B cell germline and clone intermediates using a combination of HIV envelope and non-HIV immunogens. The invention also relates to compositions suitable for use in such a method.
    Type: Application
    Filed: December 13, 2013
    Publication date: September 4, 2014
    Inventors: Barton F. Haynes, Hua-Xin Liao, Li-Hua Ping, Ronald Swanstrom, Beatrice H. Hahn, George M. Shaw
  • N-TERMINAL DELETED GP120 IMMUNOGENS
    Publication number: 20140248311
    Abstract: The present invention relates, in general, to human immunodeficiency virus (HIV), and in particular to a vaccine for HIV-1 and to methods of making and using same.
    Type: Application
    Filed: July 5, 2012
    Publication date: September 4, 2014
    Applicants: DUKE UNIVERSITY, U.S ARMY MEDICAL RESEARCH AND MATERIEL COMMAND, CHILDREN'S MEDICAL CENTER CORPORATION
    Inventors: Jerome Kim, Stephen Harrison, Barton F. Haynes, Georgia D. Tomaras, Nelson Michael