Patents by Inventor Beatrice Guardiola

Beatrice Guardiola has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5310739
    Abstract: The invention relates to the compounds of general formula ##STR1## in which R.sub.1, R.sub.2, R.sub.4, R.sub.5 and A are as defined in the description.their isomers, diastereoisomers, and enantiomers as well as their addition salts with a pharmaceutically acceptable inorganic or organic acid, andmedicinal products containing the same which are usable for the treatment of psycho-behavioral disorders.
    Type: Grant
    Filed: May 13, 1992
    Date of Patent: May 10, 1994
    Assignee: Adir et Compagnie
    Inventors: Henri P. Husson, Jean C. Quirion, Martine Bonin, Beatrice Guardiola, Gerard Adam, Pierre Renard
  • Patent number: 5308866
    Abstract: The invention relates to a compound selected from those of formula (I): ##STR1## in which Ar', R.sub.1 and R.sub.2 are as defined in the specification, an optical isomer,and an addition salt thereof with a pharmaceutically-acceptable acid or base.Medicinal product which is useful in treating or in preventing a disorder of the melatoninergic system.
    Type: Grant
    Filed: July 19, 1993
    Date of Patent: May 3, 1994
    Assignee: Adir et Compagnie
    Inventors: Daniel Lesieur, Said Yous, Patrick Depreux, Jean Andrieux, Gerard Adam, Daniel H. Caignard, Beatrice Guardiola
  • Patent number: 5300507
    Abstract: Compounds of general formula (I): ##STR1## where R, X, A, B and p are defined in the description. Medicinal products useful for treating sleeping disorders comprising the same.
    Type: Grant
    Filed: April 28, 1993
    Date of Patent: April 5, 1994
    Assignee: Adir et Compagnie
    Inventors: Said Yous, Isabelle Lesieur, Patrick Depreux, Daniel H. Caignard, Beatrice Guardiola, Gerard Adam, Pierre Renard
  • Patent number: 5296477
    Abstract: Compounds of general formula (I): ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, n, X and A are defined in the description.Medicinal products containing the same are useful as antidepressives or anxiolytics due to their 5-HT1A receptor agonist activity.
    Type: Grant
    Filed: December 1, 1992
    Date of Patent: March 22, 1994
    Assignee: Adir et Compagnie
    Inventors: Thierry Taverne, Isabelle Lesieur, Patrick Depreux, Daniel H. Caignard, Beatrice Guardiola, Gerard Adam, Pierre Renard
  • Patent number: 5276051
    Abstract: The invention relates to a compound selected from those of formula (I): ##STR1## in which Ar', R.sub.1 and R.sub.2 are as defined in the specification, an optical isomer,and an addition salt thereof with a pharmaceutically-acceptable acid or base.Medicinal product which is useful in treating or in preventing a disorder of the melatoninergic system.
    Type: Grant
    Filed: August 12, 1992
    Date of Patent: January 4, 1994
    Assignee: Adir et Compagnie
    Inventors: Daniel Lesieur, Said Yous, Patrick Depreux, Jean Andrieux, Gerard Adam, Daniel H. Caignard, Beatrice Guardiola
  • Patent number: 5273994
    Abstract: The invention relates to the derivatives of general formula (I): ##STR1## in which: Z represents an oxygen atom or a sulfur atom,R.sub.1 represents a hydrogen atom or an alkyl group,R.sub.2 represents a hydrogen atom or an alkyl group,1.ltoreq.n.ltoreq.6,R.sub.3 represents a nitrile group, an optionally substituted amino group or any one of the groups described in the description, andmedicinal products containing the same.
    Type: Grant
    Filed: October 9, 1992
    Date of Patent: December 28, 1993
    Assignee: Adir et Compagnie
    Inventors: Gerald Guillaumet, Beatrice Guardiola
  • Patent number: 5268381
    Abstract: Compounds of general formula (I): ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, n, X and A are defined in the description. Medicinal products containing the same are useful as antidepressives or anxiolytics due to their 5-HT1A receptor agonist activity.
    Type: Grant
    Filed: September 16, 1992
    Date of Patent: December 7, 1993
    Assignee: Adir et Compagnie
    Inventors: Thierry Taverne, Isabelle Lesieur, Patrick Depreux, Daniel H. Caignard, Beatrice Guardiola, Gerard Adam, Pierre Renard
  • Patent number: 5252578
    Abstract: The invention relates to the derivatives of general formula (I): ##STR1## in which: Z represents an oxygen atom or a sulfur atom,R.sub.1 represents a hydrogen atom or an alkyl group,R.sub.2 represents a hydrogen atom or an alkyl group,1.ltoreq.n.ltoreq.6,R.sub.3 represents a nitrile group, an optionally substituted amino group or any one of the groups described in the description, and medicinal products.
    Type: Grant
    Filed: March 29, 1991
    Date of Patent: October 12, 1993
    Assignee: Adir et Compagnie
    Inventors: Gerald Guillaumet, Beatrice Guardiola
  • Patent number: 5240919
    Abstract: Compounds of general formula (I): ##STR1## where R, X, A, B and p are defined in the description. Medicinal products useful for treating sleep disorders comprising the same.
    Type: Grant
    Filed: March 9, 1992
    Date of Patent: August 31, 1993
    Assignee: Adir et Compagnie
    Inventors: Said Yous, Isabelle Lesieur, Patrick Depreux, Daniel H. Caignard, Beatrice Guardiola, Gerard Adam, Pierre Renard
  • Patent number: 5234924
    Abstract: Compound of general formula (I): ##STR1## where R.sub.1, R.sub.2, R.sub.3, n and X are defined in the description. Medicinal products.
    Type: Grant
    Filed: December 5, 1991
    Date of Patent: August 10, 1993
    Assignee: Adir et Compagnie
    Inventors: Thierry Taverne, Isabelle Lesieur, Patrick Depreux, Daniel H. Caignard, Beatrice Guardiola, Gerard Adam, Pierre Renard
  • Patent number: 5225442
    Abstract: Compounds of general formula: ##STR1## in which A and R are defined in the description. Medicaments containing the same and useful for the treatment of melatoninergic disorders.
    Type: Grant
    Filed: January 3, 1992
    Date of Patent: July 6, 1993
    Assignee: Adir et Compagnie
    Inventors: Jean Andrieux, Raymond Houssin, Said Yous, Beatrice Guardiola, Daniel Lesieur
  • Patent number: 5225409
    Abstract: Benzoxazinone compounds of general formula (I): ##STR1## useful in the treatment of serotoninergic disorders, especially anxiety and schizophrenia, requiring for their treatment compounds which are 5-HT.sub.1A receptor agonists, wherein R.sub.1, R.sub.2, R.sub.3, and n are as defined in the description, and medicinal products containing the same, are disclosed.
    Type: Grant
    Filed: September 26, 1991
    Date of Patent: July 6, 1993
    Assignee: Adir et Compagnie
    Inventors: Thierry Taverne, Isabelle Lesieur, Patrick Depreux, Daniel H. Caignard, Beatrice Guardiola, Gerard Adam, Pierre Renard
  • Patent number: 5196434
    Abstract: Compound of general formula (I): ##STR1## where R.sub.1, R.sub.2, R.sub.3, n, X and A are defined in the description.Medicinal products.
    Type: Grant
    Filed: September 26, 1991
    Date of Patent: March 23, 1993
    Assignee: Adir et Compagnie
    Inventors: Thierry Taverne, Isabelle Lesieur, Patrick Depreux, Daniel H. Caignard, Beatrice Guardiola, Gerard Adam, Pierre Renard
  • Patent number: 5194614
    Abstract: Compounds of general formula: ##STR1## in which A and R are defined in the description.
    Type: Grant
    Filed: February 26, 1991
    Date of Patent: March 16, 1993
    Assignee: Adir et Compagnie
    Inventors: Jean Andrieux, Raymond Houssin, Said Yous, Beatrice Guardiola, Daniel Lesieur
  • Patent number: 5190939
    Abstract: The invention relates to compounds of general formula I: ##STR1## in which: R.sub.1 represents a radical of general formula (Z.sub.0), (Z.sub.1), (Z.sub.2), (Z.sub.3) or (Z.sub.4) ##STR2## R.sub.2 represents a methylene radical, a hydroxymethylene radical, a carbonyl radical or a radical of general formula (Y.sub.1), (Y.sub.2), (Y.sub.3) or (Y.sub.4): ##STR3## or, with R.sub.12 and the nitrogen atom to which they are attached, forms a radical of general formula (W): ##STR4## R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8, R.sub.9, R.sub.10, R.sub.11, R.sub.12 and n being as defined in the description, medicinal products containing the same and a method-of-treating metabolic ailments therewith.
    Type: Grant
    Filed: March 7, 1991
    Date of Patent: March 2, 1993
    Assignee: Adir et Compagnie
    Inventors: Sylvain Rault, Michel Boulouard, Patrick Dallemagne, Max Robba, Beatrice Guardiola, Michelle Devissaguet
  • Patent number: 5190960
    Abstract: Compounds of general formula (I): ##STR1## in which: R.sub.1 and R.sub.2 each represent a hydrogen atom or, with the nitrogen and oxygen which bear them, form an --O--CO--N link,W represents a halogen atom or a lower alkyl or alkoxy group optionally substituted with one or more halogen atoms, such as trifluoromethyl, and m being between 0 and 3,A is a linear or branched alkyl radical comprising from 1 to 6 carbon atoms,R.sub.3 and R.sub.4 are defined in the description.
    Type: Grant
    Filed: November 12, 1991
    Date of Patent: March 2, 1993
    Assignee: Adir et Compagnie
    Inventors: Gerald Guillaumet, Christine Flouzat, Daniel H. Caignard, Pierre Renard, Michelle Devissaguet, Beatrice Guardiola
  • Patent number: 5179091
    Abstract: Compounds of general formula (I): in which: ##STR1## R.sub.1, X, Y, Z, T, R.sub.2, R.sub.3 and R.sub.4 are defined in the description. Medicinal products.
    Type: Grant
    Filed: June 3, 1991
    Date of Patent: January 12, 1993
    Assignee: Adir et Compagnie
    Inventors: Daniel Lesieur, Daniel H. Caignard, Isabelle Lesieur, Michelle Devissaguet, Beatrice Guardiola
  • Patent number: 5155116
    Abstract: Compounds of general formula (I): ##STR1## in which: R.sub.1 and R.sub.2 each represent a hydrogen atom or, with the nitrogen and oxygen which bear them, form an --O--CO--N link,W represents a halogen atom or a lower alkyl or alkoxy group optionally substituted with one or more halogen atoms, such as trifluoromethyl, and m being between 0 and 3,A is a linear or branched alkyl radical comprising from 1 to 6 carbon atoms,R.sub.3 and R.sub.4 are defined in the description have medicinal properties.
    Type: Grant
    Filed: June 6, 1991
    Date of Patent: October 13, 1992
    Assignee: Adir et Compagnie
    Inventors: Gerald Guillaumet, Christine Flouzat, Daniel H. Caignard, Pierre Renard, Michelle Devissaguet, Beatrice Guardiola
  • Patent number: 5153190
    Abstract: The invention relates to pyrrolo [1,2-a] thieno [3,2-f][1,4]diazepine compounds of the formula (I) ##STR1## in which: R.sub.1 is hydrogen; alkyl optionally substituted with alkoxy, hydroxy, cycloalkyl, or phenyl; or alkyl- or arylsulfonyl; R.sub.2 is hydrogen, phenyl, or phenylalkyl; alkyl optionally substituted with hydroxyl, alkoxy, oxo, cycloalkyl or phenyl; or optionally substituted amino; R.sub.3 represents hydrogen or alkyl, and R.sub.4 and R.sub.5 independently represent: hydrogen, alkyl optionally substituted with alkoxy, cycloalkyl, or phenyl; or phenyl; their isomers, diastereoisomers and enantiomers as well as their addition salts with pharmaceutically-acceptable acids. The compounds are useful for treating cerebral ischemia, hypertriglyceridemia, hypercholesterolemia, hyperlipidemia, and hyperglycemia and are obtained in a few steps from the corresponding substituted 2-(1-pyrrolyl)thiophenes ##STR2## Y=--CHO or H; X= CN, CONH.sub.2, CH.sub.2 NHCOR.sub.2, or CH.sub.2 NH.sub.2.
    Type: Grant
    Filed: March 7, 1991
    Date of Patent: October 6, 1992
    Assignee: Adir et Compagnie
    Inventors: Sylvain Rault, Michel Boulouard, Marie P. Foloppe, Max Robba, Beatrice Guardiola, Michelle Devissague
  • Patent number: 5147883
    Abstract: Compounds of general formula (I): ##STR1## in which: R.sub.1 represents a hydrogen atom or a lower alkyl group,A represents a hydrogen atom, and in this case B represents a group CO-G, G being:either a heteroaryl group selected from furan, indole, pyrrole, pyridine, quinoline, isoquinoline and benzofuran, optionally substituted with one or more lower alkyl or lower alkoxy groups or a halogen atoms,or a linear or branched lower alkyl group substituted with a carboxyl group,or a linear or branched lower alkenyl group substituted with a carboxyl group,or a phenyl or naphthyl group substituted with a carboxyl group,or alternatively A forms with B a group CO(CH.sub.2).sub.n CH(CH.sub.
    Type: Grant
    Filed: May 31, 1991
    Date of Patent: September 15, 1992
    Assignee: Adir et Compagnie
    Inventors: Hocine Aichaioui, Daniel Lesieur, Charles Lespagnol, Michelle Devissaguet, Beatrice Guardiola