Abstract: A sampling apparatus is characterized by a sampler body having a bore and a forward opening from the bore communicating with the interior of a vessel containing fluidized product in which strands, viscous strings and particles may be entrained. A plunger assembly in the bore is generally cylindrical along a longitudinal axis and has a sample receiver and cutters. The sample receiver is generally tubular and has a plurality of arcuately spaced longitudinal slots extending radially between an outer surface and a hollow interior of the sample receiver, and individual cutters are in facing relationship at opposite ends of the bore. A pneumatic motor reciprocates the plunger in the bore in a forward direction to a sample obtaining position where the sample receiver and cutters are extended at least partly out of the forward bore opening and into the interior of the process line to obtain a sample of fluidized product that flows into and fills the sample receiver passages and hollow interior.

Abstract: This invention relates to novel compounds, their synthesis and use as selective .alpha..sub.1a adrenergic receptor antagonists. One application of the compounds is in the treatment of benign prostatic hyperplasia. The compounds are selective in their ability to relax smooth muscle tissue enriched in the .alpha..sub.1a receptor subtype without at the same time inducing hypotension. One such tissue is found surrounding the urethral lining. Therefore, one utility of the instant compounds is to provide acute relief to males suffering from benign prostatic hyperplasia, by permitting less hindered urine flow. Another utility of the instant compounds is provided by combination with a human 5-alpha reductase inhibitory compound, such that both acute and chronic relief from the effects of benign prostatic hyperplasia are achieved.

Abstract: A sampling apparatus is characterized by a sampler housing coupled to a movable valve of a connecting device. The housing and the movable valve have bores that are in communication and axial alignment. One end of the valve bore communicates with the interior of a liquid containing vessel. A plunger is in the housing bore and has an annular recess intermediate its ends. The plunger is reciprocated in the housing and valve bores to project the recess into the vessel to receive a sample of liquid therein, and to then retract the recess from the vessel and through the valve and housing bores to a sample collection point in the housing. Plunger seals maintain a liquid seal between the vessel interior and the sample collection point in the housing during reciprocation of the plunger. The valve is movable between an operative position where the one end of its bore communicates with the vessel interior and an inoperative position where the one end of its bore is out of communication with the vessel interior.

Abstract: Compounds of the formula X--Y--R, or the pharmaceutically acceptable salts and esters thereof, wherein X is ##STR1## Y is --SO.sub.2 --, --(CH.sub.2).sub.p -- or --CO--(CH.sub.2).sub.p --; R is unsubstituted or substituted phenyl where said substitutents are one or more of R.sup.5, R.sup.6 or R.sup.7 ; R.sup.1 is hydrogen, cyano, phenyl, --CONHR.sup.2, --CONR.sup.2 R.sup.2, --(CH.sub.2).sub.m --OR.sup.2, --(CH.sub.2).sub.p --S(O).sub.r --R.sup.2, --(CH.sub.2).sub.m --CO.sub.2 R.sup.2, --(CH.sub.2).sub.m --N.sub.3, --(CH.sub.2).sub.m --NH.sub.2 or --(CH.sub.2).sub.m --NR.sup.2 R.sup.2 ; R.sup.2 is hydrogen, C.sub.3-8 cycloalkyl or C.sub.1-5 alkyl; R.sup.5 and R.sup.6 are each independently selected from hydrogen, C.sub.1-5 alkoxy, halogen or --(CH.sub.2).sub.n --N(R.sup.2)--C(O)--R.sup.18 ; R.sup.7 is hydrogen or ##STR2## R.sup.11 is selected from hydrogen, C.sub.1-5 alkyl-carbonyl, --Z--R.sup.13, ##STR3## or substituted C.sub.

Abstract: An apparatus for cleaning vessels is inserted into a vessel to automatically clean the interior thereof. The apparatus is particularly adapted to clean rail tank cars and similar vessels, and includes a spray nozzle that is moved at a controlled speed back and forth across the length and width of deposits within the tank to blast loose and flush the deposits out of a drain from the tank. The spray nozzle is carried at a lower end of a support trunk, and is rotated back and forth about respective longitudinal and transverse axes to direct a jet stream of solvent against the deposits. The support trunk is pivotable to shift the spray nozzle from side to side within the vessel to clean behind obstructions often found in tanks, and vertically movable to position the spray nozzle at selected heights within the tank. The apparatus can be rotated about a vertical axis to rotate the longitudinal and transverse axes about which the spray nozzle is rotated.

Abstract: Compounds of formula (I) wherein X is (a) or (b), R is Het as defined in the description. These compounds are oxytocin and vasopressin antagonists useful in the treatment of preterm labor, dysmenorrhea, and for the stoppage of labor preparatory to Cesarean delivery.

Abstract: A method for beneficiating a low brightness fine particle size discolored kaolin crude to produce a high brightness coating clay. By combining the two beneficiating techniques of selective flocculation and ozonation, a synergistic phenomena occurs and a clay product of superior brightness and whiteness can be obtained from fine discolored clays that cannot be achieved by beneficiation with either process singularly. By passing the flocced clay through ozonation, the flocculant polymer left in the clay can be completely destroyed.

Abstract: Compounds of the formula X-Y-Z-R.sup.1 wherein:X is ##STR1## Y is --CO-- or --SO.sub.2 --; Z is an optional substituent selected from --NH--, --O--, --CHR--, --CH.dbd.CH--, --CH.dbd., --(CH.sub.2).sub.m -- or--CHCHOH--; andR.sup.1 is --CH.sub.3 --, --CH(CH.sub.3).sub.2, or substituted phenyl are tocolytic oxytocin antagonists useful in the treatment of pre-term labor, stripping labor preparatory to Caesarean delivery and dysmenorrhea.

Abstract: Compounds of the formula ##STR1## X is --O--, --NH-- and --NR.sup.8 --; Y is --CH.sub.2 --, --CHR.sup.8 -- and --C(R.sup.8).sub.2 --; R.sup.1 is camphor-10-yl, C.sub.1-5 alkoxyl, styryl, hydroxystyryl, furyl, unsubstituted or substituted thienyl, naphthyl, indolyl, tetrahydronaphthyl, unsubstituted, mono- or di-substituted pyridyl, pyrazinyl, unsubstituted or substituted cyclohexyl where the substituent is R.sup.4, and unsubstituted or substituted phenyl where the substituents on phenyl are R.sup.5, R.sup.6 and R.sup.7 ; R.sup.2 is hydrogen, C.sub.1-5 alkoxy, C.sub.1-5 alkyl, amino, C.sub.1-5 alkylcarbonylamino, nitro or halogen; R.sup.3 is hydrogen, C.sub.1-5 alkoxycarbonyl, cyano or carbamoyl; R.sup.4 is one to two of hydrogen, oxo, hydroxy, C.sub.1-5 alkoxy, C.sub.1-5 alkoxycarbonylamino-C.sub.1-5 alkyl and amino-C.sub.1-5 alkyl; R.sup.5, R.sup.6 are each independently selected from hydrogen, halogen, C.sub.1-5 alkyl, hydroxyl and C.sub.1-5 alkoxy; R.sup.7 is ##STR2## W is CO or SO.sub.

Abstract: A sampling apparatus is characterized by a housing having a liquid product flow passage and an outlet port extending between the passage and the housing exterior. A plunger having a recess toward its nose extends across the passage and the nose of the plunger is received in the outlet port. The plunger is reciprocable between a first position where the recess is in communication with the passage to receive in the recess a sample of liquid product and a second position where the recess is moved out of the passage and through the outlet port into communication with a sample collection point to the exterior of the housing to deliver the product sample to the collection point. A seal is always maintained through the outlet port between the passage and the housing exterior, and a sample collection bottle is releasably carried by the housing at the collection point.

Abstract: A sampling apparatus is characterized by a housing having a bore communicating at one end with the interior of a vessel containing fluidized product. A plunger assembly in the bore has a sample chamber intermediate its ends and is reciprocated to project the sample chamber out of the bore and into the vessel to receive a sample of product therein, and to then retract the sample chamber from the vessel and into the bore to a sample collection point. Forward and rearward seals on the plunger to opposite sides of the sample chamber always maintain a liquid seal between the one end of the bore and the sample collection point. The rearward seal comprises a shear bearing having a circumferential groove that receives and retains fluidized product in sealing relation to the bore to seal the shear beating and thereby the plunger assembly to the bore.

Abstract: Compounds of the formula X--Y--R, or the pharmaceutically acceptable salts and esters thereof, wherein X is ##STR1## Y is --SO.sub.2 --, --(CH.sub.2).sub.p -- or --CO--(CH.sub.2).sub.p --; R is unsubstituted or substituted phenyl where said substitutents are one or more of R.sup.5, R.sup.6 or R.sup.7 ; R.sup.1 is hydrogen, cyano, phenyl,--CONHR.sup.2, --CONR.sup.2 R.sup.2, --(CH.sub.2).sub.m --OR.sup.2, --(CH.sub.2).sub.p --S(O).sub.r --R.sup.2, --(CH.sub.2).sub.m --CO.sub.2 R.sup.2, --(CH.sub.2).sub.m --N.sub.3, --(CH.sub.2).sub.m --NH.sub.2 or --(CH.sub.2).sub.m --NR.sup.2 R.sup.2 ; R.sup.2 is hydrogen, C.sub.3-8 cycloalkyl or C.sub.1-5 alkyl; R.sup.5 and R.sup.6 are each independently selected from hydrogen, C.sub.1-5 alkoxy, halogen or --(CH.sub.2).sub.n --N(R.sup.2)--C(O)--R.sup.18 ; R.sup.7 is hydrogen or ##STR2## R.sup.11 is selected from hydrogen, C.sub.1-5 alkylcarbonyl, ##STR3## or substituted C.sub.

Abstract: Benzodiazepine analogs of the formula: ##STR1## wherein: R.sup.3 is ##STR2## --NH(CH.sub.2).sub.2 --.sub.3 NHCOR.sup.7, ##STR3## or --X.sup.11 NR.sup.18 SO.sub.2 (CH.sub.2).sub.q R.sup.7 ; R.sup.7 is O,S,HH, or NR.sup.15 with the proviso that X.sup.7 can be NR.sup.15 only when R.sup.1 is not H.are disclosed which are antagonists of gastrin and cholecystokinin (CCK) with enhanced aqueous solubility and have properties useful in the treatment of disorders of gastric secretion, appetite regulation, gastrointestinal motility, pancreatic secretion, and dopaminergic function, as well as in treatment producing potentiation of morphine and other opiate analgesics.

Abstract: This invention relates to certain .beta.-carbolines, which are antagonists of the functions of cholecystokinin (CCK) and gastrin, to pharmaceutical compositions comprising these compounds, and to the use of these compounds in the prevention and treatment of disorders of the gastrointestinal, central nervous and appetite-regulatory systems of mammals, especially of humans.

Abstract: Pharmaceutical compositions containing aromatic 2-benzazepines with fused 5- or 6-membered heterocyclic rings are disclosed which are useful in the treatment of panic disorder or anxiety disorder.

Abstract: Benzolactam analogs of the formula: ##STR1## are disclosed which are antagonists of gastrin and cholecystokinin (CCK).

Abstract: Pharmaceutical compositions containing benzodiazepines of the formula: ##STR1## are disclosed which are useful in the treatment of panic disorder or anxiety disorder.

Abstract: Compounds of the formula: ##STR1## where R.sup.1 is hydrogen or hydroxy and R.sup.2 is a substituted amino group, a substituted heterocyclic ring or a substituted alkyl. These compounds are oxytocin and vasopressin antagonists useful in the treatment of preterm labor, dysmenorrhea and for the stoppage of labor preparatory to cesarean delivery, timing of parturition, uterine hyperactivity, endometriosis, hypertension, congestive heart failure, hyponatremia and cognitive disorders. Also disclosed are pharmaceutical compositions containing these compounds, methods of their use and methods of their preparation.