Abstract: Device and method for determining an efficacy of chronic pain treatment including providing a first set of at least one stimulus to a subject, obtaining first measurements of at least two physiological parameters in response to the first set of at least one stimulus, providing chronic pain treatment to the subject, providing a second set of at least one stimulus to the subject, obtaining second measurements of the at least two physiological parameters in response to the second set of at least one stimulus; and determining an efficacy of the chronic pain treatment by applying a classification algorithm on the first and second measurements of the at least two physiological parameters.

Abstract: A system and method for maintaining an oxygen concentration of a biological sample. The oxygen concentration can be maintained by measuring the oxygen concentration within the biological sample and adjusting a rate of an oxygen supplier in response to this measurement. For example, when the oxygen concentration is below a threshold, oxygen can be delivered to the biological sample at a higher rate.

Abstract: The present disclosure provides, according to some embodiments, methods and systems for selectively reducing, blocking or inhibiting at least part of the neural activity in an organ of a subject. In preferred embodiments, the method and system are used for selectively blocking at least part of the neural activity in a duodenum of a subject in need thereof. According to some embodiments, the selective blocking occurs through use of laser radiation. According to some embodiments, the selective blocking comprises causing damage to at least part of sensory nerves located within a target area while maintaining functional activity of tissue surrounding the sensory nerves. According to some embodiments, the sensory nerves include neurons configured to transmit signals triggered by food passing through the duodenum, such as, but not limited to, neurohormonal signals.

Abstract: Provided herein are methods of treating or preventing cancer in a subject in need thereof, the methods comprise administering to the subject in need thereof (a) one or more nucleic acids encoding an elephant p53 protein, an elephant LIF protein, and/or combinations thereof, or (b) one or more elephant p53 proteins, elephant LIF proteins, and/or combinations thereof. Also provided are pharmaceutical compositions comprising a pharmaceutically acceptable carrier and (a) one or more nucleic acids encoding an elephant p53 protein, an elephant LIF protein, and/or combinations thereof, or (b) one or more elephant p53 proteins, elephant LIF proteins, and/or combinations thereof.

Abstract: A system determines an accuracy of a set containing a plurality of sensor location measurements of a client device and generating a set of sensor location measurements labeled with an associated accuracy estimate, is presented. The system receives a plurality of sensor location measurements of the client device generated by a location sensor. The system may determine the accuracy of a sensor location measurement by comparing the sensor location measurement to a reference location measurement, such as VIO location measurements computed using VIO data. The system computes a first set of location translations for the set of sensor location measurements and a second set of location translations for the set of VIO location measurements. The system may calculate a measurement difference between each corresponding pair of location translations from the first and second set, identify measurement differences that exceed a threshold, and label the corresponding sensor location measurement as inaccurate.

Abstract: One variation of the method includes: receiving a first electronic communication sent by a sender and designating a recipient address associated with a recipient. The method further includes, in response to association of the recipient address to insufficient communication security: generating an instance of a secure web portal; initializing a secure communication thread accessible within the instance of the secure web portal; populating the secure communication thread with contents of the first electronic communication; associating access to the instance of the secure web portal and secure communication thread with a hyperlink; generating a notification including the hyperlink to the instance of the secure web portal containing contents of the first electronic communication; and transmitting the notification to the recipient address in place of the first electronic communication.

Abstract: Various aspects of the present disclosure relate to methods, apparatuses, and systems that support angle-based positioning. For instance, an angular search window and associated uncertainty for positioning (e.g., sidelink positioning) can be determined based on an approximate position and/or range of a target-UE. Further, reporting of per path measurements is provided to in multipath environments. Implementations are also provided for triggering, configuring, and reporting angle information including angle of arrival (AoA) and/or angle of departure (AoD) (e.g., sidelink AoA and/or sidelink AoD) in terms of a Global Coordinate System (GCS) and a Local Coordinate System (LCS).

Abstract: An electronic assembly with heat spreading coating is having a PCB carrying conducting traces heat producing electronic components. An electrically isolating polymeric coating is applied over the electric the traces and the heat producing electronic components. The electrically isolating polymeric coating conforms with an irregular structure of the PCB. A heat spreading layer is applied over the polymeric coating.

Abstract: The systems and methods relate to cyclically inflating and deflating a lung. The lung can be stored and transported while pumping a gas into the lung and removing another gas from the lung. The cyclical inflation and deflation of the lung can be performed at a rate enhanced or optimized for lung performance.

Abstract: A device and method for employing a machine learning model using processor circuitry to intelligently predict user permissions within a network environment and output a restriction recommendation for modifying user permissions.

Abstract: A system and method in at least one embodiment generates, transmits and distributes a diamagnetic field using a flux field generator and a distribution system. In at least one embodiment, the flux field generator is mounted on a platform or a vehicle. In a further embodiment, the flux field generator is not vehicle based.

Abstract: An aerosol-generating system may include a liquid storage portion configured to hold liquid aerosol-forming substrate, a vaporizer including a heating element with an internal passage at least partially defined by a surface of the heating element, and a micro pump configured to deliver liquid aerosol-forming substrate from the liquid storage portion to the internal passage of the heating element, such that the vaporizer is configured to heat the delivered liquid aerosol-forming substrate at the internal passage to a temperature sufficient to volatilize at least a part of the delivered liquid aerosol-forming substrate. The micro pump may be configured to deliver a particular amount of liquid aerosol-forming substrate to the internal passage based on the micro pump performing an individual pump cycle.

Abstract: A plurality of computing devices are communicatively coupled to each other via a network, and each of the plurality of computing devices is operably coupled to one or more of a plurality of storage devices. Each computing device is operable to access one or more memory blocks within the storage devices and maintain a registry over the same one or more memory blocks. The registry may be adaptively resized according to the access of the one or more memory blocks.

Abstract: The present invention relates to the use of limited amounts of cysteine and tryptophan in the cell culture medium during production of recombinant proteins, and in particular antibodies. Proteins and antibodies produced under such controlled conditions exhibit reduced heterogeneity, in particular reduced charge variants heterogeneity.

Abstract: Systems and methods herein generally relate to prolonging viability of bodily tissue, especially an organ, by adjusting pressure as needed to maintain a constant pressure within the organ even during external pressure fluctuations due, for example, to transportation of the organ in an airplane. The systems and methods herein can include an electronic pump that pumps gas into an organ and a mechanical pressure regulator to release gas based on organ pressure.

Abstract: This invention provides a system and method inspecting transparent or translucent features on a substrate of an object. A vision system camera, having an image sensor that provides image data to a vision system processor, receives light from a field of view that includes the object through a light-polarizing filter assembly. An illumination source projects polarized light onto the substrate within the field of view. A vision system process locates and registers the substrate, and locates thereon, based upon registration, the transparent or translucent features. A vision system process then performs inspection on the features using predetermined thresholds. The substrate can be a shipping box on a conveyor, having flaps sealed at a seam by transparent tape. Alternatively, a plurality of illuminators or cameras can project and receive polarized light oriented in a plurality of polarization angles, which generates a plurality of images that are combined into a result image.

Abstract: Methods, apparatus and systems for providing secondary frequency regulation support to a power transmission system. In some embodiments, a real-time central controller requests current status data from a power distribution network which includes a plurality of distributed energy resources (DERs) and at least one substation battery energy storage system (BESS). The real-time central controller also receives an Automatic Generation Control (AGC) signal from a system operator, calculates a mismatch value, determines that the absolute value of the mismatch value is greater than a predetermined tolerance, and sets an optimal setpoint value for each of the plurality of DERs and an optimal setpoint value for the BESS. In some implementations, the real-time central controller next transmits a secondary frequency response that includes the optimal setpoint values to each of the plurality of DERs and the optimal setpoint value to the at least one BESS, thus providing secondary frequency regulation support.

Abstract: The present invention provides a method for modulating (e.g. decreasing) the alkaloid content of a plant (e.g. a tobacco plant), the method comprising modifying said plant by modulating the activity or expression of at least one gene encoding a SOUL haem-binding protein. The present invention also provides for the use of at least one gene encoding a SOUL haem-binding protein for modulating the alkaloid content of a plant, as well as tobacco cells, plants, plant propagation materials, harvested leaves, processed tobaccos, or tobacco products obtainable in accordance with the invention.

Abstract: A system can train a neural network model at a first edge device regarding respective amounts of time to process data at the first edge device compared to corresponding amounts of time to process the data at cloud computing equipment that is connected to the first edge device via a communications network, wherein the data is generated at the first edge device. The system can update the neural network model to produce an updated neural network model based on information received from a second edge device regarding a performance of the cloud computing equipment in processing the data, wherein the first edge device and the second edge device having respective different processing capabilities. The system can determine whether to process first data, generated at the first edge device, locally at the first edge device.