Abstract: Provided herein are compounds, compositions and methods for the treatment of liver disease and conditions, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents.

Abstract: A device for the transportation and temporary storage of a medical instrument including an instrument bag material substantially impermeable to bodily fluids, the bag having a bag opening. A label has a first portion adhered to an external surface of the bag adjacent to the bag opening and has a second portion disposed beyond the bag opening and which has a lower surface at least part of which is adhesive. The first portion of the label includes a pocket for receiving a sachet or data carrier. The second portion of the label includes a tamper-evident portion which exhibits a first visual appearance when first adhered to a surface of the bag, and which exhibits a second visual appearance after it has been adhered to and then removed from a surface of the bag, and subsequently adhered to the same surface of the bag.

Abstract: The present invention generally relates to a rail transport system having no internal drive, and in particular to an improved rail transport system for conveying bulk materials. The rail transport system includes horizontal and vertical drive stations that include a drive tire that rotates on a plane parallel to the track. In this arrangement, force is applied on a different plane than earlier systems, and the reaction force is separated out of the tensioning device. The improvements of the drive stations provide for a reduction of steel used in the system, improved manufacturability and, therefore, reduction in system component costs as compared to previous drive stations. Moreover, the drive stations allow for improved maintainability and access to the drive tires.

Abstract: Systems and methods for sensing a train position of a train with no internal drive operating in an automated train system are provided. According to one embodiment, a train system comprises a track extending in a travel direction, a plurality of cars riding on the track and connected to form a train, a position sensing unit, and a programmable logic controller (PLC) in signal communication with the position sensing unit and configured to determine a train position based on inputs therefrom.

Abstract: Provided herein are compounds, compositions and methods for the treatment of Flaviviridae infections, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents. In certain embodiments, the compounds are 4?-OR nucleosides of Formula I: or a pharmaceutically acceptable salt thereof, wherein Base, PD, R, Z1, Z2, Z3, and Z4 are as defined herein.

Abstract: The invention relates to resin compositions for epoxy adhesives, comprising a di-functional aromatic epoxy compound. The resin compositions and/or uncured adhesive compositions having low viscosity at low temperatures. Adhesives made therefrom have good strength and bulk properties. The invention includes methods of making and using the compositions, as well as adhesives made from the compositions.

Abstract: The present invention generally relates to a rail transport system having no internal drive, and in particular to an improved rail transport system for conveying bulk materials. The rail transport system includes improvements in functionality, manufacturability and/or modularity and, therefore, can result in a reduction in system component costs, manpower and/or implementation. The rail transport system includes a dump loop and components thereof for enabling unloading of the rail cars in a predetermined location. The components thereof may be designed to be modular to allow for ease of manufacture and installation of the dump loop. The components may be prefabricated for later use on site.

Abstract: According to a first embodiment of the present invention there is disclosed a tool handle comprising an elongate handle sized to be grasped by a user extending between its first and second ends along an axis, where the first end may be adapted to be engaged with and retain a tool therein, and the second end includes a notch in an end surface thereof adapted to engage upon a corner of a board. The handle may include an insert secured to a handle base having the second end thereon.

Abstract: A method for electronically transmitting data based on a physical gesture includes: storing at least one gesture pair, wherein each gesture pair includes at least a physical gesture and an associated data conveyance, the physical gesture being stored as one or more data points telegraphing three-dimensional movement; capturing a plurality of movement data points based on movement of one or more motion capturing devices; identifying a specific gesture pair where at least one of the captured plurality of movement data points corresponds to the included physical gesture; establishing a communication channel with an external computing device; and transmitting the associated data conveyance included in the identified specific gesture pair to the external computing device using the established communication channel.

Abstract: A method for conveying a data message using a public ledger includes: generating, by a generation module of a processing server, a data message, wherein the data message comprises one or more data values; electronically transmitting, by a transmitting device of the processing server, a data signal superimposed with the generated data message to a first computing system; receiving, by a receiving device of the processing server, a data signal superimposed with an encrypted message from the first computing system, wherein the encrypted message is generated via application of one or more encryption algorithms to the generated data message using at least one encryption key; appending, by the generation module of the processing server, an identification value to the encrypted message; and submitting, by the transmitting device of the processing server, the appended encrypted message to a public ledger associated with a second computing system.

Abstract: Systems and methods for authenticating payment transactions using a payment card processing system are disclosed. A method for processing one or more payment transactions using a payment processing system in communication with a computer readable storage medium includes receiving a push or pull request from a first device associated with a first user, wherein the push or pull request relates to a transaction with a second device associated with a second user, receiving a first biometric measurement from the first device, and receiving a second biometric measurement from the second device. The method further includes, responsive to determining that the first biometric measurement identifies the first user, determining that the second biometric measurement identifies the second user, and determining that the first device and second device are within a predetermined relative proximity, effecting the transaction based on the push or pull request.

Abstract: The present invention generally relates to support frames and rail cars comprising first and second side drive plates, first and second cross members connecting the respective ends of the side drive plates, third and fourth cross members connecting the side drive plates at a select distance from the first and second cross members, a coupling assembly situated at the first cross member and adapted to connect another rail car thereto, and first and second diagonal support members connected to the first cross member at an angle sufficient to substantially direct forces from the coupling assembly to the third cross member and side drive plates. The support frames and rail cars may be used for conveying bulk materials on a rail transport system.

Abstract: A method includes receiving from a mobile device context data derived from one or more sensors, determining the occurrence of a trigger based, at least in part, upon the received context data, utilizing the context data and at least one purchase datum to determine a reward and transmitting the reward to the mobile device.

Abstract: Provided herein are spray-dried particles comprising a 5,5-fused heteroarylene hepatitis C virus inhibitor compound and methods of their preparation. Also provided herein are pharmaceutical compositions comprising a 5,5-fused heteroarylene hepatitis C virus inhibitor compound, method of their preparation, and their use for treating or preventing hepatitis C virus infection.

Abstract: Provided herein are crystalline and salt forms of methyl N-{(1R)-2-[(2S)-2-{5-[4-(6-{2-[(2S)-1-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl} pyrrolidin-2-yl]-3H-benzimidazol-5-yl}thieno[3,2-b]thiophen-3-yl)phenyl]-1H-imidazol-2-yl}pyrrolidin-1-yl]-2-oxo-1-phenylethyl} carbamate, a Flaviviridae, including hepatitis C, virus inhibitor, pharmaceutical compositions comprising the compound, and processes of preparation thereof. Also provided are methods of its use for the treatment of a Flaviviridae, including HCV, infection in a subject in need thereof.

Abstract: Provided herein are compounds, compositions and methods for the treatment of Flaviviridae infections, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents.

Abstract: A method and system to provide multi-layered access control for healthcare datasets are disclosed. The method comprises defining an information policy for each of healthcare datasets, wherein the information policy comprises information access permissions. Further, an organization policy is defined for each of the healthcare datasets, wherein the organization policy comprises license permissions for organizations accessing the healthcare datasets. Thereafter, a user account master policy is defined for each of the healthcare datasets, wherein the user account master policy comprises account permissions assigned to users of the organizations. Subsequently, a master user policy is generated for each of the users based on the information policy, the organization policy, the user account master policy, or a combination thereof, wherein the master user policy comprises access control permissions to provide each of the users access to the healthcare datasets.

Abstract: An epoxy adhesive composition is provided that has superior wash-off resistance after pre-gelling, and may be used, for example, in manufacturing processes, for example, in the automobile industry. The composition also provides unique viscosity profile after pre-gelling to significantly reduce failure mode in subsequent processing steps. In preferred embodiments the adhesive composition comprises an epoxy type resin and a gelling agent selected from polyesterdiols and polyvinyl butyrals.

Abstract: A method of and system for monitoring and providing notification of changes to a data environment. Parameters of interest for monitoring changes made to a metadata data store are stored. Instructions are stored related to notifying a recipient of a communication about the changes. The metadata is monitored for changes related to the parameters of interest, and a change notification communication is generated with transmission initiated to the recipient. The instructions related to notification of the changes may include the identity of a recipient, mechanism for notification, and format and content of notification. A computer readable memory system and a computer program product may be provided that is encoded with a data structure for notifying data consumers of changes to a data environment that includes metadata.

Abstract: A method of and system for monitoring and providing notification of changes to a data environment. Parameters of interest for monitoring changes made to a metadata data store are stored. Instructions are stored related to notifying a recipient of a communication about the changes. The metadata is monitored for changes related to the parameters of interest, and a change notification communication is generated with transmission initiated to the recipient. The instructions related to notification of the changes may include the identity of a recipient, mechanism for notification, and format and content of notification. A computer readable memory system and a computer program product may be provided that is encoded with a data structure for notifying data consumers of changes to a data environment that includes metadata.