Abstract: Devices are provided to automatically access blood from beneath or within skin. These devices include an injector configured to drive a needle into the skin and subsequently to retract the needle from the skin. These devices additionally include a seal to which suction is applied. To drive the needle into the skin, the needle is first driven through the seal, creating at least one hole in the seal. The suction applied to the seal acts to draw blood from the puncture formed in the skin by the needle, through the at least one hole in the seal, and to a sensor, blood storage element, or other payload. These devices can be wearable and configured to automatically access blood from skin, for example, to access blood from the skin at one or more points in time while a wearer of a device is sleeping.

Abstract: A device for rapid detection of a tuberculosis lipoarabinomannan (TB-LAM) is provided. The device includes a pre-concentrator unit for concentrating the TB-LAM comprising: an ion-exchange medium comprising one or more ligands configured to capture the TB-LAM from the source biological sample, wherein the captured-TB-LAM is eluted from the ion-exchange medium as an eluate comprising a concentrated form of TB-LAM; a cassette; a lateral flow assay unit disposed in the cassette; and an integration unit attached to the pre-concentrator unit and the cassette. The integration unit is configured to operatively couple and de-couple the pre-concentrator unit and the cassette. The pre-concentrator unit and the lateral flow assay unit disposed in the cassette are in a fluidic communication in a coupled form. The device for rapid detection of TB-LAM further comprises a dilutor unit.

Abstract: A power supply unit for an illumination device that includes a multi-mode power supply configured to supply power to an illumination device having one or more LED modules and a control circuit. The multi-mode power supply includes a primary power supply component configured to supply power to non-essential components of the illumination device, and a secondary power supply component configured to supply power to only essential components of the illumination device. The nonessential components include the one or more LED modules, and the essential components include the control circuit but not the one or more LED modules.

Abstract: Methods, systems, and computer-readable media for implementing template generation for deployable units are disclosed. An indication of a deployable unit is received by a catalog system. A deployment template is generated that represents one or more directives for deploying the deployable unit. The deployment template is generated based at least in part on analysis of the deployable unit by the catalog system. The deployable unit is deployed to one or more resources of a multi-tenant provider network. The deployable unit is deployed based at least on part on the directives of the deployment template.

Abstract: An anti-counterfeiting method, system, and non-transitory computer readable medium including a transfer circuit configured to transfer a Directed Self-Assembly (DSA) pattern including a unique and randomized pattern onto a strip, an embedding circuit configured to embed the strip on a document, and a verification circuit configured to verify that the unique and randomized pattern embedded on the document corresponds to the document.

Abstract: A design layout for a semiconductor chip includes information on shapes desired to be fabricated. Clusters of photolithographic exposure “shots” are generated and subject to a measure of shot density to approximate a mask shape that generates the desired fabricated shapes when exposed during wafer fabrication. A simulation is run on the clusters of shots to estimate the resulting fabrication shapes that the clusters of shots create. The clusters of shots are modified to align the estimated fabrication shapes more closely with desired fabrication shapes. The process of simulating and modifying the shots is iterative, repeating until the estimated fabrication shapes are within a desired error difference of the planned fabrication shape.

Abstract: Provided herein are methods for the modulation of appearance or material properties within items of apparel or equipment. Also provided herein are design articles having alterable designs. Generally, such design articles comprise (1) a microfluidic circuit, and (2) an inlet and an outlet, the alterable design capable of being modulated through use of a docking system to deliver fluid to the microfluidic circuit.

Abstract: The present invention provides methods and compositions for inducing expression of Ube3a in a cell by contacting the cell with a topoisomerase inhibitor. Particular embodiments include a method of treating a genomic imprinting disorder, such as Angelman syndrome, in a subject by administering to the subject an effective amount of a topoisomerase inhibitor.

Abstract: A biocompatible composite material for controlled release is disclosed, comprising a biocompatible metal oxide structure with a loaded network of pores. The pore network of the biocompatible composite material is filled with a uniformly distributed biologically active micellizing amphiphilic molecule, the size of these pores ranging from about 0.5 to about 100 nanometers. The material is characterized in that when exposed to phosphate-buffered saline (PBS), the controlled release of the active amphiphilic molecule is predominantly diffusion-driven over time.

Abstract: An SMA actuation assembly comprising SMA actuator wires connected in tension between a support structure and a movable element is controlled to drive movement of the movable element with respect to the support structure by supplying drive signals to the SMA actuator wire. Target signals representing desired positions of the movable element are set, varying within a predetermined spatial envelope. Measures of resistance of the SMA actuator wires are derived and the power of the drive signals is controlled under closed loop control on the basis of the target signals and feedback signals obtained from the measures of resistance. Electrical characteristics of the SMA actuator wires are monitored and used to detect when a motion limit of the movement is reached. In response thereto, the spatial envelope is adjusted to restrict the movement to be within the detected motion limit.

Abstract: A service provider system may implement an enterprise catalog service that manages software products and portfolios of software products on behalf of service provider customer organizations. A graph processing service of the enterprise catalog service may create a graph representation of the enterprise catalog service data, including principals, product listings, portfolios, and constraints (and the relationships between them) that may be used to manage access control, launch contexts, and searches within the enterprise catalog service. A primary (key-value) store may maintain an adjacency list and a secondary index of de-normalized edges. A secondary (document) store may maintain the de-normalized edges. In response to various queries directed to the graph processing service, the service may query the adjacency list or the secondary index. For example, one query may return a list of products that an end user can access, and another may return a count of products within a portfolio.

Abstract: Automated system configured to perform and methods for performing one or more slide processing operations on slides bearing biological samples. The system and methods enable high sample throughput while also minimizing or limiting the potential for cross-contamination of slides. The automated systems can include features that facilitate consistency, controllability of processing time, and/or processing temperature.

Abstract: An illumination device includes a light emitting diode (LED) module and a control circuit. The control substrate comprises at least one essential circuit component and at least one non-essential circuit component. The device also includes a multi-mode power supply configured to supply power to the LED module and the control circuit. The multi-mode power supply comprises: (i) a primary power supply component configured to supply power to the at least one essential circuit component, the LED module, and the at least one non-essential circuit component; and (ii) a secondary power supply component configured to supply power to only the at least one essential circuit component.

Abstract: The present disclosure includes systems and methods for off-the-record communication including expiring messages. An example method comprises receiving an electronic communication from a source device, the electronic communication including at least one expiring message, temporarily storing content of the expiring message in a non-durable memory for a predetermined amount of time, durably storing envelope information associated with the expiring message in a durable memory, and determining whether a recipient device for the expiring message is available to accept transmission of the expiring message and determining whether an expiration event has occurred.

Abstract: A kit or assembly for a ceiling fan can include a downrod and a set of electrical wires. The downrod can include a sidewall defining an interior. An opening can be provided in the sidewall for accessing the interior. The set of electrical wires can extend through the interior of the downrod, having first and second sets of wire tips, and can be longer than the downrod. An optional electrical connector can be provided on one of the first or second sets of wire tips.

Abstract: Aspects of the disclosure may reduce motion noise by mounting vector component sensors on a bottom-weighted instrument platform that is supported with a spherical bearing. An apparatus for data acquisition is provided. The apparatus includes a base assembly, a spherical bearing mounted to the base assembly, and an instrument platform having at least one vector component sensor fixed thereto. The instrument platform is mounted on and supported by the spherical bearing. The spherical bearing couples the instrument platform to the base assembly and allows free angular rotation of the instrument platform, within a tilt angle range. The instrument platform is bottom weighted in that it has a center of mass disposed below its center of rotation. The apparatus may include a controller that receives and/or stores data from the at least one sensor.

Abstract: A rotating machine having a rotor mounted to rotate in a casing and bearing at least a plurality of impellers is provided. The machine may include at least one seal ring disposed radially between the rotor and the casing and mounted to move radially in a seal support of the casing, and wherein it includes a damping system for the seal ring disposed radially between the seal ring and the seal support. The damping system is configured to damp the seal.

Abstract: A lighting system includes a lighting device that further includes a housing, and light emitting diode (LED) modules positioned in an opening of the housing to emit light away from the housing. Each LED module includes a substrate, a plurality of module-level conductors, and a plurality of LED sets, each of which comprises a first section including a first group of LEDs, one or more additional sections (each including an additional group of LEDs), a first conductive element that electrically connects the first section to a first one of the module-level conductors, and one or more additional conductive elements. The lighting system also includes control circuitry configured to generate commands to control drive currents delivered to a first group of LEDs in each LED set and each additional group of LEDs in each LED set so that the lighting device emits light of a specified color temperature.

Abstract: Disclosed are systems, methods, and non-transitory computer-readable media for automated. VM performance tuning. An auto-tuning system implements a three stage automated VM performance tuning process to optimize garbage collection. In the first stage, the auto-tuning system analyzes garbage collection logs to calculate garbage collection parameters to configure the new generation portion of the memory heap (e.g., maximum tenuring age, maximum new size and survivor ratio). In the second stage, the auto-tuning system implements the calculated garbage collection parameter and monitors garbage collection activity for the VM to determine the resulting effects. In the third stage, the auto-tuning system tunes the old generation portion of the memory heap based on the monitored garbage collection activity.

Abstract: Devices to improve lung function in a patient having restricted ventilation. The device may include an entry or access port for an implantable airway bypass device that relieves trapped air. The device of the present invention comprises an expandable structure (164) to be implanted in lung tissue and defining an air capture chamber, a first conduit (174) having a first end from which extends the expandable structure, and a second end to be coupled to a first end of a second conduit (161), the second end of the second conduit being joined to an external anchor (175) to rest against an outer skin surface of the chest of the patient.