Abstract: The invention relates to prodrug compounds of formula I: wherein R2, R3, R5, R7 and X are as defined herein. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including pain. The compounds of formula I possess advantageous solubility and physicochemical properties.

Abstract: A water heater system includes a tank having internal capacity no greater than 1 gallon, a water inlet, and a water outlet. A flow of water into the tank through the water inlet and out of the tank through the water outlet is a downstream water flow. An absence of downstream water flow is a standby condition of the water heater. The water heater includes a heating element for heating water in the tank, a first temperature sensor positioned to sense a temperature of the water flowing into the tank, and a second temperature sensor positioned to sense a temperature of the water flowing out of the tank. The water heater further includes a damper upstream of the second temperature sensor to reduce fluctuations in the temperature readings of the second temperature sensor to reduce false detection of downstream water flow.

Abstract: Described herein are systems and methods for determining or quantifying tinnitus conditions within a patient, including determining if a patient has some form of tinnitus as well as categorizing or determining the severity of a tinnitus condition, if present. The described systems and methods are also useful in evaluating the efficacy a tinnitus treatment by measuring the degree of reduction of tinnitus symptoms in a patient. The described systems and methods also provide a personalized profile for each specific patient, allowing for more effective treatment options as various forms or causes of tinnitus become apparent.

Abstract: A device can communicate with a set of devices to obtain input data from a set of data sources. The device can process the input data to determine a state of a first job, of a plurality of jobs, based on the state of the vehicle and the state of the operator of the vehicle. The device can determine, based on the state of the first job, a plurality of estimated times of arrival of the vehicle at two or more downstream jobs, of the plurality of jobs, occurring after the first job. The device can determine, based on the plurality of estimated times of arrival, a set of alerts or a set of response actions relating to the plurality of estimated times of arrival of the vehicle. The device can communicate with at least one customer device to provide the alert or implement the response action.

Abstract: The present invention features processes for preparing compounds, such as (R)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)—N—(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide (Compound 1), useful for treating CFTR mediated diseases such as cystic fibrosis.

Abstract: The present invention relates to processes and intermediates for preparing compounds useful as inhibitors of ATR kinase, such as aminopyrazine-isoxazole derivatives and related molecules. The present invention also relates to compounds useful as inhibitors of ATR protein kinase. The invention relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and solid forms of the compounds of this invention. The compounds of this invention have formula I or II: wherein the variables are as defined herein.

Abstract: The trackpad assemblies described herein maintain minimum overall stiffness, weight, and cost requirements of a trackpad assembly, while permitting a decrease in trackpad assembly thickness as compared to conventional trackpad assemblies. The trackpad assemblies may include one or more of a four-layer PCB, structural adhesives, a structural PCB stiffener, and a structural shield assembly. These stiffening features permit increasingly thinner trackpad assemblies and associated computing devices.

Abstract: This disclosure describes non-naturally occurring protein scaffolds and methods of making and using the protein scaffolds. In one aspect, therefore, this disclosure describes a non-naturally occurring protein scaffold that includes a plurality of structural domains and a plurality of loop regions that include an amino acid sequence that varies from a naturally-occurring loop region by at least one amino acid deletion, substitution, or addition. Generally, the structural domain or domains can include at least one ? structure and/or at least one a helix.

Abstract: A hollow preform impact extruded from a metal billet to produce a progressing wall at a transition wall thickness. An axially forward portion of the progressing wall is ironed by extrusion past an extrusion point to form a sidewall portion of a lesser thickness. Extruding is stopped while some of the billet remains to form the closed bottom end. The preform has a bottom portion, a sidewall portion and a transition wall portion extending between the bottom portion and the sidewall portion. The transition wall portion is thicker than the sidewall portion and can be formed into at least part of the rim of an expansion shaped container. An impact extrusion punch has a central axis, an axially forward, impact surface for impacting metal to be extruded, a transition region for directing material displaced by the impact surface and a rear extrusion point for ironing material extruded past the transition region.

Abstract: The invention relates to prodrug compounds of formula I: wherein R2, R3, R5, R7 and X are as defined herein. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including pain. The compounds of formula I possess advantageous solubility and physicochemical properties.

Abstract: Systems and methods for providing supplemental information with a response to a command are provided herein. In some embodiments, audio data representing a spoken command may be received by a cloud-based information system. A response to the command may be retrieved from a category related to the context of the command. A supplemental information database may also be provided that is pre-populated with supplemental information related to an individual having a registered account on the cloud-based information system. In response to retrieving the response to the command, supplemental information may be selected from the supplemental information database to be appended to the response to the command. A message may then be generated including the response and the supplemental information appended thereto, which in turn may be converted into audio data representing the message, which may be sent to a voice-controlled electronic device of the individual.

Abstract: Systems, methods, apparatuses, and computer program products for utilizing cellular technology to communicate from locations that are separate or physically distant from the location of a subscriber identity module (SIM) and/or physically separate from a mobile or cellular device are provided. One method may include receiving a request from a user to remotely access at least one physical SIM that is assigned to a global network of radio communications gateways, and assigning at least one of the SIMs to one of the radio communications gateways, so that the assigned SIM is able to route communication to or from the user via its assigned radio communications gateway.

Abstract: The present disclosure provides embodiments of compression-type electrical connectors used to connect one or more branch wires or conductors to one or more run wires or conductors.

Abstract: The present invention relates to processes and intermediates for preparing compounds useful as inhibitors of ATR kinase, such as aminopyrazine-isoxazole derivatives and related molecules. The present invention also relates to compounds useful as inhibitors of ATR protein kinase. The invention relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and solid forms of the compounds of this invention. The compounds of this invention have formula I or II: wherein the variables are as defined herein.

Abstract: The trackpad assemblies described herein maintain minimum overall stiffness, weight, and cost requirements of a trackpad assembly, while permitting a decrease in trackpad assembly thickness as compared to conventional trackpad assemblies. The trackpad assemblies may include one or more of a four-layer PCB, structural adhesives, a structural PCB stiffener, and a structural shield assembly. These stiffening features permit increasingly thinner trackpad assemblies and associated computing devices.

Abstract: This disclosure describes a non-naturally occurring protein scaffold that specifically binds to hepatocyte growth factor receptor (MET) and methods of using such protein scaffolds. Generally, the protein scaffold includes a frame and at least one loop region that specifically binds hepatocyte growth factor receptor (MET). The frame generally includes a plurality of structural domains that include at least one ? structure or at least one ? helix. The loop region generally includes an amino acid sequence that varies from a naturally-occurring loop region by at least one amino acid deletion, amino acid substitution, or amino acid addition.

Abstract: Disclosed is a mobile device vehicle apparatus comprising a housing portion having a wiring harness and a shelf portion having an inclined surface and lip, the lip extending away from the inclined surface, wherein the housing portion or the shelf portion further comprising a wireless data transmission module, a wiring harness, and a wireless charger; and wherein the wireless charger is provided behind the inclined surface of the shelf portion.

Abstract: The present application describes systems and methods of performing self-interference cancellation. According to an embodiment, the method sends a transmit signal through a circulator to substantially isolate the transmit signal from a receiver, with at least a portion of the transmit signal entering a receive path towards the receiver. The method also generates a reflected signal from an antenna. The reflected signal is at substantially less power than an incident power to the antenna. The reflected signal includes a transmitter carrier signal and a transmitter noise. The method also routes a received signal from the antenna to the receiver, and routes the reflected signal through a phase shifter in the receive path. Further, the method combines the reflected, phase shifted transmitter noise with the received signal in the receive path to cancel the portion of the transmit signal that entered the receive path towards the receiver.

Abstract: A radiation measuring device for measuring electromagnetic radiation originating from an external source. The radiation measuring device includes, a spectrometer, a pyranometer, a pyrgeometer, a diffuser, and a control unit. The spectrometer and a pyranometer are positioned in a sensor zone of a housing of the radiation measuring device. The spectrometer measures visible shortwave radiation and near-infrared shortwave radiation received at the sensor zone. The pyranometer measures shortwave radiation received at the sensor zone. The pyrgeometer is positioned in another sensor zone of the housing and measures longwave radiation received at the other sensor zone. The control unit receives radiation measurements from the spectrometer, pyranometer, and pyrgeometer. A corrected amount of radiation received at the sensor zones of the radiation measuring device is determined from the received radiation measurements. Other embodiments are described and claimed.

Abstract: Systems and methods for eye tracking calibration in a wearable system are described. The wearable system can present three-dimensional (3D) virtual content and allow a user to interact with the 3D virtual content using eye gaze. During an eye tracking calibration, the wearable system can validate that a user is indeed looking at a calibration target while the eye tracking data is acquired. The validation may be performed based on data associated with the user's head pose and vestibulo-ocular reflex.