Abstract: The N-benzylindole- and benzopyrazole derivatives of the general formula 1 ##STR1## possess anti-asthmatic, anti-allergic, anti-inflammatory and immunomodulating effect and are suitable for the preparation of medicaments.

Abstract: A process for preparation of pure flupertine maleate and the pure A crystalline form of flupertine maleate by the use of water soluble alcohols during synthesis and/or purification.

Abstract: Phospholipid derivatives containing higher elements of the Vth main group (P, As, Sb, Bi), their method of preparation and antineoplastic and antimicrobially active medications that can be prepared from the phospholipid derivatives.

Abstract: New LH-RH antagonists are disclosed, in particular peptidomimetics and peptides modified in a side chain, their salts with pharmaceutically acceptable acids and a process for preparing these LH-RH antagonists and their salts. The disclosed peptides represent analogues of the luteinising hormone releasing hormone (LH-RH). The disclosed compounds have a high antagonistic power and are free of undesirable side effects, in particular edematogenic effects.

Abstract: The invention relates to novel modifications of the compound 2-amino-4-(4-fluorobenzylamino)-1-ethoxy-carbonylaminobenzene of the formula I ##STR1## processes for their preparation and their use in pharmaceutical compositions.

Abstract: Long-chain, unbranched alkylamides of the general formulaCH.sub.3 --(CH.sub.2).sub.n N--NH--Rin which n=11-20 and R=amino acid, its D- and L-enantiomers, di- and tripeptides, forms derived by N-protective groups, and terminal ethyl esters as well as its physiologically compatible salt forms as active pharmaceutical substances with anti-proliferative and anti-inflammatory properties.

Abstract: This disclosure describes two technical procedures for the high-yield synthesis of heterocyclic seven-membered ring-systems by Dieckmann-condensation avoiding usual dilution techniques and long reaction times. Thus, it significantly increases the overall yields of the pharmaceutically active ingredients azelastine and flezelastine, whose synthesis, starting from these seven-membered heterocyclic rings, is reported elsewhere. Yields range from 80-89%, avoiding waste and increasing economics of the synthesis.

Abstract: Cis-?trans-1,2-cyclobutanebis (methylamine)-N,N'!-?(2S)-lactate-O.sup.1,O.sup.2)-platinum (II) trihydrate (lobaplatin trihydrate) and its preparation.

Abstract: The invention relates to novel pyrido?3,2-e!pyrazinones, processes for their preparation and their pharmaceutical use.The compounds have anti-asthmatic and anti-allergic effects.

Abstract: Phospholipid derivatives containing higher elements of the Vth main group (P, As, Sb, Bi), their method of preparation and antineoplastic and antimicrobially active medications that can be prepared from the phospholipid derivatives.

Abstract: Use of 7-amino-L-glycero-L-gulo-2,6-anhydro-7-desoxy-heptonic acid and 2-benzoxycarbonylamino-0.sup.1 -methyl-2-desoxy-.beta.-glucopyranuronic acid, their derivatives and the enantiomorphous compounds for incorporation and for manufacture in pharmacologically active peptide hormones.

Abstract: Phthalazinone derivatives and their optical isomers are used as medications to combat heart rhythm disturbances, to combat pain and to break through multi-drug resistance.

Abstract: A process for the production of azophenothiazine derivatives having either of the following structures: ##STR1## where X and Y include alkyl, alkoxy, halogen, hydrogen, carboxy, or carboxy alkyl substituents. These compounds are precursors to pharmaceutically active compounds such as pipacetate. The process involves the reaction of a 2-chloropyridine with a 2-mercaptoaniline or a dimer of 2-(2-mercaptophenylamino)pyridine in an inert solvent, e.g., .gradient.-methylpyrolidone in the presence of an oxidizing agent, e.g., performic acid.

Abstract: 6-amino carboxylic acid derivatives having antiasthmatic and antiallergic properties which can be used for the preparation of medicaments. The compounds have the formula: ##STR1## wherein R.sub.1 and R.sub.2 represent hydrogen, a straight-chain or branched alkyl radical with 1-6 carbon atoms, benzyl or phenylethyl, R.sub.3 represents hydrogen, a straight-chain or branched alkyl radical with 1-6 carbon atoms or benzyl, X represents hydrogen, halogen, C.sub.1 -C.sub.6 -alkyl or C.sub.1 -C.sub.6 -alkoxy, Y.sub.1 and Y.sub.2 represent hydrogen, halogen, C.sub.1 -C.sub.6 -alkyl or C.sub.1 -C.sub.6 -alkoxy, where m, n and o can assume the values from 0-4.

Abstract: Phospholipid derivatives containing higher elements of the Vth main group (P, As, Sb, Bi), their method of preparation and antineoplastic and antimicrobially active medications that can be prepared from the phospholipid derivatives.

Abstract: 6-aza-benzo[b]-phenothiazine derivatives having the formula, ##STR1## wherein X and Y can be any of hydrogen, lower alkyl, lower haloalkyl, carboxyl or carboxy alkyl are obtained through a reaction of 2-quinioline derivatives having the formula ##STR2## with a suitable 2-mercaptoaniline derivatives or dimers thereof under oxidative or free radical conditions.The 6-aza-benzo[b]-phenothiazine derivative are valuable precursors for pharmaceutically active substances such as pipacetate, isothioperdyl and prothiperdyl.

Abstract: Novel compounds of the formula ##STR1## where the phenyl ring can also contain a nitrogen atom instead of a CH group, R.sub.1 is C.sub.2 -C.sub.6 -alkenyl, C.sub.2 -C.sub.6 -alkynyl, hydroxy, C.sub.1 -C.sub.6 -alkoxy, C.sub.3 -C.sub.6 -alkenyloxy, C.sub.3 -C.sub.6 -alkynyloxy, C.sub.2 -C.sub.6 -alkanoyloxy, benzoyloxy, morpholinocarbonyloxy, C.sub.1 -C.sub.6 -alkyloxycarbonyloxy, C.sub.1 -C.sub.6 -alkylaminocarbonyloxy, C.sub.1 -C.sub.6 -dialkylaminocarbonyloxy or the group -Alk-A, where Alk represents C.sub.1 -C.sub.6 -alkyl, C.sub.2 -C.sub.6 -hydroxyalkyl or C.sub.3 -C.sub.6 -cycloalkyl and the symbol A represents hydrogen or other substituents.R.sub.2, R.sub.3 and R.sub.4 represent various substituents, where R.sub.1 may also be hydrogen, when R.sub.2 is the group ##STR2## and R.sub.5 represents phenyl, C.sub.1 -C.sub.4 -alkoxyphenyl or diphenylmethyl and R.sub.3 and R.sub.4 are hydrogen and their salts. The compounds provide anti-allergic, anti-asthmatic, anxiolytic and hypotensive effects.

Abstract: Pharmacologically active 1,2,4-triaminobenzene derivatives of the General Formula I: ##STR1## where the symbols R1' R2' R3' R4' R5' Ar and Alk have the following meanings:where the symbols R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, Ar and Alk have the following meanings:R.sub.1 : hydrogen, C.sub.1 -C.sub.6 -alkyl, C.sub.2 -C.sub.6 -alkanoyl or the radical Ar;R.sub.2 : hydrogen or C.sub.1 -C.sub.6 -alkyl;R.sub.3 : C.sub.1 -C.sub.6 -alkoxy, NH.sub.2, C.sub.1 -C.sub.6 -alkylamino, C.sub.1 -C.sub.6 -dialkylamino, amino substituted by the radical Ar, C.sub.1 -C.sub.6 -alkyl, C.sub.2 -C.sub.6 -alkenyl, C.sub.2 -C.sub.6 -alkynyl, the radical Ar or the radical ArO--;R.sub.4 : hydrogen, C.sub.1 -C.sub.6 -alkyl or the radical Ar;R.sub.5 : hydrogen or C.sub.1 -C.sub.6 -alkyl or the radical Ar;Alk: a straight or branched alkylene group containing 1-9 carbon atoms, which can also be substituted by the radical Ar.

Abstract: Pharmacologically active compounds of the General Formula ##STR1## where X is oxygen or sulphur and the radical R represents a quinuclidyl radical, an C.sub.1 -C.sub.6 -alkyl radical, a phenyl radical, a pyridyl radical, a phenyl or pyridyl radical substituted by the radicals R.sub.1, R.sub.2, and/or R.sub.3, a C.sub.1 -C.sub.6 -alkyl radical substituted by pyridyl or alkylpyridyl or a C.sub.1 -C.sub.6 -alkyl radical substituted by phenyl, where each phenyl radical may also be substituted by the radicals R.sub.1, R.sub.2 and/or R.sub.3 and the radicals R.sub.1, R.sub.2 and R.sub.3 are the same or different and represent hydrogen, halogen, trihalogenmethyl, C.sub.1 -C.sub.6 -alkyl, C.sub.1 -C.sub.6 -alkoxy, carboxy, Carb-C.sub.1 -C.sub.6 -alkoxy, amino, C.sub.1 -C.sub.6 -alkylamino, C.sub.1 -C.sub.6 -dialkylamino, C.sub.1 -C.sub.6 -trialkylamino, C.sub.2 -C.sub.6 -alkanoylamino, or C.sub.2 -C.sub.

Abstract: Octadecyl-[2-(N-methylpiperidino)-ethyl]-phosphate and a process for its preparation. This compound is useful for the treatment of cancer.