Abstract: A method may include obtaining localization information and control signal information relating to an autonomous vehicle (AV). The method may include computing first kinematic characteristics of the AV based on the localization information and the control signal information and generating a first vehicle model based on the first kinematic characteristics. The method may include determining one or more first control commands that provide instructions for actuating a driving operation of the AV. The first control commands may be determined based on the first vehicle model. The method may include simulating first movement of the AV according to the first control commands and the first vehicle model.

Abstract: An internally emulsified polyurethane dispersion, which is prepared by using a combined chain extender system of a hydrophilic amino siloxane compound and a polyetheramine compound, is provided. The internally emulsified polyurethane dispersion can be used to prepare a synthetic leather product having good anti-stickiness, wrinkle resistance, color fastness and superior mechanical properties. A laminated synthetic leather article prepared with said internally emulsified polyurethane dispersion as well a method for preparing the synthetic leather article are also provided.

Abstract: A method may include obtaining localization information and control signal information relating to an autonomous vehicle (AV). The method may include computing first kinematic characteristics of the AV based on the localization information and the control signal information and generating a first vehicle model based on the first kinematic characteristics. The method may include determining one or more first control commands that provide instructions for actuating a driving operation of the AV. The first control commands may be determined based on the first vehicle model. The method may include simulating first movement of the AV according to the first control commands and the first vehicle model.

Abstract: The present disclosure relates to a molecular delivery system that facilitates the internalization of LNPs into a specific target of choice, such as a specific cell type, ex vivo and/or in vivo. The present disclosure also relates to methods, molecules, and compositions for enhancing the targeted delivery of compounds within a living system. In particular, embodiments provided herein relate to methods, molecules, and compositions for the targeted delivery of lipid nanoparticles containing therapeutic molecules into a cell or system of choice, such as a T cell. The present disclosure also relates to methods of administering the enhanced targeting system to a patient or system, compositions for use in such methods, and further methods of use of the targeting system as part of T cell-based immunotherapy.

Abstract: The present invention provides a chimeric antigen receptor (CAR) which binds a low density target antigen, which comprises a Fab antigen binding domain. The invention also relates to cells expressing such a CAR and their use in the treatment of disease.

Abstract: The present invention provides a chimeric antigen receptor (CAR) which binds a low density target antigen, which comprises a Fab antigen binding domain. The invention also relates to cells expressing such a CAR and their use in the treatment of disease.

Abstract: A settlement driving control structure for forced-settlement rectification and a settlement driving control method for forced-settlement rectification are provided. The settlement driving control structure includes: a vertical hole is formed in a raft of a building, a lower end of an anchor bolt is anchored at the bottom of the vertical hole and the other end of the anchor bolt extends out of the vertical hole to be connected to a tensioning device, two grouting pipes are configured for grouting to form an anchorage body, and two waterstop rubber rings are spaced apart on a position of the anchor bolt above the anchorage body. For a building with a great load on the upper part, a building foundation and a deep stable stratum are connected as a whole by stress application through the device.

Abstract: An autonomous driving computing system may include an on-board computing system that is configured to perform first operations that include obtaining sensor data relating to an autonomous vehicle (AV). The first operations may include sending the obtained sensor data to an off-board cloud computing system. The autonomous driving computing system may include the off-board cloud computing system, which may be configured to perform second operations that include receiving the sensor data and performing computations relating to the driving operation of the AV based on the obtained sensor data. The second operations may include determining a control signal corresponding to a driving operation and sending the control signal to the on-board computing system. The first operations may involve the on-board computing system receiving, from the off-board cloud computing system, the control signal corresponding to the driving operation of the AV and performing the driving operation by implementing the control signal.

Abstract: A method may include obtaining input information representative of an autonomous vehicle. The input information may include a plurality of data types. Each data type of the plurality of data types may be asynchronous. The method may also include aligning the input information to a point in time. In addition, the method may include determining odometry information indicating a state of the autonomous vehicle at the point in time based on the aligned input information. Further, the method may include sending the odometry information to a downstream system.

Abstract: The invention relates to a method of determining the T cell receptor ? chain (TRBC) gene type of a cell, the method comprising (a) determining the J gene type expressed in said cell, and (b) inferring from (a) the TRBC gene type expressed in said cell. The invention further relates to use of a CAR T cell targeted to a T cell receptor ? chain (TRBC) type 1, or a CAR T cell targeted to a T cell receptor ? chain (TRBC) type 2. The invention further relates to a method of medical treatment, and to nucleic acid probes.

Abstract: The present invention provides a chimeric antigen receptor (CAR) which binds a target antigen having a bulky extra-cellular domain, wherein the CAR comprises a Fab antigen binding domain. The present invention also provides nucleic acid sequences and constructs encoding such a CAR, cells expressing such a CAR and their therapeutic uses.

Abstract: A method may include obtaining sensor data about a total measurable world around an autonomous vehicle. The sensor data may be captured by sensor units co-located with the autonomous vehicle. The method may include generating a mapping dataset including the obtained sensor data and identifying data elements that each represents a point in the mapping dataset. The method may include sorting the data elements according to a structural data categorization that is a template for a high-definition map of the total measurable world and determining a mapping trajectory of the autonomous vehicle. The mapping trajectory may describe a localization and a path of motion of the autonomous vehicle. The method may include generating the high-definition map based on the structural data categorization and relative to the mapping trajectory of the autonomous vehicle, and the high-definition map may be updated based on the path of motion of the autonomous vehicle.

Abstract: A polyclonal antiserum composition including a repertoire of antigen-specific artificial immunoglobulins, each antigen-specific artificial immunoglobulin including: one or more human heavy chain VH segment(s); one or more D segment(s); one or more J segment(s); and one or more constant region segment(s).

Abstract: The present invention provides a chimeric antigen receptor (CAR) which binds a low density target antigen, which comprises a Fab antigen binding domain. The invention also relates to cells expressing such a CAR and their use in the treatment of disease.

Abstract: A method may include obtaining input information relating to an environment in which an autonomous vehicle (AV) operates, the input information describing at least one of: a state of the AV, an operation of the AV within the environment, a property of the environment, or an object included in the environment. The method may include identifying a first object in the vicinity of the AV based on the obtained input information. The method may include determining a first object rule corresponding to the first object, the first object rule indicating suggested driving behavior for interacting with the first object. The method may include determining a first decision that follows the first object rule and sending an instruction to a control system of the AV, the instruction describing a given operation of the AV responsive to the first object rule according to the first decision.

Abstract: A method may include obtaining sensor data describing a total measurable world around a motion sensor. The method may include processing the sensor data to generate a pre-compensation scan of the total measurable world around the motion sensor based on the sensor data. The method may include determining a delay between the obtaining the sensor data and the generation of the pre-compensation scan. The method may include obtaining motion data corresponding to motion of the motion sensor and generating a motion model of the motion sensor based on the motion data. The method may include generating an after-compensation scan of the motion sensor using the delay and the motion model to compensate for continued motion during the delay.

Abstract: The invention relates to transgenic animals useful for optimal production of functional immunoglobulins with human idiotypes.

Abstract: A waterborne polyurethane dispersion is provided. The waterborne polyurethane dispersion is prepared by using a tri-functionality polyether polyol as part of the polyols for forming the prepolymer and a hydrophilic amino siloxane co-chain extender, and can exhibit superior performance properties such as enhanced color fastness, improved low temperature stability, good anti-stickiness, bally flex resistance, anti-abrasion and mechanical properties. A laminated synthetic leather article prepared with said waterborne polyurethane dispersion as well the method for preparing the synthetic leather article are also provided.

Abstract: The present invention provides a chimeric antigen receptor (CAR) which binds a target antigen having a bulky extracellular domain, wherein the CAR comprises a Fab antigen binding domain. The present invention also provides nucleic acid sequences and constructs encoding such a CAR, cells expressing such a CAR and their therapeutic uses.