Abstract: A method may include obtaining first sensor data captured by a first sensor system and second sensor data captured by a second sensor system of a different type from the first sensor system. The method may include detecting a first object included in the first sensor data and a second object included in the second sensor data. The method may include assigning a first label to the first object and a second label to the second object after comparing the first and the second sensor data. The first and second labels may indicate degrees to which the first and the second objects match. Responsive to the first and second labels indicating that the first and the second objects match, the method may include designating a matched object representative of the first object and the second object and sending the matched object to a downstream computing system of an autonomous vehicle.

Abstract: A method may include obtaining sensor data from one or more LiDAR units and determining a point-cloud corresponding to the sensor data obtained from each respective LiDAR unit. The method may include aggregating the point-clouds as an aggregated point-cloud and generating an initial proposal for a two-dimensional ground model made of multiple grid blocks. The method may include filtering out unrelated raw data points from each grid block of the plurality of grid blocks to generate a filtered point-cloud matrix. The method may include identifying one or more surface-points and one or more object-points included in the filtered point-cloud matrix and generating an array of extracted objects based on the object-points.

Abstract: A method may include obtaining sensor data from one or more LiDAR units and determining a point-cloud corresponding to the sensor data obtained from each respective LiDAR unit. The method may include aggregating the point-clouds as an aggregated point-cloud. A number of data points included in the aggregated point-cloud may be decreased by filtering out one or more of the data points according to one or more heuristic rules to generate a reduced point-cloud. The method may include determining an operational granularity level for the reduced point-cloud. An array of existence-based objects may be generated based on the reduced point-cloud and the operational granularity level.

Abstract: A method may include determining an alignment time based on a zero-crossing point corresponding to a LiDAR sensor and a horizontal field of view corresponding to an image-capturing sensor. The method may include determining a delay timing for initiating image capturing by the image-capturing sensor in which the delay timing is based on at least one of: the alignment time, a packet capture timing corresponding to the LiDAR sensor, and an average frame exposure duration corresponding to the image-capturing sensor. The method may include initiating data capture by the LiDAR sensor, and after the initiating of data capture by the LiDAR sensor and after the delay timing has elapsed, initiating data capture by the image-capturing sensor.

Abstract: The present invention provides a chimeric antigen receptor (CAR) which binds a low density target antigen, which comprises a Fab antigen binding domain. The invention also relates to cells expressing such a CAR and their use in the treatment of disease.

Abstract: Provided is a protein comprising an antibody or antigen-binding fragment and an interleukin molecule operably linked to the antibody or antigen-binding fragment. The antibody or antigen-binding fragment specifically binds to an immune checkpoint protein. The interleukin molecule is IL-10.

Abstract: The present invention provides a chimeric antigen receptor (CAR) which binds a target antigen having a bulky extracellular domain, wherein the CAR comprises a Fab antigen binding domain. The present invention also provides nucleic acid sequences and constructs encoding such a CAR, cells expressing such a CAR and their therapeutic uses.

Abstract: Provided herein is related generally to the field of molecular biology and growth factor regulation. More specifically, provided herein are methods useful for treating cancer patient using c-Met inhibitor based on the identification of an increased c-Met expression and at least one c-Met gene alteration, e.g. c-Met mutation, c-Met fusion gene and c-Met gene amplification.

Abstract: A waterborne polyurethane dispersion is provided. The waterborne polyurethane dispersion is prepared by using a tri-functionality polyether polyol as part of the polyols for forming the prepolymer and a hydrophilic amino siloxane co-chain extender, and can exhibit superior performance properties such as enhanced color fastness, improved low temperature stability, good anti-stickiness, bally flex resistance, anti-abrasion and mechanical properties. A laminated synthetic leather article prepared with said waterborne polyurethane dispersion as well the method for preparing the synthetic leather article are also provided.

Abstract: Provided is a waterborne polyurethane dispersion. The waterborne polyurethane dispersion is prepared in the presence of a hydrophilic amino siloxane compound and exhibits good anti-stickiness while retaining superior mechanical properties. A laminated synthetic leather article prepared with said waterborne polyurethane dispersion as well the method for preparing the synthetic leather article are also provided.

Abstract: Virtual bumpers for autonomous vehicles improve effectiveness and safety as such vehicles are operated. One or more sensor systems having a Lidar sensor and a camera sensor determine proximity of objects around the vehicle and facilitate identification of the environment around the vehicle. The sensor systems are placed at various locations around the vehicle. The vehicle identifies an object and one or more properties of the identified object using the sensor systems. Based on the identified object and the properties of the object, a virtual bumper may be created for that object. For example, if the object is identified as another vehicle moving with a certain velocity, the vehicle may determine a minimum space to avoid the other vehicle, either by changing direction or reducing the velocity of the vehicle, with the minimum space constituting a virtual bumper.

Abstract: The present invention provides a chimeric antigen receptor (CAR) which binds a low density target antigen, which comprises a Fab antigen binding domain. The invention also relates to cells expressing such a CAR and their use in the treatment of disease.

Abstract: The invention relates to a method of determining the T cell receptor ? chain (TRBC) gene type of a cell, the method comprising (a) determining the J gene type expressed in said cell, and (b) inferring from (a) the TRBC gene type expressed in said cell. The invention further relates to use of a CAR T cell targeted to a T cell receptor ? chain (TRBC) type 1, or a CAR T cell targeted to a T cell receptor ? chain (TRBC) type 2. The invention further relates to a method of medical treatment, and to nucleic acid probes.

Abstract: The present invention relates to a partition library which comprises a plurality of partitions which are useful for the analysis of the transcriptional response of a CAR to a target antigen. Further, the present invention relates to assays for the analysis of the transcriptional response of a CAR to a target antigen. The present invention also relates to kits comprising the plurality of partitions.

Abstract: Virtual bumpers for autonomous vehicles improve effectiveness and safety as such vehicles are operated. One or more sensor systems having a Lidar sensor and a camera sensor determine proximity of objects around the vehicle and facilitate identification of the environment around the vehicle. The sensor systems are placed at various locations around the vehicle. The vehicle identifies an object and one or more properties of the identified object using the sensor systems. Based on the identified object and the properties of the object, a virtual bumper may be created for that object. For example, if the object is identified as another vehicle moving with a certain velocity, the vehicle may determine a minimum space to avoid the other vehicle, either by changing direction or reducing the velocity of the vehicle, with the minimum space constituting a virtual bumper.

Abstract: The present disclosure relates to a bispecific reagent and a detection agent which are useful for the identification of an antibody-producing cell which produces an antibody that binds specifically to a target antigen. Further, the present disclosure relates to an assay for the identification of an antibody-producing cell which produces an antibody that binds specifically to a target antigen. The present disclosure also relates to kits comprising the bispecific reagent and the detection agent.

Abstract: The present invention provides a chimeric antigen receptor (CAR) which binds a target antigen having a bulky extracellular domain, wherein the CAR comprises a Fab antigen binding domain. The present invention also provides nucleic acid sequences and constructs encoding such a CAR, cells expressing such a CAR and their therapeutic uses.

Abstract: Systems and methods for determining an order accepting mode for a target service provider are provided. A method includes receiving a request for determining an order accepting mode for the target service provider. The method also includes obtaining an order accepting evaluation parameter with respect to the target service provider in response to the request. The method also includes determining an order accepting mode for the target service providers based on the order accepting evaluation parameter. The order accepting mode includes at least one of an order designating mode, an order striving mode, or an order quick-accepting mode.