Abstract: Provided is a waterborne polyurethane dispersion. The waterborne polyurethane dispersion is prepared in the presence of a hydrophilic amino siloxane compound and exhibits good anti-stickiness while retaining superior mechanical properties. A laminated synthetic leather article prepared with said waterborne polyurethane dispersion as well the method for preparing the synthetic leather article are also provided.

Abstract: Virtual bumpers for autonomous vehicles improve effectiveness and safety as such vehicles are operated. One or more sensor systems having a Lidar sensor and a camera sensor determine proximity of objects around the vehicle and facilitate identification of the environment around the vehicle. The sensor systems are placed at various locations around the vehicle. The vehicle identifies an object and one or more properties of the identified object using the sensor systems. Based on the identified object and the properties of the object, a virtual bumper may be created for that object. For example, if the object is identified as another vehicle moving with a certain velocity, the vehicle may determine a minimum space to avoid the other vehicle, either by changing direction or reducing the velocity of the vehicle, with the minimum space constituting a virtual bumper.

Abstract: The present invention provides a chimeric antigen receptor (CAR) which binds a low density target antigen, which comprises a Fab antigen binding domain. The invention also relates to cells expressing such a CAR and their use in the treatment of disease.

Abstract: The invention relates to a method of determining the T cell receptor ? chain (TRBC) gene type of a cell, the method comprising (a) determining the J gene type expressed in said cell, and (b) inferring from (a) the TRBC gene type expressed in said cell. The invention further relates to use of a CAR T cell targeted to a T cell receptor ? chain (TRBC) type 1, or a CAR T cell targeted to a T cell receptor ? chain (TRBC) type 2. The invention further relates to a method of medical treatment, and to nucleic acid probes.

Abstract: The present invention relates to a partition library which comprises a plurality of partitions which are useful for the analysis of the transcriptional response of a CAR to a target antigen. Further, the present invention relates to assays for the analysis of the transcriptional response of a CAR to a target antigen. The present invention also relates to kits comprising the plurality of partitions.

Abstract: Virtual bumpers for autonomous vehicles improve effectiveness and safety as such vehicles are operated. One or more sensor systems having a Lidar sensor and a camera sensor determine proximity of objects around the vehicle and facilitate identification of the environment around the vehicle. The sensor systems are placed at various locations around the vehicle. The vehicle identifies an object and one or more properties of the identified object using the sensor systems. Based on the identified object and the properties of the object, a virtual bumper may be created for that object. For example, if the object is identified as another vehicle moving with a certain velocity, the vehicle may determine a minimum space to avoid the other vehicle, either by changing direction or reducing the velocity of the vehicle, with the minimum space constituting a virtual bumper.

Abstract: The present disclosure relates to a bispecific reagent and a detection agent which are useful for the identification of an antibody-producing cell which produces an antibody that binds specifically to a target antigen. Further, the present disclosure relates to an assay for the identification of an antibody-producing cell which produces an antibody that binds specifically to a target antigen. The present disclosure also relates to kits comprising the bispecific reagent and the detection agent.

Abstract: The present invention provides a chimeric antigen receptor (CAR) which binds a target antigen having a bulky extracellular domain, wherein the CAR comprises a Fab antigen binding domain. The present invention also provides nucleic acid sequences and constructs encoding such a CAR, cells expressing such a CAR and their therapeutic uses.

Abstract: Systems and methods for determining an order accepting mode for a target service provider are provided. A method includes receiving a request for determining an order accepting mode for the target service provider. The method also includes obtaining an order accepting evaluation parameter with respect to the target service provider in response to the request. The method also includes determining an order accepting mode for the target service providers based on the order accepting evaluation parameter. The order accepting mode includes at least one of an order designating mode, an order striving mode, or an order quick-accepting mode.

Abstract: A cloud server maintains a neighboring vehicle data structure storing vehicle information of vehicles coupled to the cloud server over a network. The server receives a first request from a first of the vehicles, including a first vehicle identifier (ID) and current vehicle metadata of the first vehicle. In response to the first request, the server traverses the neighboring vehicle data structure to update a first node corresponding to the first vehicle based on the first vehicle ID and the current vehicle information of the first vehicle. The server transmits to the first vehicle over the network a list of one or more vehicle IDs identifying one or more vehicles that are within a predetermined geographic proximity of the first autonomous vehicles to allow the first vehicle to directly communicate with any vehicle in the list via a wireless local area network.

Abstract: The invention relates to transgenic animals useful for optimal production of functional immunoglobulins with human idiotypes.

Abstract: Systems and methods for determining an order accepting mode for a target service provider are provided. A method includes receiving a request for determining an order accepting mode for the target service provider. The method also includes obtaining an order accepting evaluation parameter with respect to the target service provider in response to the request. The method also includes determining an order accepting mode for the target service providers based on the order accepting evaluation parameter. The order accepting mode includes at least one of an order designating mode, an order striving mode, or an order quick-accepting mode.

Abstract: Virtual bumpers for autonomous vehicles improve effectiveness and safety as such vehicles are operated. One or more sensor systems having a Lidar sensor and a camera sensor determine proximity of objects around the vehicle and facilitate identification of the environment around the vehicle. The sensor systems are placed at various locations around the vehicle. The vehicle identifies an object and one or more properties of the identified object using the sensor systems. Based on the identified object and the properties of the object, a virtual bumper may be created for that object. For example, if the object is identified as another vehicle moving with a certain velocity, the vehicle may determine a minimum space to avoid the other vehicle, either by changing direction or reducing the velocity of the vehicle, with the minimum space constituting a virtual bumper.

Abstract: The present invention provides a cell comprising first and second chimeric antigen receptors (CARs), which bind to different antigens, wherein the first CAR binds to Transmembrane activator and calcium modulator and cyclophilin ligand (CAML) interactor (TACI). The present invention also provides a cell comprising a tan CAR comprising first and second antigen-binding domains which bind to different antigens, wherein the first antigen binding domain binds the antigen Transmembrane activator and calcium modulator and cyclophilin ligand (CAML) interactor (TACI). The present invention further provides corresponding nucleic acid sequences and/or constructs, kits and vectors comprising said nucleic acid sequences and/or constructs, molecules and methods for making such cells. The cells may be used in cellular immunotherapy approaches for treating diseases such as multiple myeloma.

Abstract: The invention relates to polynucleotides, particularly chimeric polynucleotides useful for optimal production of functional immunoglobulins with human idiotypes in rodents. The invention further relates to rodents comprising such polynucleotides.

Abstract: In one embodiment, a server receives a request from a first autonomous vehicle for content delivery. In response to the request, a vision analysis is performed on an image obtained from the request to determine three-dimensional (3D) positioning information of the image. A list of content items are identified based on current vehicle information of the first autonomous vehicle in view of a user profile of a user ridding the first autonomous vehicle. A first content item selected from the list of content items is augmented onto the image based on the 3D positioning information of the image, generating an augmented image. The augmented image is transmitted to the first autonomous vehicle, where the augmented image is to be displayed on a display device within the autonomous vehicle in a virtual reality manner.

Abstract: The present invention discloses a series of piperidine derivatives as orexin receptor antagonists and compositions thereof, and relates to the application thereof in preparing medications for the treatment of insomnia, chronic obstructive pulmonary disease, obstructive sleep apnea, hypersomnia, anxiety, obsessive-compulsive disorder, panic attack, nicotine addiction, or binge eating disorder.

Abstract: A cloud server maintains a neighboring vehicle data structure storing vehicle information of vehicles coupled to the cloud server over a network. The server receives a first request from a first of the vehicles, including a first vehicle identifier (ID) and current vehicle metadata of the first vehicle. In response to the first request, the server traverses the neighboring vehicle data structure to update a first node corresponding to the first vehicle based on the first vehicle ID and the current vehicle information of the first vehicle. The server transmits to the first vehicle over the network a list of one or more vehicle IDs identifying one or more vehicles that are within a predetermined geographic proximity of the first autonomous vehicles to allow the first vehicle to directly communicate with any vehicle in the list via a wireless local area network.

Abstract: In one embodiment, a vehicle identifier (ID) and vehicle information of a first autonomous vehicle is transmitted to a cloud server over a network, where the cloud server is communicatively coupled to a plurality of autonomous vehicles. A list of one or more vehicle identifiers (IDs) are received from the cloud server. The vehicle IDs identify one or more autonomous vehicles are within a predetermined geographic proximity of the first autonomous vehicle. The first autonomous vehicle communicates with a second autonomous vehicle that is selected from the list of one or more autonomous vehicles via a wireless local area network to exchange an operational status of the first autonomous vehicle with the second autonomous vehicle.

Abstract: In one embodiment, a vehicle identifier (ID) and vehicle information of a first autonomous vehicle is transmitted to a cloud server over a network, where the cloud server is communicatively coupled to a plurality of autonomous vehicles. A list of one or more vehicle identifiers (IDs) are received from the cloud server. The vehicle IDs identify one or more autonomous vehicles are within a predetermined geographic proximity of the first autonomous vehicle. The first autonomous vehicle communicates with a second autonomous vehicle that is selected from the list of one or more autonomous vehicles via a wireless local area network to exchange an operational status of the first autonomous vehicle with the second autonomous vehicle.