Abstract: The instant application describes novel compounds that modulate (in particular, inhibit) Sirt2, with structures according to Formulas (1) and (2) provided herein. The invention is also directed to pharmaceutical compositions thereof, methods of treatment (i.e., cancer and neurodegenerative disease) by administration of the modulating compounds, assay methods for finding modulators of Sirt2, and kits for practicing the assay method.

Abstract: A method for positioning in a communication network with a cellular coverage is disclosed, wherein comprising the following steps: receiving location-dependent data concerning a mobile device; from a plurality of fingerprints, each of which corresponds to one of locations within the coverage, retrieving one having the highest similarity to the location-dependent data; and determining the location corresponding to the fingerprint with the highest similarity as the mobile device's location if the highest similarity exceeds a predetermined threshold.

Abstract: Embodiments of a system are described. In one embodiment, the system is a device for performing operations and supporting transactions. The device is configured to receive a transaction comprising a command and data. The device writes the data to a transaction manager on a persistent memory device. The transaction manager also maintains a status of the transaction and reference to entries within memory that are manipulated by the transaction. The device also creates an in-memory log of the transaction in a first hash directory. The device then commits a copy of the first hash directory to a second hash directory maintained on a persistent memory device.

Abstract: A system and method for cardiac activation imaging includes non-invasively or minimally invasively acquiring data about an electrical activation of a heart of a subject using at least one sensor. An activation image of the heart of the subject is reconstructed using a weighted sparse constrained reconstruction.

Abstract: Embodiments of the present disclosure concern methods and compositions for prognosis, diagnosis, and/or treatment of prostate cancer or breast cancer, for example. Certain embodiments of the disclosure concern assaying for the expression level of TDRDl. Particular embodiments concern treating an individual with a particular cancer therapy when the expression level of TDRDl is overexpressed.

Abstract: The instant application describes novel compounds that modulate (in particular, inhibit) Sirt2, with structures according to Formulas (1) and (2) provided herein. The invention is also directed to pharmaceutical compositions thereof, methods of treatment (i.e., cancer and neurodegenerative disease) by administration of the modulating compounds, assay methods for finding modulators of Sirt2, and kits for practicing the assay method.

Abstract: An apparatus includes a magnetic energy source to provide a magnetic signal and a detector to detect an acoustic energy signal from a sample stimulated by the magnetic energy signal. A method includes applying a magnetic signal to a biological sample, detecting an acoustic signal from the sample, and processing the acoustic signal to determine the electrical impedance distribution of the sample, and identify disease in the biological sample. A method includes applying a magnetic signal to a sample, detecting a magnetic or electrical signal within the sample, and processing the magnetic or electrical signal to reconstruct electrical impedance distribution of the sample.

Abstract: The instant application describes novel compounds that modulate (in particular, inhibit) Sirt2 , with structures according to Formulas (1) and (2) provided herein. The invention is also directed to pharmaceutical compositions thereof, methods of treatment (i.e., cancer and neurodegenerative disease) by administration of the modulating compounds, assay methods for finding modulators of Sirt2 , and kits for practicing the assay method.

Abstract: A system and method for determining an electrical activity in a subject using ultrasound and electromagnetics are provided. In some aspects, the method includes directing ultrasound energy to a portion of a subject's anatomy using an ultrasound system, wherein the ultrasound energy inducing a perturbation to locations in the subject's anatomy, and sensing, using sensors arranged about the subject, a plurality of electromagnetic signals representing an electrical activity of the subject. The method also includes identifying electromagnetic signals that are modulated by the perturbation, and generating a report of the electrical activity using the identified electromagnetic signals.

Abstract: Techniques for reducing a number of computations in a data storage process are provided. One or more computational elements are identified in the data storage process. An ordered structure of one or more nodes is generated using the one or more computational elements. Each of the one or more nodes represents one or more computational elements. Further, a weight is assigned to each of the one or more nodes. An ordered structure of one or more reusable nodes is generated by deleting one or more nodes in accordance with the assigned weights. The ordered structure of one or more reusable nodes is utilized to reduce the number of computations in the data storage process. The data storage process converts data from a first format into a second format, and stores the data in the second format on a computer readable medium for data analysis purposes.

Abstract: There is provided a conductive fibrous material comprising a plurality of carbonaceous fibers, wherein each carbonaceous fiber is fused to at least one other fiber. The carbonaceous fibers may be fused at fiber-to-fiber contact points by a polymer. The process of making the conductive fibrous material comprises mixing a phenolic polymer with a second polymer to form a polymer solution, preparing phenolic fibers having nano- or micro-scale diameters by electrospinning the polymer solution, and subsequent carbonization of the obtained phenolic fibers, thereby generating carbonaceous fibers, wherein each carbonaceous fiber is fused to at least one other fiber. The conductive fibrous material may be useful in electrode materials for energy storage devices.

Abstract: Embodiments of the present invention provide a system, method and computer program products for memory space management for storage class memory. One embodiment comprises a method for information storage in an information technology environment. The method comprises storing data in a storage class memory (SCM) space, and storing storage management metadata corresponding to said data, in the SCM in a first data structure. The method further includes buffering storage management metadata corresponding to said data, in a main memory in a second data structure.

Abstract: A method of preparing a fiber-reinforced polymer composite is provided. The method includes (a) providing a swollen clay material; (b) chemically modifying a surface of the swollen clay material with an organosilane to form a silane-modified clay material; (c) intercalating the silane-modified clay material with a binder to form an intercalated clay material; and (d) melt compounding the intercalated clay material with a mixture comprising a polymer and fiber to form the fiber-reinforced polymer composite. A fiber-reinforced polymer composite is also provided.

Abstract: A method of data loading for large information warehouses includes performing checkpointing concurrently with data loading into an information warehouse, the checkpointing ensuring consistency among multiple tables; and recovering from a failure in the data loading using the checkpointing. A method is also disclosed for performing versioning concurrently with data loading into an information warehouse. The versioning method enables processing undo and redo operations of the data loading between a later version and a previous version. Data load failure recovery is performed without starting a data load from the beginning but rather from a latest checkpoint for data loading at an information warehouse level using a checkpoint process characterized by a state transition diagram having a multiplicity of states; and tracking state transitions among the states using a system state table.

Abstract: Embodiments of the present invention provide a system, method and computer program products for memory space management for storage class memory. One embodiment comprises a method for information storage in an information technology environment. The method comprises storing data in a storage class memory (SCM) space, and storing storage management metadata corresponding to said data, in the SCM in a first data structure. The method further includes buffering storage management metadata corresponding to said data, in a main memory in a second data structure.

Abstract: Embodiments of the invention relate to technology prediction. A technical dictionary of technical terms is constructed based on a collection of documents. The technical terms are partitioned into equivalence classes. A table is generated that correlates technical terms across equivalence classes based on temporal co-occurrence of the technical terms across the equivalence classes. For a given technical term the table is accessed to determine a first set of technical terms that correlate to the given technical term. The table is accessed again to determine a second set of technical terms that correlate to the first set of technical terms. It is predicted that the second set of technical terms will correlate to the given technical term in the future.

Abstract: The present invention relates to a method and a positioning server in a radio access network for collecting radio fingerprint positioning data records from different nodes. The data records comprise geographical positions and radio network communication parameters and are stored and grouped in clusters in the positioning server. A geometrical shape representing a geographical area based on the network communication parameters in the collected positioning data records in the cluster is computed. When a notification about changed network configuration parameters for a radio cell is received, known positioning servers simply erase all positioning data records related to that radio cell. This results in the unavailability of still valid positioning data. The present invention overcomes this problem by selectively erase positioning data records in the positioning server only when the configuration parameters have changed beyond a predefined value range.

Abstract: Method and device for transmitting media stream are provided to solve the problem of quality reduction in audio and video caused by packet loss, jitter, link breakage in a media stream transmission process in the conventional art. The method includes: a media capability negotiation between a calling terminal and a called terminal is conducted according to a link establishment request message transmitted by the calling terminal and a response message transmitted by the called terminal in response to the link establishment request message, and at least two media channels are established; a media stream is transmitted through a first media channel according to negotiated media capabilities; and when an abnormity is detected to appear in the media stream transmission of the first media channel, another one of the at least two media channels is selected as a second media channel, and the media stream is switched from the first media channel to the second media channel for transmission.

Abstract: An extraction tower includes a housing defining a light phase outlet at a top thereof, a heavy phase inlet at an upper portion thereof, a light phase inlet at a lower portion thereof and a heavy phase outlet at a bottom thereof; a heavy phase distributor disposed in the housing and communicated with the heavy phase inlet; a light phase distributor disposed in the housing and communicated with the light phase inlet; a packing layer disposed in the housing and located between the heavy phase distributor and the light phase distributor; and at least one layer of vertical plates disposed in at least one of the packing layers, each layer of the vertical plates comprising at least two vertical plates parallel or cross to each other, each vertical plate disposed in an axial direction.

Abstract: A method for implementing multicast data exchange over a partitioned network having an encrypted domain with HAIPE devices at the edges consists of proxies running at an ingress edge and at egress edges of the encrypted domain. The proxies at the ingress edge device modify the multicast data packet to replace the destination address with the address of a proxy running on an egress edge device, such that the encrypted domain routes the packet directly to the proxy at the egress edge device without processing it as a multicast data packet. At the egress edge devices, the proxies restore the original address and send the multicast packets to the appropriate destinations.