Abstract: Provided are a fusion protein, and an immunoconjugate, a nucleic acid molecule, a carrier, a composition, a cell and a preparation method related thereto, for treating tumors and/or autoimmune diseases.

Abstract: The invention relates to the technical field of oil and gas drilling, and discloses an amphiphilic block polymer ultralow-permeability agent and an intelligent temporary plugging type water-based drilling fluid. The ultralow-permeability agent contains a structural unit provided by styryl hydrophobic monomer, maleic anhydride and acrylamide; the drilling fluid contains two or more of water, sodium bentonite, Pac-Lv, the ultralow-permeability agent, calcium carbonate, one-way plugging agent, white asphalt and barite which are stored in a mixed manner or independently stored.

Abstract: The embodiments of the invention provide an intelligent prediction method and apparatus for reservoir sensitivity, belonging to the technical field of reservoir sensitivity prediction. The method includes: acquiring a reservoir sensitivity influence factor item related to a reservoir sensitivity result to be predicted and numerical values of corresponding reservoir sensitivity influence factors; determining a corresponding type of database according to the reservoir sensitivity influence factor item; determining whether numerical values of reservoir sensitivity influence factors corresponding to core parameters in the numerical values of the reservoir sensitivity influence factors include a first upper boundary value or a first lower boundary value; and using, according to whether the first upper boundary value or the first lower boundary value is included, different intelligent sensitivity prediction models to calculate the reservoir sensitivity result to be predicted.

Abstract: A PCIe/SAS female connector includes a frame body, a terminal assembly, and a cover member; the frame body including a groove disposed on an end thereof; the terminal assembly including a Serial Advanced Technology Attachment (SATA) 7 pin signal and grounding terminal inserted in the frame body and having a head portion and a foot. When the SATA 7 pin signal and grounding terminal is inserted in the frame body, the head portion is in the groove. The cover member includes an elastic plate and a foot; the elastic plate disposed on the head portion of the cover member. When the PCIe/SAS female connector is engaged with a male connector, the head portion of the SATA 7 pin signal and grounding terminal contacts the elastic plate of the cover member. The foot of the SATA 7 pin signal and grounding terminal and the foot of the cover member are welded in an identical Printed Circuit Board (PCB) pad.

Abstract: An ultralow-permeability agent contains a structural unit provided by styryl hydrophobic monomer, maleic anhydride and acrylamide; the drilling fluid contains two or more of water, sodium bentonite, Pac-Lv, the ultralow-permeability agent, calcium carbonate, one-way plugging agent, white asphalt and barite which are stored in a mixed manner or independently stored. When the amphiphilic block polymer provided by the invention is used as the ultralow-permeability agent of the intelligent temporary plugging type water-based drilling fluid, the self-adaptive characteristic is realized; according to the amphiphilic block polymer, temporary plugging layer gaps formed in pore and throats by plugging materials in drilling fluid can be fully filled under the condition that the sizes and the distribution of the pore and throats of reservoirs are not required to be clear, so that the permeability of temporary plugging layer is greatly reduced, ultralow-permeability is realized.

Abstract: A PCIe/SAS female connector includes a frame body, a terminal assembly, and a cover member; the frame body including a groove disposed on an end thereof; the terminal assembly including a Serial Advanced Technology Attachment (SATA) 7 pin signal and grounding terminal inserted in the frame body and having a head portion and a foot. When the SATA 7 pin signal and grounding terminal is inserted in the frame body, the head portion is in the groove. The cover member includes an elastic plate and a foot; the elastic plate disposed on the head portion of the cover member. When the PCIe/SAS female connector is engaged with a male connector, the head portion of the SATA 7 pin signal and grounding terminal contacts the elastic plate of the cover member. The foot of the SATA 7 pin signal and grounding terminal and the foot of the cover member are welded in an identical Printed Circuit Board (PCB) pad.

Abstract: A PCIe SAS direct link connector includes a cable end and a back board; the cable end fixed on the back board and including a direct link female head, a high-speed line, and a 15 pin plug terminal; the back board including a primary and a secondary cavity position; the direct link female head connected with the high-speed line; the 15 pin plug terminal being an asymmetric bow shape and having a short and a long side, a first contact point disposed on the short side, and a second contact point disposed on the long side; the 15 pin plug terminal connected with the high-speed line; when the 15 pin plug terminal is combined with a server board end connector, the first contact point and the second contact point contact a terminal of the server board end connector, respectively, simplifying the connection structure and improving heat dissipation.

Abstract: The embodiments of the invention provide an intelligent prediction method and apparatus for reservoir sensitivity, belonging to the technical field of reservoir sensitivity prediction. The method includes: acquiring a reservoir sensitivity influence factor item related to a reservoir sensitivity result to be predicted and numerical values of corresponding reservoir sensitivity influence factors; determining a corresponding type of database according to the reservoir sensitivity influence factor item; determining whether numerical values of reservoir sensitivity influence factors corresponding to core parameters in the numerical values of the reservoir sensitivity influence factors include a first upper boundary value or a first lower boundary value; and using, according to whether the first upper boundary value or the first lower boundary value is included, different intelligent sensitivity prediction models to calculate the reservoir sensitivity result to be predicted.

Abstract: A method of simultaneously modifying degradation rates of at least two compounds including a first compound having a first unmodified degradation rate constant k1 and a second compound having a second unmodified degradation rate k2 is provided. The method includes combining a first composition including the first compound with a second composition including the second compound, degrading the first compound and forming a first degradation product; and degrading the second compound and forming a second degradation product. The second degradation product modifies the first unmodified degradation rate constant k1 of the first compound to a first modified degradation rate k1? and the first degradation product modifies the second unmodified degradation rate k2 of the second compound to a second modified degradation rate k2?. Compositions resulting from the method are also provided.

Abstract: The invention relates to the field of drilling fluid, in particular to a saturated salt water drilling fluid of salt response type intelligent polymer and preparation method thereof. The drilling fluid contains two or more of the following components stored in admixture or separately: bentonite, NaOH, KCl, calcium carbonate, barite, NaCl, supramolecular fluid loss additive, supramolecular shear-enhancing agent, plugging agent, coating agent and water. The drilling fluid provided by the invention has the characteristics of salt response and self-assembly, can keep rheological properties such as rapid recovery of the sheared structure, low extreme high shear rate viscosity, good shear dilution property and the like in a high-salt environment, has good fluid loss reduction performance, reservoir protection performance and debris dispersion inhibition performance, and has good temperature resistance and pollution resistance performance.

Abstract: An apparatus in the field of optics technology, can include a reflector, a reflector substrate, and an extinction component. The reflector can be mounted on the reflector substrate. The extinction component can be arranged on a front surface of the reflector substrate. The reflector can be configured to reflect incident light signals. The extinction component can be configured to reduce the scattered light produced by the incident light signal on the reflector substrate. An optical scanning device (for example, lidar) having such features may greatly reduce the scattered light inside the lidar, reduce the detection blind area caused by the stray light, and greatly improve the receiving and detecting capabilities of the lidar.

Abstract: Provided is a fusion protein, comprising a first binding domain that specifically binds a tumor-associated antigen, and a second binding domain that specifically binds a CD47 protein, wherein the second binding domain comprises a mutant of a human SIRP? variant 1. Also provided are an immunoconjugate, nucleic acid molecules, vectors, compositions, and cells related to the fusion protein and preparation methods therefor, and the uses thereof in the preparation of medicaments.

Abstract: The present invention relates to the technical field of oil and gas drilling, and discloses a biodiesel-based constant rheological property drilling fluid containing intelligent temperature responsive polymer, which contains two or more of the following components which are stored in admixture or separately: base oil biodiesel, aqueous phase, emulsifier, organic soil, constant rheological property flow pattern modifier, hydrolysis inhibitor, filtrate reducer and weighting material; the constant rheological property flow pattern modifier is an intelligent temperature responsive polymer, and the polymer contains structural units provided by bis-hydroxyethyl bis-hydroxypropyl stearyl ammonium chloride, ethylene bis-stearamide and dimerized fatty acid.

Abstract: Disclosed are a coating liquid of a lithium ion battery separator, a lithium ion battery separator, and a lithium ion battery. The raw materials of the coating liquid include a nanowire, ceramic powder, an adhesive, and a solvent; the nanowire is at least one of nano cellulose, carbon nanotube, silver nanowire, boron carbide nanowire, copper hydroxide nanowire, aramid nano fiber, silicon monoxide nanowire, and hydroxyapatite nanowire; the diameter of the nanowire is 1-100 nm, and the length is 0.1-100 ?m. The lithium ion battery separator consisting of a separator body and a coating layer loaded on the separator body is obtained by applying the coating liquid that is obtained by mixing the nanowire, the ceramic powder, the adhesive and the like onto the surface of the separator body, and performing curing; the lithium ion battery has good thermal stability and puncture resistance, etc.

Abstract: An apparatus in the field of optics technology, can include a reflector, a reflector substrate, and an extinction component. The reflector can be mounted on the reflector substrate. The extinction component can be arranged on a front surface of the reflector substrate. The reflector can be configured to reflect incident light signals. The extinction component can be configured to reduce the scattered light produced by the incident light signal on the reflector substrate. An optical scanning device (for example, lidar) having such features may greatly reduce the scattered light inside the lidar, reduce the detection blind area caused by the stray light, and greatly improve the receiving and detecting capabilities of the lidar.

Abstract: Provided is an antibody or an antigen-binding fragment thereof, having one or more properties selected from the group consisting of: 1) being capable of binding to an AXL protein by a KD value of 1×10?8M or lower; 2) being capable of specifically recognizing an AXL protein expressed on a cell surface; and 3) being capable of mediating internalization after binding to the AXL protein expressed on the cell surface. The antibody may further used for constructing an immunoconjugate. The antibody and the immunoconjugate may inhibit the proliferation of tumor cells.

Abstract: Provided by the present invention are a fusion protein binding to a CD47 protein and an application thereof, wherein the fusion protein is capable of binding to a CD47 protein by using a KD value of 1×10?8M or lower. The fusion protein may specifically block the interaction between a CD47 protein and SIRP? without causing a blood coagulation reaction, and may further inhibit the growth and/or proliferation of tumors or tumor cells.

Abstract: A gel polymer coating separator with a multi-core-single-shell structure and a preparation method thereof for making lithium-ion batteries.

Abstract: Provided by the invention is an antibody or an antigen-binding fragment thereof, which binds to a CD38 protein at a KD value below 1×10-9M. The antibody or an antigen-binding fragment thereof has strong specific recognition and binding capabilities for CD38 protein, and may kill CD38+ cells by means of antibody-dependent cell-mediated cytotoxicity (ADCC), complement-dependent cytotoxicity (CDC) and/or apoptosis. Further provided by the present invention is an application of the antibody or antigen-binding fragment thereof in preventing and treating tumors.

Abstract: Disclosed are a battery, and a battery diaphragm and a manufacturing method therefor, which belong to the field of batteries. The battery diaphragm has a composite structure constituted by a first member and a second member. The diaphragm includes: the first element is manufactured from a modification material provided to improve the thermal stability of the diaphragm, the first element being a stack of nanowires distributed in layers; and the second element is manufactured from a base material provided to serve as the body of the diaphragm, the first element being loaded on the second element and supported by the second element.