Abstract: A card connector includes an insulating housing, a plurality of conductive terminals and a retaining plate. The insulating housing has a base portion, an upper face, a lower face, a mating frame with a mating cavity which has a mating face parallel to the lower face. The conductive terminals have contacting portions extending into the mating cavity. The base portion has a retaining space recessed upwardly from the lower face and a platform located at the upper face of the base portion, and the retaining space upwardly runs through the platform. A stopping portion is formed between the retaining space and the mating frame. The retaining plate is retained in the retaining space and has a plurality of soldering legs extending downwardly out of the lower face and a latch portion extending upwardly and latching with the stopping portion.

Abstract: A card connector comprises an insulative housing, a plurality of contacts received in the insulative housing and a metallic cover covering the insulative housing. The contact includes a retaining portion, an extending portion horizontally and forwardly extending from the retaining portion, a connecting portion downwardly and forwardly aslant extending from the extending portion, a floating portion downwardly from the connecting portion and a contacting portion further downwardly extending from the floating portion. There are two bending points on linking portions of the connecting portion connecting with the floating portion and the extending portion, respectively. By such arrangement, when the electrical card is inserted, the contact can rotate about the two bending points in turn, that can improve an elasticity of the contact.

Abstract: An electrical connector, for receiving an electrical card, includes an insulative housing, a plurality of conductive contacts retained in the insulative housing and a metallic shell covering the insulative housing. The metallic cover and the insulative housing define a receiving cavity. The shell has a top plate, the top plate is formed with a plurality of openings, a plurality of resisting pieces bent downwardly from front edges of the openings, and a plurality of gaps defined between each two adjacent resisting pieces. Each contact has a conductive portion extending into the receiving cavity, and the conductive portions and the gaps of the top plate are alternatively disposed.

Abstract: An electronic device includes a housing and a display module received in the housing. The display module includes a display panel, a touch panel positioned on the display panel, a light guide plate positioned on the touch panel, a light source positioned at a side of the light guide plate, and a hardened layer positioned on the light guide plate. The light guide plate and the display panel are respectively positioned at opposite sides of the touch panel. The hardened layer covers a surface of the light guide plate away from the touch panel.

Abstract: An electrical connector comprises an insulative housing, a plurality of contacts retained in the insulative housing, an inner shell covering the insulative housing and an exterior shell stacked over the inner shell. The insulative housing has a base portion and a tongue portion extending forwardly. The tongue portion has a mating face with a plurality of receiving slots recessed therein. The contacts have a plurality of contact portions received in the receiving slots. The inner shell has a mating chamber surrounding the tongue portion and a top wall with a through hole; The exterior shell has a main plate overlapping on the top wall of the inner shell. The main plate has an opening extending through thereof and a beam connecting with at least one edge of the opening. The beam has a resilient portion protruding into the mating chamber through the through hole.

Abstract: An electrical connector 100 includes an insulative housing 1, a plurality of contacts 2 retained in the insulative housing 1 and a spacer 3 mounted in the insulative housing 1. The contacts 2 include a plurality of first contacts 210 each having a first extending portion 213 extending downwardly and a plurality of second contacts 220 each having a second extending portion 223 extending downwardly. The first extending portions 213 and the second extending portions 223 form two rows, respectively. The spacer 3 includes a base 31 and a lump 33 extending upwardly from the base 31. The lump 33 separates the first extending portions 213 from the second extending portions 223 along a front-to-rear direction to improve signal transmission quality of the electrical connector 100.

Abstract: An electrical connector comprises an insulative block, a plurality of contacts received in the insulative block. The contacts each include a retaining portion retaining in the insulative block, a contacting portion extending forwardly from the retaining portion and a soldering portion. The contacts include a plurality of differential signal contacts and a plurality of grounding contacts. The soldering portion of differential signal contacts arranged to a plurality of rows and the soldering portion of grounding contacts arranged to a plurality of another rows which parallel to the row of the differential contacts. The row of the differential contacts and the row of the grounding contacts are spaced from each other.

Abstract: A method for determining the presence of multiple nucleotide sequences of interest in multiple samples while preserving the identity of each sample, by contacting the samples with a plurality of probe sets. The probes are designed to indicate the presence of the sequences of interest and the identity of the sample containing the sequence of interest in complex mixtures. Applications of the method include genotyping, expression analysis, and identification of individual species in complex samples. Kits of probe sets for use in the methods are also provided.

Abstract: A method for detecting nucleic acids by (a) providing a sample having target nucleic acids, each nucleic acid having contiguous first, second, and third domains; (b) contacting the sample with probe sets to form hybridization complexes, wherein each probe set includes (i) a first probe having a sequence that is complementary to the first domain; and (ii) a second probe having a sequence substantially complementary to the third domain; (c) extending the first probes along the second domains of the complexes while the complexes are immobilized on a solid support; (d) ligating the extended first probes to the second probes to form templates; (e) amplifying the templates with primers that are complementary to the first and second priming sequences to produce amplicons; and (f) detecting the amplicons on the surface of a nucleic acid array.

Abstract: The present invention is directed to methods and compositions for the use of micro sphere arrays to detect and quantify a number of nucleic acid reactions. The invention finds use in genotyping, i.e. the determination of the sequence of nucleic acids, particularly alterations such as nucleotide substitutions (mismatches) and single nucleotide polymorphisms (SNPs). Similarly, the invention finds use in the detection and quantification of a nucleic acid target using a variety of amplification techniques, including both signal amplification and target amplification. The methods and compositions of the invention can be used in nucleic acid sequencing reactions as well. All applications can include the use of adapter sequences to allow for universal arrays.

Abstract: Presented herein are methods and compositions for determining haplotypes in a sample. The methods are useful for obtaining sequence information regarding, for example, HLA type and haplotype. Also presented herein are methods of determining haplotypes in a sample based on a plurality sequence reads.

Abstract: Embodiments of the present disclosure provide methods and systems for determining the haplotype of a biological sample. Particular embodiments provide methods for long range haplotyping of a genome.

Abstract: An electrical connector 100 includes an insulative housing 1, a plurality of contacts 2 retained in the insulative housing 1 and a spacer 3 mounted in the insulative housing 1. The contacts 2 include a plurality of first contacts 210 each having a first extending portion 213 extending downwardly and a plurality of second contacts 220 each having a second extending portion 223 extending downwardly. The first extending portions 213 and the second extending portions 223 form two rows, respectively. The spacer 3 includes a base 31 and a lump 33 extending upwardly from the base 31. The lump 33 separates the first extending portions 213 from the second extending portions 223 along a front-to-rear direction to improve signal transmission quality of the electrical connector 100.

Abstract: A method for detecting nucleic acids by (a) providing a sample having target nucleic acids, each nucleic acid having contiguous first, second, and third domains; (b) contacting the sample with probe sets to form hybridization complexes, wherein each probe set includes (i) a first probe having a sequence that is complementary to the first domain; and (ii) a second probe having a sequence substantially complementary to the third domain; (c) extending the first probes along the second domains of the complexes while the complexes are immobilized on a solid support; (d) ligating the extended first probes to the second probes to form templates; (e) amplifying the templates with primers that are complementary to the first and second priming sequences to produce amplicons; and (f) detecting the amplicons on the surface of a nucleic acid array.

Abstract: The present disclosure provides a method for cancer relapse prediction that provides higher resolution grading than Gleason score alone. In particular, the method provides for prediction of prostate cancer relapse that correlates gene expression of each individual signature gene and deriving a prostate cancer gene expression (GEX) score in the plurality of prostate cancer tissue samples; and correlating said GEX score with the clinical outcome for each prostate carcinoma tissue sample. A set of signature genes is provided that encompasses all or a sub-combination of GI_2094528, KIP2, NRG1, NBL1, Prostein, CCNE2, CDC6, FBP1, HOXC6, MKI67, MYBL2, PTTG1, RAMP, UBE2C, Wnt5A, MEMD, AZGP1, CCK, MLCK, PPAP2B, and PROK1.

Abstract: The invention is directed to a variety of multiplexing methods used to amplify and/or genotype a variety of samples simultaneously.

Abstract: A method for determining the presence of multiple nucleotide sequences of interest in multiple samples while preserving the identity of each sample, by contacting the samples with a plurality of probe sets. The probes are designed to indicate the presence of the sequences of interest and the identity of the sample containing the sequence of interest in complex mixtures. Applications of the method include genotyping, expression analysis, and identification of individual species in complex samples. Kits of probe sets for use in the methods are also provided.

Abstract: The present disclosure provides a method for cancer relapse prediction that provides higher resolution grading than Gleason score alone. In particular, the method provides for prediction of prostate cancer relapse that correlates gene expression of each individual signature gene and deriving a prostate cancer gene expression (GEX) score in the plurality of prostate cancer tissue samples; and correlating said GEX score with the clinical outcome for each prostate carcinoma tissue sample. A set of signature genes is provided that encompasses all or a sub-combination of GI_2094528, KIP2, NRG1, NBL1, Prostein, CCNE2, CDC6, FBP1, HOXC6, MKI67, MYBL2, PTTG1, RAMP, UBE2C, Wnt5A, MEMD, AZGP1, CCK, MLCK, PPAP2B, and PROK1.

Abstract: The present invention provides a method for identification of differentially methylated genomic CpG dinucleotide sequences within genomic target sequences that are associated with cancer in an individual by obtaining a biological sample comprising genomic DNA from the individual measuring the level or pattern of methylated genomic CpG dinucleotide sequences for two or more of the genomic targets in the sample, and comparing the level of methylated genomic CpG dinucleotide sequences in the sample to a reference level of methylated genomic CpG dinucleotide sequences, wherein a difference in the level or pattern of methylation of the genomic CpG dinucleotide sequences in the sample compared to the reference level identifies differentially methylated genomic CpG dinucleotide sequences associated with cancer. As disclosed herein, the methods of the invention have numerous diagnostic and prognostic applications.

Abstract: The present invention provides a method for identification of differentially methylated genomic CpG dinucleotide sequences within genomic target sequences that are associated with cancer in an individual by comparing the level of methylated genomic CpG dinucleotide sequences in the sample to a reference level of methylated genomic CpG dinucleotide sequences.