Abstract: Compounds that inhibit Protein Arginine N-Methyl Transferase 5 (PRMT5) activity, as well as method for their preparation and use are provided. Specifically, a compound of Formula (I), a pharmaceutically acceptable salt thereof, an ester thereof, a prodrug thereof, a stereoisomer thereof or isotopic derivative thereof, as well as method for their preparation and use are provided.

Abstract: This application provide a data processing method performed by a computer device. The method includes: receiving a request for a cross-regional resource transfer service submitted by a first user at a first terminal to a second user at a second terminal; setting a state machine of the cross-regional resource transfer service to a first state according to a state identifier in the request; executing a first service logic corresponding to the first state; adjusting the state machine to a second state according to an execution result of the first service logic; executing a second service logic corresponding to the second state; and returning a service execution result of the cross-regional resource transfer service to the first user at the first terminal and the second user at the second terminal according to an execution result of the second service logic when the second state is a termination state.

Abstract: Compounds that inhibit Protein Arginine N-Methyl Transferase 5(PRMT5) activity, as well as method for their preparation and use are provided. Specifically, compounds of Formula (I) and pharmaceutically acceptable salts, hydrates and solvates, as well as method for their preparation and use are provided.

Abstract: The present application relates to an anti-Nectin-4 antibody, a drug conjugate and a preparation method and use thereof, which can be effectively used for the treatment and/or prevention of Nectin-4 positive tumors, including cancers, such as breast cancer and bladder cancer.

Abstract: Embodiments of this application provide a data processing method and apparatus, a computer device, and a readable storage medium.

Abstract: Compounds that inhibit Protein Arginine N-Methyl Transferase 5(PRMT5) activity, as well as method for their preparation and use are provided. Specifically, compounds of Formula (I) and pharmaceutically acceptable salts, hydrates and solvates, as well as method for their prepation and use are provided.

Abstract: The present disclosure relates to an electronic device and its execution method and a computer-readable medium. An electronic device includes: a memory, in which instructions are stored; and a processor, configured to execute the instructions stored in the memory to cause the electronic device to execute the following operations: determining a plurality of different time periods; collecting information about the viewing habits for the plurality of different time periods; and generating a recommended list in real time for each of the plurality of different time periods based on the collected information; wherein the recommended list for each time period is based on the collected information about the viewing habits for that time period of that day.

Abstract: The present application provides an anti-CLDN18.2 antibody and an antibody-drug conjugate prepared from the antibody. The antibody or the antibody-drug conjugate can effectively treat CLDN18.2 positive tumors, comprising but not limited to cancers represented by gastric cancer and pancreatic cancer.

Abstract: Described herein are crystalline forms of 1-(4-(benzylamino)-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidin-2-yl)-2-methyl-1H-indole-4-carboxamide, and pharmaceutically acceptable salts and solvates thereof. Also described herein are pharmaceutical formulations of 1-(4-(benzylamino)-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidin-2-yl)-2-methyl-1H-indole-4-carboxamide, and pharmaceutically acceptable salts and solvates thereof.

Abstract: A network device receives, from multiple smart cameras located at different road segments of multiple real-world road segments, first data describing a location and configuration of each of the multiple real-world road segments, and second data describing movement of one or more objects at each of the multiple real-world road segments. The network device generates multiple virtual road segments based on the first data, wherein each of the multiple virtual road segments describes one of the multiple real-world road segments; and uses a physics engine to simulate, based on the generated multiple virtual road segments and the second data, movement of vehicles or pedestrians through the multiple real-world road segments to analyze traffic characteristics, trends or events. The network device generates road segment alterations for reconfiguring one or more of the multiple real-world road segments based on the analysis of the traffic characteristics, trends, or events.

Abstract: Embodiments of this application provide a data processing method and apparatus, a computer device, and a readable storage medium.

Abstract: The present disclosure relates to an electronic device and its execution method and a computer-readable medium. An electronic device, comprising: a memory, in which instructions are stored; and a processor, configured to execute the instructions stored in the memory to cause the electronic device to execute the following operations: receiving a request for entering a sleep mode; obtaining expected time to fall asleep; obtaining current volume value and/or current brightness value of a playback device; selecting a decay type; and determining a required amount of change per unit time of the brightness value and/or volume value of the playback device according to the decay type, expected time to fall asleep, and the current volume value and/or current brightness value.

Abstract: A construction method for a shallow-buried multi-arch tunnel under water-rich geological conditions includes the following steps: cleaning a grouting ground surface; marking a grouting reinforcement scope; performing survey setting-out; drawing a cross-section diagram to scale; calculating out coordinates and angles of anchor points that need to be set; marking drilling positions; nailing small wooden piles at the drilling positions for identifying; determining a setting depth of the anchor rods according to ground elevation; drilling holes, cleaning bottom of hole, grouting, performing construction preparation, performing long pipe shed construction at the entrance after an earth-rock of a tunnel entrance and an open cut tunnel is excavated to flush with a springing line of the tunnel. A down-the-hole drill is used for drilling in construction. Long pipe shed grouting is designed based on solidifying a soil mass in limited scope around a consolidation pipe shed.

Abstract: The present invention relates to a novel molecule with protein tyrosine kinase inhibitory activity, and the synthesis and usage thereof. Specifically, the present invention relates to compound by formula A, pharmaceutically acceptable salts, hydrates or solvates thereof, and the synthesis and usage thereof.

Abstract: With the conventional optical deflection elements using polarization gratings (PGs), it has been difficult to independently switch multiple optical beams at one time in a variety of angular ranges and angular steps at high speed on the ?-second time scale, and it has been impossible to achieve a highly reliable optical deflection element module capable of operating at different ambient temperatures. Provided is an optical deflection element including: a polarization grating plate having a rectangular or circular segment structure, in which the cycles ? of PGs are not uniform within the plate plane and the cycle and/or the rotational direction of a birefringence axis varies; and a phase panel having a segment structure that is accordingly segmented within the same plane are bonded together, wherein their corresponding segments overlap with each other, and optical switches of the polarization gratings are controlled by a voltage change in the phase panel.

Abstract: A method and an apparatus are for monitoring the state of a device in process industries and a medium. The method includes: collecting and saving data of the multi-dimensional state of a device in the process industry; performing correlation analysis on the collected historical data of the multi-dimensional state of the device to obtain state dimensions having correlation; acquiring, according to the obtained state dimensions having correlation, historical data of the dimensional states having correlation, and modeling the acquired historical data of the dimensional states to obtain a device state reference model; acquiring real-time data of the dimensional states having correlation corresponding to the device state reference model in real time, and determining whether the current state of the device is normal according to a preset device state determination condition and the acquired real-time data of the dimensional states having correlation, and in combination with the device state reference model.

Abstract: With the conventional optical deflection elements using polarization gratings (PGs), it has been difficult to independently switch multiple optical beams at one time in a variety of angular ranges and angular steps at high speed on the ?-second time scale, and it has been impossible to achieve a highly reliable optical deflection element module capable of operating at different ambient temperatures. Provided is an optical deflection element including: a polarization grating plate having a rectangular or circular segment structure, in which the cycles A of PGs are not uniform within the plate plane and the cycle and/or the rotational direction of a birefringence axis varies; and a phase panel having a segment structure that is accordingly segmented within the same plane are bonded together, wherein their corresponding segments overlap with each other, and optical switches of the polarization gratings are controlled by a voltage change in the phase panel.

Abstract: A device can receive data related to a roadway. The data can include video data of the roadway. The device can determine a pixel area of objects shown in the video data. The device can determine that a vehicle and an individual are associated with the roadway at a same time. The device can determine a protective zone around the individual based on a first pixel area of the individual. The protective zone can be associated with detecting a potential collision between the vehicle and the individual. The device can determine a first location and movement of the vehicle relative to a second location and movement of the individual. The device can predict that a second pixel area of the vehicle is to intersect the protective zone of the individual. The device can detect the potential collision. The device can perform one or more actions.

Abstract: A network device receives, from multiple smart cameras located at different road segments of multiple real-world road segments, first data describing a location and configuration of each of the multiple real-world road segments, and second data describing movement of one or more objects at each of the multiple real-world road segments. The network device generates multiple virtual road segments based on the first data, wherein each of the multiple virtual road segments describes one of the multiple real-world road segments; and uses a physics engine to simulate, based on the generated multiple virtual road segments and the second data, movement of vehicles or pedestrians through the multiple real-world road segments to analyze traffic characteristics, trends or events. The network device generates road segment alterations for reconfiguring one or more of the multiple real-world road segments based on the analysis of the traffic characteristics, trends, or events.

Abstract: Provided is a method of detecting a chromosome abnormality in an embryo by using blastocyst culture. The method comprises: detecting embryonic circulating cell-free DNA in early embryonic in-vitro culture, i.e., blastocyst culture, performing uniform whole genome amplification on trace DNA, and then using a method, such as next generation sequencing, to perform analysis on the amplified DNA product, so as to determine a chromosome condition of an embryo, namely, whether aneuploidy or partial aneuploidy of chormosomes occurs.