Abstract: A lateral diffused metal-oxide-semiconductor field-effect transistor structure including a P substrate, an N+ buried layer, an N epitaxial layer, a P well, an N well, a drain region, a source region, and a body region is disclosed. The N+ buried layer is located between the P substrate and the N epitaxial layer, the P well contacts the N+ buried layer, the source region and the body region are located in the P well, the N well is located in the N epitaxial layer, and the drain region is located in the N well. When a high voltage is applied to the drain and the P substrate is grounded, a breakdown voltage with the P substrate is raised because of the N+ buried layer isolating the P substrate from the N epitaxial layer, so as to be able to avoid PN junction breakdown.

Abstract: A cladding is provided at an outer periphery of a solid-core doped with rare earth ions, and a metal layer is formed to be adjacent to the cladding to provide an optical fiber for a fiber laser device. The metal layer having an inner metal layer and an outer metal layer is disposed along an entire length of the optical fiber for a fiber laser device. An exciting light is incident to the optical fiber for a fiber laser device, and the exciting light is reflection-excited to emit a high power laser oscillation light. A monitoring current is constantly flown into the metal layer. When the disconnection of the optical fiber for a fiber laser device is detected based on the monitoring current, the energization of the optical fiber for a fiber laser device is stopped.

Abstract: Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of one or more mitotic kinesins are disclosed.

Abstract: An optical fiber which, at an optical fiber connecting end having a plurality of voids around the periphery of a core, has a light-permeable substance, such as a resin or glass whose refractive index is lower than that of quartz type substances, filled in the voids adjacent to the connecting end. An optical fiber connecting section where an optical fiber having a plurality of voids in a clad around the periphery of a core is connected to another optical fiber, wherein the optical fiber is connected end-to-end to aforesaid another optical fiber through a refractive index matching agent whose refractive index at the minimum temperature in actual use is lower than that of the core.

Abstract: The present invention provides an optical fiber, for use in a fiber laser, from which a high-quality single-mode laser beam with high optical power is obtained and also provides a fiber laser that uses the optical fiber. The novel optical fiber, which includes a core to which a rare earth element is doped and a cladding formed around the core, amplifies excitation light to oscillate a laser beam. A mode filter is formed at a predetermined position in the longitudinal direction of the optical fiber.

Abstract: Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of one or more mitotic kinesins are disclosed.

Abstract: Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of one or more mitotic kinesins are disclosed.

Abstract: Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of one or more mitotic kinesins are disclosed.

Abstract: Provided are compounds of Formula V and pharmaceutically acceptable salts thereof which may be useful for the treatment of cancer or other proliferative disorders.

Abstract: Chemical entities that modulate smooth muscle myosin and/or non-muscle myosin, pharmaceutical compositions and methods of treatment of diseases and conditions associated with smooth muscle myosin and/or non-muscle myosin are described.

Abstract: Provided are compounds of Formula I and pharmaceutically acceptable salts thereof which may be useful for the treatment of cancer or other proliferative disorders.

Abstract: An optical fiber includes a core, a clad having a plurality of air holes at a periphery of the core, and a hardening resin filled in a sealed portion at an end of the plurality of air holes. The hardening resin after hardening has a fill length of 7 mm to 8 mm. An optical fiber connection structure includes the optical fiber with an end face butt-connected to another optical fiber. An optical connector includes the optical fiber, and a ferrule to which the optical fiber is attached.

Abstract: An optical fiber laser, according to the present invention, has an optical fiber including a core to which a rare earth element is added and a clad disposed around the core, and also has an excitation light source for emitting excitation light incident on a side of the optical fiber. The optical fiber has a corrugated shape on the outer circumference of the clad along the longitudinal direction thereof; and the optical fiber is wound in a spiral form and is bundled in such a way that adjacent sides of the clad are brought into contact with one another.

Abstract: The optical fiber 1 for an optical fiber laser is provided with a rare earth element doped core 2 doped with a rare earth element, and a cladding 3 formed at an outer periphery of the rare earth element doped core 2. In the optical fiber 1 for an optical fiber laser, the rare earth element doped core 2 is divided into a plurality of core regions 2a, 2b, . . . , 2n?1, 2n along a longitudinal direction of the optical fiber 1 and dopant concentrations of the rare earth element in respective core regions 2a, 2b, . . . , 2n?1, 2n are different from each other, in order to flatten a temperature distribution of the optical fiber 1 along the longitudinal direction.

Abstract: A plurality of light emitting elements 11 are arranged in parallel with a constant pitch to provide a semiconductor laser bar 10. An optical waveguide 20 has a core part 21 for guiding a light emitted from each of the light emitting elements 11 and a cladding part 22 formed around the core part 21. An optical fiber 30 has a core 31 and a cladding 32 formed around the core 31 for confining the light to the core 31. The optical waveguide is bonded to a side surface of the optical fiber 30, and the light emitted from the semiconductor laser bar 10 is inputted to a side surface of the core 31 of the optical fiber 30 via the core part 21 of the optical waveguide 20.

Abstract: The optical fiber 1 for an optical fiber laser is provided with a rare earth element doped core 2 doped with a rare earth element, a cladding 3 formed at an outer periphery of the rare earth element doped core 2, a core vicinity part 3? of the cladding 3 provided in vicinity of the rare earth element doped core 2 being doped with a refractive index increasing agent which reduces a relative refractive index difference between the core vicinity part 3? and the rare earth element doped core 2 to be 0.1% or less.

Abstract: An optical fiber includes a core, a clad having a plurality of air holes at a periphery of the core, and a hardening resin filled in a sealed portion at an end of the plurality of air holes. The hardening resin after hardening has a fill length of 7 mm to 8 mm. An optical fiber connection structure includes the optical fiber with an end face butt-connected to another optical fiber. An optical connector includes the optical fiber, and a ferrule to which the optical fiber is attached.

Abstract: An optical fiber includes a rare-earth element-added core for serving as a gain medium, and a cladding formed on a periphery of the core. Pump light propagated through the cladding is coupled into the core. The cladding is in an undulation shape in the longitudinal direction of the cladding. The undulation shape of the cladding is formed according to a grating period at which the pump light is totally reflected and propagated in the cladding. The core includes an undulation shape in a longitudinal direction of the core. The cladding includes an undulating inner cladding, and an outer cladding provided on a periphery of the inner cladding. The core and/or the cladding is circular or abnormally circular in its transverse cross section.

Abstract: Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of one or more mitotic kinesins are disclosed.

Abstract: An optical fiber which, at an optical fiber connecting end having a plurality of voids around the periphery of a core, has a light-permeable substance, such as a resin or glass whose refractive index is lower than that of quartz type substances, filled in the voids adjacent to the connecting end. An optical fiber connecting section where an optical fiber having a plurality of voids in a clad around the periphery of a core is connected to another optical fiber, wherein the optical fiber is connected end-to-end to aforesaid another optical fiber through a refractive index matching agent whose refractive index at the minimum temperature in actual use is lower than that of the core.