Abstract: Disclosed herein are ACE2 fusion proteins that can be used to block infection of cells by SARS-CoV-2. The fusion proteins may have additional functionality such as inhibition of complement. The fusion protein may also include a polypeptide or a moiety that increases serum or blood half-life of the ACE2 fusion protein.

Abstract: Methods and apparatus are provided for controlling a vehicle. In one embodiment, a method includes: receiving, by a processor, vehicle position data from the vehicle; processing, by the processor, vehicle position data with vehicle position data from other vehicles to determine a lane topology; processing, by the processor, the vehicle position data to determine traffic conditions within a lane of the lane topology; generating, by the processor, a map for controlling the vehicle based on the lane topology and the traffic conditions.

Abstract: According to various embodiments, an integrated circuit may include an upper inter-level dielectric (ILD) layer, a lower ILD layer, and an interlayer arranged between the upper ILD layer and the lower ILD layer. The integrated circuit may further include a capacitor device and a resistor device. The capacitor device may include a top plate disposed in a first region of the interlayer and a bottom plate disposed in the lower ILD layer. The resistor device may include a resistive element and a plurality of vias disposed in a second region of the interlayer. The plurality of vias may extend from the resistive element to the lower ILD layer. A distance between the top plate and the lower ILD layer may be at least substantially equal to a height of each via of the plurality of vias.

Abstract: A highly integrated, fully automatic chemiluminescence detection equipment and its operation method are disclosed. The chemiluminescence detection equipment comprises a control module, a first electrical machine, a reagent wheel disc tank, a sampling module, a washing module, a second electrical machine and a detection module. Compared with the traditional large-scale chemiluminescence detection equipment, the chemiluminescence detection equipment of the present invention has the advantage of high integration, and greatly reduces the overall volume and weight of the chemiluminescence detection equipment.

Abstract: A semiconductor device includes a semiconductor substrate, a gate structure, and source/drain regions. The gate structure comprises an yttrium oxide layer over the semiconductor substrate, an aluminum oxide layer over the yttrium oxide layer, and a gate electrode on the aluminum oxide layer. The source/drain regions are on the semiconductor substrate and on opposite sides of the gate structure.

Abstract: A computer-implemented method, a computer program product, and a computer system for creating malware domain sinkholes by domain clustering. The computer system clusters malware domains into domain clusters. The computer system collects domain metrics in the domain clusters. The computer system sorts clustered malware domains in the respective ones of the domain clusters, based on the domain metrics. The computer system selects, from the clustered malware domains in the respective ones of the domain clusters, a predetermined number of top domains as candidates of respective domain sinkholes, wherein the respective domain sinkholes are created for the respective ones of the domain clusters.

Abstract: A vehicle crowd sensing system and method of selective sensing for the vehicle crowd sensing system. The method, in one implementation, involves receiving a plurality of detection reports from a first set of vehicles, each detection report including an event, a position qualifier of the event, and a severity qualifier of the event; developing an inherent error model for the event that includes a compilation of the position qualifiers of the event and the severity qualifiers of the event; and determining a resampling instruction for the event. The resampling instruction is based on an action model and the action model is at least partly a factor of the inherent error model.

Abstract: A system and method for passively and actively monitoring and determining the location of at least one mechanical anomaly for a power steering system of a vehicle is disclosed. The system includes one or more processors and a memory coupled to the processors. The memory stores a baseline waveform and data comprising program code that, when executed by the one or more processors, causes the system to receive at least one excitation signal and at least one response signal. The power steering system creates the response signal in response to receiving the excitation signal. In response to receiving the excitation signal and the response signal, the system is caused to estimate the frequency response between the excitation signal and the response signal based on a fast Fourier transform (FFT) algorithm. The frequency response is represented by an estimated waveform.

Abstract: The present disclosure provides humanized and affinity matured antibodies (mAbs) and fragments thereof that specifically bind to CD79 with high affinity. The anti-CD79 mAbs and fragments thereof can be used to treat antibody-associated conditions, including autoimmune diseases, allergies, transplant rejection, or immune-mediated rejection of a therapeutics optionally in combination with an additional therapeutic agent. Furthermore, the anti-CD79 mAbs and fragments thereof can be used for diagnostic purposes, including to detect CD79 cells in biological samples and to diagnose B-cell associated disorders.

Abstract: A dimming module having: a calculating circuit, configured to receive a preset current duty cycle reference signal, a preset current magnitude reference signal and a feedback voltage of an associated light-emitting device string, and to provide a current duty cycle reference signal and a current magnitude reference signal; and a current regulating circuit, configured to receive the feedback voltage of the associated light-emitting device string, the current duty cycle reference signal and the current magnitude reference signal, and to control a duty cycle and a magnitude of the current flowing through the associated light-emitting device string; wherein the current magnitude reference signal provided to the light-emitting device string with the minimum feedback voltage is lower than the preset current magnitude reference signal, while the current magnitude reference signal provided to each other light-emitting device string is higher than the preset current magnitude reference signal.

Abstract: The present invention provides a method and compositions utilizing the CRISPR system to disrupt a target gene in eukaryotic cells to produce double allele knock outs. The method finds use in producing afucosylated antibodies with enhanced ADCC activity.

Abstract: A short to ground protecting circuit for an LED driver for providing a power supply voltage for N LED strings. The LED driver has an output terminal for providing a power supply voltage for the N LED strings and N feedback terminals having N detecting voltages respectively. For each i from 1 to N, the ith LED string is coupled between the output terminal and the ith feedback terminal, and the ith feedback terminal is configured to have the ith detecting voltage. The short to ground protecting circuit receives a short threshold voltage and N open fault signals, and generates N short indicating signals. And on the premise of the ith open fault signal is valid, and if the ith detecting voltage is less than the short threshold voltage for a preset time period, the ith short indicating signal is valid.

Abstract: The medical image recognition method includes the following steps: transmitting an accession number to a recognition module through a prediction unit; receiving an accession number and a human body image by a recognition model, and importing the human body image into a set of neural network models respectively; wherein each of the neural network models outputs at least one recognition result; the recognition module returns the recognition results to the prediction unit, and then the recognition results are stored in database.

Abstract: Embodiments of the present disclosure provide a method and apparatus for outputting a structured query sentence. The method may include: acquiring a to-be-converted natural language sentence; inputting the to-be-converted natural language sentence into a pre-trained sequence to sequence model to obtain an action sequence corresponding to the to-be-converted natural language sentence; generating a directed acyclic graph according to the action sequence; and outputting a structured query sentence corresponding to the generated directed acyclic graph according to a preset corresponding relationship between a directed acyclic graph and a structured query sentence.

Abstract: In one example aspect, a method for integrated circuit (IC) fabrication comprises providing a device structure including a substrate, a source/drain (S/D) feature on the substrate, a gate stack on the substrate, a contact hole over the S/D feature; and a dummy feature over the S/D feature and between the gate stack and the contact hole. The method further comprises forming in the contact hole a contact plug that is electrically coupled to the S/D feature, and, after forming the contact plug, selectively removing the dummy feature to form an air gap that extends higher than a top surface of the gate stack. The method further comprises forming over the contact plug a seal layer that covers the air gap.

Abstract: A short to ground protecting circuit for an LED driver for providing a power supply voltage for N LED strings. The LED driver has an output terminal for providing a power supply voltage for the N LED strings and N feedback terminals having N detecting voltages respectively. For each i from 1 to N, the ith LED string is coupled between the output terminal and the ith feedback terminal, and the ith feedback terminal is configured to have the ith detecting voltage. The short to ground protecting circuit receives a short threshold voltage and N open fault signals, and generates N short indicating signals. And on the premise of the ith open fault signal is valid, and if the ith detecting voltage is less than the short threshold voltage for a preset time period, the ith short indicating signal is valid.

Abstract: A boost power conversion circuit includes an inductor, a first switch module, a second switch module, a first unilateral conduction component, a second unilateral conduction component, a flying capacitor, an upper bus capacitor, a lower bus capacitor, and a third unilateral conduction component. The power supply, the inductor, the first switch module, and the second switch module are connected in series to form a loop. The first unilateral conduction component, the second unilateral conduction component, the upper bus capacitor and the lower bus capacitor are connected in series. The flying capacitor is electrically connected between a reverse cut-off end of the first unilateral conduction component and a forward conduction end of the second unilateral conduction component. The third unilateral conduction component is configured to clamp a voltage stress of the second switch module to a lower-bus voltage.

Abstract: A system and method for locating a traffic light at a host vehicle. A probe vehicle obtains image data on an intersection that includes the traffic light when the probe vehicle is at the intersection and identifies the traffic light in the intersection from the data. A remote processor creates an observed node in a digital map corresponding to the traffic light and updates a mapped position of a mapped node within the digital map based on an observed position of the observed node. The host vehicle uses the mapped node of the digital map to locate the traffic light when the host vehicle is at the intersection.

Abstract: A dimming module having: a calculating circuit, configured to receive a preset current duty cycle reference signal, a preset current magnitude reference signal and a feedback voltage of an associated light-emitting device string, and to provide a current duty cycle reference signal and a current magnitude reference signal; and a current regulating circuit, configured to receive the feedback voltage of the associated light-emitting device string, the current duty cycle reference signal and the current magnitude reference signal, and to control a duty cycle and a magnitude of the current flowing through the associated light-emitting device string; wherein the current magnitude reference signal provided to the light-emitting device string with the minimum feedback voltage is lower than the preset current magnitude reference signal, while the current magnitude reference signal provided to each other light-emitting device string is higher than the preset current magnitude reference signal.

Abstract: A power source supply system for a magnetic resonance imaging (MRI) apparatus that has multiple loads operating in a magnetic field environment, has an AC/DC conversion circuit that converts a supplied AC current to a first DC current having a predetermined first voltage, a branching element that supplies the first DC current in separate paths respectively to the multiple loads, a switching power source, disposed in each of the loads that converts the first DC current to a second DC current having a second voltage capable of being supplied to the load, with a switching frequency of the switching power source being set such that a positive integer frequency multiple thereof is offset from the Larmor frequency of the MRI apparatus.