Patents by Inventor Braydon Charles Guild

Braydon Charles Guild has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Lipid Nanoparticle Compositions and Methods for mRNA Delivery
    Publication number: 20250108126
    Abstract: Disclosed herein are compositions and methods for modulating the production of a protein in a target cell. The compositions and methods disclosed herein are capable of amcliorating diseases associated with protein or enzyme deficiencies.
    Type: Application
    Filed: August 15, 2024
    Publication date: April 3, 2025
    Applicant: Translate Bio, Inc.
    Inventors: Frank DeRosa, Braydon Charles Guild, Michael Heartlein
  • IONIZABLE CATIONIC LIPIDS
    Publication number: 20240425442
    Abstract: Disclosed herein are novel compounds, pharmaceutical compositions comprising such compounds and related methods of their use. The compounds described herein are useful, e.g., as liposomal delivery vehicles to facilitate the delivery of encapsulated polynucleotides to target cells and subsequent transfection of said target cells, and in certain embodiments are characterized as having one or more properties that afford such compounds advantages relative to other similarly classified lipids.
    Type: Application
    Filed: April 25, 2024
    Publication date: December 26, 2024
    Inventors: Frank DeRosa, Braydon Charles Guild, Michael Heartlein
  • Lyophilized Pharmaceutical Compositions Comprising a Lipid Nanoparticle
    Publication number: 20240408020
    Abstract: Disclosed herein are novel compounds, pharmaceutical compositions comprising such compounds and related methods of their use. The compounds described herein are useful, e.g., as liposomal delivery vehicles to facilitate the delivery of encapsulated polynucleotides to target cells and subsequent transfection of said target cells, and in certain embodiments are characterized as having one or more properties that afford such compounds advantages relative to other similarly classified lipids.
    Type: Application
    Filed: August 27, 2024
    Publication date: December 12, 2024
    Applicant: Translate Bio, Inc.
    Inventors: Braydon Charles Guild, Michael Heartlein, Frank DeRosa, Jerry Chi Zhang
  • IONIZABLE CATIONIC LIPIDS
    Publication number: 20240383841
    Abstract: Disclosed herein are novel compounds, pharmaceutical compositions comprising such compounds and related methods of their use. The compounds described herein are useful, e.g., as liposomal delivery vehicles to facilitate the delivery of encapsulated polynucleotides to target cells and subsequent transfection of said target cells, and in certain embodiments are characterized as having one or more properties that afford such compounds advantages relative to other similarly classified lipids.
    Type: Application
    Filed: August 7, 2024
    Publication date: November 21, 2024
    Inventors: Frank DeRosa, Braydon Charles Guild, Michael Heartlein
  • Lipid nanoparticle compositions and methods for mRNA delivery
    Patent number: 12121592
    Abstract: Disclosed herein are compositions and methods for modulating the production of a protein in a target cell. The compositions and methods disclosed herein are capable of ameliorating diseases associated with protein or enzyme deficiencies.
    Type: Grant
    Filed: June 3, 2022
    Date of Patent: October 22, 2024
    Assignee: Translate Bio, Inc.
    Inventors: Frank DeRosa, Braydon Charles Guild, Michael Heartlein
  • Liver Specific Delivery of Messenger RNA
    Publication number: 20240342307
    Abstract: Disclosed herein are compositions and methods of modulating the expression of gene or the production of a protein by transfecting target cells with nucleic acids. The compositions disclosed herein demonstrate a high transfection efficacy and are capable of ameliorating diseases associated with protein or enzyme deficiencies.
    Type: Application
    Filed: February 2, 2024
    Publication date: October 17, 2024
    Applicant: Translate Bio, Inc.
    Inventors: Braydon Charles Guild, Frank DeRosa, Michael Heartlein
  • Cleavable lipids
    Patent number: 12102720
    Abstract: Disclosed herein are novel compounds, pharmaceutical compositions comprising such compounds and related methods of their use. The compounds described herein are useful, e.g., as liposomal delivery vehicles to facilitate the delivery of encapsulated polynucleotides to target cells and subsequent transfection of said target cells, and in certain embodiments are characterized as having one or more properties that afford such compounds advantages relative to other similarly classified lipids.
    Type: Grant
    Filed: December 20, 2021
    Date of Patent: October 1, 2024
    Assignee: Translate Bio, Inc.
    Inventors: Braydon Charles Guild, Michael Heartlein, Frank DeRosa, Jerry Chi Zhang
  • Ionizable cationic lipids
    Patent number: 11999675
    Abstract: Disclosed herein are novel compounds, pharmaceutical compositions comprising such compounds and related methods of their use. The compounds described herein are useful, e.g., as liposomal delivery vehicles to facilitate the delivery of encapsulated polynucleotides to target cells and subsequent transfection of said target cells, and in certain embodiments are characterized as having one or more properties that afford such compounds advantages relative to other similarly classified lipids.
    Type: Grant
    Filed: August 3, 2020
    Date of Patent: June 4, 2024
    Assignee: TRANSLATE BIO, INC.
    Inventors: Frank DeRosa, Braydon Charles Guild, Michael Heartlein
  • LIVER SPECIFIC DELIVERY OF MESSENGER RNA
    Publication number: 20240123084
    Abstract: Disclosed herein are compositions and methods of modulating the expression of gene or the production of a protein by transfecting target cells with nucleic acids. The compositions disclosed herein demonstrate a high transfection efficacy and are capable of ameliorating diseases associated with protein or enzyme deficiencies.
    Type: Application
    Filed: June 13, 2023
    Publication date: April 18, 2024
    Inventors: Braydon Charles Guild, Frank DeRosa, Michael Heartlein
  • Lipid nanoparticle compositions and methods for MRNA delivery
    Patent number: 11951180
    Abstract: Disclosed herein are compositions and methods for modulating the production of a protein in a target cell. The compositions and methods disclosed herein are capable of ameliorating diseases associated with protein or enzyme deficiencies.
    Type: Grant
    Filed: April 3, 2023
    Date of Patent: April 9, 2024
    Assignee: Translate Bio, Inc.
    Inventors: Frank DeRosa, Braydon Charles Guild, Michael Heartlein
  • Lipid nanoparticle compositions and methods for mRNA delivery
    Patent number: 11951181
    Abstract: Disclosed herein are compositions and methods for modulating the production of a protein in a target cell. The compositions and methods disclosed herein are capable of ameliorating diseases associated with protein or enzyme deficiencies.
    Type: Grant
    Filed: April 3, 2023
    Date of Patent: April 9, 2024
    Assignee: Translate Bio, Inc.
    Inventors: Frank DeRosa, Braydon Charles Guild, Michael Heartlein
  • Lipid nanoparticle compositions and methods for MRNA delivery
    Patent number: 11951179
    Abstract: Disclosed herein are compositions and methods for modulating the production of a protein in a target cell. The compositions and methods disclosed herein are capable of ameliorating diseases associated with protein or enzyme deficiencies.
    Type: Grant
    Filed: April 3, 2023
    Date of Patent: April 9, 2024
    Assignee: Translate Bio, Inc.
    Inventors: Frank DeRosa, Braydon Charles Guild, Michael Heartlein
  • LIPID NANOPARTICLE COMPOSITIONS AND METHODS FOR MRNA DELIVERY
    Publication number: 20230330262
    Abstract: Disclosed herein are compositions and methods for modulating the production of a protein in a target cell. The compositions and methods disclosed herein are capable of ameliorating diseases associated with protein or enzyme deficiencies.
    Type: Application
    Filed: April 3, 2023
    Publication date: October 19, 2023
    Applicant: Translate Bio, Inc.
    Inventors: Frank DeRosa, Braydon Charles Guild, Michael Heartlein
  • CFTR MRNA COMPOSITIONS AND RELATED METHODS AND USES
    Publication number: 20230302039
    Abstract: Materials, formulations, production methods, and methods for delivery of CFTR mRNA for induction of CFTR expression, including in the mammalian lung are provided. The present invention is particularly useful for treating cystic fibrosis.
    Type: Application
    Filed: October 24, 2022
    Publication date: September 28, 2023
    Inventors: Michael Heartlein, Braydon Charles Guild, Frank DeRosa, Carsten Rudolph, Christian Plank, Lianne Smith
  • LIPID NANOPARTICLE COMPOSITIONS AND METHODS FOR MRNA DELIVERY
    Publication number: 20230293723
    Abstract: Disclosed herein are compositions and methods for modulating the production of a protein in a target cell. The compositions and methods disclosed herein are capable of ameliorating diseases associated with protein or enzyme deficiencies.
    Type: Application
    Filed: April 3, 2023
    Publication date: September 21, 2023
    Applicant: Translate Bio, Inc.
    Inventors: Frank DeRosa, Braydon Charles Guild, Michael Heartlein
  • LIPID NANOPARTICLE COMPOSITIONS AND METHODS FOR MRNA DELIVERY
    Publication number: 20230285592
    Abstract: Disclosed herein are compositions and methods for modulating the production of a protein in a target cell. The compositions and methods disclosed herein are capable of ameliorating diseases associated with protein or enzyme deficiencies.
    Type: Application
    Filed: April 3, 2023
    Publication date: September 14, 2023
    Applicant: Translate Bio, Inc.
    Inventors: Frank DeRosa, Braydon Charles Guild, Michael Heartlein
  • LIPID NANOPARTICLE COMPOSITIONS AND METHODS FOR MRNA DELIVERY
    Publication number: 20230285593
    Abstract: Disclosed herein are compositions and methods for modulating the production of a protein in a target cell. The compositions and methods disclosed herein are capable of ameliorating diseases associated with protein or enzyme deficiencies.
    Type: Application
    Filed: April 3, 2023
    Publication date: September 14, 2023
    Applicant: Translate Bio, Inc.
    Inventors: Frank DeRosa, Braydon Charles Guild, Michael Heartlein
  • Lipid nanoparticle compositions and methods for mRNA delivery
    Patent number: 11730825
    Abstract: Disclosed herein are compositions and methods for modulating the production of a protein in a target cell. The compositions and methods disclosed herein are capable of ameliorating diseases associated with protein or enzyme deficiencies.
    Type: Grant
    Filed: December 21, 2021
    Date of Patent: August 22, 2023
    Assignee: TRANSLATE BIO, INC.
    Inventors: Braydon Charles Guild, Frank DeRosa, Michael Heartlein
  • Lipid nanoparticle compositions and methods for MRNA delivery
    Patent number: 11547764
    Abstract: Disclosed herein are compositions and methods for modulating the production of a protein in a target cell. The compositions and methods disclosed herein are capable of ameliorating diseases associated with protein or enzyme deficiencies.
    Type: Grant
    Filed: December 20, 2021
    Date of Patent: January 10, 2023
    Assignee: TRANSLATE BIO, INC.
    Inventors: Braydon Charles Guild, Frank DeRosa, Michael Heartlein
  • Nuclease Resistant Polynucleotides and Uses Thereof
    Publication number: 20220411791
    Abstract: The invention provides, among other things, methods of stabilizing mRNA and nuclease resistant mRNA prepared in accordance with such methods. hi certain embodiments, the nuclease resistant mRNA encodes a functional protein, such as enzyme, and is characterized by its resistance to nuclease digestion, increased half-life and/or its ability to produce increased amounts of the functional protein (e.g., enzyme) encoded thereby.
    Type: Application
    Filed: January 10, 2022
    Publication date: December 29, 2022
    Inventors: Michael Heartlein, Braydon Charles Guild, Frank DeRosa