Patents by Inventor Braydon Charles Guild

Braydon Charles Guild has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • LIPID NANOPARTICLE COMPOSITIONS AND METHODS FOR MRNA DELIVERY
    Publication number: 20200085973
    Abstract: Disclosed herein are compositions and methods for modulating the production of a protein in a target cell. The compositions and methods disclosed herein are capable of ameliorating diseases associated with protein or enzyme deficiencies.
    Type: Application
    Filed: November 12, 2019
    Publication date: March 19, 2020
    Inventors: Braydon Charles Guild, Frank DeRosa, Michael Heartlein
  • Methods and compositions for delivering mRNA coded antibodies
    Patent number: 10584165
    Abstract: The present invention provides, among other things, methods and compositions for delivering an antibody in vivo by administering to a subject in need thereof one or more mRNAs encoding a heavy chain and a light chain of an antibody, and wherein the antibody is expressed systemically in the subject. In some embodiments, the one or more mRNAs comprise a first mRNA encoding the heavy chain and a second mRNA encoding the light chain of the antibody.
    Type: Grant
    Filed: September 12, 2018
    Date of Patent: March 10, 2020
    Assignee: Translate Bio, Inc.
    Inventors: Michael Heartlein, Frank DeRosa, Anusha Dias, Braydon Charles Guild
  • CFTR MRNA COMPOSITIONS AND RELATED METHODS AND USES
    Publication number: 20200046752
    Abstract: Materials, formulations, production methods, and methods for delivery of CFTR mRNA for induction of CFTR expression, including in the mammalian lung are provided. The present invention is particularly useful for treating cystic fibrosis.
    Type: Application
    Filed: August 14, 2019
    Publication date: February 13, 2020
    Inventors: Michael Heartlein, Braydon Charles Guild, Frank DeRosa, Carsten Rudolph, Christian Plank, Lianne Smith
  • Lipid nanoparticle compositions and methods for mRNA delivery
    Patent number: 10507249
    Abstract: Disclosed herein are compositions and methods for modulating the production of a protein in a target cell. The compositions and methods disclosed herein are capable of ameliorating diseases associated with protein or enzyme deficiencies.
    Type: Grant
    Filed: July 3, 2019
    Date of Patent: December 17, 2019
    Assignee: Translate Bio, Inc.
    Inventors: Braydon Charles Guild, Frank DeRosa, Michael Heartlein
  • Cleavable lipids
    Patent number: 10507183
    Abstract: Disclosed herein are novel compounds, pharmaceutical compositions comprising such compounds and related methods of their use. The compounds described herein are useful, e.g., as liposomal delivery vehicles to facilitate the delivery of encapsulated polynucleotides to target cells and subsequent transfection of said target cells, and in certain embodiments are characterized as having one or more properties that afford such compounds advantages relative to other similarly classified lipids.
    Type: Grant
    Filed: February 2, 2018
    Date of Patent: December 17, 2019
    Assignee: Translate Bio, Inc.
    Inventors: Braydon Charles Guild, Michael Heartlein, Frank DeRosa, Jerry Chi Zhang
  • LIPID NANOPARTICLE COMPOSITIONS AND METHODS FOR MRNA DELIVERY
    Publication number: 20190321489
    Abstract: Disclosed herein are compositions and methods for modulating the production of a protein in a target cell. The compositions and methods disclosed herein are capable of ameliorating diseases associated with protein or enzyme deficiencies.
    Type: Application
    Filed: July 3, 2019
    Publication date: October 24, 2019
    Inventors: Braydon Charles Guild, Frank DeRosa, Michael Heartlein
  • Cleavable Lipids
    Publication number: 20190314284
    Abstract: Disclosed herein are novel compounds, pharmaceutical compositions comprising such compounds and related methods of their use. The compounds described herein are useful, e.g. as liposomal delivery vehicles to facilitate the delivery of encapsulated polynucleotides to target cells and subsequent transfection of said target cells, and in certain embodiments are characterized as having one or more properties that afford such compounds advantages relative to other similarly classified lipids.
    Type: Application
    Filed: June 25, 2019
    Publication date: October 17, 2019
    Inventors: Braydon Charles Guild, Michael Heartlein, Frank DeRosa, Jerry Chi Zhang
  • CFTR MRNA compositions and related methods and uses
    Patent number: 10420791
    Abstract: The present invention is particularly useful for treating cystic fibrosis. The disclosure concerns method and compositions for treating cystic fibrosis. The method comprises inducing CFTR expression in epithelial cells in a lung of a mammal by contacting the epithelial cells in the lung of the mammal with a composition, where the composition is a pharmaceutical composition comprising in vitro transcribed mRNA.
    Type: Grant
    Filed: June 16, 2017
    Date of Patent: September 24, 2019
    Assignee: Translate Bio, Inc.
    Inventors: Michael Heartlein, Braydon Charles Guild, Frank DeRosa, Carsten Rudolph, Christian Plank, Lianne Smith
  • Lipid nanoparticle compositions and methods for mRNA delivery
    Patent number: 10413618
    Abstract: Disclosed herein are compositions and methods for modulating the production of a protein in a target cell. The compositions and methods disclosed herein are capable of ameliorating diseases associated with protein or enzyme deficiencies.
    Type: Grant
    Filed: December 26, 2018
    Date of Patent: September 17, 2019
    Assignee: Translate Bio, Inc.
    Inventors: Braydon Charles Guild, Frank DeRosa, Michael Heartlein
  • Compositions and methods for antibodies targeting complement protein C5
    Patent number: 10407496
    Abstract: The present invention relates to antibodies targeting complement protein C5 and compositions and methods of use thereof.
    Type: Grant
    Filed: November 17, 2016
    Date of Patent: September 10, 2019
    Assignee: Novartis AG
    Inventors: Beate Diefenbach-Streiber, Adina Eberth, Braydon Charles Guild, Yong-In Kim, Michael Roguska, Igor Splawski
  • Synergistic Enhancement of the Delivery of Nucleic Acids via Blended Formulations
    Publication number: 20190216843
    Abstract: Disclosed herein are pharmaceutical compositions that comprise “blends” of lipid nanoparticles and related methods of using such blended compositions to deliver polynucleotides to one or more target cells, tissues or organs. The blended compositions are generally characterized as being able to efficiently deliver polynucleotides to target cells and by their ability to enhance the expression of such polynucleotides and the production of functional proteins by target cells.
    Type: Application
    Filed: October 10, 2018
    Publication date: July 18, 2019
    Inventors: Frank DeRosa, Lianne Smith, Michael Heartlein, Braydon Charles Guild
  • PULMONARY DELIVERY OF MRNA TO NON-LUNG TARGET CELLS
    Publication number: 20190216730
    Abstract: Compositions comprising mRNA formulated for pulmonary administration and related method for delivery of the mRNA and/or encoded protein to a non-lung cell or tissue. The compositions and methods may be used to prevent or ameliorate the symptoms of diseases associated with the mRNA encoded protein.
    Type: Application
    Filed: January 25, 2019
    Publication date: July 18, 2019
    Inventors: Michael Heartlein, Braydon Charles Guild, Frank DeRoas, Carsten Rudolph, Christian Plank
  • Lipid nanoparticle compositions and methods for mRNA delivery
    Patent number: 10350303
    Abstract: Disclosed herein are compositions and methods for modulating the production of a protein in a target cell. The compositions and methods disclosed herein are capable of ameliorating diseases associated with protein or enzyme deficiencies.
    Type: Grant
    Filed: February 26, 2019
    Date of Patent: July 16, 2019
    Assignee: Translate Bio, Inc.
    Inventors: Braydon Charles Guild, Frank DeRosa, Michael Heartlein
  • LIVER SPECIFIC DELIVERY OF MESSENGER RNA
    Publication number: 20190192690
    Abstract: Disclosed herein are compositions and methods of modulating the expression of gene or the production of a protein by transfecting target cells with nucleic acids. The compositions disclosed herein demonstrate a high transfection efficacy and are capable of ameliorating diseases associated with protein or enzyme deficiencies.
    Type: Application
    Filed: February 26, 2019
    Publication date: June 27, 2019
    Inventors: Braydon Charles Guild, Frank DeRosa, Michael Heartlein
  • LIPID NANOPARTICLE COMPOSITIONS AND METHODS FOR MRNA DELIVERY
    Publication number: 20190192689
    Abstract: Disclosed herein are compositions and methods for modulating the production of a protein in a target cell. The compositions and methods disclosed herein are capable of ameliorating diseases associated with protein or enzyme deficiencies.
    Type: Application
    Filed: February 26, 2019
    Publication date: June 27, 2019
    Inventors: Braydon Charles Guild, Frank DeRosa, Michael Heartlein
  • LIPID-DERIVED NEUTRAL NANOPARTICLES
    Publication number: 20190192435
    Abstract: Disclosed herein are novel lipids and liposomal compositions prepared using such compounds and related methods of neutralizing or otherwise modifying such liposomal compositions. The lipids described herein are useful for example, as liposomal vehicles to facilitate the delivery of encapsulated polynucleotides to target cells and the subsequent transfection of such target cells. In certain embodiments, one or more of the compounds that comprise the liposomal delivery vehicle may be neutralized or further modified such that the properties of the liposomal delivery vehicle are modified.
    Type: Application
    Filed: November 6, 2018
    Publication date: June 27, 2019
    Inventors: Frank DeRosa, Braydon Charles Guild, Michael Heartlein
  • IONIZABLE CATIONIC LIPIDS
    Publication number: 20190185410
    Abstract: Disclosed herein are novel compounds, pharmaceutical compositions comprising such compounds and related methods of their use. The compounds described herein are useful, e.g., as liposomal delivery vehicles to facilitate the delivery of encapsulated polynucleotides to target cells and subsequent transfection of said target cells, and in certain embodiments are characterized as having one or more properties that afford such compounds advantages relative to other similarly classified lipids.
    Type: Application
    Filed: August 10, 2018
    Publication date: June 20, 2019
    Inventors: Frank DeRosa, Braydon Charles Guild, Michael Heartlein
  • Lipid Nanoparticle Compositions and Methods for mRNA Delivery
    Publication number: 20190175761
    Abstract: Disclosed herein are compositions and methods for modulating the production of a protein in a target cell. The compositions and methods disclosed herein are capable of ameliorating diseases associated with protein or enzyme deficiencies.
    Type: Application
    Filed: December 26, 2018
    Publication date: June 13, 2019
    Inventors: Braydon Charles Guild, Frank DeRosa, Michael Heartlein
  • Nuclease Resistant Polynucleotides and Uses Thereof
    Publication number: 20190100753
    Abstract: The invention provides, among other things, methods of stabilizing mRNA and nuclease resistant mRNA prepared in accordance with such methods. In certain embodiments, the nuclease resistant mRNA encodes a functional protein, such as enzyme, and is characterized by its resistance to nuclease digestion, increased half-life and/or its ability to produce increased amounts of the functional protein (e.g., enzyme) encoded thereby.
    Type: Application
    Filed: May 18, 2018
    Publication date: April 4, 2019
    Inventors: Michael Heartlein, Braydon Charles Guild, Frank DeRosa
  • Pulmonary delivery of mRNA to non-lung target cells
    Patent number: 10245229
    Abstract: Compositions comprising mRNA formulated for pulmonary administration and related methods for delivery of the mRNA and/or encoded protein to a non-lung cell or tissue. The compositions and methods may be used to prevent or ameliorate the symptoms of diseases associated with the mRNA encoded protein.
    Type: Grant
    Filed: June 7, 2013
    Date of Patent: April 2, 2019
    Assignees: Translate Bio, Inc., Ethris GmbH
    Inventors: Michael Heartlein, Braydon Charles Guild, Frank DeRosa, Carsten Rudolph, Christian Plank