Patents by Inventor Braydon Charles Guild

Braydon Charles Guild has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10238754
    Abstract: Disclosed herein are compositions and methods for modulating the production of a protein in a target cell. The compositions and methods disclosed herein are capable of ameliorating diseases associated with protein or enzyme deficiencies.
    Type: Grant
    Filed: April 7, 2017
    Date of Patent: March 26, 2019
    Assignee: Translate Bio, Inc.
    Inventors: Braydon Charles Guild, Frank DeRosa, Michael Heartlein
  • Publication number: 20190071495
    Abstract: The present invention provides, among other things, methods and compositions for delivering an antibody in vivo by administering to a subject in need thereof one or more mRNAs encoding a heavy chain and a light chain of an antibody, and wherein the antibody is expressed systemically in the subject. In some embodiments, the one or more mRNAs comprise a first mRNA encoding the heavy chain and a second mRNA encoding the light chain of the antibody.
    Type: Application
    Filed: September 12, 2018
    Publication date: March 7, 2019
    Inventors: Michael Heartlein, Frank DeRosa, Anusha Dias, Braydon Charles Guild
  • Publication number: 20180353616
    Abstract: Disclosed herein are compositions and methods for modulating the production of a protein in a target cell. The compositions and methods disclosed herein are capable of ameliorating diseases associated with protein or enzyme deficiencies.
    Type: Application
    Filed: May 10, 2018
    Publication date: December 13, 2018
    Inventors: Braydon Charles Guild, Frank DeRosa, Michael Heartlein
  • Patent number: 10143758
    Abstract: Disclosed herein are compositions and methods of modulating the expression of gene or the production of a protein by transfecting target cells with nucleic acids. The compositions disclosed herein demonstrate a high transfection efficacy and are capable of ameliorating diseases associated with protein or enzyme deficiencies.
    Type: Grant
    Filed: March 13, 2013
    Date of Patent: December 4, 2018
    Assignee: Translate Bio, Inc.
    Inventors: Braydon Charles Guild, Frank DeRosa, Michael Heartlein
  • Patent number: 10137087
    Abstract: Disclosed herein are novel lipids and liposomal compositions prepared using such compounds and related methods of neutralizing or otherwise modifying such liposomal compositions. The lipids described herein are useful for example, as liposomal vehicles to facilitate the delivery of encapsulated polynucleotides to target cells and the subsequent transfection of such target cells. In certain embodiments, one or more of the compounds that comprise the liposomal delivery vehicle may be neutralized or further modified such that the properties of the liposomal delivery vehicle are modified.
    Type: Grant
    Filed: January 23, 2018
    Date of Patent: November 27, 2018
    Assignee: Translate Bio, Inc.
    Inventors: Frank DeRosa, Braydon Charles Guild, Michael Heartlein
  • Patent number: 10137086
    Abstract: Disclosed herein are novel lipids and liposomal compositions prepared using such compounds and related methods of neutralizing or otherwise modifying such liposomal compositions. The lipids described herein are useful for example, as liposomal vehicles to facilitate the delivery of encapsulated polynucleotides to target cells and the subsequent transfection of such target cells. In certain embodiments, one or more of the compounds that comprise the liposomal delivery vehicle may be neutralized or further modified such that the properties of the liposomal delivery vehicle are modified.
    Type: Grant
    Filed: January 23, 2018
    Date of Patent: November 27, 2018
    Assignee: Translate Bio, Inc.
    Inventors: Frank DeRosa, Braydon Charles Guild, Michael Heartlein
  • Patent number: 10130649
    Abstract: Disclosed herein are pharmaceutical compositions that comprise “blends” of lipid nanoparticles and related methods of using such blended compositions to deliver polynucleotides to one or more target cells, tissues or organs. The blended compositions are generally characterized as being able to efficiently deliver polynucleotides to target cells and by their ability to enhance the expression of such polynucleotides and the production of functional proteins by target cells.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: November 20, 2018
    Assignee: TRANSLATE BIO, INC.
    Inventors: Frank Derosa, Lianne Smith, Michael Heartlein, Braydon Charles Guild
  • Patent number: 10087247
    Abstract: The present invention provides, among other things, methods and compositions for delivering an antibody in vivo by administering to a subject in need thereof one or more mRNAs encoding a heavy chain and a light chain of an antibody, and wherein the antibody is expressed systemically in the subject. In some embodiments, the one or more mRNAs comprise a first mRNA encoding the heavy chain and a second mRNA encoding the light chain of the antibody.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: October 2, 2018
    Assignee: Translate Bio, Inc.
    Inventors: Michael Heartlein, Frank Derosa, Anusha Dias, Braydon Charles Guild
  • Patent number: 10065919
    Abstract: Disclosed herein are novel compounds, pharmaceutical compositions comprising such compounds and related methods of their use. The compounds described herein are useful, e.g., as liposomal delivery vehicles to facilitate the delivery of encapsulated polynucleotides to target cells and subsequent transfection of said target cells, and in certain embodiments are characterized as having one or more properties that afford such compounds advantages relative to other similarly classified lipids.
    Type: Grant
    Filed: December 2, 2016
    Date of Patent: September 4, 2018
    Assignee: Translate Bio, Inc.
    Inventors: Frank DeRosa, Braydon Charles Guild, Michael Heartlein
  • Publication number: 20180236047
    Abstract: Compositions for modulating the expression of a protein in a target cell comprising at least one RNA molecule which comprises at least one modification 5 conferring stability to the RNA, as well as related methods, are disclosed.
    Type: Application
    Filed: March 27, 2018
    Publication date: August 23, 2018
    Inventors: Braydon Charles Guild, Michael Heartlein, Frank DeRosa
  • Publication number: 20180169015
    Abstract: Disclosed herein are novel lipids and liposomal compositions prepared using such compounds and related methods of neutralizing or otherwise modifying such liposomal compositions. The lipids described herein are useful for example, as liposomal vehicles to facilitate the delivery of encapsulated polynucleotides to target cells and the subsequent transfection of such target cells. In certain embodiments, one or more of the compounds that comprise the liposomal delivery vehicle may be neutralized or further modified such that the properties of the liposomal delivery vehicle are modified.
    Type: Application
    Filed: January 23, 2018
    Publication date: June 21, 2018
    Inventors: Frank DeRosa, Braydon Charles Guild, Michael Heartlein
  • Publication number: 20180169016
    Abstract: Disclosed herein are novel lipids and liposomal compositions prepared using such compounds and related methods of neutralizing or otherwise modifying such liposomal compositions. The lipids described herein are useful for example, as liposomal vehicles to facilitate the delivery of encapsulated polynucleotides to target cells and the subsequent transfection of such target cells. In certain embodiments, one or more of the compounds that comprise the liposomal delivery vehicle may be neutralized or further modified such that the properties of the liposomal delivery vehicle are modified.
    Type: Application
    Filed: January 23, 2018
    Publication date: June 21, 2018
    Inventors: Frank DeRosa, Braydon Charles Guild, Michael Heartlein
  • Publication number: 20180169020
    Abstract: Disclosed herein are novel compounds, pharmaceutical compositions comprising such compounds and related methods of their use. The compounds described herein are useful, e.g., as liposomal delivery vehicles to facilitate the delivery of encapsulated polynucleotides to target cells and subsequent iransfection of said target cells, and in certain embodiments are characterized as having one or more properties that afford such compounds advantages relative to other similarly classified lipids.
    Type: Application
    Filed: February 2, 2018
    Publication date: June 21, 2018
    Inventors: Braydon Charles Guild, Michael Heartlein, Frank DeRosa, Jerry Chi Zhang
  • Patent number: 9956271
    Abstract: Compositions for modulating the expression of a protein in a target cell comprising at least one RNA molecule which comprises at least one modification 5 conferring stability to the RNA, as well as related methods, are disclosed.
    Type: Grant
    Filed: May 18, 2015
    Date of Patent: May 1, 2018
    Assignee: TRANSLATE BIO, INC.
    Inventors: Braydon Charles Guild, Michael Heartlein, Frank DeRosa
  • Patent number: 9877919
    Abstract: Disclosed herein are novel lipids and liposomal compositions prepared using such compounds and related methods of neutralizing or otherwise modifying such liposomal compositions. The lipids described herein are useful for example, as liposomal vehicles to facilitate the delivery of encapsulated polynucleotides to target cells and the subsequent transfection of such target cells. In certain embodiments, one or more of the compounds that comprise the liposomal delivery vehicle may be neutralized or further modified such that the properties of the liposomal delivery vehicle are modified.
    Type: Grant
    Filed: March 29, 2013
    Date of Patent: January 30, 2018
    Assignee: TRANSLATE BIO, INC.
    Inventors: Frank DeRosa, Braydon Charles Guild, Michael Heartlein
  • Publication number: 20180015116
    Abstract: Materials, formulations, production methods, and methods for delivery of CFTR mRNA for induction of CFTR expression, including in the mammalian lung are provided. The present invention is particularly useful for treating cystic fibrosis.
    Type: Application
    Filed: June 16, 2017
    Publication date: January 18, 2018
    Inventors: Michael Heartlein, Braydon Charles Guild, Frank DeRosa, Carsten Rudolph, Christian Plank, Lianne Smith
  • Publication number: 20180008543
    Abstract: Disclosed herein are novel compounds, pharmaceutical compositions comprising such compounds and related methods of their use. The compounds described herein are useful, e.g., as liposomal delivery vehicles to facilitate the delivery of encapsulated polynucleotides to target cells and subsequent iransfection of said target cells, and in certain embodiments are characterized as having one or more properties that afford such compounds advantages relative to other similarly classified lipids.
    Type: Application
    Filed: July 17, 2017
    Publication date: January 11, 2018
    Inventors: Braydon Charles Guild, Michael Heartlein, Frank DeRosa, Jerry Chi Zhang
  • Publication number: 20170260260
    Abstract: The present invention relates to antibodies targeting complement protein C5 and compositions and methods of use thereof.
    Type: Application
    Filed: November 17, 2016
    Publication date: September 14, 2017
    Inventors: Beate DIEFENBACH-STREIBER, Adina EBERTH, Braydon Charles GUILD, Yong-In KIM, Michael ROGUSKA, Igor SPLAWSKI
  • Publication number: 20170240501
    Abstract: Disclosed herein are novel compounds, pharmaceutical compositions comprising such compounds and related methods of their use. The compounds described herein are useful, e.g., as liposomal delivery vehicles to facilitate the delivery of encapsulated polynucleotides to target cells and subsequent transfection of said target cells, and in certain embodiments are characterized as having one or more properties that afford such compounds advantages relative to other similarly classified lipids.
    Type: Application
    Filed: December 2, 2016
    Publication date: August 24, 2017
    Inventors: Frank DeRosa, Braydon Charles Guild, Michael Heartlein
  • Publication number: 20170239371
    Abstract: Disclosed herein are compositions and methods for modulating the production of a protein in a target cell. The compositions and methods disclosed herein are capable of ameliorating diseases associated with protein or enzyme deficiencies.
    Type: Application
    Filed: April 7, 2017
    Publication date: August 24, 2017
    Inventors: Braydon Charles Guild, Frank DeRosa, Michael Heartlein