Patents by Inventor Braydon Charles Guild

Braydon Charles Guild has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • mRNA for use in treatment of human genetic diseases
    Patent number: 8853377
    Abstract: Compositions for modulating the expression of a protein in a target cell comprising at least one RNA molecule which comprises at least one modification conferring stability to the RNA, as well as related methods, are disclosed.
    Type: Grant
    Filed: November 29, 2011
    Date of Patent: October 7, 2014
    Assignee: Shire Human Genetic Therapies, Inc.
    Inventors: Braydon Charles Guild, Michael Heartlein
  • PULMONARY DELIVERY OF MRNA
    Publication number: 20140294939
    Abstract: Disclosed herein are compositions and methods for modulating the production of a protein in a target cell. The compositions and methods disclosed herein are capable of ameliorating diseases associated with protein or enzyme deficiencies.
    Type: Application
    Filed: June 18, 2014
    Publication date: October 2, 2014
    Inventors: Braydon Charles Guild, Frank DeRosa, Michael Heartlein
  • MRNA THERAPY FOR FABRY DISEASE
    Publication number: 20140294938
    Abstract: Disclosed herein are compositions and methods for modulating the production of a protein in a target cell. The compositions and methods disclosed herein are capable of ameliorating diseases associated with protein or enzyme deficiencies.
    Type: Application
    Filed: June 18, 2014
    Publication date: October 2, 2014
    Inventors: Braydon Charles Guild, Frank DeRosa, Michael Heartlein
  • MRNA THERAPY FOR UREA CYCLE DISORDERS
    Publication number: 20140294940
    Abstract: Disclosed herein are compositions and methods of modulating the expression of gene or the production of a protein by transfecting target cells with nucleic acids. The compositions disclosed herein demonstrate a high transfection efficacy and are capable of ameliorating diseases associated with protein or enzyme deficiencies.
    Type: Application
    Filed: June 19, 2014
    Publication date: October 2, 2014
    Inventors: Braydon Charles Guild, Frank DeRosa, Michael Heartlein
  • CLEAVABLE LIPIDS
    Publication number: 20140288160
    Abstract: Disclosed herein are novel compounds, pharmaceutical compositions comprising such compounds and related methods of their use. The compounds described herein are useful, e.g., as liposomal delivery vehicles to facilitate the delivery of encapsulated polynucleotides to target cells and subsequent transfection of said target cells, and in certain embodiments are characterized as having one or more properties that afford such compounds advantages relative to other similarly classified lipids.
    Type: Application
    Filed: June 8, 2012
    Publication date: September 25, 2014
    Applicant: Shire Human Genetic Therapies, Inc.
    Inventors: Braydon Charles Guild, Michael Heartlein, Frank DeRosa, Jerry Chi Zhang
  • LIPID NANOPARTICLE COMPOSITIONS AND METHODS FOR MRNA DELIVERY
    Publication number: 20140206753
    Abstract: Disclosed herein are compositions and methods for modulating the production of a protein in a target cell. The compositions and methods disclosed herein are capable of ameliorating diseases associated with protein or enzyme deficiencies.
    Type: Application
    Filed: June 8, 2012
    Publication date: July 24, 2014
    Applicant: SHIRE HUMAN GENETIC THERAPIES, INC.
    Inventors: Braydon Charles Guild, Frank DeRosa, Michael Heartlein
  • Compositions and Methods for Antibodies Targeting Complement Protein C5
    Publication number: 20130064836
    Abstract: The present invention relates to antibodies targeting complement protein C5 and compositions and methods of use thereof.
    Type: Application
    Filed: July 25, 2012
    Publication date: March 14, 2013
    Inventors: Beate DIEFENBACH-STREIBER, Adina EBERTH, Braydon Charles GUILD, Yong-In KIM, Michael ROGUSKA, Igor SPLAWSKI
  • Compositions and Methods for Antibodies Targeting Complement Protein C5
    Publication number: 20130022615
    Abstract: The present invention relates to antibodies targeting complement protein C5 and compositions and methods of use thereof.
    Type: Application
    Filed: June 28, 2012
    Publication date: January 24, 2013
    Inventors: Beate DIEFENBACH-STREIBER, Adina EBERTH, Braydon Charles GUILD, Yong-In KIM, Michael ROGUSKA, Igor SPLAWSKI
  • Compositions and methods for antibodies targeting complement protein C5
    Patent number: 8241628
    Abstract: The present invention relates to antibodies targeting complement protein C5 and compositions and methods of use thereof.
    Type: Grant
    Filed: August 4, 2009
    Date of Patent: August 14, 2012
    Assignee: Novartis AG
    Inventors: Beate Diefenbach-Streiber, Adina Eberth, Braydon Charles Guild, Yong-In Kim, Michael Roguska, Igor Splawski
  • mRNA FOR USE IN TREATMENT OF HUMAN GENETIC DISEASES
    Publication number: 20120142756
    Abstract: Compositions for modulating the expression of a protein in a target cell comprising at least one RNA molecule which comprises at least one modification conferring stability to the RNA, as well as related methods, are disclosed.
    Type: Application
    Filed: November 29, 2011
    Publication date: June 7, 2012
    Inventors: Braydon Charles Guild, Michael Heartlein
  • DELIVERY OF MRNA FOR THE AUGMENTATION OF PROTEINS AND ENZYMES IN HUMAN GENETIC DISEASES
    Publication number: 20110244026
    Abstract: Disclosed herein are compositions and methods of modulating the expression of gene or the production of a protein by transfecting target cells with nucleic acids. The compositions disclosed herein demonstrate a high transfection efficacy and are capable of ameliorating diseases associated with protein or enzyme deficiencies.
    Type: Application
    Filed: November 30, 2010
    Publication date: October 6, 2011
    Inventors: Braydon Charles Guild, Frank DeRosa, Michael Heartlein
  • COMPOSITIONS AND METHODS FOR ANTIBODIES TARGETING COMPLEMENT PROTEIN C3B
    Publication number: 20100291106
    Abstract: The present invention relates to antibodies and antigen binding fragments thereof that bind to both human and cynomolgus complement protein C3b, as well as compositions and methods of use thereof.
    Type: Application
    Filed: May 4, 2010
    Publication date: November 18, 2010
    Inventors: Bijan Etemad-Gilbertson, Braydon Charles Guild, Yong-In Kim, Ingo Klagge, Alexandra Kraus, Michael Roguska, Igor Splawski, Kehao Zhao
  • C5 Antigens and Uses Thereof
    Publication number: 20100166748
    Abstract: The present invention pertains to the use of a complement inhibitor in methods of treatment of ocular disorders and the use of a complement inhibitor in the manufacture of a medicament in the treatment of an ocular disorder.
    Type: Application
    Filed: March 19, 2008
    Publication date: July 1, 2010
    Inventors: Braydon Charles Guild, Mark Taylor Keating, Mariusz Milik, Dmitri Mikhailov, Michael Roguska, Igor Splawski, Kehao Zhao
  • Compositions and Methods for Antibodies Targeting Complement Protein C5
    Publication number: 20100034809
    Abstract: The present invention relates to antibodies targeting complement protein C5 and compositions and methods of use thereof.
    Type: Application
    Filed: August 4, 2009
    Publication date: February 11, 2010
    Inventors: Beate Diefenbach-Streiber, Adina Eberth, Braydon Charles Guild, Yong-In Kim, Michael Roguska, Igor Splawski
  • Molecules and Methods for Modulating Complement Component
    Publication number: 20090175875
    Abstract: Compositions that bind to C3b epitopes and methods of using the compositions are described herein.
    Type: Application
    Filed: November 3, 2008
    Publication date: July 9, 2009
    Inventors: Bijan ETEMAD-GILBERTSON, Braydon Charles Guild, Mark Taylor Keating, Yong-In Kim, Lloyd B. Klickstein, Dmitri Mikhailov, Mariusz Milik, Michael Roguska, Igor Splawski, Kehao Zhao