Abstract: Disclosed herein are methods for predicting immunogenicity of a candidate peptide. The method comprises obtaining a three-dimensional candidate structural representation of the candidate peptide bound to an antigen presenting molecule; obtaining a plurality of candidate measurements; and predicting, with an electronic processor, the immunogenicity of the candidate peptide based upon the plurality of candidate measurements. Further disclosed herein are methods for producing vaccines. The method for producing a vaccine comprises predicting immunogenicity of one or more candidate peptides using the methods described herein, and producing a vaccine comprising one or more peptides predicted to be immunogenic.

Abstract: Described are methods for predicting affinity of a candidate molecule for a second molecule. The method comprises obtaining a three-dimensional candidate structural representation of the candidate molecule bound to a second molecule; obtaining a plurality of candidate measurements, wherein each candidate measurement is associated with at least one feature of the candidate structural representation; and predicting, with an electronic processor, the affinity of the candidate molecule for the second molecule, wherein the electronic processor is configured to predict the affinity of the candidate molecule for the second molecule based upon the plurality of candidate measurements. The candidate molecule may be a peptide, such as a neoantigen, a viral peptide, a non-mutated self peptide, or a post-translationally modified peptide. The second molecule may be an antigen presenting molecule, such as a class I MHC molecule or a class II MHC molecule.

Abstract: A membrane based microelectronic device (200) can include a printed circuit board (202), a polymer film (210) laminated onto the circuit board, and one or more microelectromechanical components (208) integrated into the printed circuit board (202). At least a portion of the polymer film (210) forms a membrane element of the one or more microelectromechanical components (208).

Abstract: A magnetically-driven electricity-producing generator having an anti-lock assembly generates electricity indicative of a full pulse wave environment while creating a repulsive force that reduces the force necessary to rotate the shaft. The generator includes three rotor assemblies, each having three longitudinally extending rotor magnets oriented such that outwardly facing poles establish a N-S-N pattern that, when passed in proximity to a corresponding coil pack, produces electricity having a full pulse wave form. The magnetic anti-lock device utilizes opposing magnets to reduce the varying force required to rotate the shaft and increases efficiency of the rotating shaft. The magnetic anti-lock device includes at least one inner magnet attached to the rotating shaft and at least one outer magnet fixed in position relative to the rotating shaft. The inner magnet passes the outer magnet each time the shaft rotates creating a repulsive force that reduces the force necessary to rotate the shaft.

Abstract: A method, apparatus, and system are directed towards providing advertisement insertions at a point of consumption into digital content, such as broadcast television content. A content provider may initially mark the content for advertisement insertion, and create a metadata file indicating constraints, targets, expirations, or the like. A downstream user employs a plug-in component and provides an initial user profile, in part, to access the content with advertisements. As the content is played, and an advertising marker is encountered, fast forwarding or other skipping features are disabled, and an advertisement stream is spliced into the content stream. The advertisement stream is determined based on the user profile and/or other metadata. Moreover, the advertisement stream may be obtained over a network such that advertisements may be refreshed even years after the content has been acquired by the user. In one embodiment, the advertisement consumption may be tracked and reported.

Abstract: A magnetic anti-lock device for a rotating shaft is described. The magnetic anti-lock device utilizes opposing magnets to reduce the varying force required to rotate the shaft and increases efficiency of the rotating shaft. The magnetic anti-lock device includes at least one inner magnet attached to the rotating shaft, and at least one outer magnet fixed in position relative to the rotating shaft. The inner magnet passes the outer magnet each time the shaft rotates creating a repulsive force to reduce the force necessary to rotate the shaft.

Abstract: A method, apparatus, and system are directed towards providing advertisement insertions at a point of consumption into digital content, such as broadcast television content. A content provider may initially mark the content for advertisement insertion, and create a metadata file indicating constraints, targets, expirations, or the like. A downstream user employs a plug-in component and provides an initial user profile, in part, to access the content with advertisements. As the content is played, and an advertising marker is encountered, fast forwarding or other skipping features are disabled, and an advertisement stream is spliced into the content stream. The advertisement stream is determined based on the user profile and/or other metadata. Moreover, the advertisement stream may be obtained over a network such that advertisements may be refreshed even years after the content has been acquired by the user. In one embodiment, the advertisement consumption may be tracked and reported.

Abstract: An apparatus is disclosed as including a first material volume with at least a hardened portion and a second material volume that includes at least two layers. The first material volume is composed of at least a hardenable alloy of steel. The at least two layers is located adjacent to a first surface comprising the hardened portion of the first material volume. The at least two layers includes a first layer composed of at least a ductile low-carbon alloy of steel and a second layer composed of at least a cobalt-based hardfacing over the first layer. The apparatus is applicable in preparing shear ram blocks and shear ram blades to provide a hardened blade edge with an adjacent hardfacing surface.

Abstract: While a fracturing stack on a well is at fracturing pressure, receiving a perforating string in a section of the center bore of the fracturing stack. The section is a section above a fracturing head of the fracturing stack. While the fracturing stack is at fracturing pressure, sealing the section of the center bore to maintain a fracturing pressure in and below the fracturing head. Equalizing pressure in the section to atmospheric pressure. Receiving, at atmospheric pressure, a well drop in the section. Equalizing pressure in the section to pressure in the fracturing stack below the section. Releasing the well drop into the center bore of the fracturing head and to the well.

Abstract: Reconfigurable processors and methods for collecting computer program instruction execution statistics are disclosed. According to an aspect, a method includes providing a reconfigurable processor configured to execute a set of central processing unit (CPU) instructions that each have a function. The method also includes modifying the function of one or more of the CPU instructions that identifies an instruction address and a destination address pair of the CPU instruction(s) based on a defined test case. Further, the method includes using the reconfigurable processor to execute the set of CPU instructions. The method also includes identifying an instruction address and destination address pair of the CPU instruction(s) having the modified function when the CPU instruction(s) having the modified function is executed during execution of the set of CPU instructions.

Abstract: The present disclosure provides methods for the prevention or treatment of metabolic disorders. In exemplary embodiments, methods of administering an anti-CGRP antibody are provided, optionally in combination with a second agent, wherein peripheral and/or hepatic glucose utilization is increased, thereby preventing or treating diseases and disorders associated with insulin resistance. Compositions comprising an anti-CGRP antibody are also provided, optionally in combination with a second agent, which are suitable for administration to increase peripheral and/or hepatic glucose utilization and thereby prevent or treat diseases and disorders associated with insulin resistance.

Abstract: Molecular constructs and dual recognition constructs having a sequence encoding a TCR affinity weakening motif, and DNA and RNA sequences corresponding thereto, are presented. Modified T-cells and other cells transformed with the molecular contracts express a modified TCR that imparts a reduction, in non-specific binding, -an enhancement of binding specificity and an enhancement of binding affinity for a target antigen, compared to non-transformed (wild-type, native) T-cells, are described. The modified TCRs possess an affinity enhancing motif and an affinity weakening motif. Methods of transforming cells and methods of using enriched populations of transformed cells, in the treatment of cancer and infections arid T-cell mediated pathologies are provided. The affinity weakening motif imparts a weakened interaction, of a TCR with major histocompatibility complex proteins, such as HLA proteins in humans.

Abstract: An apparatus is disclosed as including a first material volume with at least a hardened portion and a second material volume that includes at least two layers. The first material volume is composed of at least a hardenable alloy of steel. The at least two layers is located adjacent to a first surface comprising the hardened portion of the first material volume. The at least two layers includes a first layer composed of at least a ductile low-carbon alloy of steel and a second layer composed of at least a cobalt-based hardfacing over the first layer. The apparatus is applicable in preparing shear ram blocks and shear ram blades to provide a hardened blade edge with an adjacent hardfacing surface.

Abstract: An internal quench system for cooling pipes being coated is provided. The system comprises an internal quench lance having spray nozzles configured at one end of the internal quench lance. There is also provided wheels and retractable supports to support the internal quench lance without hindering the movement of the pipes. Each retract support is provided with a liquid coolant supplying means to provide liquid coolant to the internal quench lance. A process for using the internal quench system for cooling pipes being coated is also provided.

Abstract: While a fracturing stack on a well is at fracturing pressure, receiving a perforating string in a section of the center bore of the fracturing stack. The section is a section above a fracturing head of the fracturing stack. While the fracturing stack is at fracturing pressure, sealing the section of the center bore to maintain a fracturing pressure in and below the fracturing head. Equalizing pressure in the section to atmospheric pressure. Receiving, at atmospheric pressure, a well drop in the section. Equalizing pressure in the section to pressure in the fracturing stack below the section. Releasing the well drop into the center bore of the fracturing head and to the well.

Abstract: A high temperature, high strength Ni—Co—Cr alloy is provided. The alloy includes, in weight percent (wt. %): 23.5 to 25.5% Cr, 15.0 to 22.0% Co, 1.1 to 2.0% Al, 1.0 to 1.8% Ti, 0.95 to 2.2% Nb, less than 1.0% Mo, less than 1.0% Mn, up to 0.24% Si, less than 3.0% Fe, less than 0.3% Ta, less than 0.3% W, 0.005 to 0.08% C, 0.01 to 0.3% Zr, 0.0008 to 0.006% B, up to 0.05% rare earth metals, and a balance of Ni plus trace impurities.

Abstract: This disclosure provides a new internal weld blasting system for blasting the internal surfaces of pipes, and the method of use thereof. The system comprises a control cage having two relatively narrow openings. An impeller forces abrasives onto a blast wheel, which in turn sprays the abrasives onto the internal surfaces of the pipes.

Abstract: A magnetic anti-lock device for a rotating shaft is described. The magnetic anti-lock device utilizes opposing magnets to reduce the varying force required to rotate the shaft and increases efficiency of the rotating shaft. The magnetic anti-lock device includes at least one inner magnet attached to the rotating shaft, and at least one outer magnet fixed in position relative to the rotating shaft. The inner magnet passes the outer magnet each time the shaft rotates creating a repulsive force to reduce the force necessary to rotate the shaft.

Abstract: A high temperature, high strength Ni—Co—Cr alloy is provided. The alloy includes, in weight percent (wt. %): 23.5 to 25.5% Cr, 15.0 to 22.0% Co, 1.1 to 2.0% Al, 1.0 to 1.8% Ti, 0.95 to 2.2% Nb, less than 1.0% Mo, less than 1.0% Mn, up to 0.24% Si, less than 3.0% Fe, less than 0.3% Ta, less than 0.3% W, 0.005 to 0.08% C, 0.01 to 0.3% Zr, 0.0008 to 0.006% B, up to 0.05% rare earth metals, and a balance of Ni plus trace impurities.

Abstract: A method of producing a nickel alloy clad steel pipe including: providing a hollow cylinder of nickel alloy cladding material and a hollow cylinder of steel, placing the hollow cylinder of the nickel alloy cladding material concentrically inside the hollow cylinder of steel or the hollow cylinder of the steel concentrically inside the hollow cylinder of nickel alloy cladding material to form a composite billet, heating the composite billet to 1121-1260° C., and extruding the composite billet, wherein the nickel alloy cladding material comprises 6.0-12.0 wt. % molybdenum, 19.0-27.0 wt. % chromium, 1.0 wt. % maximum tungsten, 0.6 wt. % maximum aluminum, 0.6 wt. % maximum titanium, 0.001-0.05 wt. % carbon, 0.001-0.035 wt. % nitrogen, 0.001-0.3 wt. % silicon, 1.0 wt. % maximum niobium, 2.5 wt. % maximum iron, 0.5 wt. % maximum manganese, 0.015 wt. % maximum phosphorous, 0.015 wt. % maximum sulfur, 1.0 wt. % maximum cobalt, and the balance nickel and may have a solidus temperature greater than 1312° C.