Abstract: A high temperature, high strength Ni—Co—Cr alloy possessing essentially fissure-free weldability for long-life service at 538° C. to 816° C. contains in % by weight about: 23.5 to 25.5% Cr, 15-22% Co, 1.1 to 2.0% Al, 1.0 to 1.8 % Ti, 0.95 to 2.2% Nb, less than 1.0% Mo, less than 1.0% Mn, less than 0.3% Si, less than 3% Fe, less than 0.3% Ta, less than 0.3% W, 0.005 to 0.08% C, 0.01 to 0.3% Zr, 0.0008 to 0.006% B, up to 0.05% rare earth metals, 0.005% to 0.025% Mg plus optional Ca and the balance Ni including trace additions and impurities. The strength and stability is assured at 760° C. when the Al/Ti ratio is constrained to between 0.95 and 1.25. Further, the sum of Al+Ti is constrained to between 2.25 and 3.0. The upper limits for Nb and Si are defined by the relationship: (% Nb+0.95)+3.32(% Si)<3.16.

Abstract: A method, apparatus, and system are directed towards providing advertisement insertions at a point of consumption into digital content, such as broadcast television content. A content provider may initially mark the content for advertisement insertion, and create a metadata file indicating constraints, targets, expirations, or the like. A downstream user employs a plug-in component and provides an initial user profile, in part, to access the content with advertisements. As the content is played, and an advertising marker is encountered, fast forwarding or other skipping features are disabled, and an advertisement stream is spliced into the content stream. The advertisement stream is determined based on the user profile and/or other metadata. Moreover, the advertisement stream may be obtained over a network such that advertisements may be refreshed even years after the content has been acquired by the user. In one embodiment, the advertisement consumption may be tracked and reported.

Abstract: This disclosure provides a new internal weld blasting system for blasting the internal surfaces of pipes, and the method of use thereof. The system comprises a control cage having two relatively narrow openings. An impeller forces abrasives onto a blast wheel, which in turn sprays the abrasives onto the internal surfaces of the pipes.

Abstract: An internal quench system for cooling pipes being coated is provided. The system comprises an internal quench lance having spray nozzles configured at one end of the internal quench lance. There is also provided wheels and retractable supports to support the internal quench lance without hindering the movement of the pipes. Each retract support is provided with a liquid coolant supplying means to provide liquid coolant to the internal quench lance. A process for using the internal quench system for cooling pipes being coated is also provided.

Abstract: A method, apparatus, and system are directed towards providing advertisement insertions at a point of consumption into digital content, such as broadcast television content. A content provider may initially mark the content for advertisement insertion, and create a metadata file indicating constraints, targets, expirations, or the like. A downstream user employs a plug-in component and provides an initial user profile, in part, to access the content with advertisements. As the content is played, and an advertising marker is encountered, fast forwarding or other skipping features are disabled, and an advertisement stream is spliced into the content stream. The advertisement stream is determined based on the user profile and/or other metadata. Moreover, the advertisement stream may be obtained over a network such that advertisements may be refreshed even years after the content has been acquired by the user. In one embodiment, the advertisement consumption may be tracked and reported.

Abstract: Molecular constructs and dual recognition constructs having a sequence encoding a TCR affinity weakening motif, and DNA and RNA sequences corresponding thereto, are presented. Modified T-cells and other cells transformed with the molecular contracts express a modified TCR that imparts a reduction, in non-specific binding, an enhancement of binding specificity and an enhancement of binding affinity for a target antigen, compared to non-transformed (wild-type, native) T-cells, are described. The modified TCRs possess an affinity enhancing motif and an affinity weakening motif. Methods of transforming cells and methods of using enriched populations of transformed cells, in the treatment of cancer and infections arid T-cell mediated pathologies are provided. The affinity weakening motif imparts a weakened interaction, of a TCR with major histocompatibility complex proteins, such as HLA proteins in humans.

Abstract: The present disclosure provides methods for the prevention or treatment of metabolic disorders. In exemplary embodiments, methods of administering an anti-CGRP antibody are provided, optionally in combination with a second agent, wherein peripheral and/or hepatic glucose utilization is increased, thereby preventing or treating diseases and disorders associated with insulin resistance. Compositions comprising an anti-CGRP antibody are also provided, optionally in combination with a second agent, which are suitable for administration to increase peripheral and/or hepatic glucose utilization and thereby prevent or treat diseases and disorders associated with insulin resistance.

Abstract: The disclosure provided herein provides systems, devices, and methods for analyzing cultured cells. Also disclosed herein are systems, devices, and methods for analyzing interactions between two different groups of cells. Also disclosed herein are systems and methods of producing and analyzing a three-dimensional cell culture.

Abstract: Optimizing computer hardware usage in a computing system that includes a plurality of populated central processing unit (‘CPU’) sockets, including: determining, by a socket configuration module, a number of CPUs to be utilized during operation of the computing system; determining, by the socket configuration module, performance characteristics associated with each available CPU, the performance characteristics associated with each available CPU including information describing computing devices such as memory devices, input/output (‘I/O) devices, and other downstream devices that are coupled to one or more of the available CPUs; and selecting, by the socket configuration module in dependence upon the performance characteristics associated with each available CPU and a predetermined performance policy, a target CPU to utilize as a boot CPU.

Abstract: Optimizing computer hardware usage in a computing system that includes a plurality of populated central processing unit (‘CPU’) sockets, including: determining, by a socket configuration module, a number of CPUs to be utilized during operation of the computing system; determining, by the socket configuration module, performance characteristics associated with each available CPU, the performance characteristics associated with each available CPU including information describing computing devices such as memory devices, input/output (‘I/O) devices, and other downstream devices that are coupled to one or more of the available CPUs; and selecting, by the socket configuration module in dependence upon the performance characteristics associated with each available CPU and a predetermined performance policy, a target CPU to utilize as a boot CPU.

Abstract: Optimizing computer hardware usage in a computing system that includes a plurality of populated central processing unit (‘CPU’) sockets, including: determining, by a socket configuration module, a number of CPUs to be utilized during operation of the computing system; determining, by the socket configuration module, error characteristics associated with each available CPU, wherein the error characteristics associated with each available CPU include error information for computing devices that are coupled to one or more of the available CPUs; and selecting, by the socket configuration module in dependence upon the error characteristics associated with each available CPU and a predetermined error tolerance policy, a target CPU to utilize as a boot CPU.

Abstract: Electrophysiological recording systems for analysis of cultured cells include an recording device and a housing for supporting the electrophysiological recording device. The device has a porous membrane with top and bottom surfaces and a plurality of pores extending between the top and bottom surfaces. The porous membrane defines a first cell culture region disposed on the top surface and an opposed second cell culture region disposed on the bottom surface. The electrophysiological recording device has a plurality of electrodes positioned on the porous membrane in between a first insulation layer and a second insulation layer. The plurality of electrodes extend to the first cell culture region of the porous membrane. Recording ends of the electrodes measure electrical properties of cells cultured within the first and second cell culture regions, while the contact ends of the electrodes are positioned in electrical communication with data acquisition equipment.

Abstract: Reconfigurable processors and methods for collecting computer program instruction execution statistics are disclosed. According to an aspect, a method includes providing a reconfigurable processor configured to execute a set of central processing unit (CPU) instructions that each have a function. The method also includes modifying the function of one or more of the CPU instructions that identifies an instruction address and a destination address pair of the CPU instruction(s) based on a defined test case. Further, the method includes using the reconfigurable processor to execute the set of CPU instructions. The method also includes identifying an instruction address and destination address pair of the CPU instruction(s) having the modified function when the CPU instruction(s) having the modified function is executed during execution of the set of CPU instructions.

Abstract: A welding filler metal includes, by weight percent: chromium of at least 28.0% and at most 31.5%; niobium of at least 0.60%; tantalum of at least 0.010%; molybdenum of at least 1.0% and at most 7.0%; carbon of at least 0.040% and at most 0.09%; manganese of at most 1.0%; balance nickel and inevitable impurities, wherein the sum of niobium and tantalum is at least 2.2% and at most 4.0%. A welding filler metal consumable is made from the welding filler metal. A welding deposit is formed from the welding filler metal consumable. A weldment is formed using the welding filler metal consumable.

Abstract: The invention provides, in one aspect, a method of producing a cocoa-containing beverage, or a nutritionally fortified or energy-sustaining cocoa beverage, containing beneficial cocoa polyphenols. Ready-to-drink compositions, concentrates, primary beverage components, and packets for producing the beverages are specifically disclosed and prepared from a cocoa water composition made from steeping a cocoa-containing product in water or an aqueous solution with an acid. A number of vitamins, minerals, supplements, and nutriceutical compositions can be added.

Abstract: A method of producing a nickel alloy clad steel pipe including: providing a hollow cylinder of nickel alloy cladding material and a hollow cylinder of steel, placing the hollow cylinder of the nickel alloy cladding material concentrically inside the hollow cylinder of steel or the hollow cylinder of the steel concentrically inside the hollow cylinder of nickel alloy cladding material to form a composite billet, heating the composite billet to 1121-1260° C., and extruding the composite billet, wherein the nickel alloy cladding material comprises 6.0-12.0 wt. % molybdenum, 19.0-27.0 wt. % chromium, 1.0 wt. % maximum tungsten, 0.6 wt. % maximum aluminum, 0.6 wt. % maximum titanium, 0.001-0.05 wt. % carbon, 0.001-0.035 wt. % nitrogen, 0.001-0.3 wt. % silicon, 1.0 wt. % maximum niobium, 2.5 wt. % maximum iron, 0.5 wt. % maximum manganese, 0.015 wt. % maximum phosphorous, 0.015 wt. % maximum sulfur, 1.0 wt. % maximum cobalt, and the balance nickel and may have a solidus temperature greater than 1312° C.

Abstract: A method for creating a heat resistant confectionery product is disclosed that includes incorporating one or more finely milled ingredients to a mixture containing a chocolate compatible fat. The method includes providing the mixture containing the chocolate compatible fat, incorporating a powder of one or more dry ingredients used in the confectionery product, the powder having a particle size in the range of 5 to 55 microns, agitating the mixture and the pulverized powder to form a uniform cohesive dough and thereafter solidifying the dough to form the confectionery product.

Abstract: A solid-solution nickel-based alloy for use in sour gas and oil environments, including, in percent by weight: chromium: min. of 21.0 and max. of 24.0%; iron: min. of 17.0 and max. of 21.0%; molybdenum: min. of 6.5 and max. of 8.0%; copper: min. of 1.0 and max. of 2.5%; tungsten: min. of 0.1 and max. of 1.5%; sol. nitrogen: min. of 0.08 and max. of 0.20%; manganese: max. of 4.0%; silicon: max. of 1.0%; carbon: max of. 0.015%; aluminum: max of 0.5%; and a total amount of niobium, titanium, vanadium, tantalum, and zirconium: max of 0.45%; the balance being nickel and incidental impurities, along with a method of manufacturing an article from the alloy, and an article of manufacture formed from the alloy.

Abstract: A solid-solution nickel-based alloy for use in sour gas and oil environments, including, in percent by weight: chromium: min. of 21.0 and max. of 24.0%; iron: min. of 17.0 and max. of 21.0%; molybdenum: min. of 6.5 and max. of 8.0%; copper: min. of 1.0 and max. of 2.5%; tungsten: min. of 0.1 and max. of 1.5%; sol. nitrogen: min. of 0.08 and max. of 0.20%; manganese: max. of 4.0%; silicon: max. of 1.0%; carbon: max of. 0.015%; aluminum: max of 0.5%; and a total amount of niobium, titanium, vanadium, tantalum, and zirconium: max of 0.45%; the balance being nickel and incidental impurities, along with a method of manufacturing an article from the alloy, and an article of manufacture formed from the alloy.

Abstract: A chip package comprises: an IC substrate, wherein the IC substrate comprises at least one electronic device; a photovoltaic cell, wherein the photovoltaic cell generates an electrical current when exposed to light; a light blocking shield, wherein the light blocking shield prevents light from striking the photovoltaic cell only while the chip package is mounted on a circuit board, and wherein the light blocking shield ceases to prevent light from striking the photovoltaic cell upon the chip package being dismounted from the circuit board; and a disabling logic, wherein the electrical current, which is generated by the photovoltaic cell in response to the chip package being dismounted from the circuit board, causes the disabling logic to disable the IC substrate.