Abstract: Provided are compounds of Formula (I?) or (I) below, or pharmaceutically acceptable salts thereof, and methods for their use and production.

Abstract: The present disclosure is directed to a shipping container with a corrugated medium that lines an interior pocket of the shipping container as well devices and components (e.g., corrugating rollers, corrugating machines, scoring rollers, and scoring machines) that are utilized to manufacture the shipping containers. The corrugated medium has flutes that cushion, support, and protect a product that is shipped within the shipping container. The corrugated medium may include a first portion with first flutes and a second portion with second flutes that are offset relative to the first flutes. The offset first flutes and second flutes results in peaks of the first flutes nesting within valleys of the second flutes, and peaks of the second flutes nesting within valleys of the first flutes.

Abstract: The invention disclosed herein is directed to compounds of Formula I and pharmaceutically acceptable salts thereof, which are useful in the treatment of prostate, breast, colon, pancreatic, human chronic lymphocytic leukemia, melanoma and other cancers. The invention also comprises pharmaceutical compositions comprising a therapeutically effective amount of compound of Formula I, or a pharmaceutically acceptable salt thereof. The invention disclosed herein is also directed to methods of treating prostate, breast, ovarian, liver, kidney, colon, pancreatic, human chronic lymphocytic leukemia, melanoma and other cancers. The invention disclosed herein is further directed to methods of treating prostate, breast, colon, pancreatic, chronic lymphocytic leukemia, melanoma and other cancers comprising administration of a therapeutically effective amount of a selective PPAR? antagonist.

Abstract: Disclosed are compositions, methods and apparatus for diagnosing and/or monitoring a virus-associated systemic inflammation by measurement of a host immune response. The invention can be used for diagnosis including early diagnosis, monitoring, making treatment decisions, or management of subjects suspected of having systemic inflammation associated with an infection. More particularly, the present disclosure relates to peripheral blood RNA and protein biomarkers that are useful for specifically distinguishing between the host systemic immune response to viruses as compared to the host immune response to other causes of systemic inflammation.

Abstract: The present disclosure involves systems, software, and computer implemented methods for presenting information and/or services to a user. One example method includes establishing a user session between a computing device operated by an entity and a first user device operated by a customer of the entity. The first user device provides a first interface through which the customer participates in the user session. The method also includes determining, based at least on a complexity of first information to be provided to the customer, to change the first interface to a new interface. Further, the method includes selecting, based on the complexity of the first information, a new interface, where the new interface is provided by at least a second user device. Furthermore, the method includes implementing the new interface to facilitate for the customer to participate in the user session.

Abstract: Provided herein are systems, methods and computer readable media for classification of documents using a location hierarchy.

Abstract: The present disclosure relates to systems, methods, and computer-readable media for securely verifying an identity of a user of a client device based on a signal transmitted by the client device. For example, systems disclosed herein include registering a client device and facility device via a cloud computing system to enable the client device and facility device to securely communicate a signal via a wireless connection. The systems disclosed herein additionally include determining whether a trigger condition applies based on a position of the client device relative to the facility device. The systems disclosed herein further include maintaining and updating a subset of user verification information to include personal verification of a registered user of the client device. Using the subset of user verification information, a biometric scanning device may efficiently and accurately verify an identity of an individual associated with the client device.

Abstract: Various approaches for implementing platform resource management are described. In an edge computing system deployment, an edge computing device includes processing circuitry coupled to a memory. The processing circuitry is configured to obtain, from an orchestration provider, an SLO (or SLA) that defines usage of an accessible feature of the edge computing device by a container executing on a virtual machine within the edge computing system. A computation model is retrieved based on at least one key performance indicator (KPI) specified in the SLO. The defined usage of the accessible feature is mapped to a plurality of feature controls using the retrieved computation model. The plurality of feature controls is associated with platform resources of the edge computing device that are pre-allocated to the container. The usage of the platform resources allocated to the container is monitored using the plurality of feature controls.

Abstract: Systems, methods, and apparatuses for generating and releasing iodine are described. Some embodiments may include a dressing member including a plurality of iodine-forming reagents and a water-swellable material. In some embodiments, the dressing member may include water-swellable fibers. The water-swellable fibers may each include a water-swellable material in which iodine-forming reagents are dispersed. As liquid comes into contact with and is absorbed by the water-swellable material, the iodine-forming reagents may come into contact with each other, causing an iodine-forming reaction to occur, producing iodine.

Abstract: The disclosure relates to modified orthopoxvirus vectors, as well as methods of using the same for the treatment of various cancers. The disclosure provides modified orthopoxvirus vectors that exhibit various beneficial therapeutic activities, including enhanced oncolytic activity, spread of infection, immune evasion, tumor persistence, capacity for incorporation of exogenous DNA sequences and safety. The viruses we have discovered are also amenable to large scale manufacturing protocols.

Abstract: A scrolling shifter assembly having a housing rotatably supporting a scrolling wheel having a knurled exterior edge accessible to a vehicle operator, the scrolling wheel also including an annular side detent profile. A magnet is positioned in proximity to a sensor mounted to a printed circuit board (PCBA) within the housing and displaces relative to the sensor in response to rotation of the scrolling wheel. A display component is mounted in proximity to the PCBA. At least one haptic biasing component including any of spring loaded pawl or wave spring is supported within the housing and biases against the detent profile such that, and upon the operator actuating the scrolling wheel, the pawl is caused to displace relative to the profile in order to incrementally rotate the wheel, the magnet rotating relative to the PCBA sensor to cause an associated processor to electronically instruct a shift change to an engine control unit.

Abstract: A crane fall protection system is disclosed herein for use within building or construction sites. The system may comprise a safety net and an adjustable scaffold structural member. The adjustable scaffold structural member may be provided as a deployable arm that extends from the side of a crane. In some embodiments, the system may include an access flap that enables an operator to access a ladder of the crane without removing the safety net. In some embodiments, one or more tension wires may extend from the safety net and/or the scaffold structural member and attach to a pad positioned underneath an outrigger of the vehicle to provide additional support for the safety net. In some embodiments, air inflatable units may be used instead of a safety net. In some embodiments, connections to outriggers may be used to suspend the safety net instead of a scaffold structural member.

Abstract: Compounds provided herein function as thyromimetics and have utility for treating diseases such as neurodegenerative disorders and fibrotic diseases. Pharmaceutical compositions containing such compounds are also provided, as are methods of their preparation.

Abstract: Provided herein are systems, methods and computer readable media for identifying content to represent web pages and creating a representative image from the content. An example method may include retrieving a web document using a uniform resource locator (URL) contained in a dequeued work item, determining, from the web document, candidate images for creation of the representative image including extracting image references, wherein the image references are extracted by identifying image tags with source attributes, values of which are URLs locating images, filtering the URLs using a blacklist of expressions designed to match the URLs of images comprising one or more predefined undesirable characteristics, and retrieving the images which do not match any of the expressions using an HTTP client, and creating the representative image, comprising at least modifying a chosen image selected from among the candidate images.

Abstract: The present disclosure relates to systems, methods, and computer-readable media for securely verifying an identity of a user of a client device based on a signal transmitted by the client device. For example, systems disclosed herein include registering a client device and facility device via a cloud computing system to enable the client device and facility device to securely communicate a signal via a wireless connection. The systems disclosed herein additionally include determining whether a trigger condition applies based on a position of the client device relative to the facility device. The systems disclosed herein further include maintaining and updating a subset of user verification information to include personal verification of a registered user of the client device. Using the subset of user verification information, a biometric scanning device may efficiently and accurately verify an identity of an individual associated with the client device.

Abstract: A steering wheel mounted visual display including a housing incorporated at a location defined within a circumference of the steering wheel and having a graphical display output. Upon rotation of the steering wheel, the display adjusts to remain in an upright orientation. The housing further includes a main lower housing and an assemble-able upper housing sandwiching a display component providing the graphical display output. The display component further includes a stationary inner component, a display support and a PCB component cooperating for auto-updating the graphical display output in response to rotation of the steering wheel.

Abstract: The present invention is directed to a personal care composition with an effective way to impart a cooling effect on the skin upon topical application of a composition made according to the present invention. The invention thus relates to a composition comprising a synergistic combination of polyol, a sensor), modifier and water with polyoxyethylene-polyoxypropylene block copolymer.