Abstract: The invention disclosed herein is directed to compounds of Formula I and pharmaceutically acceptable salts thereof, which are useful in the treatment of prostate, breast, colon, pancreatic, human chronic lymphocytic leukemia, melanoma and other cancers. The invention also comprises pharmaceutical compositions comprising a therapeutically effective amount of compound of Formula I, or a pharmaceutically acceptable salt thereof. The invention disclosed herein is also directed to methods of treating prostate, breast, ovarian, liver, kidney, colon, pancreatic, human chronic lymphocytic leukemia, melanoma and other cancers. The invention disclosed herein is further directed to methods of treating prostate, breast, colon, pancreatic, chronic lymphocytic leukemia, melanoma and other cancers comprising administration of a therapeutically effective amount of a selective PPAR? antagonist.

Abstract: The present application describes a machine learning method for detecting tamper. The method includes a step of training a model using one or more values obtained from one or more different sensors on an integrated module. The one or more values act as training data with respect to one or more of light, acceleration, magnetic field, rotation, temperature, pressure, humidity, and audio. The method also includes a step of predicting, via the trained model, tampering of the of the integrated module. The present application also describes a system for detecting tamper.

Abstract: A service partitioned into service components requiring different resources is assigned to at least one cloud of a set of clouds. With interdependent service components, a service-placement engine is configured to coordinate assignments of individual service components. The service-placement engine receives from a client a definition of each service component and indications of components interdependence. Each cloud that satisfies compliance requirements, capability requirements, and resource requirements of a service component is considered eligible to host the service component. Selection of a specific eligible cloud is based on an overall cloud merit which depends on the service-component definition and the location of the client.

Abstract: The disclosed exemplary embodiments include computer-implemented apparatuses and methods that validate confidential data based privacy-preserving homomorphic computations involving encrypted data. For example, an apparatus may receive, from a first computing system, encrypted data that includes a first encrypted value representative of at least one of first account data or an element of cryptographic data. Based on the first encrypted value and on second encrypted values, the apparatus may generate encrypted residual values representative of second account data associated with one or more reference accounts, and the apparatus may request and receive a decrypted residual value associated with each of the encrypted residual values from a second computing system. The apparatus may transmit the decrypted residual values to the first computing system, which may validate the first account data based on at least the decrypted residual values and perform operations associated with the validated first account data.

Abstract: A vehicle shifter assembly having a housing rotatably supporting a monostable toggle knob accessible to a vehicle operator. A processor enabled printed circuit board is incorporated into the housing and, upon actuation of the knob, instructs a gear shift condition to a display component. The housing can be incorporated into any of a variety of locations accessible to the vehicle operator, including being integrated into the steering wheel so that, and upon rotation of the wheel, the housing or display is continuously reoriented so as to maintain an upright position as viewed by the operator.

Abstract: The present invention is directed to a cosmetic composition precursor that is rapidly hydratable and conducive to creating a personalized end-product. This invention thus relates to a cosmetic composition precursor having fatty acid, inorganic base, and high HLB surfactants and methods of using said precursors in creating the end-product. The invention also relates to end-use compositions made from the hydratable cosmetic composition precursor of the invention.

Abstract: A plunger lock mechanism including a housing containing a rotationally supported lever shaped component, the component including at least one notch or recess configured within an arcuate surface. An electric motor is configured to rotate a cam extending within the housing, the cam actuating at least one plunger having an extending portion aligning with a selected notch. Upon rotation of the cam by the motor, the plunger is caused to displace between either of engaged and disengaged positions with the component such that, when disengaged, permitting rotation of the component.

Abstract: An object detection system comprises two or more directional antennas arranged such that lobes of the antennas overlap within a designated area or volume. An electronic device detecting signals from at least two of the directional antennas is determined to be inside the area/volume, and a device detecting signals from none of the antennas or only one antenna is determined not to be inside the area/volume. In this manner, the system determines when a user has placed an electronic device within the area/volume, logs the time the electronic device is within the area/volume, and reports the logged time to the user and/or a central system. The area/volume can comprise a platform, a box, or other confined space.

Abstract: The present disclosure is directed to one or more embodiments of mailer package assemblies including a fixed release liner and a mailer package. The fixed release liner is removably or detachably coupled to the mailer package by an adhesive layer. The fixed release liner includes one or more wickets (e.g., openings) such that the fixed release liner may be mounted to a wall by inserting fasteners (e.g., tack(s), pin(s), etc.) into the openings. The mailer package may be removed, detached, or decoupled from the fixed release liner by pulling on the mailer package decoupling the fixed release liner from the mailer package. After the mailer package is removed, an packaging associate may place an item or product within the mailer package to be shipped to a consumer. After the mailer package is removed from the fixed release liner, the fixed release liner remains mounted to the wall.

Abstract: There is a provided a digital identity network interface system that may include a communications module and a processor. The processor may be configured to receive a signal representing a digital identity request, the digital identity request defining one or more scopes associated with the request, at least one of the scopes identifying a data type associated with the request, generate a query based on the scopes by translating at least one of the scopes into a query having a query format associated with a digital identity network, the digital identity network storing data associated with a plurality of users, send a signal representing the query to the digital identity network, send a link to an authorization device, after successful authentication, obtain data associated with the digital identity request from the digital identity network, and release at least some of the data.

Abstract: The disclosed exemplary embodiments include computer-implemented apparatuses and methods that validate confidential data based privacy-preserving homomorphic computations involving encrypted data. For example, an apparatus may receive, from a first computing system, encrypted data that includes a first encrypted value representative of at least one of first account data or an element of cryptographic data. Based on the first encrypted value and on second encrypted values, the apparatus may generate encrypted residual values representative of second account data associated with one or more reference accounts, and the apparatus may request and receive a decrypted residual value associated with each of the encrypted residual values from a second computing system. The apparatus may transmit the decrypted residual values to the first computing system, which may validate the first account data based on at least the decrypted residual values and perform operations associated with the validated first account data.

Abstract: Provided are compounds of Formula (I?) or (II?), or pharmaceutically acceptable salts thereof, and methods for their use and production.

Abstract: The disclosure relates to modified vaccinia virus vectors derived from the Copenhagen strain of vaccinia virus, as well as methods of using the same for the treatment of various cancers. The disclosure provides modified Copenhagen-derived vaccinia virus vectors that exhibit various beneficial therapeutic activities, including enhanced oncolytic activity, spread of infection, immune evasion, tumor persistence, capacity for incorporation of exogenous DNA sequences, amenability for large scale manufacturing, and safety.

Abstract: The disclosed exemplary embodiments include computer-implemented systems, apparatuses, and processes that perform homomorphic computations on encrypted third-party data within a distributed computing environment. For example, an apparatus receives a homomorphic public key and encrypted transaction data characterizing an exchange of data from a computing system, and encrypts modelling data associated with a first predictive model using the homomorphic public key. The apparatus may perform homomorphic computations that apply the first predictive model to the encrypted transaction data in accordance with the encrypted first modelling data, and transmit an encrypted first output of the homomorphic computations to the computing system, which may decrypt the encrypted first output using a homomorphic private key and generate decrypted output data indicative of a predicted likelihood that the data exchange represents fraudulent activity.

Abstract: Described is a computer implemented method for updating a treatment model for a patient. Also described is a corresponding computer system and computer program product.

Abstract: The disclosed exemplary embodiments include computer-implemented systems, devices, apparatuses, and processes that maintain data confidentiality in communications involving voice-enabled devices operating within a distributed computing environment. By way of example, an apparatus may receive, from a communications system across a public communications network, a request for an element of data generated by the computing system based on first audio content obtained at a device. The apparatus may obtain the requested data element and further, may generate acoustic data representative of at least a portion of the requested data element. The apparatus may also generate an encrypted response to the received request that includes the acoustic data, and transmit the encrypted response to the device across the public communications network.

Abstract: The disclosed exemplary embodiments include computer-implemented systems, apparatuses, and processes that perform homomorphic computations on encrypted third-party data within a distributed computing environment. For example, an apparatus receives a homomorphic public key and encrypted transaction data characterizing an exchange of data from a computing system, and encrypts modelling data associated with a first predictive model using the homomorphic public key. The apparatus may perform homomorphic computations that apply the first predictive model to the encrypted transaction data in accordance with the encrypted first modelling data, and transmit an encrypted first output of the homomorphic computations to the computing system, which may decrypt the encrypted first output using a homomorphic private key and generate decrypted output data indicative of a predicted likelihood that the data exchange represents fraudulent activity.

Abstract: A plunger lock mechanism including a housing containing a rotationally supported lever shaped component, the component including at least one notch or recess configured within an arcuate surface. An electric motor is configured to rotate a cam extending within the housing, the cam actuating at least one plunger having an extending portion aligning with a selected notch. Upon rotation of the cam by the motor, the plunger is caused to displace between either of engaged and disengaged positions with the component such that, when disengaged, permitting rotation of the component.

Abstract: The disclosed exemplary embodiments include computer-implemented systems, apparatuses, and processes that dynamically manage exchanges of data using a cryptographically secure distributed ledger and homomorphic commitments. For example, and in response to an occurrence of a triggering event, an apparatus may obtain parameter values that characterize the data exchange, first commitment values representative of the parameter values, and a first digital signature. In response to a verification of the first digital signature, the apparatus may apply a second digital signature to commitment data that includes the first commitment values and a second commitment value representative of the first digital signature. The apparatus may transmit a signal that includes the commitment data and the second digital signature to a computing system, which generates an element of distributed ledger that includes the commitment data and the second digital signature in response to a verification of the second digital signature.