Abstract: Provided are compounds of Formula (I?) or (II?), or pharmaceutically acceptable salts thereof, and methods for their use and production.

Abstract: The disclosed exemplary embodiments include computer-implemented systems, apparatuses, and processes that perform homomorphic computations on encrypted third-party data within a distributed computing environment. For example, an apparatus receives a homomorphic public key and encrypted transaction data characterizing an exchange of data from a computing system, and encrypts modelling data associated with a first predictive model using the homomorphic public key. The apparatus may perform homomorphic computations that apply the first predictive model to the encrypted transaction data in accordance with the encrypted first modelling data, and transmit an encrypted first output of the homomorphic computations to the computing system, which may decrypt the encrypted first output using a homomorphic private key and generate decrypted output data indicative of a predicted likelihood that the data exchange represents fraudulent activity.

Abstract: Described is a computer implemented method for updating a treatment model for a patient. Also described is a corresponding computer system and computer program product.

Abstract: The disclosed exemplary embodiments include computer-implemented systems, devices, apparatuses, and processes that maintain data confidentiality in communications involving voice-enabled devices operating within a distributed computing environment. By way of example, an apparatus may receive, from a communications system across a public communications network, a request for an element of data generated by the computing system based on first audio content obtained at a device. The apparatus may obtain the requested data element and further, may generate acoustic data representative of at least a portion of the requested data element. The apparatus may also generate an encrypted response to the received request that includes the acoustic data, and transmit the encrypted response to the device across the public communications network.

Abstract: The disclosed exemplary embodiments include computer-implemented systems, apparatuses, and processes that perform homomorphic computations on encrypted third-party data within a distributed computing environment. For example, an apparatus receives a homomorphic public key and encrypted transaction data characterizing an exchange of data from a computing system, and encrypts modelling data associated with a first predictive model using the homomorphic public key. The apparatus may perform homomorphic computations that apply the first predictive model to the encrypted transaction data in accordance with the encrypted first modelling data, and transmit an encrypted first output of the homomorphic computations to the computing system, which may decrypt the encrypted first output using a homomorphic private key and generate decrypted output data indicative of a predicted likelihood that the data exchange represents fraudulent activity.

Abstract: A plunger lock mechanism including a housing containing a rotationally supported lever shaped component, the component including at least one notch or recess configured within an arcuate surface. An electric motor is configured to rotate a cam extending within the housing, the cam actuating at least one plunger having an extending portion aligning with a selected notch. Upon rotation of the cam by the motor, the plunger is caused to displace between either of engaged and disengaged positions with the component such that, when disengaged, permitting rotation of the component.

Abstract: The disclosed exemplary embodiments include computer-implemented systems, apparatuses, and processes that dynamically manage exchanges of data using a cryptographically secure distributed ledger and homomorphic commitments. For example, and in response to an occurrence of a triggering event, an apparatus may obtain parameter values that characterize the data exchange, first commitment values representative of the parameter values, and a first digital signature. In response to a verification of the first digital signature, the apparatus may apply a second digital signature to commitment data that includes the first commitment values and a second commitment value representative of the first digital signature. The apparatus may transmit a signal that includes the commitment data and the second digital signature to a computing system, which generates an element of distributed ledger that includes the commitment data and the second digital signature in response to a verification of the second digital signature.

Abstract: A computer-implemented method is disclosed for training one or more machine-learned models. The method can include inputting a first image frame and a second image frame into a feature disentanglement model and receiving, as an output of the machine-learned feature disentanglement model, a state feature and a perspective feature. The method can include inputting the state feature and the perspective feature into a machine-learned decoder model and receiving, as an output of the machine-learned decoder model, the reconstructed image frame. The method can include comparing the reconstructed image frame with a third image frame corresponding with the location and the perspective orientation. The method can include adjusting one or more parameters of the machine-learned feature disentanglement model based on the comparison of the reconstructed image frame and the third image frame.

Abstract: The disclosed exemplary embodiments include computer-implemented systems, devices, apparatuses, and processes that maintain data confidentiality in communications involving voice-enabled devices operating within a distributed computing environment. By way of example, an apparatus may receive, from a communications system across a public communications network, a request for an element of data generated by the computing system based on first audio content obtained at a device. The apparatus may obtain the requested data element and further, may generate acoustic data representative of at least a portion of the requested data element. The apparatus may also generate an encrypted response to the received request that includes the acoustic data, and transmit the encrypted response to the device across the public communications network.

Abstract: A user interface of an entity-centric knowledge discovery system presents an entity profile including a mix of structured and unstructured data relating to an entity. As a user refines the entity profile based on information gathered from various sources, the changing entity profile can be used as a substantially continuously updating query to search, retrieve, and rank new and pertinent information specifically relevant to the profiled entity. The platform described herein provide an active loop for refining an entity description and searching for additional information in which human input and machine-based algorithms can cooperate to more quickly build a comprehensive description of an entity of interest.

Abstract: Vapor-permeable, substantially water-impermeable, corrosion-inhibiting composites are disclosed herein. For instance, disclosed herein are composites comprising a first layer comprising a first nonwoven; and a second layer adjacent to and mechanically integrated with the first layer, the second layer comprising a polymer having a melt flow index of about 10 g/10 mins to about 200 g/10 mins, and a corrosion inhibitor, wherein the composite has a moisture vapor transmission rate of from about 25 g/m2/day to about 1000 g/m2/day when measured at about 23° C. and about 50% relative humidity. Also disclosed herein are methods of making and using the same.

Abstract: A system for prioritizing patient information associated with one or more patients of a plurality of patients receiving treatment via respective devices of a plurality of medical devices, the system comprising memory and one or more processors coupled to the memory. The one or more processors are configured to receive patient information from each medical device of the plurality of medical devices and select the patient information from a subset of the plurality of medical devices based on one or more importance attributes associated with the patient information. The one or more processors are further configured to prioritize the selected patient information to generate a list of one or more prioritized patients of the plurality of patients and cause an output of an indication of the patient information for the one or more prioritized patients.

Abstract: A system for selecting a sensitivity level for adjusting an intensity setting for therapy provided to a patient includes one or more processors and one or more processors coupled to the memory. The one or more processors are configured to receive an indication of an input to adjust an intensity setting related to the therapy provided to the patient and determine a sensitivity level for adjustment of the intensity setting based on an efficacy of the therapy provided to the patient. The one or more processors are further configured to determine an updated intensity level for the intensity setting based on the sensitivity level and the input to adjust the intensity setting and output an instruction to cause a medical device to provide the therapy at the updated intensity level.

Abstract: A device comprising memory and processing circuitry coupled to the memory. The processing circuitry is configured to receive patient information for a medical device associated with the patient and select a communication mode for the patient based on the patient information. The processing circuitry is further configured to cause an output of the indication of the patient information using the selected communication mode.

Abstract: An air amplifier utilizes a high-pressure input stream of air to accelerate a low-velocity input stream of air to provide a high-velocity, high-volume output stream of air. A coupled air amplifier array includes multiple air amplifiers which couple their respective output streams of air to one another to form a single collective output stream of air. Multiple coupled air amplifier arrays can be utilized to form coupled air amplifier array systems to provide multiple collective output streams of air which can be focused toward to an audience within a venue. The coupled air amplifier array system can be implemented within atmospheric effects systems to provide atmospheric effects, such as wind, scent, and/or temperature to provide some examples, relating to an event. These atmospheric effects systems can present these atmospheric effects to the audience to enhance the immersion of the audience as they are viewing the event.

Abstract: A park release mechanism for a vehicle, including an upper housing and an assembleable lower housing. A cam with a projecting handle is arranged between the upper and lower housings and defines a range of pivotal rotation relative the housings. A cable is secured at one end to the cam and adapted to secure at an opposite end to a transmission of the vehicle. An unlock component is incorporated into the housing in communication with the cam and handle and, upon actuating, to shift the vehicle to and from a Park position upon actuation of the handle and displacement of the cable.

Abstract: The disclosed exemplary embodiments include computer-implemented apparatuses and methods that validate confidential data based privacy-preserving homomorphic computations involving encrypted data. For example, an apparatus may receive, from a first computing system, encrypted data that includes a first encrypted value representative of at least one of first account data or an element of cryptographic data. Based on the first encrypted value and on second encrypted values, the apparatus may generate encrypted residual values representative of second account data associated with one or more reference accounts, and the apparatus may request and receive a decrypted residual value associated with each of the encrypted residual values from a second computing system. The apparatus may transmit the decrypted residual values to the first computing system, which may validate the first account data based on at least the decrypted residual values and perform operations associated with the validated first account data.