Abstract: Disclosed are methods for conditionally immortalizing stem cells, including adult and embryonic stem cells, the cells produced by such methods, therapeutic and laboratory or research methods of using such cells, and methods to identify compounds related to cell differentiation and development or to treat diseases, using such cells. A mouse model of acute myeloid leukemia (AML) and cells and methods related to such mouse model are also described.

Abstract: Provided herein are methods for preparing differentiated cells, and the cells prepared by such methods.

Abstract: Disclosed are methods for conditionally immortalizing stem cells, including adult and embryonic stem cells, the cells produced by such methods, therapeutic and laboratory or research methods of using such cells, and methods to identify compounds related to cell differentiation and development or to treat diseases, using such cells. A mouse model of acute myeloid leukemia (AML) and cells and methods related to such mouse model are also described.

Abstract: Disclosed are methods for conditionally immortalizing stem cells, including adult and embryonic stem cells, the cells produced by such methods, therapeutic and laboratory or research methods of using such cells, and methods to identify compounds related to cell differentiation and development or to treat diseases, using such cells. A mouse model of acute myeloid leukemia (AML) and cells and methods related to such mouse model are also described.

Abstract: Articles having substantially cylindrical bodies including a plurality of circumferential layers, each layer having at least one ply of material, the material comprising a weave fabric, a non-crimp fabric, or a combination thereof.

Abstract: Provided herein are various processes for the improved production of antibody producing organisms, antibody producing tissues, antibody producing cells and antibodies. In certain embodiments, provided herein are methods for rapidly producing antibody producing organisms, tissues, cells and antibodies derived from humans, organisms, plants or cells that are genetically altered to over-express certain proteins.

Abstract: A stabilizer actuator has a first end for connecting to an aircraft support structure and a second end for connecting to a stabilizer. The actuator includes a primary load path for transmittal of loads acting on the stabilizer to the aircraft support structure, and a secondary load path for transmittal of loads acting on the stabilizer to the aircraft support structure upon failure of the primary load path. The secondary load path includes a tie rod extending along a longitudinal axis, a load path locking mechanism coupled to the tie rod, a lock housing having a central bore for receiving the locking mechanism, and at least one radially movable segment that, upon failure of the primary load path, moves radially to lock the tie rod to the lock housing against axial and/or radial movement.

Abstract: Disclosed herein are methods of modulation of the viability of a cell. Further disclosed herein are methods of modulating an immune response. Further disclosed herein are methods of identifying agents capable of modulation of the viability of a cell or an immune response. Further disclosed herein are agents and compositions capable of modulation of the viability of a cell or an immune response.

Abstract: Disclosed are methods for conditionally immortalizing stem cells, including adult and embryonic stem cells, the cells produced by such methods, therapeutic and laboratory or research methods of using such cells, and methods to identify compounds related to cell differentiation and development or to treat diseases, using such cells. A mouse model of acute myeloid leukemia (AML) and cells and methods related to such mouse model are also described.

Abstract: Disclosed are methods for manipulating and expanding stem cell populations, including adult stem cells, the cells produced by such methods, and various protein constructs related thereto.

Abstract: Disclosed herein are methods of modulation of the viability of a cell. Further disclosed herein are methods of modulating an immune response. Further disclosed herein are methods of identifying agents capable of modulation of the viability of a cell or an immune response. Further disclosed herein are agents and compositions capable of modulation of the viability of a cell or an immune response.

Abstract: Disclosed herein are methods of modulation of the viability of a cell. Further disclosed herein are methods of modulating an immune response. Further disclosed herein are methods of identifying agents capable of modulation of the viability of a cell or an immune response. Further disclosed herein are agents and compositions capable of modulation of the viability of a cell or an immune response.

Abstract: This invention generally relates to methods for the production of antibody producing cells and antibodies in protooncogene expressing animals. The invention also relates to methods for the efficient production of antibodies specific for antigens that are normally subject to immunological constraints such as self tolerance. The invention further relates to the production of antibody producing cells and antibodies without the need for the conventional fusing of antibody producing B cells with a myeloma fusion partner.

Abstract: A hydraulic manifold assembly having a block including a plurality of fluid ports provided on a common surface of the block, and a set of hydraulic fittings. Each fitting is assigned to a prescribed one of the ports. Each fitting includes a hollow bolt insertable into the prescribed fluid port, and a banjo block having a first aperture for receiving the hollow bolt and a second aperture intersecting the first aperture. The second aperture provides an external fluid port for fluidly coupling a remote device. The plurality of banjo blocks includes at least one adjacent pair of banjo blocks that are unique from each other and have exterior shapes complementary to each other to control the relative orientation therebetween when coupled to the prescribed fluid ports. The exterior shapes of the adjacent banjo blocks cooperate to prevent misassembly.

Abstract: Processes for producing near net-shape panels and panels formed thereby. The processes include forming a preform to comprise a stack of multiple plies that contain an uncured expandable foam material. The preform has regions that differ from each other by the number and/or volume of the plies therein. The preform and its plies are then cured within a restricted volume to produce a near net-shape panel. The curing step causes the expandable foam material to expand, and the restricted volume is sized so that the number and volume of the plies within the regions of the preform cause zones within the panel to have different densities and/or thicknesses.