Abstract: A removable barrier is provided that prevents flow between an exterior of a mandrel and an interior of a mandrel. In one embodiment a dissolvable shroud surrounds the ports of the gas lift valve and temporarily prevents flow between the exterior of the gas lift valve and the interior of the mandrel. In an additional embodiment, a dissolvable plug may be placed within a portion of the gas lift valve or a portion of the lug in the mandrel to temporarily prevent flow between the exterior of the gas lift valve and the interior of the mandrel. In another embodiment, a dissolvable sleeve is placed within the mandrel to cover the port within the mandrel to temporarily prevent flow between the exterior of the gas the valve in the interior of the mandrel.

Abstract: The present disclosure relates generally to the field of medical devices for treating heart disease. In particular, the present disclosure relates to medical devices, systems, and methods for delivering artificial chordae tendineae in a patient. A system for delivering a chordae tendineae into a heart may include a delivery catheter. A clamp catheter may be configured to translate through the delivery catheter. A spreader may be disposed on the clamp catheter. A first clamp may be at least partially contained in the spreader in a closed configuration and may be attached to the chordae tendineae. An anchor catheter may be configured to translate through the delivery catheter and may have an anchor attached to the chordae tendineae. A sheath may be extended over the anchor catheter and anchor and may be configured to restrain an arm of the anchor.

Abstract: In one implementation, a content processing system includes a computing platform having a hardware processor and a system memory storing a content classification software code, a natural language processor, and a computer vision analyzer. The hardware processor executes the content classification software code to receive content inputs from multiple content sources, and, for each content input, to parse the content input for metadata describing the content input, obtain a description of language-based content included in the content input from the natural language processor, and obtain a description of visual content included in the content input from the computer vision analyzer.

Abstract: Described herein are compositions for delaying onset or delaying progression of frailty, reversing aging phenotype, extending healthspan, compressing morbidity, increasing lifespan and reducing formation of senescent cells.

Abstract: In one implementation, a content processing system includes a computing platform having a hardware processor and a system memory storing a content classification software code, a natural language processor, and a computer vision analyzer. The hardware processor executes the content classification software code to receive content inputs from multiple content sources, and, for each content input, to parse the content input for metadata describing the content input, obtain a description of language-based content included in the content input from the natural language processor, and obtain a description of visual content included in the content input from the computer vision analyzer.

Abstract: A delayed opening sliding sleeve system includes a first sleeve that prevents initiating the dissolution or erosion of a dissolvable or erodible retainer. The first sleeve is opened by a pressure cycle to expose or otherwise initiate the dissolution of a retainer. The retainer holds a second sleeve in place. The second sleeve is held closed against subsequent pressure cycles until such time as the retainer is dissolved or otherwise removed. With the retainer removed the second sleeve may be opened allowing fluid communication between the exterior and the interior of the sleeve system.

Abstract: In wellbore completions it is sometimes desirable to seal the wellbore against fluid flow or to anchor a component within the wellbore. However, running such a plug into the wellbore has been problematic on occasion such as when the nose of the plug encounters an object within the wellbore such as a sand bridge or other obstruction. In those instances, the way of the tubular pushing the plug into the wellbore combined with the nose of the plug being unable to pass the instruction causes the plug to prematurely set. Such an instance the plug may need to be drilled out in order to proceed. In the present embodiment the tubular used to move the plug into the well is attached to the nose of the plug so that the force provided to the plug by the tubular is transmitted only to the nose of the plug preventing the plug from presetting and allowing the plug to push past or through an obstacle within the wellbore.

Abstract: A method of selecting an edge proxy server to serve web contents to user devices is disclosed. Domain name system (DNS) queries from a domain name resolver are received. A mapping between the domain name resolver and a corresponding list of user devices served by the domain name resolver are created based on the received DNS queries. A transformed geographical location representing the domain name resolver is determined based on the mapping. An edge proxy server is selected in response to a future DNS query received from the domain name resolver based at least in part on the transformed geographical location of the domain name resolver.

Abstract: Apparatus, systems, and methods are described for a heating system incorporated into a garment. An example garment includes: a heating element disposed proximate an internal surface of the garment; a temperature sensor configured to measure a temperature outside of the garment; a motion sensor configured to measure movement of the garment; and a controller configured to adjust power to the heating element based on signals received from the temperature sensor and the motion sensor.

Abstract: A system including two or more wearable devices includes at least one sensor in each device to detect signals related to the body of a wearer. User inputs, sensor outputs, or other information are used to determine an activity being performed or otherwise engaged in by the wearer and footsteps, heartbeats, discrete turns of the torso, or other events can be detected, from one or more of the sensor outputs, during a period of time that the user is engaged in the activity. A duration, amplitude, timing, mean value, or other characteristic of each such detected event can be determined, based on the sensor outputs, and used to generate a sample of clinically relevant information about the wearer. This information can then be used to determine the presence, stage, degree, progression, or other information about a disease state of the wearer or some other information about the wearer's body.

Abstract: A method of delivering webpages to a browser includes delivering a first webpage using a streaming protocol that optimizes delivery of content of the first webpage where the first webpage includes information that may persist in a browser cache; delivering a second webpage without using the streaming protocol where the second webpage and the first webpage both reference a first resource; and forcing revalidation of the first resource stored on the browser cache.

Abstract: A pregnancy light includes a magnetic base, a base plate, a plurality of light emitting diode (LED) lights, a control system, and an outer covering. The base plate is fixedly attached to the magnetic base. The plurality of LED lights are mounted around a periphery of the base plate. The control system is coupled to the plurality of LED lights and operable to independently and collectively produce a rotating light pattern. The magnetic base may also be equipped with suctions that can securely allow the pregnancy light to remain fixed on the surface of a motorized vehicle, in tandem with the magnetic ring attached to the base. Additionally, the covering for the magnetic base may be made of a rubber-like material to prevent movement of the pregnancy light while situated on a moving vehicle.

Abstract: The invention encompasses the novel class of compounds represented by the Formula (I) below, which are inhibitors of the TC-PTP enzyme. The invention also encompasses pharmaceutical compositions which include the compounds shown above and methods of treating or preventing TC-PTP mediated diseases, including cancer, via their use in the activation of antigen-presenting cells, like dendritic cells, for applications in the immunotherapeutic treatment of diseases.

Abstract: In wellbore completions it is desirable to cement or otherwise seal the casing to the wellbore. Many times such operations include sealing the interior of the casing against flow. In those instances a means to open the interior of the casing to fluid flow and thereby establish circulation in the well upon command is needed. Additionally it is desirable to be able to pressurize the well several times prior to establishing circulation. In an embodiment of the current invention an interior sleeve block fluid flow through ports in the housing. The inner sleeve is coupled to a j-slot so that a pressurization cycle will move the inner sleeve and cause the inner sleeve to rotate a predetermined distance. Upon reaching the access position in the j-slot the sleeve is allowed to move to a fully open position.

Abstract: The invention encompasses the novel class of compounds represented by the Formula (I) below, which are inhibitors of the TC-PTP enzyme. The invention also encompasses pharmaceutical compositions which include the compounds shown above and methods of treating or preventing TC-PTP mediated diseases, including cancer, via their use in the activation of antigen-presenting cells, like dendritic cells, for applications in the immunotherapeutic treatment of diseases.

Abstract: A method of delivering an image is disclosed. The method includes receiving a request for an image. A variation of quality signature (VoQS) of the image is determined. A VoQS of a particular image is determined based on a plurality of different levels of distortion applied to the particular image. The image is categorized into one of a plurality of clusters of images, wherein the categorization is based on a similarity between the VoQS of the image and one or more other VoQSs of one or more other images within the plurality of clusters of images. A distorted version of the image based on the categorization is delivered.

Abstract: The invention encompasses the novel class of compounds represented by the Formula (I) below, which are inhibitors of the TC-PTP enzyme. The invention also encompasses pharmaceutical compositions which include the compounds shown above and methods of treating or preventing TC-PTP mediated diseases, including cancer, via their use in the activation of antigen-presenting cells, like dendritic cells, for applications in the immunotherapeutic treatment of diseases.

Abstract: Providing interaction to an application with a collection of information stored in a Document Object Model is disclosed. The collection is maintained in the Document Object Model. A virtualization layer provides one or more collection interfaces to the collection. An indication of an interaction of the application with the collection is received. The collection interfaces include a safety buffer and the interaction of the application with the safety buffer triggers a functionality of the virtualization layer.

Abstract: The invention encompasses the novel class of compounds represented by the Formula (I) below, which are inhibitors of the TC-PTP enzyme. The invention also encompasses pharmaceutical compositions which include the compounds shown above and methods of treating or preventing TC-PTP mediated diseases, including cancer, via their use in the activation of antigen-presenting cells, like dendritic cells, for applications in the immunotherapeutic treatment of diseases.