Patents by Inventor Brian Kobilka

Brian Kobilka has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11834489
    Abstract: Disclosed herein are methods for providing a molecular efficacy of a ligand, especially when utilizing single-molecule fluorescence resonance energy transfer (“smFRET”) imaging, as well as compounds useful in such methods.
    Type: Grant
    Filed: August 31, 2018
    Date of Patent: December 5, 2023
    Assignees: CORNELL UNIVERSITY, THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
    Inventors: Scott C. Blanchard, Gabriel Glenn Gregorio, Brian Kobilka
  • Patent number: 11484525
    Abstract: Described herein, inter alia, are compositions and methods for modulating mu opioid receptor activity.
    Type: Grant
    Filed: July 6, 2020
    Date of Patent: November 1, 2022
    Assignees: The Regents of the University of California, Friedrich-Alexander-Universität Erlangen-Nürnberg, The Board of Trustees of the Leland Stanford Junior University, The University of North Carolina at Chapel Hill
    Inventors: Brian K. Shoichet, Henry Lin, Peter Gmeiner, Aashish Manglik, Brian Kobilka, Bryan L. Roth, Daniela Gisela Dengler
  • Patent number: 11352422
    Abstract: Agents that specifically bind to an opioid receptor in a conformationally specific way can be used to induce a conformational change in the receptor. Such agents have therapeutic applications and can be used in X-ray crystallography studies of the receptor. Such agents can also be used to improve drug discovery via compound screening and/or structure-based drug design.
    Type: Grant
    Filed: March 15, 2019
    Date of Patent: June 7, 2022
    Assignees: VIB VZW, Vrije Univeriteit Brussel, Board of Trustees Leland Stanford Jr University
    Inventors: Jan Steyaert, Toon Laeremans, Els Pardon, Brian Kobilka, Aashish Manglik
  • Publication number: 20220099683
    Abstract: The present invention relates to the field of GPCR structure biology and signaling. In particular, the present invention relates to protein binding domains directed against or capable of specifically binding to a functional conformational state of a G-protein-coupled receptor (GPCR). More specifically, the present invention provides protein binding domains that are capable of increasing the stability of a functional conformational state of a GPCR, in particular, increasing the stability of a GPCR in its active conformational state. The protein binding domains of the present invention can be used as a tool for the structural and functional characterization of G-protein-coupled receptors bound to various natural and synthetic ligands, as well as for screening and drug discovery efforts targeting GPCRs. Moreover, the invention also encompasses the diagnostic, prognostic and therapeutic usefulness of these protein binding domains for GPCR-related diseases.
    Type: Application
    Filed: October 21, 2021
    Publication date: March 31, 2022
    Inventors: Jan Steyaert, Els Pardon, Soren G.F. Rasmussen, Juan Jose Fung, Brian Kobilka, Toon Laeremans
  • Publication number: 20210340249
    Abstract: Agents that specifically bind to a muscarinic acetylcholine receptor in a conformationally specific way can be used to induce a conformational change in the receptor. Such agents have therapeutic applications and can be used in X-ray crystallography studies of the receptor. Such agents can also be used to improve drug discovery via compound screening and/or structure based drug design.
    Type: Application
    Filed: July 2, 2021
    Publication date: November 4, 2021
    Inventors: Jan Steyaert, Els Pardon, Brian Kobilka, Aaron Ring, Andrew Kruse, Aashish Manglik
  • Patent number: 11162953
    Abstract: The present invention relates to the field of GPCR structure biology and signaling. In particular, the present invention relates to protein binding domains directed against or capable of specifically binding to a functional conformational state of a G-protein-coupled receptor (GPCR). More specifically, the present invention provides protein binding domains that are capable of increasing the stability of a functional conformational state of a GPCR, in particular, increasing the stability of a GPCR in its active conformational state. The protein binding domains of the present invention can be used as a tool for the structural and functional characterization of G-protein-coupled receptors bound to various natural and synthetic ligands, as well as for screening and drug discovery efforts targeting GPCRs. Moreover, the invention also encompasses the diagnostic, prognostic and therapeutic usefulness of these protein binding domains for GPCR-related diseases.
    Type: Grant
    Filed: July 30, 2019
    Date of Patent: November 2, 2021
    Assignees: VIB VZW, Vrije Universiteit Brussel, Board of Trustees of Leland Stanford Jr University
    Inventors: Jan Steyaert, Els Pardon, Soren G. F. Rasmussen, Juan Jose Fung, Brian Kobilka, Toon Laeremans
  • Patent number: 11162954
    Abstract: The present invention relates to the field of GPCR structure biology and signaling. In particular, the present invention relates to protein binding domains directed against or capable of specifically binding to a functional conformational state of a G-protein-coupled receptor (GPCR). More specifically, the present invention provides protein binding domains that are capable of increasing the stability of a functional conformational state of a GPCR, in particular, increasing the stability of a GPCR in its active conformational state. The protein binding domains of the present invention can be used as a tool for the structural and functional characterization of G-protein-coupled receptors bound to various natural and synthetic ligands, as well as for screening and drug discovery efforts targeting GPCRs. Moreover, the invention also encompasses the diagnostic, prognostic and therapeutic usefulness of these protein binding domains for GPCR-related diseases.
    Type: Grant
    Filed: July 30, 2019
    Date of Patent: November 2, 2021
    Assignees: VIB VZW, Vrije Universiteit Brussel, Board of Trustees Leland Stanford Jr University
    Inventors: Jan Steyaert, Els Pardon, Soren G. F. Rasmussen, Juan Jose Fung, Brian Kobilka, Toon Laeremans
  • Publication number: 20210072155
    Abstract: Disclosed herein are methods for providing a molecular efficacy of a ligand, especially when utilizing single-molecule fluorescence resonance energy transfer (“smFRET”) imaging, as well as compounds useful in such methods.
    Type: Application
    Filed: August 31, 2018
    Publication date: March 11, 2021
    Applicant: Cornell University
    Inventors: Scott C. Blanchard, Gabriel Glenn Gregorio, Brian Kobilka
  • Publication number: 20210052548
    Abstract: Described herein, inter alia, are compositions and methods for modulating mu opioid receptor activity.
    Type: Application
    Filed: July 6, 2020
    Publication date: February 25, 2021
    Applicants: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY, THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
    Inventors: Brian K. Shoichet, Henry Lin, Peter Gmeiner, Aashish Manglik, Brian Kobilka, Bryan L. Roth, Daniela Gisela Dengler
  • Publication number: 20200308168
    Abstract: The present invention relates to fluorophenyl substituted muscarinic receptor ligands with selectivity for M3 over M2 and to the use of these compounds in the treatment of various diseases such as asthma, chronic obstructive pulmonary disease (COPD), bronchopulmonary dysplasia (BPD) and urinary incontinence.
    Type: Application
    Filed: December 3, 2018
    Publication date: October 1, 2020
    Applicants: Friedrich-Alexander-Universität Erlangen-Nürnberg, The Board of Trustees of the Leland Stanford Junior University, The Regents of the University of California
    Inventors: Ashutosh BANERJEE, Amelie BARTUSCHAT, Katrin EITEL, Peter GMEINER, Markus HEINRICH, Josefa HOFMANN, Harald HÜBNER, Hannelore RAMPP, Benjamin SCHAAKE, Brian KOBILKA, Roger SUNAHARA, Mary Joyce CLARK, Inbar FISH, Brian SHOICHET
  • Patent number: 10780078
    Abstract: Described herein, inter alia, are compositions and methods for modulating mu opioid receptor activity.
    Type: Grant
    Filed: August 17, 2018
    Date of Patent: September 22, 2020
    Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, FRIEDRICH-ALEXANDER-UNIVERSITÄT, THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
    Inventors: Brian K. Shoichet, Anat Levit, Aashish Manglik, Brian Kobilka, Peter Gmeiner, Harald Hübner, Daniela Gisela Dengler
  • Publication number: 20200239534
    Abstract: The present disclosure relates to the field of G protein coupled receptor (GPCR) structural biology and signaling. In particular, the present disclosure relates to binding domains directed against and/or specifically binding to GPCR:G protein complexes. Also provided are nucleic acid sequences encoding such binding domains and cells expressing or capable of expressing such binding domains. The binding domains of the present disclosure can be used as universal tools for the structural and functional characterization of G-protein coupled receptors in complex with downstream heterotrimeric G proteins and bound to various natural or synthetic ligands, for investigating the dynamic features of G protein activation, as well as for screening and drug discovery efforts that make use of GPCR:G protein complexes.
    Type: Application
    Filed: April 17, 2020
    Publication date: July 30, 2020
    Inventors: Jan Steyaert, Els Pardon, Toon Laeremans, Brian Kobilka, Soren G.F. Rasmussen, Sebastien Granier, Roger K. Sunahara
  • Patent number: 10702498
    Abstract: Described herein, inter alia, are compositions and methods for modulating mu opioid receptor activity.
    Type: Grant
    Filed: June 30, 2016
    Date of Patent: July 7, 2020
    Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, FRIEDRICH-ALEXANDER-UNIVERSITAT ERLANGEN-NÜRNBERG, THE BOARD OF TRUSTEES OFTHE LELAND STANFORD JUNIOR UNIVERSITY, THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
    Inventors: Brian K. Shoichet, Henry Lin, Peter Gmeiner, Aashish Manglik, Brian Kobilka, Bryan L. Roth, Daniela Gisela Dengler
  • Patent number: 10626154
    Abstract: The present disclosure relates to the field of G protein coupled receptor (GPCR) structural biology and signaling. In particular, the present disclosure relates to binding domains directed against and/or specifically binding to GPCR:G protein complexes. Also provided are nucleic acid sequences encoding such binding domains and cells expressing or capable of expressing such binding domains. The binding domains of the present disclosure can be used as universal tools for the structural and functional characterization of G-protein coupled receptors in complex with downstream heterotrimeric G proteins and bound to various natural or synthetic ligands, for investigating the dynamic features of G protein activation, as well as for screening and drug discovery efforts that make use of GPCR:G protein complexes.
    Type: Grant
    Filed: May 1, 2017
    Date of Patent: April 21, 2020
    Assignees: VIB VZW, Vrije Universiteit Brussel, The Board of Trustees of the Leland Stanford Junior University, The Regents of the University of Michigan
    Inventors: Jan Steyaert, Els Pardon, Toon Laeremans, Brian Kobilka, Soren G. F. Rasmussen, Sebastien Granier, Roger K. Sunahara
  • Publication number: 20200109126
    Abstract: Described herein, inter alia, are compositions and methods for modulating mu opioid receptor activity.
    Type: Application
    Filed: January 5, 2018
    Publication date: April 9, 2020
    Inventors: Brian K. Shoichet, Peter Gmeiner, Harald Hübner, Bryan L. Roth, Daniela Gisela Dengler, Aashish Manglik, Brian Kobilka
  • Publication number: 20200025773
    Abstract: The present invention relates to the field of GPCR structure biology and signaling. In particular, the present invention relates to protein binding domains directed against or capable of specifically binding to a functional conformational state of a G-protein-coupled receptor (GPCR). More specifically, the present invention provides protein binding domains that are capable of increasing the stability of a functional conformational state of a GPCR, in particular, increasing the stability of a GPCR in its active conformational state. The protein binding domains of the present invention can be used as a tool for the structural and functional characterization of G-protein-coupled receptors bound to various natural and synthetic ligands, as well as for screening and drug discovery efforts targeting GPCRs. Moreover, the invention also encompasses the diagnostic, prognostic and therapeutic usefulness of these protein binding domains for GPCR-related diseases.
    Type: Application
    Filed: July 30, 2019
    Publication date: January 23, 2020
    Inventors: Jan Steyaert, Els Pardon, Soren G.F. Rasmussen, Juan Jose Fung, Brian Kobilka, Toon Laeremans
  • Publication number: 20190383825
    Abstract: The present invention relates to the field of GPCR structure biology and signaling. In particular, the present invention relates to protein binding domains directed against or capable of specifically binding to a functional conformational state of a G-protein-coupled receptor (GPCR). More specifically, the present invention provides protein binding domains that are capable of increasing the stability of a functional conformational state of a GPCR, in particular, increasing the stability of a GPCR in its active conformational state. The protein binding domains of the present invention can be used as a tool for the structural and functional characterization of G-protein-coupled receptors bound to various natural and synthetic ligands, as well as for screening and drug discovery efforts targeting GPCRs. Moreover, the invention also encompasses the diagnostic, prognostic and therapeutic usefulness of these protein binding domains for GPCR-related diseases.
    Type: Application
    Filed: June 28, 2019
    Publication date: December 19, 2019
    Inventors: Jan Steyaert, Els Pardon, Soren G.F. Rasmussen, Juan Jose Fung, Brian Kobilka, Toon Laeremans
  • Publication number: 20190383827
    Abstract: The present invention relates to the field of GPCR structure biology and signaling. In particular, the present invention relates to protein binding domains directed against or capable of specifically binding to a functional conformational state of a G-protein-coupled receptor (GPCR). More specifically, the present invention provides protein binding domains that are capable of increasing the stability of a functional conformational state of a GPCR, in particular, increasing the stability of a GPCR in its active conformational state. The protein binding domains of the present invention can be used as a tool for the structural and functional characterization of G-protein-coupled receptors bound to various natural and synthetic ligands, as well as for screening and drug discovery efforts targeting GPCRs. Moreover, the invention also encompasses the diagnostic, prognostic and therapeutic usefulness of these protein binding domains for GPCR-related diseases.
    Type: Application
    Filed: July 30, 2019
    Publication date: December 19, 2019
    Inventors: Jan Steyaert, Els Pardon, Soren G.F. Rasmussen, Juan Jose Fung, Brian Kobilka, Toon Laeremans
  • Publication number: 20190383829
    Abstract: The present invention relates to the field of GPCR structure biology and signaling. In particular, the present invention relates to protein binding domains directed against or capable of specifically binding to a functional conformational state of a G-protein-coupled receptor (GPCR). More specifically, the present invention provides protein binding domains that are capable of increasing the stability of a functional conformational state of a GPCR, in particular, increasing the stability of a GPCR in its active conformational state. The protein binding domains of the present invention can be used as a tool for the structural and functional characterization of G-protein-coupled receptors bound to various natural and synthetic ligands, as well as for screening and drug discovery efforts targeting GPCRs. Moreover, the invention also encompasses the diagnostic, prognostic and therapeutic usefulness of these protein binding domains for GPCR-related diseases.
    Type: Application
    Filed: July 30, 2019
    Publication date: December 19, 2019
    Inventors: Jan Steyaert, Els Pardon, Soren G.F. Rasmussen, Juan Jose Fung, Brian Kobilka, Toon Laeremans
  • Publication number: 20190383828
    Abstract: The present invention relates to the field of GPCR structure biology and signaling. In particular, the present invention relates to protein binding domains directed against or capable of specifically binding to a functional conformational state of a G-protein-coupled receptor (GPCR). More specifically, the present invention provides protein binding domains that are capable of increasing the stability of a functional conformational state of a GPCR, in particular, increasing the stability of a GPCR in its active conformational state. The protein binding domains of the present invention can be used as a tool for the structural and functional characterization of G-protein-coupled receptors bound to various natural and synthetic ligands, as well as for screening and drug discovery efforts targeting GPCRs. Moreover, the invention also encompasses the diagnostic, prognostic and therapeutic usefulness of these protein binding domains for GPCR-related diseases.
    Type: Application
    Filed: July 30, 2019
    Publication date: December 19, 2019
    Inventors: Jan Steyaert, Els Pardon, Soren G.F. Rasmussen, Juan Jose Fung, Brian Kobilka, Toon Laeremans