Patents by Inventor Brian Kobilka

Brian Kobilka has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • EUKARYOTIC EXPRESSION SYSTEM FOR THE INCORPORATION OF STABLE ISOTOPES INTO PROTEINS
    Publication number: 20090171073
    Abstract: Methods for producing stable isotope-labeled recombinant protein are provided. The methods include isolating a stable isotope-labeled recombinant protein from a Trichoplusia ni larva expressing a recombinant protein, which Trichoplusia ni larva has ingested a food source comprising stable isotope-labeled algae, thereby resulting in incorporation of a stable isotope into the recombinant protein to produce the stable isotope-labeled recombinant protein.
    Type: Application
    Filed: December 18, 2008
    Publication date: July 2, 2009
    Inventors: Brian Kobilka, Michael Bokoch
  • GPCR crystalization method using an antibody
    Publication number: 20090148510
    Abstract: An antibody that specifically binds a three dimensional epitope on the IC3 loop of a GPCR is provided. The antibody may be employed in a method that comprises: contacting a GPCR with a monovalent version of the antibody binding conditions to form a complex; and crystallizing the complex.
    Type: Application
    Filed: September 19, 2008
    Publication date: June 11, 2009
    Inventors: Brian Kobilka, Daniel K. Rohrer, Peter Brahms, Asna Masood
  • Method and composition for crystallizing G protein-coupled receptors
    Publication number: 20090118474
    Abstract: Certain embodiments provide a method for crystallizing a GPCR. The method may employ a fusion protein comprising: a) a first portion of a G-protein coupled receptor (GPCR), where the first portion comprises the TM1, TM2, TM3, TM4 and TM5 regions of the GPCR; b) a stable, folded protein insertion; and c) a second portion of the GPCR, where the second portion comprises the TM6 and TM7 regions of the GPCR.
    Type: Application
    Filed: October 15, 2008
    Publication date: May 7, 2009
    Inventors: Brian Kobilka, Daniel Rosenbaum
  • Modified G protein sunbunits
    Patent number: 6448377
    Abstract: The present invention provides modified G protein &agr;-subunits which are characterized by constitutive localization to the plasma membrane; enhanced binding to one or more of the normal receptor binding partners for that &agr;-subunit; and efficient binding to and activation of G protein binding partners. The distribution of these modified &agr;-subunits, which are “tethered” to the plasma membrane, allows the regulation of receptor-G protein coupling, and thus G-protein signaling, in various biological systems.
    Type: Grant
    Filed: September 27, 2000
    Date of Patent: September 10, 2002
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Brian Kobilka, Tae Weon Lee