Patents by Inventor Brian M. Holmes
Brian M. Holmes has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7279107Abstract: A system and method are used in connection with processing of blood components. The processing of blood components may involve centrifugal separation and/or filtering of the blood components. In some examples, at least some blood components are centrifugally separated in a chamber and then filtered via a filter rotating along with a centrifuge rotor, wherein the filter is located closer than the chamber to an axis of rotation of the rotor. The filter may include a porous filtration medium configured to filter leukocytes, platelets, and/or red blood cells. Some examples include a pressure sensor sensing pressure of pumped blood components. The sensed pressure may be used in connection with controlling the pumping of the blood products and/or in connection with determining the location of an interface associated with the blood products. Other uses of the sensed pressure are also possible.Type: GrantFiled: April 16, 2003Date of Patent: October 9, 2007Assignee: Gambro, Inc.Inventors: Niclas Högberg, Emanuel Hällgren, Peter Pihlstedt, Brian M. Holmes, Lars Persson, Lars Strandberg, Geert Van Waeg, Frank Corbin, III
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Patent number: 7166217Abstract: A system for separating a composite fluid into component parts thereof, including: a centrifuge having a rotor with a separation space and at least two valve members disposed thereon and a container set having a separation container adapted to be disposed in the separation space of the rotor and first and second collection containers connected to the separation container by a first and a second tubes. The tubes are adapted to be disposed in operative relationship with the valve members so that flow through the tubes may be controlled thereby. Three components of the composite fluid may be separated therefrom by the present system and two components may be moved to the collection containers. The container set may further include a third collection container connected to the separation container by a tube, and a third component may thus be moved to this third container.Type: GrantFiled: August 25, 2003Date of Patent: January 23, 2007Assignee: Gambro IncInventors: Brian M. Holmes, J-P Hagström, Per-Olov Lundberg, Geert Van Waeg, Peter Nordgren
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Patent number: 6902539Abstract: An extracorporeal blood processing system is disclosed which includes a variety of novel components and which may be operated in accordance with a variety of novel methodologies. For instance, the system includes a graphical operator interface which directs the operator through various aspects of the apheresis procedure. Moreover, the system also includes a variety of features relating to loading a blood processing vessel into a blood processing channel and removing the same after completion of the procedure. Furthermore, the system also includes a variety of features relating to utilizing a blood priming of at least portions of the apheresis system in preparation for the procedure. In addition, the system includes a variety of features enhancing the performance of the apheresis system, including the interrelationship between the blood processing vessel and the blood processing vessel and the utilization of high packing factors for the procedure.Type: GrantFiled: April 3, 2003Date of Patent: June 7, 2005Assignee: GamBro IncInventors: Marlene Adele Bainbridge, Brian M. Holmes
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Publication number: 20040104182Abstract: A system for separating a composite fluid into component parts thereof, including: a centrifuge having a rotor with a separation space and at least two valve members disposed thereon and a container set having a separation container adapted to be disposed in the separation space of the rotor and first and second collection containers connected to the separation container by a first and a second tubes. The tubes are adapted to be disposed in operative relationship with the valve members so that flow through the tubes may be controlled thereby. Three components of the composite fluid may be separated therefrom by the present system and two components may be moved to the collection containers. The container set may further include a third collection container connected to the separation container by a tube, and a third component may thus be moved to this third container.Type: ApplicationFiled: August 25, 2003Publication date: June 3, 2004Applicant: Gambro, Inc.Inventors: Brian M. Holmes, Johan-Petter Hagstrom, Per-Olov Lundberg, Geert Van Waeg, Peter Nordgren
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Publication number: 20040026341Abstract: A system and method are used in connection with processing of blood components. The processing of blood components may involve centrifugal separation and/or filtering of the blood components. In some examples, at least some blood components are centrifugally separated in a chamber and then filtered via a filter rotating along with a centrifuge rotor, wherein the filter is located closer than the chamber to an axis of rotation of the rotor. The filter may include a porous filtration medium configured to filter leukocytes, platelets, and/or red blood cells. Some examples include a pressure sensor sensing pressure of pumped blood components. The sensed pressure may be used in connection with controlling the pumping of the blood products and/or in connection with determining the location of an interface associated with the blood products. Other uses of the sensed pressure are also possible.Type: ApplicationFiled: April 16, 2003Publication date: February 12, 2004Inventors: Niclas Hogberg, Emanuel Hallgren, Peter Pihlstedt, Brian M. Holmes, Lars Persson, Lars Strandberg, Geert Van Waeg, Frank Corbin
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Publication number: 20030195455Abstract: An extracorporeal blood processing system is disclosed which includes a variety of novel components and which may be operated in accordance with a variety of novel methodologies. For instance, the system includes a graphical operator interface which directs the operator through various aspects of the apheresis procedure. Moreover, the system also includes a variety of features relating to loading a blood processing vessel into a blood processing channel and removing the same after completion of the procedure. Furthermore, the system also includes a variety of features relating to utilizing a blood priming of at least portions of the apheresis system in preparation for the procedure. In addition, the system includes a variety of features enhancing the performance of the apheresis system, including the interrelationship between the blood processing vessel and the blood processing vessel and the utilization of high packing factors for the procedure.Type: ApplicationFiled: April 3, 2003Publication date: October 16, 2003Applicant: Gambro, Inc.Inventors: Marlene Adele Bainbridge, Brian M. Holmes
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Patent number: 6613009Abstract: An extracorporeal blood processing system is disclosed which includes a variety of novel components and which may be operated in accordance with a variety of novel methodologies. For instance, the system includes a graphical operator interface which directs the operator through various aspects of the apheresis procedure. Moreover, the system also includes a variety of features relating to loading a blood processing vessel into a blood processing channel and removing the same after completion of the procedure. Furthermore, the system also includes a variety of features relating to utilizing a blood priming of at least portions of the apheresis system in preparation for the procedure. In addition, the system includes a variety of features enhancing the performance of the apheresis system, including the interrelationship between the blood processing vessel and the blood processing vessel and the utilization of high packing factors for the procedure.Type: GrantFiled: August 19, 1997Date of Patent: September 2, 2003Assignee: Gambro, Inc.Inventors: Marlene Adele Bainbridge, Brian M. Holmes
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Patent number: 6231537Abstract: An extracorporeal blood processing system is disclosed which includes a variety of novel components and which may be operated in accordance with a variety of novel methodologies. For instance, the system includes a graphical operator interface which directs the operator through various aspects of the apheresis procedure. Moreover, the system also includes a variety of features relating to loading a blood processing vessel into a blood processing channel and removing the same after completion of the procedure. Furthermore, the system also includes a variety of features relating to utilizing a blood priming of at least portions of the apheresis system in preparation for the procedure. In addition, the system includes a variety of features enhancing the performance of the apheresis system, including the interrelationship between the blood processing vessel and the blood processing vessel and the utilization of high packing factors for the procedure.Type: GrantFiled: January 21, 1998Date of Patent: May 15, 2001Assignee: Gambro, Inc.Inventors: Brian M. Holmes, Jeffrey J. Blakeslee, Marlene Adele Bainbridge, Frank Corbin, III
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Patent number: 6196987Abstract: An extracorporeal blood processing system is disclosed which includes a variety of novel components and which may be operated in accordance with a variety of novel methodologies. For instance, the system includes a graphical operator interface which directs the operator through various aspects of the apheresis procedure. Moreover, the system also includes a variety of features relating to loading a blood processing vessel into a blood processing channel and removing the same after completion of the procedure. Furthermore, the system also includes a variety of features relating to utilizing a blood priming of at least portions of the apheresis system in preparation for the procedure. In addition, the system includes a variety of features enhancing the performance of the apheresis system, including the interrelationship between the blood processing vessel and the blood processing vessel and the utilization of high packing factors for the procedure.Type: GrantFiled: March 30, 1998Date of Patent: March 6, 2001Assignee: Gambro, Inc.Inventors: Brian M. Holmes, Jeffrey J. Blakeslee, Marlene Adele Bainbridge
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Patent number: 6179801Abstract: An extracorporeal blood processing system is disclosed which includes a variety of novel components and which may be operated in accordance with a variety of novel methodologies. For instance, the system includes a graphical operator interface which directs the operator through various aspects of the apheresis procedure. Moreover, the system also includes a variety of features relating to loading a blood processing vessel into a blood processing channel and removing the same after completion of the procedure. Furthermore, the system also includes a variety of features relating to utilizing a blood priming of at least portions of the apheresis system in preparation for the procedure. In addition, the system includes a variety of features enhancing the performance of the apheresis system, including the interrelationship between the blood processing vessel and the blood processing vessel and the utilization of high packing factors for the procedure.Type: GrantFiled: January 21, 1998Date of Patent: January 30, 2001Assignee: Gambro, Inc.Inventors: Brian M. Holmes, Jeffrey J. Blakeslee, Marlene Adele Bainbridge, Frank Corbin, III
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Patent number: 6129656Abstract: An extracorporeal blood processing system is disclosed which includes a variety of novel components and which may be operated in accordance with a variety of novel methodologies. For instance, the system includes a graphical operator interface which directs the operator through various aspects of the apheresis procedure. Moreover, the system also includes a variety of features relating to loading a blood processing vessel into a blood processing channel and removing the same after completion of the procedure. Furthermore, the system also includes a variety of features relating to utilizing a blood priming of at least portions of the apheresis system in preparation for the procedure. In addition, the system includes a variety of features enhancing the performance of the apheresis system, including the interrelationship between the blood processing vessel and the blood processing vessel and the utilization of high packing factors for the procedure.Type: GrantFiled: October 24, 1997Date of Patent: October 10, 2000Assignee: Cobe Laboratories, Inc.Inventors: Jeffrey J. Blakeslee, Brian M. Holmes, Victor D. Dolecek
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Patent number: 5837150Abstract: A method for processing blood in an apheresis system is disclosed. The present invention includes selecting a packing factor for separated blood component types in the separation stage(s) of a blood processing vessel. A packing factor is a number that reflects the degree with which the blood component types are packed together in the separation stage(s) and is dependent at least upon the rotational speed and the flow rate into the blood processing vessel. The method further includes providing an apheresis system and operating it under conditions to separate the blood into a plurality of blood component types and achieve the selected packing factor.Type: GrantFiled: June 7, 1995Date of Patent: November 17, 1998Assignee: COBE Laboratories, Inc.Inventors: Robert W. Langley, Brian M. Holmes, Marlene Adele Bainbridge
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Patent number: 5750025Abstract: An extracorporeal blood processing system is disclosed which includes a disposable for an apheresis system. The disposable can include a blood processing vessel and a contoured support. The blood processing vessel includes sidewalls to define the vessel and a blood inlet port and a blood component outlet port. The support is provided proximate to the blood component outlet port and exteriorly relative to the fluid-containing volume of the blood processing vessel. The support may be contoured to direct the desired blood component types(s) toward the blood component outlet port and is in an overlapping relation with the exterior surface of the blood processing vessel. The support and part of an adjacent channel wall collectively define a generally funnel-shaped collect well that collects blood components flowing thereby.Type: GrantFiled: June 7, 1995Date of Patent: May 12, 1998Assignee: Cobe Laboratories, Inc.Inventors: Brian M. Holmes, Jeffrey J. Blakeslee, Victor D. Dolecek
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Patent number: 5738644Abstract: An extracorporeal blood processing system is disclosed which includes a variety of novel components and which may be operated in accordance with a variety of novel methodologies. For instance, the system includes a graphical operator interface which directs the operator through various aspects of the apheresis procedure. Moreover, the system also includes a variety of features relating to loading a blood processing vessel into a blood processing channel and removing the same after completion of the procedure. Furthermore, the system also includes a variety of features relating to utilizing a blood priming of at least portions of the apheresis system in preparation for the procedure. In addition, the system includes a variety of features enhancing the performance of the apheresis system, including the interrelationship between the blood processing vessel and the blood processing vessel and the utilization of high packing factors for the procedure.Type: GrantFiled: June 7, 1995Date of Patent: April 14, 1998Assignee: Cobe Laboratories, Inc.Inventors: Brian M. Holmes, Jeffrey J. Blakeslee, Marlene Adele Bainbridge, Frank Corbin, III
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Patent number: 5720716Abstract: An extracorporeal blood processing system is disclosed which includes a variety of novel components and which may be operated in accordance with a variety of novel methodologies. For instance, the system includes a graphical operator interface which directs the operator through various aspects of the apheresis procedure. Moreover, the system also includes a variety of features relating to loading a blood processing vessel into a blood processing channel and removing the same after completion of the procedure. Furthermore, the system also includes a variety of features relating to utilizing a blood priming of at least portions of the apheresis system in preparation for the procedure. In addition, the system includes a variety of features enhancing the performance of the apheresis system, including the interrelationship between the blood processing vessel and the blood processing vessel and the utilization of high packing factors for the procedure.Type: GrantFiled: June 7, 1995Date of Patent: February 24, 1998Assignee: Cobe Laboratories, Inc.Inventors: Jeffrey J. Blakeslee, Brian M. Holmes, Victor D. Dolecek
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Patent number: 5702357Abstract: An extracorpeal blood processing system is disclosed which includes a variety of novel components and which may be operated in accordance with a variety of novel methodologies. For instance, the system includes a graphical operator interface which directs the operator through various aspects of the apheresis procedure. Moreover, the system also includes a variety of features relating to loading a blood processing vessel into a blood processing channel and removing the same after completion of the procedure. Furthermore, the system also includes a variety of features relating to utilizing a blood priming of at least portions of the apheresis system in preparation for the procedure. In addition, the system includes a variety of features enhancing the performance of the apheresis system, including the interrelationship between the blood processing vessel and the blood processing vessel and the utilization of high packing factors for the procedure.Type: GrantFiled: June 7, 1995Date of Patent: December 30, 1997Assignee: Cobe Laboratories, Inc.Inventors: Marlene Adele Bainbridge, Brian M. Holmes
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Patent number: 4810090Abstract: Monitoring concentration of components of blood flowing through a flowpath including flowing the components through a transparent channel, directing light to the channel along an axis intersecting the channel, detecting light passing through the channel along the axis, detecting light scattered off of the axis, and determining concentration of components based on the light passing along the axis and/or the light scattered off of the axis. Also disclosed is a movable cover to block ambient light from a photodetector after mounting of a removable transparent flow channel.Type: GrantFiled: August 24, 1987Date of Patent: March 7, 1989Assignee: Cobe Laboratories, Inc.Inventors: Terry D. Boucher, Brian M. Holmes