Patents by Inventor Brian McGonigle

Brian McGonigle has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190071690
    Abstract: Methods and compositions are provided which employ a silencing element that, when ingested by a pest, such as a Pentatomidae plant pest, decrease the expression of a target sequence in the pest. The present invention provides various target polynucleotides set forth in any one of SEQ ID NOS: 6-12, 18-40 or active variants and fragments thereof, wherein a decrease in expression of one or more the sequences in the target pest controls the pest (i.e., has insecticidal activity). Plants, plant part, bacteria and other host cells comprising the silencing elements or an active variant or fragment thereof of the invention are also provided.
    Type: Application
    Filed: November 16, 2018
    Publication date: March 7, 2019
    Applicant: E. I. DU PONT DE NEMOURS AND COMPANY
    Inventors: Brian McGonigle, James Kevin Presnail, Navdeep Mutti
  • Patent number: 10190134
    Abstract: Methods and compositions are provided which employ a silencing element that, when ingested by a pest, such as a Pentatomidae plant pest, decrease the expression of a target sequence in the pest. The present invention provides various target polynucleotides set forth in any one of SEQ ID NOS: 6-12, 18-40 or active variants and fragments thereof, wherein a decrease in expression of one or more the sequences in the target pest controls the pest (i.e., has insecticidal activity). Plants, plant part, bacteria and other host cells comprising the silencing elements or an active variant or fragment thereof of the invention are also provided.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: January 29, 2019
    Assignee: E I DU PONT DE NEMOURS AND COMPANY
    Inventors: Brian McGonigle, James Kevin Presnail, Navdeep Singh Mutti
  • Publication number: 20180030472
    Abstract: Methods and compositions are provided which employ a silencing element that, when ingested by a pest, such as a Pentatomidae plant pest or a N. viridula, Acrosternum hilare, Piezodorus guildini, and/or Halymorpha halys plant pest, decrease the expression of a target sequence in the pest. In specific embodiments, the decrease in expression of the target sequence controls the pest and thereby the methods and compositions are capable of limiting damage to a plant. The present invention provides various target polynucleotides set forth in any one of SEQ ID NOS: 1-292 or 302-304 or active variants and fragments thereof, wherein a decrease in expression of one or more the sequences in the target pest controls the pest (i.e., has insecticidal activity). Further provided are silencing elements which when ingested by the pest decrease the level of the target polypeptide and thereby control the pest. In specific embodiment, the pest is Pentatomidae.
    Type: Application
    Filed: October 11, 2017
    Publication date: February 1, 2018
    Applicants: PIONEER HI-BRED INTERNATIONAL, INC., E. I. DU PONT DE NEMOURS AND COMPANY
    Inventors: KAREN E. BROGLIE, DAVID CHARLES CERF, RAFAEL HERRMANN, ALBERT L. LU, BRIAN MCGONIGLE, JAMES KEVIN PRESNAIL
  • Patent number: 9816105
    Abstract: Methods and compositions are provided which employ a silencing element that, when ingested by a pest, such as a Pentatomidae plant pest or a N. viridula, Acrosternum hilare, Piezodorus guildini, and/or Halymorpha halys plant pest, decrease the expression of a target sequence in the pest. In specific embodiments, the decrease in expression of the target sequence controls the pest and thereby the methods and compositions are capable of limiting damage to a plant. The present invention provides various target polynucleotides set forth in any one of SEQ ID NOS: 1-292 or 302-304 or active variants and fragments thereof, wherein a decrease in expression of one or more the sequences in the target pest controls the pest (i.e., has insecticidal activity). Further provided are silencing elements which when ingested by the pest decrease the level of the target polypeptide and thereby control the pest. In specific embodiment, the pest is Pentatomidae.
    Type: Grant
    Filed: October 28, 2014
    Date of Patent: November 14, 2017
    Assignees: PIONEER HI-BRED INTERNATIONAL, INC., E. I. DU PONT DE NEMOURS AND COMPANY
    Inventors: Karen E. Broglie, David Charles Cerf, Rafael Herrmann, Albert L. Lu, Brian McGonigle, James Kevin Presnail
  • Patent number: 9719102
    Abstract: Methods and compositions are provided which allow for a single microRNA (miRNA) to reduce the level of expression of at least two members of the same protein and/or gene family. While a single 21 base pair miRNA can cause cleavage of a variety of species of mRNAs, an entire gene family cannot be silenced unless that gene family shares near identity within a 21 base pair region that is also able to be cleaved by a single miRNA. In certain embodiments, all members of a given protein and/or gene family can be suppressed with a miRNA expression construct disclosed herein even if they do not share near identity within a 21 base pair region that is also able to function as a miRNA. Such methods and compositions employ miRNA expression constructs having a structure such that the most abundant form of miRNA produced from the construct is a 22-nucleotide miRNA.
    Type: Grant
    Filed: May 20, 2015
    Date of Patent: August 1, 2017
    Assignee: E I DU PONT DE NEMOURS AND COMPANY
    Inventor: Brian McGonigle
  • Publication number: 20170122802
    Abstract: Various implementations relate generally to multi-sensor devices. Some implementations more particularly relate to a multi-sensor device including a ring of radially-oriented photosensors. Some implementations more particularly relate to a multi-sensor device that is orientation-independent with respect to a central axis of the ring. Some implementations of the multi-sensor devices described herein further include one or more additional sensors. For example, some implementations include an axially-directed photosensor. Some implementations also can include one or more temperature sensors configured to sense an exterior temperature, for example, an ambient temperature of an outdoors environment around the multi-sensor. Additionally or alternatively, some implementations include one or more of an infrared sensor or infrared sensors, a cellular communication circuit, and a GPS module.
    Type: Application
    Filed: October 6, 2016
    Publication date: May 4, 2017
    Inventors: Stephen Clark Brown, Dhairya Shrivastava, Jason Zedlitz, Trevor Frank, Jenny Wang, Brian McGonigle, Alexander Rumer, Dennis Mullins, Kevin Kazuo Kaneshiro
  • Publication number: 20170097259
    Abstract: Various implementations relate generally to a multi-sensor device. Some implementations more particularly relate to a multi-sensor device including a ring of radially-oriented photosensors. Some implementations more particularly relate to a multi-sensor device that is orientation-independent with respect to a central axis of the ring. Some implementations of the multi-sensor devices described herein also include one or more additional sensors. For example, some implementations include an axially-directed photosensor. Some implementations also can include one or more temperature sensors configured to sense an exterior temperature, for example, an ambient temperature of an outdoors environment around the multi-sensor. Additionally or alternatively, some implementations can include a temperature sensor configured to sense an interior temperature within the multi-sensor device. Particular implementations provide, characterize, or enable a compact form factor.
    Type: Application
    Filed: October 6, 2015
    Publication date: April 6, 2017
    Inventors: STEPHEN C. BROWN, Dhairya Shrivastava, Jason Zedlitz, Trevor Frank, Jenny Wang, Brian McGonigle, Alex Rumer, Dennis Mullins
  • Patent number: 9598701
    Abstract: Isolated nucleic acid fragments comprising precursor miRNAs, and artificial miRNAs and their use in down-regulating gene expression of fatty acid biosynthetic genes are described.
    Type: Grant
    Filed: January 23, 2013
    Date of Patent: March 21, 2017
    Assignee: E I DU PONT DE NEMOURS AND COMPANY
    Inventors: Howard Glenn Damude, Brian McGonigle
  • Patent number: 9574204
    Abstract: This invention is in the field of plant molecular biology. More specifically, this invention pertains to isolated nucleic acid fragments encoding PAE or PAE-Like proteins in plants and seeds and the use of such fragments to modulate expression of a gene encoding PAE or PAE-Like protein activity in a transformed host cell.
    Type: Grant
    Filed: June 29, 2011
    Date of Patent: February 21, 2017
    Assignee: E I DUPONT DE NEMOURS AND COMPANY
    Inventors: Knut Meyer, Brian McGonigle, Kevin L Stecca
  • Patent number: 9546374
    Abstract: Isolated nucleic acid fragments comprising precursor miRNAs, and artificial miRNAs and their use in down-regulating gene expression are described.
    Type: Grant
    Filed: December 11, 2014
    Date of Patent: January 17, 2017
    Assignee: E I DU PONT DE NEMOURS AND COMPANY
    Inventor: Brian McGonigle
  • Publication number: 20160152995
    Abstract: Compositions and methods are provided which employ a chemical-gene switch which may comprise at least three components. The first component comprises a polynucleotide encoding a chemically-regulated transcriptional repressor; the second component comprises a repressible promoter operably linked to a polynucleotide of interest, and the third component comprises a gene silencing construct operably linked to a second repressible promoter, wherein the gene silencing construct encodes a silencing element that decreases the level of mRNA encoding the chemically-regulated transcriptional repressor. Expression of the polynucleotide of interest and the silencing construct is controlled by providing the appropriate chemical ligand. Transient induction from the chemical ligand leads to the production of the silencing element, and the destruction of the mRNA encoding the chemically-regulated transcriptional repressor.
    Type: Application
    Filed: March 11, 2014
    Publication date: June 2, 2016
    Inventors: Kevin E. McBride, Brian McGonigle, Narendra S. Yadav
  • Publication number: 20160108425
    Abstract: Methods and compositions are provided which employ a silencing element that, when ingested by a pest, such as a Pentatomidae plant pest, decrease the expression of a target sequence in the pest. The present invention provides various target polynucleotides set forth in any one of SEQ ID NOS: 6-12, 18-40 or active variants and fragments thereof, wherein a decrease in expression of one or more the sequences in the target pest controls the pest (i.e., has insecticidal activity). Plants, plant part, bacteria and other host cells comprising the silencing elements or an active variant or fragment thereof of the invention are also provided.
    Type: Application
    Filed: March 13, 2014
    Publication date: April 21, 2016
    Inventors: BRIAN MCGONIGLE, JAMES KEVIN PRESNAIL, NAVDEEP SINGH MUTTI
  • Publication number: 20160060304
    Abstract: Compositions and methods relating to the use of sulfonylurea-responsive repressors are provided. Compositions include polypeptides that specifically bind to an operator, wherein the specific binding is regulated by a sulfonylurea compound. Compositions also include polynucleotides encoding the polypeptides as well as constructs, vectors, prokaryotic and eukaryotic cells, and eukaryotic organisms including plants and seeds comprising the polynucleotide, and/or produced by the methods. Also provided are methods to provide a sulfonylurea-responsive repressor to a cell or organism, and to regulate expression of a polynucleotide of interest in a cell or organism, including a plant or plant cell.
    Type: Application
    Filed: November 13, 2015
    Publication date: March 3, 2016
    Inventors: MICHAEL LASSNER, Loren L. Looger, Kevin E. McBride, Brian McGonigle
  • Publication number: 20160032307
    Abstract: The present disclosure provides methods and compositions for modifying fatty acids in Camelina sativa oil. Fatty Acid Desaturase 2 (FAD2), Fatty Acid Desaturase 3 (FADS), and/or Fatty Acid Elongase 1 (FAE1) genes regulate fatty acid composition in camelina oil.
    Type: Application
    Filed: May 6, 2015
    Publication date: February 4, 2016
    Inventors: Debra M. PUTTICK, Andrea T. TODD, Carlene T. SARVAS, Howard G. DAMUDE, Brian MCGONIGLE
  • Publication number: 20160024518
    Abstract: Disclosed herein are methods for reducing the expression of target nucleotide sequences using microRNAs. Also disclosed herein are recombinant DNA constructs comprising nucleotide sequences encoding such microRNAs. Plants or plant part thereof comprising these recombinant DNA constructs and microRNAs are also provided.
    Type: Application
    Filed: March 13, 2014
    Publication date: January 28, 2016
    Inventor: BRIAN MCGONIGLE
  • Patent number: 9206432
    Abstract: Compositions and methods relating to the use of sulfonylurea-responsive repressors are provided. Compositions include polypeptides that specifically bind to an operator, wherein the specific binding is regulated by a sulfonylurea compound. Compositions also include polynucleotides encoding the polypeptides as well as constructs, vectors, prokaryotic and eukaryotic cells, and eukaryotic organisms including plants and seeds comprising the polynucleotide, and/or produced by the methods. Also provided are methods to provide a sulfonylurea-responsive repressor to a cell or organism, and to regulate expression of a polynucleotide of interest in a cell or organism, including a plant or plant cell.
    Type: Grant
    Filed: March 6, 2015
    Date of Patent: December 8, 2015
    Assignees: E I DU PONT DE NEMOURS AND COMPANY, PIONEER HI-BRED INTERNATIONAL INC
    Inventors: Michael Lassner, Loren L Looger, Kevin E McBride, Brian McGonigle
  • Patent number: 9150874
    Abstract: Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding delta-9 elongases along with a method of making long-chain polyunsaturated fatty acids (PUFAs) using these delta-9 elongases in plants.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: October 6, 2015
    Assignee: E I DU PONT DE NEMOURS AND COMPANY
    Inventors: Howard Glenn Damude, Brian McGonigle, Quinn Qun Zhu, Zhixiong Xue
  • Publication number: 20150252376
    Abstract: Methods and compositions are provided which allow for a single microRNA (miRNA) to reduce the level of expression of at least two members of the same protein and/or gene family. While a single 21 base pair miRNA can cause cleavage of a variety of species of mRNAs, an entire gene family cannot be silenced unless that gene family shares near identity within a 21 base pair region that is also able to be cleaved by a single miRNA. In certain embodiments, all members of a given protein and/or gene family can be suppressed with a miRNA expression construct disclosed herein even if they do not share near identity within a 21 base pair region that is also able to function as a miRNA. Such methods and compositions employ miRNA expression constructs having a structure such that the most abundant form of miRNA produced from the construct is a 22-nucleotide miRNA.
    Type: Application
    Filed: May 20, 2015
    Publication date: September 10, 2015
    Inventor: BRIAN MCGONIGLE
  • Publication number: 20150240253
    Abstract: The invention provides methods and compositions useful in altering gene expression. The invention provides polynucleotide constructs comprising useful for altering gene expression, as well as cells, plants and seeds comprising the polynucleotides. The invention also provides methods for using lincRNAs to alter gene expression.
    Type: Application
    Filed: August 28, 2013
    Publication date: August 27, 2015
    Inventors: Brian McGonigle, Thomas D. Moloshok
  • Publication number: 20150184169
    Abstract: Compositions and methods relating to the use of sulfonylurea-responsive repressors are provided. Compositions include polypeptides that specifically bind to an operator, wherein the specific binding is regulated by a sulfonylurea compound. Compositions also include polynucleotides encoding the polypeptides as well as constructs, vectors, prokaryotic and eukaryotic cells, and eukaryotic organisms including plants and seeds comprising the polynucleotide, and/or produced by the methods. Also provided are methods to provide a sulfonylurea-responsive repressor to a cell or organism, and to regulate expression of a polynucleotide of interest in a cell or organism, including a plant or plant cell.
    Type: Application
    Filed: March 6, 2015
    Publication date: July 2, 2015
    Inventors: MICHAEL LASSNER, Loren L Looger, Kevin E McBride, Brian McGonigle