Patents by Inventor Brian McGonigle

Brian McGonigle has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20100075387
    Abstract: The present invention relates to ?9 elongases, which have the ability to convert linoleic acid [18:2, LA] to eicosadienoic acid [20:2, EDA]. Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding ?9 elongase along with methods of making long-chain polyunsaturated fatty acids (PUFAs) using these ?9 elongases in plants and oleaginous yeast are disclosed.
    Type: Application
    Filed: November 17, 2009
    Publication date: March 25, 2010
    Applicant: E. I. DU PONT DE NEMOURS AND COMPANY
    Inventors: HOWARD GLENN DAMUDE, BRIAN MCGONIGLE, ZHIXIONG XUE, QUINN QUN ZHU
  • Patent number: 7645604
    Abstract: The present invention relates to ?9 elongases, which have the ability to convert linoleic acid [18:2, LA] to eicosadienoic acid [20:2, EDA]. Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding ?9 elongase along with methods of making long-chain polyunsaturated fatty acids (PUFAs) using these ?9 elongases in plants and oleaginous yeast are disclosed.
    Type: Grant
    Filed: November 16, 2006
    Date of Patent: January 12, 2010
    Assignee: E.I. Du Pont de Nemours and Company
    Inventors: Howard Glenn Damude, Brian McGonigle, Zhixiong Xue, Quinn Qun Zhu
  • Publication number: 20090320161
    Abstract: Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding novel delta-9 elongases along with a method of making long-chain polyunsaturated fatty acids (PUFAs) using these delta-9 elongases in plants.
    Type: Application
    Filed: June 19, 2009
    Publication date: December 24, 2009
    Applicant: E.I. DU PONT DE NEMOURS AND COMPANY
    Inventors: Brian McGonigle, Anthony J. Kinney, Howard Glenn Damude
  • Publication number: 20090155909
    Abstract: Isolated nucleic acid fragments comprising precursor miRNA, and artificial miRNAs and their use in down-regulating gene expression are described.
    Type: Application
    Filed: December 16, 2008
    Publication date: June 18, 2009
    Inventor: Brian McGonigle
  • Publication number: 20090155910
    Abstract: Isolated nucleic acid fragments comprising precursor miRNAs, and artificial miRNAs and their use in down-regulating gene expression are described.
    Type: Application
    Filed: December 16, 2008
    Publication date: June 18, 2009
    Inventor: Brian McGonigle
  • Publication number: 20090119795
    Abstract: Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding delta-9 elongases along with a method of making long-chain polyunsaturated fatty acids (PUFAs) using these delta-9 elongases in plants.
    Type: Application
    Filed: November 16, 2006
    Publication date: May 7, 2009
    Inventors: Howard Glenn Damude, Brian McGonigle, Quinn Qun Zhu, Zhixiong Xue
  • Publication number: 20080276333
    Abstract: Recombinant constructs useful for reducing the expression of at least one target nucleic acid fragment of interest and any substantially similar endogenous nucleic acid fragment of interest are disclosed. In particular, a recombinant construct comprising at least one nucleic acid of interest is inserted between two convergent promoters. A plant or plant organ stably transformed with this construct will have a reduction in expression of the target nucleic acid fragments of interest.
    Type: Application
    Filed: June 9, 2005
    Publication date: November 6, 2008
    Inventors: Brian McGonigle, Johan M. Stoop
  • Patent number: 7323621
    Abstract: This invention pertains to methods for decreasing the ratio of liquiritigenin-derived isoflavones relative to total isoflavone levels in isoflavonoid-producing plants and plant parts by transforming plants with a recombinant DNA construct comprising a nucleic acid sequence of at least 200 nucleotides and having at least 75% sequence identity to a polynucleotide encoding a chalcone reductase. More preferably, this invention pertains to methods for decreasing the ratios of daidzein and glycitein and their conjugates relative to total isoflavone levels in soybean plants and soybean plant parts by transforming plants with a recombinant DNA construct comprising a nucleic acid sequence of at least 200 nucleotides and having at least 75% sequence identity to a polynucleotide encoding a chalcone reductase.
    Type: Grant
    Filed: December 11, 2003
    Date of Patent: January 29, 2008
    Assignee: E.I. du Pont de Nemours and Company
    Inventor: Brian McGonigle
  • Publication number: 20070118929
    Abstract: Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding delta-9 elongases along with a method of making long-chain polyunsaturated fatty acids (PUFAs) using these delta-9 elongases in plants.
    Type: Application
    Filed: November 16, 2006
    Publication date: May 24, 2007
    Inventors: Howard Damude, Brian McGonigle, Quinn Zhu, Zhixiong Xue
  • Publication number: 20070117190
    Abstract: The present invention relates to ?9 elongases, which have the ability to convert linoleic acid [18:2, LA] to eicosadienoic acid [20:2, EDA]. Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding ?9 elongase along with methods of making long-chain polyunsaturated fatty acids (PUFAs) using these ?9 elongases in plants and oleaginous yeast are disclosed.
    Type: Application
    Filed: November 16, 2006
    Publication date: May 24, 2007
    Inventors: Howard Damude, Brian McGonigle, Zhixiong Xue, Quinn Zhu
  • Publication number: 20070107081
    Abstract: This invention is in the field of plant molecular biology. More specifically, this invention pertains to compositions having increased levels of at least one phytosterol, said compositions being obtained from plants or plant parts, and methods thereof. The plants may have decreased levels of triterpene saponins. The plants or plant parts may comprise at least one recombinant DNA molecule comprising a promoter operably linked to at least a portion of at least one polynucleotide from at least one oxidosqualene cyclase gene, said recombinant DNA molecule sufficient to increase the production of at least one phytosterol; or any progeny of said plant, wherein said progeny comprise said recombinant DNA molecule. Compositions, oils, as well as food and feed products obtained from or prepared with said compositions are also part of the invention.
    Type: Application
    Filed: November 7, 2006
    Publication date: May 10, 2007
    Inventors: Brian McGonigle, Carl Maxwell, Aideen Hession
  • Patent number: 7202398
    Abstract: An isolated nucleic acid fragment encoding a chalcone isomerase is disclosed. Also of concern is the synthesis of a recombinant DNA construct encoding all or a portion of the chalcone isomerase, in sense or antisense orientation, wherein expression of the recombinant DNA construct results in production of altered levels of the chalcone isomerase in a transformed host cell.
    Type: Grant
    Filed: August 15, 2003
    Date of Patent: April 10, 2007
    Assignee: E. I. du Pont de Nemours and Company
    Inventor: Brian McGonigle
  • Patent number: 7189895
    Abstract: This invention pertains to methods of increasing isoflavonoid production in isoflavonoid-producing plants by transforming plants with at least one construct expressing at least a portion of a flavanone 3-hydroxylase, a C1 myb transcription factor, and an R-type myc transcription factor that regulate expression of genes in the phenylpropanoid pathway.
    Type: Grant
    Filed: June 11, 2003
    Date of Patent: March 13, 2007
    Assignee: E. I. du Pont de Nemours and Company
    Inventors: Brian McGonigle, Joan T. Odell
  • Publication number: 20070016982
    Abstract: The invention relates to plants with increased levels of triterpene saponins. The plant may have an increased activity of at least one oxidosqualene cyclase that catalyzes the cyclization of 2,3-oxidosqualene to form a cyclyzed triterpene. The plant may be transformed with at least one recombinant DNA molecule comprising a promoter operably linked to at least one polynucleotide encoding an oxidosqualene cyclase, said recombinant DNA molecule sufficient to increase production of a triterpene saponin; or any progeny of said plant, wherein said progeny comprise said recombinant DNA molecule.
    Type: Application
    Filed: July 12, 2006
    Publication date: January 18, 2007
    Inventors: Carl Maxwell, Brian McGonigle, Aideen Hession
  • Publication number: 20060277636
    Abstract: This invention relates to an isolated nucleic acid fragment encoding an oxidosqualene cyclase. The invention also relates to the construction of a chimeric gene encoding all or a portion of the isolated polynucleotides of the invention, in sense or antisense orientation, operably linked to a suitable regulatory sequence.
    Type: Application
    Filed: August 8, 2006
    Publication date: December 7, 2006
    Inventors: Gregory Bryan, Brian McGonigle, Carl Maxwell, Susan Potter, Der-Chyan Hwang
  • Patent number: 7135624
    Abstract: This invention relates to an isolated nucleic acid fragment encoding an oxidosqualene cyclase. The invention also relates to the construction of a chimeric gene encoding all or a portion of the isolated polynucleotides of the invention, in sense or antisense orientation, operably linked to a suitable regulatory sequence.
    Type: Grant
    Filed: March 9, 2001
    Date of Patent: November 14, 2006
    Assignee: E. I. du Pont de Nemours and Company
    Inventors: Gregory T. Bryan, Brian McGonigle, Carl A. Maxwell
  • Publication number: 20060242735
    Abstract: This invention relates to an isolated nucleic acid sequence encoding isoflavone synthase. The invention also relates to the construction of chimeric sequences encoding all or a substantial portion of the enzymes, in sense or antisense orientation, wherein expression of the chimeric sequence results in production of altered levels of the enzyme in a transformed host cell.
    Type: Application
    Filed: June 29, 2006
    Publication date: October 26, 2006
    Inventors: Gary Fader, Woosuk Jung, Brian McGonigle, Joan Odell, Xiaodan Yu
  • Patent number: 7098011
    Abstract: This invention relates to an isolated nucleic acid sequence encoding isoflavone synthase. The invention also relates to the construction of chimeric sequences encoding all or a substantial portion of the enzymes, in sense or antisense orientation, wherein expression of the chimeric sequence results in production of altered levels of the enzyme in a transformed host cell.
    Type: Grant
    Filed: January 26, 2000
    Date of Patent: August 29, 2006
    Assignee: E. I. du Pont de Nemours and Company
    Inventors: Gary M. Fader, Woosuk Jung, Brian McGonigle, Joan T. Odell, Xiaodan Yu
  • Publication number: 20060156430
    Abstract: This invention relates to an isolated polynucleotide encoding a cytochrome P450 monooxygenase that in the presence of linoleic acid results in production of 1-octen-3-ol. The invention also relates to the construction of a recombinant DNA construct comprising all or a portion of the polynucleotide encoding the cytochrome P450 monooxygenases of the invention, in sense or antisense orientation, wherein expression of the recombinant DNA construct results in production of altered levels 1-octen-3-ol in a transformed host cell.
    Type: Application
    Filed: January 10, 2006
    Publication date: July 13, 2006
    Inventors: Brian McGonigle, Saverio Falco, John Everard, Nicole Swinson
  • Publication number: 20060041957
    Abstract: Recombinant constructs useful for reducing the expression of at least one target nucleic acid fragment of interest and any substantially similar endogenous nucleic acid fragment of interest are disclosed. In particular, a recombinant construct comprising at least one nucleic acid of interest is inserted between two convergent promoters. A plant or plant organ stably transformed with this construct will have a reduction in expression of the target nucleic acid fragments of interest.
    Type: Application
    Filed: June 9, 2005
    Publication date: February 23, 2006
    Inventors: Brian McGonigle, Johan Stoop