Patents by Inventor Brian McGonigle

Brian McGonigle has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20060031961
    Abstract: This invention relates to an isolated polynucleotide encoding an aldehyde reductase enzyme. The invention also relates to the construction of a recombinant construct encoding an aldehyde reductase enzyme wherein expression of the recombinant construct results in production of altered levels of aldehyde reductase enzyme in a transformed host cell. The present invention also concerns soybean products made from seeds obtained from soybean plants transformed with this recombinant construct wherein such seeds having increased aldehyde reductase activity.
    Type: Application
    Filed: August 5, 2005
    Publication date: February 9, 2006
    Inventors: Brian McGonigle, John Everard, David Nekoukar
  • Publication number: 20060005276
    Abstract: The present invention concerns a transgenic soybean plant producing seed having reduced activity of seed lipoxygenases, when compared to a soybean plant expressing wild type activity of native seed lipoxygenases, the transgenic soybean plant having a nucleic acid fragment from at least a portion of at least one soybean seed lipoxygenase gene, wherein the nucleic acid fragment is capable of suppressing expression of native seed lipoxygenases and has been introduced into the soybean plant by transformation.
    Type: Application
    Filed: March 9, 2005
    Publication date: January 5, 2006
    Inventors: Saverio Falco, Brian McGonigle, Carl Maxwell
  • Publication number: 20050198710
    Abstract: Recombinant constructs for reducing flavonol levels in a flavonol-producing plants are described. Such constructs comprise a promoter operably linked to a stem-loop structure wherein a nucleic acid sequence of at least 200 nucleotides and having at least 75% sequence identity to SEQ ID NO:4 forms part of loop part of the structure. Methods for reducing flavonol levels are also described.
    Type: Application
    Filed: April 7, 2004
    Publication date: September 8, 2005
    Inventors: Brian McGonigle, Carl Maxwell, Aideen Hession
  • Publication number: 20040172674
    Abstract: An isolated nucleic acid fragment encoding a chalcone isomerase is disclosed. Also of concern is the synthesis of a recombinant DNA construct encoding all or a portion of the chalcone isomerase, in sense or antisense orientation, wherein expression of the recombinant DNA construct results in production of altered levels of the chalcone isomerase in a transformed host cell.
    Type: Application
    Filed: August 15, 2003
    Publication date: September 2, 2004
    Inventor: Brian McGonigle
  • Publication number: 20040128714
    Abstract: This invention pertains to methods for decreasing the ratio of liquiritigenin-derived isoflavones relative to total isoflavone levels in isoflavonoid-producing plants and plant parts by transforming plants with a recombinant DNA construct comprising a nucleic acid sequence of at least 200 nucleotides and having at least 75% sequence identity to a polynucleotide encoding a chalcone reductase. More preferably, this invention pertains to methods for decreasing the ratios of daidzein and glycitein and their conjugates relative to total isoflavone levels in soybean plants and soybean plant parts by transforming plants with a recombinant DNA construct comprising a nucleic acid sequence of at least 200 nucleotides and having at least 75% sequence identity to a polynucleotide encoding a chalcone reductase.
    Type: Application
    Filed: December 11, 2003
    Publication date: July 1, 2004
    Inventor: Brian McGonigle
  • Publication number: 20040121439
    Abstract: This invention relates to an isolated nucleic acid fragment encoding a squalene metabolic enzyme. The invention also relates to the construction of a chimeric gene encoding all or a portion of the squalene metabolic enzyme, in sense or antisense orientation, wherein expression of the chimeric gene results in production of altered levels of the squalene metabolic enzyme in a transformed host cell.
    Type: Application
    Filed: June 27, 2003
    Publication date: June 24, 2004
    Inventors: Saverio Carl Falco, Omolayo O. Famodu, William D. Hitz, Anthony J. Kinney, J. Antoni Rafalski, Brian McGonigle, Karin N. Lohman
  • Publication number: 20040010818
    Abstract: This invention relates to the use of recombinant DNA fragments encoding at least a portion of an oxidosqualene cyclase to lower the level of a triterpene in plants and seeds. Plants, plant parts, and seeds with a low level of triterpene are part of the invention. Included are food and feed products obtained from the plants, plant parts, or seeds or the invention.
    Type: Application
    Filed: May 1, 2003
    Publication date: January 15, 2004
    Inventors: Brian McGonigle, Carl A. Maxwell, Aideen O. Hession
  • Publication number: 20040010822
    Abstract: This invention relates to isolated nucleic acid fragments encoding a hydroperoxide lyases, more specifically soybean (Glycine max) hydroperoxide lyases. The invention also relates to the construction of a recombinant DNA construct encoding all or a portion of a hydroperoxide lyase of the present invention, in sense or antisense orientation, wherein expression of the recombinant DNA construct results in production of altered levels of hydroperoxide lyase in a transformed host cell.
    Type: Application
    Filed: May 9, 2003
    Publication date: January 15, 2004
    Inventor: Brian McGonigle
  • Publication number: 20040006795
    Abstract: This invention pertains to methods of increasing isoflavonoid production in isoflavonoid-producing plants by transforming plants with at least one construct expressing at least a portion of a flavanone 3-hydroxylase, a C1 myb transcription factor, and an R-type myc transcription factor that regulate expression of genes in the phenylpropanoid pathway.
    Type: Application
    Filed: June 11, 2003
    Publication date: January 8, 2004
    Inventors: Brian McGonigle, Joan T. Odell
  • Publication number: 20030217384
    Abstract: This invention relates to an isolated nucleic acid fragment encoding a cytochrome P450, more specifically obtusifoliol 14&agr;-demethylase. The invention also relates to the construction of a recombinant DNA construct encoding all or a portion of obtusifoliol 14&agr;-demethylase, in sense or antisense orientation, wherein expression of the recombinant DNA construct results in production of altered levels of obtusifoliol 14&agr;-demethylase in a transformed host cell.
    Type: Application
    Filed: January 23, 2003
    Publication date: November 20, 2003
    Inventors: Leslie T. Harvell, Brian McGonigle, Stephen O. Pember
  • Publication number: 20030208791
    Abstract: This invention relates to an isolated nucleic acid fragment encoding an oxidosqualene cyclase. The invention also relates to the construction of a chimeric gene encoding all or a portion of the isolated polynucleotides of the invention, in sense or antisense orientation, operably linked to a suitable regulatory sequence.
    Type: Application
    Filed: September 9, 2002
    Publication date: November 6, 2003
    Inventors: Gregory T Bryan, Brian McGonigle, Carl A Maxwell, Susan M Potter, Der-Chyan Hwang
  • Patent number: 6545200
    Abstract: This invention relates to an isolated nucleic acid fragment encoding a sterol biosynthetic enzyme. The invention also relates to the construction of a chimeric gene encoding all or a portion of the sterol biosynthetic enzyme, in sense or antisense orientation, wherein expression of the chimeric gene results in production of altered levels of the sterol biosynthetic enzyme in a transformed host cell.
    Type: Grant
    Filed: December 15, 1999
    Date of Patent: April 8, 2003
    Assignee: E. I. du Pont de Nemours and Company
    Inventors: Rebecca E. Cahoon, Omolayo O. Famodu, Brian McGonigle, J. Antoni Rafalski, Hajime Sakai
  • Patent number: 6171839
    Abstract: This invention relates to isolated nucleic acid fragments encoding all or a substantial portion of soybean (Glycine max) glutathione-S-transferase (GST) enzymes involved in the detoxification of xenobiotic compounds in plants and seeds; this invention further relates to isolated GST enzymes. The invention also relates to the construction of chimeric genes encoding all or a substantial portion of soybean GST enzymes, host cells transformed with those genes and methods for the recombinant production of soybean GST enzymes. Methods of constructing transgenic plants having altered levels of GST enzymes and screens for identifying soybean GST enzyme substrates and soybean GST enzyme inhibitors are also provided.
    Type: Grant
    Filed: April 22, 1999
    Date of Patent: January 9, 2001
    Assignee: E. I. du Pont de Nemours & Company
    Inventors: Brian McGonigle, Daniel P. O'Keefe
  • Patent number: 6168954
    Abstract: This invention relates to isolated nucleic acid fragments encoding all or a substantial portion of soybean glutathione-S-transferase (GST) enzymes involved in the detoxification of xenobiotic compounds in plants and seeds. The invention also relates to the construction of chimeric genes encoding all or a substantial portion of soybean GST enzymes, host cells transformed with those genes and methods for the recombinant production of soybean GST enzymes. Methods of constructing transgenic plants having altered levels of GST enzymes and screens for identifying soybean GST enzyme substrates and soybean GST enzyme inhibitors are also provided.
    Type: Grant
    Filed: February 10, 1999
    Date of Patent: January 2, 2001
    Assignee: E. I. du Pont de Nemours & Company
    Inventors: Brian McGonigle, Daniel P. O'Keefe
  • Patent number: 6096504
    Abstract: This invention relates to isolated nucleic acid fragments encoding all or a substantial portion of maize glutathione-S-transferase (GST) enzymes involved in the detoxification of xenobiotic compounds in plants and seeds. The invention also relates to the construction of chimeric genes encoding all or a substantial portion of maize GST enzymes, host cells transformed with those genes and methods of the recombinant production of maize GST enzymes. Methods of constructing transgenic plants having altered levels of GST enzymes and screens for identifying maize GST enzyme substrates and maize GST enzyme inhibitor, are also provided.
    Type: Grant
    Filed: February 10, 1999
    Date of Patent: August 1, 2000
    Assignee: E. I. du Pont Nemours and Company
    Inventors: Brian McGonigle, Daniel P. O'Keefe
  • Patent number: 6063570
    Abstract: This invention relates to isolated nucleic acid fragments encoding all or a substantial portion of soybean glutathione-S-transferase (GST) enzymes involved in the detoxification of xenobiotic compounds in plants and seeds. The invention also relates to the construction of chimeric genes encoding all or a substantial portion of soybean GST enzymes, host cells transformed with those genes and methods for the recombinant production of soybean GST enzymes. Methods of constructing transgenic plants having altered levels of GST enzymes and screens for identifying soybean GST enzyme substrates and soybean GST enzyme inhibitors are also provided.
    Type: Grant
    Filed: September 5, 1997
    Date of Patent: May 16, 2000
    Assignee: E. I. du Pont de Nemours and Company
    Inventors: Brian McGonigle, Daniel P. O'Keefe
  • Patent number: 6054638
    Abstract: This invention relates to the isolation of nucleic acid fragments from soybean that encode ADP ribosylation factor (ARF) protein. This invention also relates to nucleic acid fragments encoding proteins that are capable of conferring herbicide tolerance to chlorimuron-ethyl, a sulfonylurea herbicide. The invention encompasses genetic screens for crop protection chemicals, transgenic plants, and breeding methods.
    Type: Grant
    Filed: December 3, 1997
    Date of Patent: April 25, 2000
    Assignee: E. I. du Pont de Nemours and Company
    Inventors: Brian McGonigle, Daniel P. O'Keefe
  • Patent number: 5962229
    Abstract: This invention relates to isolated nucleic acid fragments encoding all or a substantial portion of maize glutathione-S-transferase (GST) enzymes involved in the detoxification of xenobiotic compounds in plants and seeds. The invention also relates to the construction of chimeric genes encoding all or a substantial portion of maize GST enzymes, host cells transformed with those genes and methods of the recombinant production of maize GST enzymes. Methods of constructing transgenic plants having altered levels of GST enzymes and screens for identifying maize GST enzyme substrates and maize GST enzyme inhibitor, are also provided.
    Type: Grant
    Filed: September 5, 1997
    Date of Patent: October 5, 1999
    Assignee: E.I. du Pont de Nemours and Company
    Inventors: Brian McGonigle, Daniel P. O'Keefe