Abstract: Presented herein are systems and methods related to a scalable and platform-agnostic framework that facilitates the creation of personal genetic profile products. In particular, in certain embodiments, the systems and methods described herein facilitate the creation, storage, organization, and maintenance (e.g. updating) of data corresponding to the relationships between particular variations that may occur in an individual's DNA (e.g. variants of different specific SNPs) and the health-related phenotypes that they influence. The data stored in this manner can be used as a template not only for presenting personal genetic profile assessments to an individual in an informative and user-friendly manner, but also for the rapid, automated creation of personal genetic profile assessments of a plurality of individuals from data corresponding to genotyping measurements of biological samples provided by the individuals.

Abstract: A method of non-rotatably securing a target to a shaft extending along a longitudinal axis within an enclosed proximity switch assembly is described. The target support at least one target magnet and a hub having a body portion extending along the longitudinal axis. The body portion includes an outer surface and a shaft aperture extending along the longitudinal axis, and further includes at least one threaded body aperture extending from the outer surface to the shaft aperture. The shaft is inserted into the shaft aperture, and a set screw is inserted into one of the body apertures. A torque is applied to the set screw to threadably engage the set screw with the one of the body apertures such that a distal end of the set screw contacts an outer surface of the shaft. The set screw is sealed within the body aperture with a high-temperature potting.

Abstract: A method for removing an ionic liquid from an aqueous sample is provided. In some embodiments, the method includes: (a) combining an aqueous sample including an ionic liquid with an ion exchanger composition including an ion exchanger counterion to produce a solution including a fluorous salt of the ionic liquid, where at least one of the ionic liquid and the ion exchanger counterion is fluorinated; (b) contacting the solution with a fluorous affinity material, thereby removing fluorous salt from the solution and producing an aqueous eluate; and (c) collecting the aqueous eluate. In certain embodiments, the method further includes: contacting a cell with an ionic liquid composition to lyse the cell and produce an aqueous sample; and contacting the aqueous sample with a reverse phase substrate, thereby adsorbing proteins and/or lipids of the cell on the substrate. Compositions, kits and systems for practicing the subject methods are also provided.

Abstract: The present invention provides a method for accurately determining the power usage on an unbalanced two phase electrical circuit having both two phase and single phase loads using a single current transformer (CT). The method includes a learning algorithm stored in a memory of a monitoring device, the algorithm configured to be implemented by a processor. The learning algorithm determines whether the CT is monitoring the conductor that supplies the single phase load and alerting the installer if it is not monitoring the conductor supplying the single phase load. Upon determining that the CT is monitoring the conductor that supplies the single phase load the learning algorithm will learn the characteristics of at least the single phase load and store the learned characteristic in a memory associated of the monitoring device.

Abstract: Disclosed herein is a bin that has a first portion configured to hold at least one item therein and an adjustable second portion. The adjustable second portion is configured to couple with the first portion and slide relative to the first portion between a collapsed position and an expanded position. The collapsed position provides a minimum combined height for the first portion and the adjustable second portion in which the adjustable second portion encapsulates the first portion in order for the bin to be placed inside a receptacle. The expanded position provides a maximum combined height for the first portion and the adjustable second portion in order for the bin to interface with a mechanical device for disposing of the at least one item. The bin also includes one or more holding mechanisms for securing the bin in at least one of the collapsed and expanded positions.

Abstract: Provided herein is a method of sample analysis. In certain embodiments, the method comprises: a) cross-linking protein of a cell using a first compound to produce a first cross-linked product comprising cross-linked protein, and RNA; b) contacting the first cross-linked product and a second compound under conditions by which an oligonucleotide portion of the second compound hybridizes to the RNA; c) activating a reaction the first and second compound, thereby covalently crosslinking the oligonucleotide to the cross-linked protein to produce a second cross-linked product; d) isolating the second cross-linked product using an affinity tag; and e) analyzing the isolated second cross-linked product. Compounds for performing the method are also provided.

Abstract: Data storage in a distributed computing system may involve the implementation of key/value stores across multiple storage structures of the distributed computing system, where a key may represent an index and a value may represent an object to store and/or retrieve. A given key/value store may be accessed by multiple compute nodes of the distributed computing system. Duplication and/or versioning may be implemented in or across one or more of the key/value stores.

Abstract: Provided in this disclosure are methods and compositions that find use in a variety of multiplex cellular/tissue section analyses. In certain aspects, a tissue section (or planar cellular slide) is stained with a combination of “visible” labels and “invisible” labels for specific targets of interest. The visible labels are observed to obtain a result and then, based on the result, one or more of the invisible labels are detected, e.g., using digital microscopy.

Abstract: Improvements in an expandable goal net are disclosed. The expandable goal net is foldable and can be taken from a full size goal to a smaller size that can be easily compacted for transportation. The vertical legs telescope inside each other to essentially reduce the height of the vertical members to essentially half. The horizontal cross posts fold in half thereby to compact the expandable goal net into a vertical folded rectangle. The folding joints are on the horizontal members. Joints lock into a horizontal orientation and can be released to allow the joints to fold essentially 180 degrees. Corners use similar hinged joints that allow the horizontal members to bend to essentially 90 degrees. Vertical members have locking slides that telescope to reduce the total length of the vertical members. The expandable goal net is made from aluminum tubes and formed or molded plastic components.

Abstract: A storage receptacle can include a storage bin and a pedal mounted to the receptacle. The pedal can rotate downward when pressure is applied in order to pull on a first cable coupled to the pedal. The first cable is connected to a spring, and the spring is connected to a second cable. The second cable connects the spring to a door via an upper pulley of the receptacle. The second cable causes the door to open when the second cable is pulled based on force applied to the pedal. A bottom pulley can be coupled to the pedal via the first cable and configured to translate an upward pull of the first cable to a downward pull of the spring and second cable. The spring controls the motion of the door such that the door does not open too quickly upon a force being applied to the pedal.

Abstract: Compound tags and shifting agents are provided that find use in ion mobility spectrometry (IMS), mass spectrometry (MS), or a combination of IMS and MS, and which can substantially increase separation of multiple components in complex samples and facilitate quantitative and multiplexed analyses. In some cases, the compounds include a linker and a normalizing group, each including a structural unit and separated by a cleaveable group, and a crown ether. Also provided are methods for analyzing peptides in a sample. In some cases, the method includes coupling the compound to peptides which include a terminal guanidinium moiety capable of forming an intra-molecular complex with the crown ether.

Abstract: Methods and apparatus consistent with the invention provide the ability to organize and build understandings of machine data generated by a variety of information-processing environments. Machine data is a product of information-processing systems (e.g., activity logs, configuration files, messages, database records) and represents the evidence of particular events that have taken place and been recorded in raw data format. In one embodiment, machine data is turned into a machine data web by organizing machine data into events and then linking events together.

Abstract: An assembly is disclosed for sealing the sliding interface between two objects capable of sliding or moving with respect to one another, but where the sliding interface must provide a substantial seal against pressure loss therethrough, such as where an assembly seals the sliding interface between a piston and a cylinder or between a rod and a bushing. The sliding interface includes a seal located in a seal groove, wherein the seal ring height is less than the height of the seal groove and the inner diameter of the seal is greater than the base of the groove. In one aspect, the difference in height is set by a shim and a piece of material of the same height as that of the seal ring.

Abstract: An assembly is disclosed for sealing the sliding interface between two objects capable of sliding or moving with respect to one another, but where the sliding interface must provide a substantial seal against pressure loss therethrough, such as where an assembly seals the sliding interface between a piston and a cylinder or between a rod and a bushing. The sliding interface includes a seal located in a seal groove, wherein the seal ring height is less than the height of the seal groove and the inner diameter of the seal is greater than the base of the groove. In one aspect, the difference in height is set by a shim and a piece of material of the same height as that of the seal ring.

Abstract: Methods and apparatus consistent with the invention provide the ability to organize and build understandings of machine data generated by a variety of information-processing environments. Machine data is a product of information-processing systems (e.g., activity logs, configuration files, messages, database records) and represents the evidence of particular events that have taken place and been recorded in raw data format. In one embodiment, machine data is turned into a machine data web by organizing machine data into events and then linking events together.

Abstract: Systems, methods, and computer-readable storage media for dynamically adjusting nodes in a mesh network embedded in objects. The nodes, which are individually capable of sensing and/or transmitting data, are paired together such that when one node is active, the other node is collecting energy via solar, wind, or other energy collecting means. When a node reaches a certain energy level, the nodes can switch status, such that the passive node becomes active and vice versa. Exemplary objects in which the systems can be embedded include benches, receptacles, and light fixtures.

Abstract: A method for removing an ionic liquid from an aqueous sample is provided. In some embodiments, the method includes: (a) combining an aqueous sample including an ionic liquid with an ion exchanger composition including an ion exchanger counterion to produce a solution including a fluorous salt of the ionic liquid, where at least one of the ionic liquid and the ion exchanger counterion is fluorinated; (b) contacting the solution with a fluorous affinity material, thereby removing fluorous salt from the solution and producing an aqueous eluate; and (c) collecting the aqueous eluate. In certain embodiments, the method further includes: contacting a cell with an ionic liquid composition to lyse the cell and produce an aqueous sample; and contacting the aqueous sample with a reverse phase substrate, thereby adsorbing proteins and/or lipids of the cell on the substrate. Compositions, kits and systems for practicing the subject methods are also provided.

Abstract: An assembly is disclosed for sealing the sliding interface between two objects capable of sliding or moving with respect to one another, but where the sliding interface must provide a substantial seal against pressure loss therethrough, such as where an assembly seals the sliding interface between a piston and a cylinder or between a rod and a bushing. The sliding interface includes a seal located in a seal groove, wherein the seal ring height is less than the height of the seal groove and the inner diameter of the seal is greater than the base of the groove. In one aspect, the difference in height is set by a shim and a piece of material of the same height as that of the seal ring.

Abstract: A system and method for facilitating a financial transaction over a network including use of a passphrase account identifier is described herein. In one embodiment, a system for facilitating a financial transaction over a network comprises a communication interface; and a payment provider system configured to receive via the communication interface a passphrase account identifier from a merchant system, match the passphrase account identifier to a corresponding funding instrument number of a corresponding funding instrument, communicate the corresponding funding instrument number to an issuer system, receive from the issuer system a notification indication of one of acceptance of the funding instrument or decline of the funding instrument, and communicate back to the merchant system the notification indication.

Abstract: Methods and apparatus consistent with the invention provide the ability to organize and build understandings of machine data generated by a variety of information-processing environments. Machine data is a product of information-processing systems (e.g., activity logs, configuration files, messages, database records) and represents the evidence of particular events that have taken place and been recorded in raw data format. In one embodiment, machine data is turned into a machine data web by organizing machine data into events and then linking events together.